Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11301
[ "p65", ",", "p50", ",", "and", "c-Rel", "activities", "were", "found", "in", "both", "CD4-", "and", "CD8-positive", "thymocytes", "." ]
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11302
[ "These", "observations", "suggest", "that", "p65", "and", "c-Rel", "complexes", "play", "distinct", "roles", "in", "gene", "expression", "and", "that", "both", "forms", "of", "NF-kappa", "B", "play", "critical", "roles", "during", "late", "stages", "of", "the", "intrathymic", "maturation", "of", "T", "cells", "." ]
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11303
[ "ALY", ",", "a", "context-dependent", "coactivator", "of", "LEF-1", "and", "AML-1", ",", "is", "required", "for", "TCRalpha", "enhancer", "function", "." ]
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11304
[ "LEF-1", "is", "a", "transcription", "factor", "that", "participates", "in", "the", "regulation", "of", "the", "T-cell", "receptor", "alpha", "(", "TCR", "alpha", ")", "enhancer", "by", "facilitating", "the", "assembly", "of", "multiple", "proteins", "into", "a", "higher", "order", "nucleoprotein", "complex", "." ]
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11305
[ "The", "function", "of", "LEF-1", "is", "dependent", ",", "in", "part", ",", "on", "the", "HMG", "domain", "that", "induces", "a", "sharp", "bend", "in", "the", "DNA", "helix", ",", "and", "on", "an", "activation", "domain", "that", "stimulates", "transcription", "only", "in", "a", "specific", "context", "of", "other", "enhancer-binding", "proteins", "." ]
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11306
[ "With", "the", "aim", "of", "gaining", "insight", "into", "the", "function", "of", "context-dependent", "activation", "domains", ",", "we", "cloned", "ALY", ",", "a", "novel", "LEF-1-interacting", "protein", "." ]
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11307
[ "ALY", "is", "a", "ubiquitously", "expressed", ",", "nuclear", "protein", "that", "specifically", "associates", "with", "the", "activation", "domains", "of", "LEF-1", "and", "AML-1", "(", "CBF", "alpha2", ",", "PEBP2", "alpha", "(", "B", ")", ",", "which", "is", "another", "protein", "component", "of", "the", "TCR", "alpha", "enhancer", "complex", "." ]
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11308
[ "In", "addition", ",", "ALY", "can", "increase", "DNA", "binding", "by", "both", "LEF-1", "and", "AML", "proteins", "." ]
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11309
[ "Overexpression", "of", "ALY", "stimulates", "the", "activity", "of", "the", "TCR", "alpha", "enhancer", "complex", "reconstituted", "in", "transfected", "nonlymphoid", "HeLa", "cells", ",", "whereas", "down-regulation", "of", "ALY", "by", "anti-sense", "oligonucleotides", "virtually", "eliminates", "TCR", "alpha", "enhancer", "activity", "in", "T", "cells", "." ]
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11310
[ "Similar", "to", "LEF-1", ",", "ALY", "can", "stimulate", "transcription", "in", "the", "context", "of", "the", "TCR", "alpha", "enhancer", "but", "apparently", "not", "when", "tethered", "to", "DNA", "through", "an", "heterologous", "DNA-binding", "domain", "." ]
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11311
[ "We", "propose", "that", "ALY", "mediates", "context-dependent", "transcriptional", "activation", "by", "facilitating", "the", "functional", "collaboration", "of", "multiple", "proteins", "in", "the", "TCR", "alpha", "enhancer", "complex", "." ]
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11312
[ "AML1a", "but", "not", "AML1b", "inhibits", "erythroid", "differentiation", "induced", "by", "sodium", "butyrate", "and", "enhances", "the", "megakaryocytic", "differentiation", "of", "K562", "leukemia", "cells", "." ]
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11313
[ "AML1", "may", "play", "a", "role", "in", "growth", "and", "differentiation", "of", "cells", "along", "erythroid", "and/or", "megakaryocytic", "lineages", ",", "because", "a", "significant", "level", "of", "the", "AML1", "gene", "is", "expressed", "in", "these", "cells", "." ]
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11314
[ "We", "overexpressed", "AML1a", "(", "without", "the", "transcription-activating", "domain", ")", "and", "AML1b", "(", "with", "the", "domain", ")", "proteins", "in", "K562", "leukemia", "cells", ",", "which", "can", "be", "induced", "to", "differentiate", "into", "hemoglobin-producing", "cells", "and", "megakaryocytes", "." ]
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11315
[ "The", "AML1a-transfected", "K562", "cells", "had", "a", "reduced", "capacity", "to", "differentiate", "in", "the", "presence", "of", "sodium", "n-butyrate", "but", "not", "in", "the", "presence", "of", "other", "inducers", ",", "such", "as", "hemin", ",", "1-beta-D-arabinofuranosylcytosine", ",", "and", "herbimycin", "A", "." ]
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11316
[ "The", "AML1", "antisense", "oligodeoxynucleotide", "but", "not", "the", "sense", "oligomer", "recovered", "its", "differentiation-inducing", "capacity", "in", "the", "presence", "of", "butyrate", "." ]
