siddharthtumre/Revised-JNLPBA · Datasets at Hugging Face

id stringlengths 1 5	tokens sequence	ner_tags sequence
11101	[ "However", ",", "the", "major", "problem", "still", "remains", "the", "high", "incidence", "of", "leukemic", "relapse", "following", "autologous", "PBSCT", ",", "which", "may", "be", "caused", "by", "the", "reinfusion", "of", "PBSC", "contaminated", "by", "leukemic", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0 ]
11102	[ "Recently", ",", "we", "have", "developed", "a", "quantitative", "assay", "using", "competitive", "reverse", "transcriptase", "polymerase", "chain", "reaction", "that", "estimates", "the", "number", "of", "AML1/ETO", "transcripts", "in", "t", "(", "8", ";", "21", ")", "acute", "myelogenous", "leukemia", "(", "AML", ")", ",", "in", "order", "to", "determine", "the", "degree", "of", "leukemic", "cell", "contamination", "in", "PBSC", "harvests", ",", "and", "to", "monitor", "minimal", "residual", "disease", "(", "MRD", ")", "quantitatively", "in", "patients", "with", "t", "(", "8", ";", "21", ")", "AML", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11103	[ "Our", "data", "indicate", "that", "although", "PBSC", "harvests", "collected", "after", "consolidation", "chemotherapy", "are", "contaminated", "by", "leukemic", "cells", ",", "the", "degree", "of", "leukemic", "cell", "contamination", "decreases", "with", "repeated", "cycles", "of", "chemotherapy", "." ]	[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
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11106	[ "However", ",", "a", "substantial", "decrease", "of", "AML1/ETO", "transcripts", "was", "seen", "following", "autologous", "PBSCT", "." ]	[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0 ]
11107	[ "Thus", ",", "the", "quantitative", "analysis", "of", "AML1/ETO", "transcripts", "may", "be", "clinically", "useful", "in", "patients", "with", "t", "(", "8", ";", "21", ")", "AML", "." ]	[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11108	[ "Upregulation", "of", "c-Fos", "in", "activated", "T", "lymphoid", "and", "monocytic", "cells", "by", "human", "immunodeficiency", "virus-1", "Tat", "protein", "." ]	[ 0, 0, 9, 0, 0, 7, 8, 8, 8, 8, 0, 9, 10, 10, 10, 10, 0 ]
11109	[ "The", "regulatory", "Tat", "protein", "of", "the", "human", "immunodeficiency", "virus", "type-1", "(", "HIV-1", ")", "is", "essential", "for", "viral", "replication", "and", "also", "shows", "pleiotropic", "activities", "on", "various", "cell", "functions", "." ]	[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11110	[ "To", "get", "further", "insights", "into", "the", "molecular", "mechanisms", "underlying", "the", "biological", "activity", "of", "Tat", ",", "we", "investigated", "the", "effect", "of", "endogenous", "and", "exogenous", "Tat", "protein", "on", "c-fos", "gene", "expression", "in", "T", "lymphoblastoid", "(", "Jurkat", ")", "and", "monocytic", "(", "U937", ")", "cell", "lines", ",", "as", "well", "as", "in", "primary", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 1, 2, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 7, 0, 0 ]
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11112	[ "This", "effect", "was", "specifically", "due", "to", "Tat", ",", "since", "Jurkat", "and", "U937", "cells", "cotransfected", "either", "with", "tat", "cDNA", "in", "antisense", "orientation", "(", "tat/AS", ")", ",", "tat", "carrying", "a", "mutation", "in", "the", "aminoacid", "cys22-gly22", "(", "tat", "22/S", ")", "or", "with", "the", "backbone", "vector", "alone", "(", "pRPneo-SL3", ")", "did", "not", "show", "any", "significant", "difference", "in", "c-fos", "promoter", "activity", "as", "compared", "to", "cells", "transfected", "with", "FC3", "plasmid", "alone", "." ]	[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 0, 5, 6, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11113	[ "By", "using", "deletion", "mutants", "of", "the", "c-fos", "promoter", ",", "we", "found", "that", "the", "minimal", "DNA", "sequence", "required", "for", "Tat", "activity", "was", "located", "between", "nucleotides", "-404/-220", "and", "that", "the", "serum", "responsive", "element", "(", "SRE", ",", "-317/-288", ")", ",", "present", "within", "this", "region", ",", "was", "still", "responsive", "to", "Tat", "." ]	[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11114	[ "A", "single", "point", "mutation", "in", "the", "SRE", "completely", "abrogated", "the", "responsiveness", "to", "tat/S", "." ]	[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]
11115	[ "Exogenous", "recombinant", "Tat", "protein", "was", "also", "able", "to", "upregulate", "c-fos", "promoter", "activity", "in", "serum-activated", "Jurkat", "and", "U937", "cells", ",", "as", "well", "as", "endogenous", "c-fos", "mRNA", "expression", "and", "c-Fos", "protein", "synthesis", "in", "both", "serum-activated", "cell", "lines", "and", "primary", "PBMC", "." ]	[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 3, 4, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
11116	[ "c-Fos", "protein", "was", "shown", "essential", "for", "an", "optimal", "transactivation", "of", "the", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "by", "Tat", ":", "incubation", "of", "Jurkat", "cells", "with", "antisense", ",", "but", "not", "sense", ",", "c-fos", "oligonucleotides", "significantly", "reduced", "either", "the", "Tat", "-enhanced", "expression", "of", "an", "LTR-CAT", "reporter", "construct", "or", "the", "levels", "of", "gag", "p24", "in", "the", "culture", "supernatants", "of", "Jurkat", "cells", "and", "PBMC", "acutely", "infected", "with", "HIV-1", "." ]	[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 5, 6, 0, 7, 0, 0, 0, 0, 0 ]
