Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11501
[ "Dexamethasone", "(", "10", "(", "-8", ")", "M", ")", "repressed", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "production", "by", "75", "%", "in", "the", "wild-type", "fragment", "but", "not", "in", "a", "deletion", "mutant", "lacking", "the", "19-bp", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11502
[ "A", "protein", "of", "about", "150", "kD", "that", "bound", "to", "this", "negative", "regulatory", "sequence", "was", "identified", "by", "UV", "cross-linking", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0 ]
11503
[ "This", "is", "the", "first", "description", "of", "a", "negative", "regulatory", "region", "responsive", "to", "glucocorticoids", "in", "a", "cytokine", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11504
[ "Interaction", "of", "transcription", "factors", "RFX1", "and", "MIBP1", "with", "the", "gamma", "motif", "of", "the", "negative", "regulatory", "element", "of", "the", "hepatitis", "B", "virus", "core", "promoter", "." ]
[ 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
11505
[ "The", "negative", "regulatory", "element", "(", "NRE", ")", "of", "the", "hepatitis", "B", "virus", "(", "HBV", ")", "core", "promoter", "contains", "three", "subregions", "which", "act", "synergistically", "to", "suppress", "core", "promoter", "activity", "." ]
[ 0, 1, 2, 2, 0, 1, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11506
[ "One", "of", "these", "subregions", ",", "NRE", "gamma", ",", "is", "active", "in", "both", "HeLa", "cervical", "carcinoma", "cells", "and", "Huh7", "hepatoma", "cells", "and", "was", "found", "to", "be", "bound", "by", "a", "protein", "factor", "present", "in", "both", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11507
[ "Here", "we", "show", "that", "the", "transcription", "factor", "RFX1", "can", "bind", "to", "NRE", "gamma", "and", "transactivate", "the", "core", "promoter", "through", "this", "site", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11508
[ "Mutations", "which", "abrogated", "the", "gene-suppressive", "activity", "of", "NRE", "gamma", "prevented", "RFX1", "from", "binding", "to", "NRE", "gamma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 0, 0, 1, 2, 0 ]
11509
[ "In", "addition", ",", "RFX1", "can", "bind", "simultaneously", ",", "most", "likely", "as", "a", "heterodimer", ",", "with", "the", "transcription", "factor", "MIBP1", "to", "NRE", "gamma", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 1, 2, 0 ]
11510
[ "In", "the", "absence", "of", "a", "cloned", "MIBP1", "gene", "for", "further", "studies", ",", "we", "hypothesize", "that", "RFX1", "acts", "with", "MIBP1", "to", "negatively", "regulate", "the", "core", "promoter", "activity", "through", "the", "NRE", "gamma", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
11511
[ "The", "ability", "of", "RFX1", "to", "transactivate", "the", "core", "promoter", "raises", "the", "possibility", "that", "RFX1", "may", "play", "a", "dual", "role", "in", "regulating", "HBV", "gene", "expression" ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11512
[ "Use", "of", "arsenic", "trioxide", "(", "As2O3", ")", "in", "the", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", ":", "II", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11513
[ "Clinical", "efficacy", "and", "pharmacokinetics", "in", "relapsed", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
11514
[ "The", "therapeutic", "effect", "of", "arsenic", "trioxide", "(", "As2O3", ")", "in", "the", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "was", "evaluated", "among", "15", "APL", "patients", "at", "relapse", "after", "all-trans", "retinoic", "acid", "(", "ATRA", ")", "induced", "and", "chemotherapy", "maintained", "complete", "remission", "(", "CR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11515
[ "As2O3", "was", "administered", "intravenously", "at", "the", "dose", "of", "10", "mg/d", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11516
[ "Clinical", "CR", "was", "achieved", "in", "nine", "of", "10", "(", "90", "%", ")", "patients", "treated", "with", "As2O3", "alone", "and", "in", "the", "remaining", "five", "patients", "treated", "by", "the", "combination", "of", "As2O3", "and", "low-dose", "chemotherapeutic", "drugs", "or", "ATRA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11517