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11317
[ "On", "the", "other", "hand", ",", "AML1b", "conferred", "a", "similar", "differentiation-inducing", "capacity", "upon", "K562", "cells", "transfected", "with", "vector", "alone", "." ]
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11318
[ "AML1a", "expression", "was", "associated", "with", "enhanced", "sensitivity", "to", "megakaryocytic", "differentiation", "induced", "by", "phorbol", "ester", "." ]
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11319
[ "These", "results", "provide", "evidence", "that", "AML1", "proteins", "play", "a", "role", "in", "erythroid", "and", "megakaryocytic", "differentiation", "." ]
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11320
[ "Identification", "of", "sequence", "alterations", "in", "the", "upstream", "regulatory", "region", "of", "the", "estrogen", "receptor", "gene", "in", "an", "ER-negative", "breast", "cancer", "cell", "line", "." ]
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11321
[ "Given", "the", "important", "role", "of", "the", "estrogen", "receptor", "(", "ER", ")", "in", "the", "development", "and", "physiology", "of", "the", "breast", ",", "it", "is", "essential", "to", "delineate", "the", "mechanisms", "responsible", "for", "its", "failed", "expression", "in", "some", "breast", "tumors", "." ]
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11322
[ "We", "have", "cloned", "and", "sequenced", "a", "portion", "of", "the", "ER", "upstream", "regulatory", "region", "from", "the", "ER-positive", "MCF-7", "and", "the", "ER-negative", "MDA-MB-231", "breast", "cancer", "cell", "lines", "to", "determine", "if", "sequence", "alterations", "in", "this", "region", "account", "for", "the", "ER", "-negative", "phenotype", "of", "some", "tumors", "." ]
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11323
[ "From", "this", ",", "we", "identified", "a", "number", "of", "variations", "between", "the", "sequences", ",", "two", "of", "which", "were", "determined", "to", "be", "associated", "with", "a", "50", "%", "decrease", "in", "CAT", "activity", "." ]
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11324
[ "Suppression", "by", "azelastine", "hydrochloride", "of", "NF-kappa", "B", "activation", "involved", "in", "generation", "of", "cytokines", "and", "nitric", "oxide", "." ]
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11325
[ "The", "influence", "of", "the", "anti-allergy", "agent", "azelastine", "hydrochloride", "(", "Azeptin", ")", "on", "NF-kappa", "B", "activation", "associated", "with", "the", "generation", "of", "cytokines", "and", "nitric", "oxide", "(", "NO", ")", "was", "investigated", "in", "various", "kinds", "of", "human", "and", "mouse", "cells", "." ]
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11326
[ "Azeptin", "dose-dependently", "suppressed", "both", "DNA", "and", "protein", "synthesis", "in", "human", "gingival", "fibroblasts", "(", "HF", ")", "and", "also", "suppressed", "blastogenesis", "of", "human", "peripheral", "blood", "lymphocytes", "(", "PBL", ")", ".", "Generation", "of", "tumor", "necrosis", "factor-alpha", ",", "interleukin", "1-beta", ",", "granulocyte-macrophage", "colony-stimulating", "factor", "and", "interleukin-6", "from", "10", "(", "-5", ")", "M", "Azeptin-treated", "PBL", "and", "human", "monocytes", "(", "HM", ")", "was", "decreased", "to", "approximately", "1/3", "to", "2/3", "of", "the", "control", "levels", "." ]
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11327
[ "In", "parallel", "with", "the", "decreased", "cytokine", "generation", ",", "each", "cytokine", "mRNA", "was", "less", "expressed", "in", "the", "presence", "of", "10", "(", "-5", ")", "M", "Azeptin", "." ]
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11328
[ "In", "addition", ",", "both", "inducible", "nitric", "oxide", "synthase", "-mRNA", "level", "and", "NO", "generation", "in", "mouse", "peritoneal", "macrophages", "were", "suppressed", "by", "10", "(", "-5", ")", "M", "Azeptin", "." ]
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11329
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11330
[ "These", "results", "appear", "to", "indicate", "that", "suppression", "of", "cytokine", "and", "NO", "generation", "by", "Azeptin", "results", "at", "least", "partially", "from", "the", "inhibition", "of", "NF-kappa", "B", "activation", "." ]
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11331
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11332
[ "The", "immunomodulatory", "cytokine", "IL-4", "affects", "cells", "of", "most", "hemopoietic", "lineages", "." ]
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11333
[ "IL-4", "is", "secreted", "by", "activated", "Th2", "but", "not", "Th1", "cells", "and", "plays", "a", "major", "role", "in", "the", "immune", "response", "by", "modulating", "the", "differentiation", "of", "naive", "Th", "cells", "toward", "the", "Th2", "phenotype", "." ]
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11334
[ "We", "have", "previously", "identified", "an", "enhancer", "element", ",", "PRE-I", ",", "that", "is", "essential", "for", "the", "function", "of", "the", "human", "IL-4", "promoter", "." ]