11117	[ "Our", "data", "suggest", "that", "the", "c-fos", "upregulation", "mediated", "by", "Tat", "might", "play", "a", "significant", "role", "in", "the", "control", "of", "viral", "gene", "transactivation", "." ]	[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11118	[ "Cytokine", "signal", "networks", "and", "a", "new", "era", "in", "biomedical", "research", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11119	[ "Elucidation", "of", "the", "biochemical", "nature", "of", "the", "signal", "transduction", "pathway", "that", "regulate", "transcription", "and", "replication", "is", "the", "focus", "of", "attention", "in", "molecular", "biology", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11120	[ "This", "research", "may", "make", "feasible", "manipulation", "of", "growth", "and", "differentiation", "of", "mammalian", "cells", ",", "which", "in", "turn", "would", "have", "profound", "implication", "in", "biomedical", "research", "on", "cell", "and", "gene", "therapy", ",", "and", "development", "of", "pharmaceutical", "products", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11121	[ "Cytokines", "control", "growth", ",", "differentiation", ",", "death", ",", "and", "function", "of", "cells", "of", "lymphocytic", ",", "hemopoietic", "systems", ",", "and", "together", "with", "nerve", "cells", "provide", "a", "pertinent", "model", "to", "study", "intercellular", "communications", "and", "intercellular", "signal", "networks", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11122	[ "This", "review", "outlines", "general", "features", "of", "signal", "transduction", "and", "several", "aspects", "of", "cytokine", "networks", "are", "discussed", "with", "emphasis", "on", ":", "transcriptional", "regulation", "of", "Th1", "and", "Th2-specific", "cytokine", "genes", "in", "T", "cells", ",", "the", "roles", "of", "cytokines", "and", "their", "receptors", "in", "growth", "and", "differentiation", "of", "hemopoietic", "cells", ",", "and", "the", "manipulation", "of", "cytokine", "networks", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
11123	[ "Regulation", "of", "the", "tissue", "factor", "gene", "in", "human", "monocytic", "cells", "." ]	[ 0, 0, 0, 1, 2, 2, 0, 7, 8, 8, 0 ]
11124	[ "Role", "of", "AP-1", ",", "NF-kappa", "B/Rel", ",", "and", "Sp1", "proteins", "in", "uninduced", "and", "lipopolysaccharide-induced", "expression", "." ]	[ 0, 0, 9, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
11125	[ "Tissue", "factor", "(", "TF", ")", "expression", "by", "peripheral", "blood", "monocytes", "during", "sepsis", "initiates", "intravascular", "thrombosis", "." ]	[ 9, 10, 0, 9, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]
11126	[ "Bacterial", "lipopolysaccharide", "(", "LPS", ")", "rapidly", "induces", "TF", "gene", "transcription", "in", "monocytes", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 0 ]
11127	[ "The", "human", "TF", "promoter", "contains", "binding", "sites", "for", "the", "transcription", "factors", "AP-1", ",", "c-Rel/p65", ",", "Egr-1", ",", "and", "Sp1", "." ]	[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 0, 0, 9, 0 ]
11128	[ "NF-kappa", "B/Rel", "proteins", "have", "been", "shown", "to", "physically", "interact", "with", "both", "AP-1", "and", "Sp1", "proteins", "." ]	[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]
11129	[ "In", "this", "study", ",", "we", "investigated", "the", "role", "of", "these", "transcription", "factors", "in", "uninduced", "and", "LPS-induced", "TF", "gene", "expression", "in", "human", "monocytic", "THP-1", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 5, 6, 6, 6, 0 ]
11130	[ "Deletional", "analysis", "indicated", "that", "five", "Sp1", "sites", "mediated", "basal", "expression", "in", "uninduced", "cells", "." ]	[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
11131	[ "The", "two", "AP-1", "sites", "bound", "c-Fos/c-Jun", "heterodimers", "in", "both", "unstimulated", "and", "LPS-stimulated", "cells", "." ]	[ 0, 0, 1, 2, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
11132	[ "Maximal", "LPS", "induction", "of", "the", "TF", "promoter", "required", "the", "two", "AP-1", "sites", "and", "the", "kappa", "B", "site", "within", "the", "LPS", "response", "element", "." ]	[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]
11133	[ "Disruption", "of", "the", "conserved", "spacing", "between", "the", "proximal", "AP-1", "site", "and", "the", "kappa", "B", "site", "abolished", "LPS", "induction", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0 ]
11134	[ "Replacement", "of", "the", "two", "AP-1", "sites", "with", "intrinsically", "bent", "DNA", "partially", "restored", "LPS", "induction", ",", "suggesting", "an", "additional", "structural", "role", "for", "the", "AP-1", "sites", "." ]	[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
11135	[ "Synergistic", "transactivation", "of", "the", "LPS", "response", "element", "in", "Drosophila", "Schneider", "cells", "by", "coexpression", "of", "c-Fos", ",", "c-Jun", ",", "c-Rel", ",", "and", "p65", "or", "c-Jun", "and", "p65", "required", "the", "transactivation", "domains", "of", "c-Jun", "and", "p65", "." ]	[ 0, 0, 0, 0, 1, 2, 2, 0, 5, 6, 6, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
11136	[ "These", "data", "indicated", "that", "c-Fos", "/c-Jun", ",", "c-Rel", "/p65", ",", "and", "Sp1", "regulate", "TF", "gene", "expression", "in", "human", "monocytic", "cells", "." ]	[ 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 0, 1, 2, 0, 0, 7, 8, 8, 0 ]
11137	[ "Inhibitory", "effect", "of", "growth", "hormone", "on", "TNF-alpha", "secretion", "and", "nuclear", "factor-kappaB", "translocation", "in", "lipopolysaccharide-stimulated", "human", "monocytes", "." ]	[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0 ]
11138	[ "Several", "studies", "have", "pointed", "to", "a", "link", "between", "immune", "and", "endocrine", "systems", ",", "including", "a", "regulatory", "function", "of", "GH", "on", "monocyte", "activation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
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11198	[ "The", "high", "prevalence", "of", "promoter", "methylation", "suggests", "that", "this", "molecular", "abnormality", "can", "be", "used", "to", "monitor", "disease", "activity", "during", "therapy", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11199	[ "In", "addition", ",", "new", "technology", "allows", "the", "sensitive", "identification", "of", "gene", "hypermethylation", "in", "a", "background", "of", "normal", "cells", ",", "suggesting", "possible", "new", "strategies", "for", "the", "detection", "of", "minimal", "residual", "disease", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
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11101