[ "During", "the", "treatment", "with", "As2O3", ",", "there", "was", "no", "bone", "marrow", "depression", "and", "only", "limited", "side", "effects", "were", "encountered", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11518
[ "Pharmacokinetic", "studies", ",", "which", "were", "performed", "in", "eight", "patients", ",", "showed", "that", "after", "a", "peak", "level", "of", "5.54", "micromol/L", "to", "7.30", "micromol/L", ",", "plasma", "arsenic", "was", "rapidly", "eliminated", ",", "and", "the", "continuous", "administration", "of", "As2O3", "did", "not", "alter", "its", "pharmacokinetic", "behaviors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11519
[ "In", "addition", ",", "increased", "amounts", "of", "arsenic", "appeared", "in", "the", "urine", ",", "with", "a", "daily", "excretion", "accounting", "for", "approximately", "1", "%", "to", "8", "%", "of", "the", "total", "daily", "dose", "administered", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11520
[ "Arsenic", "contents", "in", "hair", "and", "nail", "were", "increased", ",", "and", "the", "peak", "content", "of", "arsenic", "could", "reach", "2.5", "to", "2.7", "microg/g", "tissue", "at", "CR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11521
[ "On", "the", "other", "hand", ",", "a", "decline", "of", "the", "arsenic", "content", "in", "hair", "and", "nail", "was", "observed", "after", "withdrawal", "of", "the", "drug", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11522
[ "We", "conclude", "that", "As2O3", "treatment", "is", "an", "effective", "and", "relatively", "safe", "drug", "in", "APL", "patients", "refractory", "to", "ATRA", "and", "conventional", "chemotherapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11523
[ "Nucleolin", "is", "one", "component", "of", "the", "B", "cell-specific", "transcription", "factor", "and", "switch", "region", "binding", "protein", ",", "LR1", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11524
[ "LR1", "is", "a", "B", "cell-specific", ",", "sequence-specific", "DNA", "binding", "activity", "that", "regulates", "transcription", "in", "activated", "B", "cells", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11525
[ "LR1", "also", "binds", "Ig", "heavy", "chain", "switch", "region", "sequences", "and", "may", "function", "in", "class", "switch", "recombination", "." ]
[ 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11526
[ "LR1", "contains", "two", "polypeptides", ",", "of", "106", "kDa", "and", "45", "kDa", ",", "and", "here", "we", "report", "that", "the", "106-kDa", "component", "of", "LR1", "is", "nucleolin", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
11527
[ "This", "identification", ",", "initially", "made", "by", "microsequence", "analysis", ",", "was", "verified", "by", "showing", "that", "(", "i", ")", "LR1", "-DNA", "binding", "activity", "increased", "in", "B", "cells", "transfected", "with", "a", "nucleolin", "cDNA", "expression", "construct", ";", "(", "ii", ")", "LR1", "-DNA", "binding", "activity", "was", "recognized", "by", "antibodies", "raised", "against", "recombinant", "human", "nucleolin", ";", "and", "(", "iii", ")", "in", "B", "cells", "transfected", "with", "epitope-tagged", "nucleolin", "expression", "constructs", ",", "the", "LR1-DNA", "complex", "was", "recognized", "by", "the", "anti-tag", "antibody", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11528
[ "Nucleolin", "is", "an", "abundant", "nucleolar", "protein", "which", "is", "believed", "to", "play", "a", "role", "in", "rDNA", "transcription", "or", "organization", ",", "or", "rRNA", "processing", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11529
[ "Homology", "between", "nucleolin", "and", "histone", "H1", "suggests", "that", "nucleolin", "may", "alter", "DNA", "organization", "in", "response", "to", "cell", "cycle", "controls", ",", "and", "the", "nucleolin", "component", "of", "LR1", "may", "therefore", "function", "to", "organize", "switch", "regions", "before", ",", "during", ",", "or", "after", "switch", "recombination", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11530
[ "The", "demonstration", "that", "nucleolin", "is", "a", "component", "of", "a", "B", "cell-specific", "complex", "that", "binds", "switch", "region", "sequences", "suggests", "that", "the", "G-rich", "switch", "regions", "may", "have", "evolved", "from", "rDNA", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11531