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11335
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11336
[ "We", "show", "that", "PRE-I", "interacts", "with", "PMA", "-and", "PMA/ionomycin-inducible", ",", "cyclosporin", "A-sensitive", "nuclear", "factors", "." ]
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11337
[ "Using", "anti-C/EBPbeta", "(", "NF-IL6", ")", ",", "anti-C/EBPdelta", "(", "NF-IL6beta", ")", ",", "anti-NF-ATc", ",", "anti-NF-ATp", ",", "anti-Fos", ",", "and", "anti-Jun", "Abs", "we", "demonstrate", "that", "the", "previously", "identified", "PRE-I", "binding", "factor", "POS-1", "is", "composed", "of", "different", "transcription", "factors", "in", "different", "Th", "cell", "subsets", "." ]
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11338
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11339
[ "In", "the", "mouse", "Th2", "D10", "cells", "and", "in", "the", "human", "Th2", "clones", ",", "POS-1", "(", "designated", "POS-1b", ")", "contains", "NF-IL6beta", ",", "Jun", ",", "and", "NF-ATc/p", "." ]
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11340
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11341
[ "These", "findings", "suggest", "that", "PRE-I", "may", "play", "a", "role", "in", "the", "differential", "regulation", "of", "IL-4", "gene", "expression", "levels", "." ]
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11342
[ "Regulation", "of", "human", "epsilon", "germline", "transcription", ":", "role", "of", "B-cell-specific", "activator", "protein", "." ]
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11343
[ "Germline", "transcripts", "initiate", "from", "promoters", "upstream", "of", "the", "immunoglobulin", "switch", "region", ",", "and", "are", "necessary", "to", "target", "the", "appropriate", "switch", "region", "for", "recombination", "and", "switching", "." ]
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11344
[ "Different", "cytokines", "activate", "transcription", "at", "the", "appropriate", "germline", "promoter", "." ]
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11345
[ "Because", "binding", "sites", "for", "B-cell-specific", "activator", "protein", "(", "BSAP", ")", "are", "located", "upstream", "of", "several", "switch", "regions", "in", "the", "immunoglobulin", "heavy", "chain", "gene", "cluster", ",", "BSAP", "might", "play", "a", "role", "in", "the", "regulation", "of", "germline", "transcription", "and", "isotype", "switching", "." ]
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11346
[ "We", "investigated", "whether", "BSAP", "plays", "a", "role", "in", "the", "transcriptional", "regulation", "of", "the", "epsilon", "germline", "promoter", "in", "human", "B", "cells", "." ]
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11347
[ "Our", "results", "showed", "that", "BSAP", "plays", "a", "role", "in", "both", "IL-4", "-dependent", "induction", "and", "CD40", "-mediated", "upregulation", "of", "human", "epsilon", "germline", "transcription", "." ]
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11348
[ "BSAP", "is", "unique", "among", "the", "transcription", "factors", "that", "regulate", "epsilon", "germline", "expression", ",", "because", "it", "is", "B", "cell", "specific", ",", "and", "is", "at", "the", "merging", "point", "of", "two", "signalling", "pathways", "that", "are", "critical", "for", "IgE", "switching", "." ]
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11349
[ "Experimental", "expression", "in", "mice", "and", "spontaneous", "expression", "in", "human", "SLE", "of", "polyomavirus", "T-antigen", "." ]
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11350
[ "A", "molecular", "basis", "for", "induction", "of", "antibodies", "to", "DNA", "and", "eukaryotic", "transcription", "factors", "." ]
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11351
[ "We", "have", "previously", "demonstrated", "that", "experimental", "expression", "of", "the", "polyomavirus", "transcription", "factor", "T-antigen", "has", "the", "potential", "to", "induce", "anti-DNA", "antibodies", "in", "mice", "." ]
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11352
[ "Two", "sets", "of", "independent", "evidences", "are", "presented", "here", "that", "demonstrate", "a", "biological", "relevance", "for", "this", "model", "." ]
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11353
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11354
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11367
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11371
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11374
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11375
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11376
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11378
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11379
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11380
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11382
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11383
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