[ "Glucocorticoid-resistance", "in", "peripheral-blood", "lymphocytes", "does", "not", "correlate", "with", "number", "of", "affinity", "of", "glucocorticoid-receptors", "in", "chronic", "renal", "failure", "patients", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
11532
[ "Glucocorticoid", "(", "GC", ")", "resistance", "in", "patients", "with", "chronic", "renal", "failure", "(", "CRF", ")", "seriously", "impairs", "successive", "GC", "therapy", "after", "renal", "transplantation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11533
[ "We", "examined", "the", "relationship", "between", "GC-receptor", "(", "GC-R", ")", "parameters", "in", "peripheral-blood", "mononuclear", "cells", "(", "PBMC", ")", "and", "PBMC", "resistance", "to", "GC", "in", "21", "CRF", "patients", "and", "18", "healthy", "subjects", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11534
[ "Each", "subject", "group", "was", "divided", "into", "two", "subgroups", "according", "to", "PBMC", "sensitivity", "to", "prednisolone", "in", "a", "mitogen", "assay", "procedure", ";", "i.e.", ",", "sensitive", "(", "IC50", "<", "381", "ng/mL", ")", "and", "resistant", "(", "IC50", ">", "381", "ng/mL", ")", "groups", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11535
[ "In", "healthy", "subjects", ",", "the", "mean", "GC-R", "Bmax", "and", "Kd", "in", "quiescent", "PBMC", "of", "the", "GC-sensitive", "group", "were", "2.89", "+/-", "1.23", "fmol/10", "(", "6", ")", "cells", "and", "4.00", "+/-", "2.24", "nM", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11536
[ "The", "Bmax", "in", "these", "subjects", "significantly", "increased", "to", "6.61", "+/-", "2.02", "(", "257.7", "+/-", "107.8", "%", ")", "after", "24", "h", "stimulation", "with", "concanavalin", "A", "(", "p", "<", "0.01", ")", ",", "while", "the", "Kd", "change", "was", "not", "significant", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11537
[ "The", "GC-R", "Bmax", "and", "Kd", "in", "quiescent", "PBMC", "of", "the", "GC-resistant", "group", "were", "5.33", "+/-", "1.37", "fmol/10", "(", "6", ")", "cells", "and", "3.20", "+/-", "1.39", "nM", ",", "respectively", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11538
[ "Both", "of", "these", "parameters", ",", "however", ",", "did", "not", "change", "significantly", "after", "mitogen", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11539
[ "There", "was", "a", "significant", "negative", "correlation", "between", "IC50S", "of", "prednisolone", "and", "increase-ratios", "(", "post/pre", "ratio", ")", "of", "Bmax", "after", "mitogen", "stimulation", "(", "p", "<", "0.05", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11540
[ "In", "CRF", "patients", ",", "Bmax", "and", "Kd", "in", "quiescent", "PBMC", "of", "the", "GC-sensitive", "group", "were", "6.04", "+/-", "2.35", "fmol/10", "(", "6", ")", "cells", "and", "3.49", "+/-", "1.72", "nM", ",", "respectively", ",", "while", "those", "in", "PBMC", "of", "the", "GC-resistant", "group", "were", "5.13", "+/-", "2.31", "fmol/10", "(", "6", ")", "cells", "and", "4.04", "+/-", "1.62", "nM", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11541
[ "The", "Bmax", "and", "Kd", "were", "not", "significantly", "changed", "after", "mitogen", "stimulation", "in", "both", "subgroups", "of", "CRF", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11542
[ "Moreover", ",", "in", "contrast", "to", "healthy", "subjects", ",", "there", "was", "no", "correlation", "between", "IC50", "and", "GC-R", "parameters", "in", "CRF", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
11543
[ "We", "concluded", "that", ",", "in", "healthy", "subjects", ",", "decreased", "PBMC", "capacity", "to", "amplify", "GC-R", "numbers", "in", "response", "to", "mitogen", "is", "correlated", "with", "GC", "resistance", ",", "whereas", "in", "CRF", "patients", "the", "resistant", "mechanism", "is", "not", "correlated", "with", "GC-R", "parameters", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11544
[ "An", "unknown", "event", "might", "be", "involved", "in", "GC-resistance", "of", "CRF", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11545
[ "Alteration", "of", "a", "single", "serine", "in", "the", "basic", "domain", "of", "the", "Epstein-Barr", "virus", "ZEBRA", "protein", "separates", "its", "functions", "of", "transcriptional", "activation", "and", "disruption", "of", "latency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11546
[ "The", "ZEBRA", "protein", "from", "Epstein-Barr", "virus", "(", "EBV", ")", "activates", "a", "switch", "from", "the", "latent", "to", "the", "lytic", "expression", "program", "of", "the", "virus", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11547
[ "ZEBRA", ",", "a", "member", "of", "the", "bZIP", "family", "of", "DNA-binding", "proteins", ",", "is", "a", "transcriptional", "activator", "capable", "of", "inducing", "expression", "from", "viral", "lytic", "cycle", "promoters", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11548
[ "It", "had", "previously", "been", "thought", "that", "ZEBRA", "'s", "capacity", "to", "disrupt", "EBV", "latency", "resided", "primarily", "in", "its", "ability", "to", "activate", "transcription", "of", "genes", "that", "encode", "products", "required", "for", "lytic", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11549
[ "We", "generated", "a", "point", "mutant", "of", "ZEBRA", ",", "Z", "(", "S186A", ")", ",", "that", "was", "not", "impaired", "in", "its", "ability", "to", "activate", "transcription", ";", "however", ",", "this", "mutation", "abolished", "its", "ability", "to", "initiate", "the", "viral", "lytic", "cascade", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11550
[ "The", "mutant", ",", "containing", "a", "serine-to-alanine", "substitution", "in", "the", "DNA-binding", "domain", "of", "the", "protein", ",", "bound", "to", "several", "known", "ZEBRA-binding", "sites", "and", "activated", "transcription", "from", "reporters", "bearing", "known", "ZEBRA-responsive", "promoters", "but", "did", "not", "disrupt", "latency", "in", "EBV-infected", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11551
[ "Therefore", ",", "initiation", "of", "the", "EBV", "lytic", "cycle", "by", "the", "ZEBRA", "protein", "requires", "a", "function", "in", "addition", "to", "transcriptional", "activation", ";", "a", "change", "of", "serine", "186", "to", "alanine", "in", "the", "DNA-binding", "domain", "of", "ZEBRA", "abolished", "this", "additional", "function", "and", "uncovered", "a", "new", "role", "for", "the", "ZEBRA", "protein", "in", "disruption", "of", "EBV", "latency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
11552
[ "The", "additional", "function", "that", "is", "required", "for", "initiation", "of", "the", "lytic", "viral", "life", "cycle", "is", "likely", "to", "require", "phosphorylation", "of", "serine", "186", "of", "the", "ZEBRA", "protein", ",", "which", "may", "influence", "either", "DNA", "recognition", "or", "transcriptional", "activation", "of", "lytic", "viral", "promoters", "in", "a", "chromatinized", "viral", "episome", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11553
[ "Immune", "hyperactivation", "of", "HIV-1-infected", "T", "cells", "mediated", "by", "Tat", "and", "the", "CD28", "pathway", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 9, 0, 0, 9, 0, 0 ]
11554
[ "Human", "immunodeficiency", "virus-type", "1", "(", "HIV-1", ")", "infection", "is", "characterized", "by", "a", "chronic", "state", "of", "immune", "hyperactivation", "in", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11555
[ "Infection", "of", "human", "peripheral", "blood", "lymphocytes", "with", "HIV-1", "in", "vitro", "resulted", "in", "increased", "interleukin-2", "(", "IL-2", ")", "secretion", "in", "response", "to", "T", "cell", "activation", "via", "the", "CD3", "and", "CD28", "receptors", "." ]
[ 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0, 9, 10, 0 ]
11556
[ "Expression", "of", "the", "HIV-1", "transactivator", "Tat", "recapitulated", "this", "phenotype", "and", "was", "associated", "with", "increased", "IL-2", "secretion", "in", "response", "to", "costimulation", "with", "CD3", "plus", "CD28", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
11557
[ "IL-2", "superinduction", "by", "Tat", "occurred", "at", "the", "transcriptional", "level", ",", "was", "mediated", "by", "the", "CD28-responsive", "element", "in", "the", "IL-2", "promoter", ",", "and", "was", "exclusively", "dependent", "on", "the", "29", "amino", "acids", "encoded", "by", "the", "second", "exon", "of", "Tat", "." ]
[ 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
11558
[ "Response", "to", "intranasal", "fluticasone", "propionate", "in", "perennial", "allergic", "rhinitis", "not", "associated", "with", "glucocorticoid", "receptor", "characteristics", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
11559
[ "BACKGROUND", ":", "The", "reduction", "of", "symptoms", "due", "to", "treatment", "with", "corticosteroids", "varies", "among", "patients", "with", "perennial", "rhinitis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11560
[ "Most", "patients", "will", "respond", "but", "a", "few", "patients", "respond", "less", "to", "these", "drugs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11561
[ "OBJECTIVE", ":", "To", "investigate", "the", "association", "in", "reduction", "of", "symptoms", "due", "to", "glucocorticoids", "and", "glucocorticoid", "receptor", "characteristics", "in", "patients", "with", "perennial", "allergic", "rhinitis", ",", "in", "vitro", "glucocorticoid", "receptor", "binding", "studies", "were", "performed", "with", "peripheral", "blood", "mononuclear", "cells", "using", "dexamethasone", "and", "in", "vitro", "production", "of", "mediators", "were", "measured", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11562
[ "METHODS", ":", "During", "a", "double-blind", "placebo-controlled", "crossover", "study", ",", "200", "micrograms", "fluticasone", "propionate", "aqueous", "nasal", "spray", "(", "in", "the", "active", "treatment", "period", ")", "and", "placebo", "(", "in", "the", "placebo", "treatment", "period", ")", "were", "administered", "twice", "daily", "for", "2", "weeks", "to", "22", "patients", "allergic", "to", "house", "dust", "mite", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11563
[ "At", "the", "end", "of", "both", "treatment", "periods", "symptoms", "were", "scored", "after", "allergen", "provocation", "(", "100", ",", "1000", ",", "10000", "BU/mL", ")", "and", "during", "the", "9.5", "hours", "after", "this", "challenge", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11564
[ "Receptor", "binding", "studies", "with", "dexamethasone", "were", "performed", "with", "peripheral", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
11565
[ "Leukotriene", "B4", "produced", "by", "monocytes", "in", "vitro", "and", "soluble", "interleukin-2", "receptor", "released", "by", "lymphocytes", "in", "vitro", "and", "cortisol", "levels", "in", "plasma", "were", "determined", "." ]
[ 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 10, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11566
[ "RESULTS", ":", "No", "significant", "partial", "correlations", "of", "the", "number", "of", "the", "peripheral", "blood", "mononuclear", "cell", "glucocorticoid", "receptors", "(", "6821", "+/-", "5669", "binding", "sites", "per", "cell", ")", "and", "the", "affinity", "(", "Kd", ":", "16.5", "+/-", "13.51", "nmol/L", ")", "for", "the", "glucocorticoid", "receptors", "with", "the", "symptom", "score", "(", "placebo", ":", "4.3", "+/-", "2.45", "pts", ";", "fluticasone", ":", "2.4", "+/-", "1.55", "pts", ")", "after", "active", "treatment", "were", "found", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11567
[ "Also", "no", "significant", "partial", "correlations", "of", "the", "levels", "of", "leukotriene", "B4", "(", "45.6", "+/-", "105.3", "ng/10", "(", "6", ")", "cells", ")", "produced", "by", "monocytes", "in", "vitro", ",", "soluble", "interleukin-2", "receptor", "(", "734", "+/-", "237", "ng/10", "(", "6", ")", "cells", ")", "released", "by", "lymphocytes", "in", "vitro", "and", "cortisol", "levels", "(", "571", "+/-", "236", "ng/mL", ")", "in", "plasma", "with", "the", "symptom", "score", "after", "active", "treatment", "were", "found", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11568
[ "CONCLUSIONS", ":", "The", "reduction", "of", "symptoms", "due", "to", "topical", "fluticasone", "propionate", "in", "patients", "with", "rhinitis", "and", "allergy", "to", "house", "dust", "mite", "is", "not", "correlated", "with", "the", "characteristics", "of", "the", "glucocorticoid", "receptor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
11569
[ "Constitutive", "expression", "of", "p50", "homodimer", "in", "freshly", "isolated", "human", "monocytes", "decreases", "with", "in", "vitro", "and", "in", "vivo", "differentiation", ":", "a", "possible", "mechanism", "influencing", "human", "immunodeficiency", "virus", "replication", "in", "monocytes", "and", "mature", "macrophages", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 0 ]
11570
[ "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "replicates", "more", "efficiently", "in", "vitro", "in", "differentiated", "macrophages", "than", "in", "freshly", "isolated", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 7, 0 ]
11571
[ "We", "investigated", "whether", "this", "may", "be", "partly", "explained", "by", "changes", "in", "expression", "of", "NF-kappaB", "with", "monocyte", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0, 0 ]
11572
[ "We", "demonstrated", "that", "constitutive", "expression", "of", "NF-kappaB", "in", "primary", "human", "monocytes", "changed", "significantly", "with", "differentiation", "in", "vitro", "to", "monocyte-derived", "macrophages", "(", "MDMs", ")", "and", "differentiation", "in", "vivo", "to", "alveolar", "macrophages", "(", "AMs", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0 ]
11573
[ "Freshly", "isolated", "monocytes", "constitutively", "expressed", "high", "levels", "of", "transcriptionally", "inactive", "p50", "homodimer", "which", "decreased", "with", "time", "in", "culture", "in", "favor", "of", "the", "transcriptionally", "active", "p50/p65", "and", "p50/RelB", "heterodimers", "." ]
[ 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]
11574
[ "As", "in", "MDMs", ",", "AMs", "constitutively", "expressed", "p50/p65", "and", "p50/RelB", "although", "at", "lower", "levels", "." ]
[ 0, 0, 7, 0, 7, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0 ]
11575
[ "HIV", "infection", "of", "fresh", "monocytes", "failed", "to", "induce", "p50/p65", "as", "seen", "in", "MDMs", "." ]
[ 0, 0, 0, 0, 7, 0, 0, 0, 9, 0, 0, 0, 7, 0 ]
11576
[ "The", "replacement", "of", "p50", "homodimers", "with", "transcriptionally", "active", "heterodimers", "following", "time", "in", "culture", "may", "partially", "explain", "the", "progressive", "increase", "in", "susceptibility", "of", "monocytes", "to", "HIV", "infection", "during", "in", "vitro", "culture", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
11577
[ "The", "change", "in", "NF-kappaB", "components", "with", "monocyte", "differentiation", "in", "vivo", "may", "also", "explain", "the", "different", "transcriptional", "activities", "of", "these", "cell", "populations", "in", "HIV-infected", "individuals", "." ]
[ 0, 0, 0, 9, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11578
[ "NF-kappa", "B", "-independent", "suppression", "of", "HIV", "expression", "by", "ascorbic", "acid", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11579
[ "Ascorbic", "acid", "(", "ascorbate", "or", "vitamin", "C", ")", "has", "been", "shown", "to", "suppress", "the", "induction", "of", "HIV", "in", "latently", "infected", "T", "lymphocytic", "cells", "following", "stimulation", "with", "a", "tumor", "promoter", "(", "PMA", ")", "and", "inflammatory", "cytokine", "(", "TNF-alpha", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11580
[ "To", "assess", "whether", "this", "inhibition", "was", "mediated", "via", "modulation", "of", "the", "cellular", "transcription", "factor", ",", "NF-kappa", "B", ",", "we", "carried", "out", "gel", "shift", "analysis", "on", "nuclear", "extracts", "prepared", "under", "different", "conditions", "of", "cell", "stimulation", "in", "the", "presence", "or", "absence", "of", "ascorbate", ",", "N-acetylcysteine", "(", "NAC", ")", ",", "or", "zidovudine", "(", "AZT", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11581
[ "Pretreatment", "of", "ACH-2", "T", "cells", "by", "NAC", "followed", "by", "stimulation", "with", "PMA", ",", "TNF-alpha", ",", "or", "hydrogen", "peroxide", "(", "H2O2", ")", "resulted", "in", "strong", "suppression", "of", "NF-kappa", "B", "activation", "." ]
[ 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
11582
[ "In", "contrast", ",", "neither", "ascorbate", "nor", "AZT", "affected", "NF-kappa", "B", "activity", "under", "all", "three", "induction", "conditions", "in", "the", "ACH-2", "cell", "line", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
11583
[ "Ascorbate", "and", "AZT", "also", "had", "no", "effect", "on", "NF-kappa", "B", "activation", "following", "TNF-alpha-", "or", "PMA-induced", "stimulation", "of", "U1", "promonocytic", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
11584
[ "These", "results", "suggest", "that", "the", "molecular", "mechanism", "of", "HIV", "inhibition", "by", "ascorbate", "is", "not", "mediated", "via", "NF-kappa", "B", "inhibition", ",", "unlike", "that", "seen", "with", "other", "antioxidants", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11585
[ "A", "T", "cell-specific", "enhancer", "in", "the", "interleukin-3", "locus", "is", "activated", "cooperatively", "by", "Oct", "and", "NFAT", "elements", "within", "a", "DNase", "I-hypersensitive", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 1, 2, 2, 0 ]
11586
[ "Interleukin-3", "(", "IL-3", ")", "is", "a", "cytokine", "that", "is", "expressed", "primarily", "in", "activated", "T", "cells", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11587
[ "Here", "we", "identified", "an", "inducible", "T", "cell-specific", "enhancer", "14", "kb", "upstream", "of", "the", "IL-3", "gene", "that", "responded", "to", "activation", "of", "T", "cell", "receptor", "signaling", "pathways", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]
11588
[ "The", "IL-3", "enhancer", "spanned", "an", "inducible", "cyclosporin", "A-sensitive", "DNase", "I-hypersensitive", "site", "found", "only", "in", "T", "cells", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 7, 8, 0 ]
11589
[ "Four", "NFAT-like", "elements", "exist", "within", "the", "enhancer", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0 ]
11590
[ "The", "two", "most", "active", "NFAT-like", "elements", "were", "located", "at", "the", "center", "of", "the", "DNase", "I-hypersensitive", "site", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
11591
[ "One", "of", "these", "NFAT-like", "elements", "encompassed", "overlapping", "Oct-", "and", "NFATp/c-binding", "sites", ",", "which", "functioned", "in", "a", "highly", "synergistic", "manner", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11592
[ "We", "suggest", "that", "the", "T", "cell-specific", "expression", "of", "the", "IL-3", "gene", "is", "partly", "controlled", "through", "the", "enhancer", "by", "cooperation", "between", "Oct", "and", "NFAT", "family", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]
11593
[ "Adenovirus", "E1B", "19K", "protein", "is", "required", "for", "efficient", "DNA", "replication", "in", "U937", "cells", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
11594
[ "The", "adenovirus", "E1B", "19K", "gene", "plays", "an", "essential", "role", "in", "transformation", "of", "primary", "rodent", "cells", "in", "cooperation", "with", "E1A", "and", "in", "the", "inhibition", "of", "apoptosis", "during", "lytic", "infection", "." ]
[ 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11595
[ "It", "has", "been", "shown", "that", "this", "E1B", "19K", "protein", "is", "not", "necessary", "for", "viral", "DNA", "replication", "in", "human", "cell", "lines", ",", "such", "as", "HeLa", "and", "KB", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0 ]
11596
[ "We", "reported", "here", "that", "the", "E1B", "19K", "mutant", "viruses", "were", "unable", "to", "replicate", "efficiently", "in", "a", "monocyte", "cell", "line", ",", "U937", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0 ]
11597
[ "Viral", "DNA", "synthesis", "and", "late", "gene", "expression", "were", "found", "to", "be", "defective", "in", "U937", "cells", "infected", "with", "E1B", "19K", "mutants", "compared", "with", "wild-type", "virus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]
11598
[ "Early", "viral", "RNA", "splicing", "patterns", "also", "differ", "between", "wild-type", "and", "dl337-infected", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11599
[ "Furthermore", ",", "the", "defect", "in", "viral", "replication", "could", "be", "complemented", "by", "dl312", "virus", "defective", "in", "E1A", "expression", "4", "days", "after", "infection", "with", "E1B", "mutants", ",", "suggesting", "persistence", "of", "the", "E1B", "mutant", "genome", "in", "the", "infected", "cells", "despite", "defective", "onset", "of", "the", "late", "phase", "of", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11600
[ "These", "results", "imply", "that", "E1B", "19K", "is", "required", "for", "efficient", "viral", "DNA", "replication", "in", "U937", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]