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11102

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11103

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11104

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11105

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11106

[ "However", ",", "a", "substantial", "decrease", "of", "AML1/ETO", "transcripts", "was", "seen", "following", "autologous", "PBSCT", "." ]

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11107

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11108

[ "Upregulation", "of", "c-Fos", "in", "activated", "T", "lymphoid", "and", "monocytic", "cells", "by", "human", "immunodeficiency", "virus-1", "Tat", "protein", "." ]

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11109

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11110

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11111

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11112

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11113

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11114

[ "A", "single", "point", "mutation", "in", "the", "SRE", "completely", "abrogated", "the", "responsiveness", "to", "tat/S", "." ]

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11115

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11116

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11117

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11118

[ "Cytokine", "signal", "networks", "and", "a", "new", "era", "in", "biomedical", "research", "." ]

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11119

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11120

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11121

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11122

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11123

[ "Regulation", "of", "the", "tissue", "factor", "gene", "in", "human", "monocytic", "cells", "." ]

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11124

[ "Role", "of", "AP-1", ",", "NF-kappa", "B/Rel", ",", "and", "Sp1", "proteins", "in", "uninduced", "and", "lipopolysaccharide-induced", "expression", "." ]

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11125

[ "Tissue", "factor", "(", "TF", ")", "expression", "by", "peripheral", "blood", "monocytes", "during", "sepsis", "initiates", "intravascular", "thrombosis", "." ]

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11126

[ "Bacterial", "lipopolysaccharide", "(", "LPS", ")", "rapidly", "induces", "TF", "gene", "transcription", "in", "monocytes", "." ]

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11127

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11128

[ "NF-kappa", "B/Rel", "proteins", "have", "been", "shown", "to", "physically", "interact", "with", "both", "AP-1", "and", "Sp1", "proteins", "." ]

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11129

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11130

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11131

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11132

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11133

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11134

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11135

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11136

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11137

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11138

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11139

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11140

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11141

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11142

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11143

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11144

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11145

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11146

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11147

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11148

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11149

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11150

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11151

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11152

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11153

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11154

[ "Involvement", "in", "the", "potentiation", "of", "platelet", "aggregation", "." ]

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11155

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11156

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11157

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11158

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11159

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11160

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11161

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11162

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11163

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11164

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11165

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11166

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11167

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11168

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11169

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11170

[ "Characterization", "of", "the", "cellular", "transcription", "factors", "interacting", "with", "the", "human", "T", "cell", "lymphotropic", "virus", "type", "I", "(", "HTLV-I", ")", "long", "terminal", "repeat", "(", "LTR", ")", "is", "essential", "to", "dissecting", "the", "mechanisms", "involved", "in", "viral", "transcription", "that", "may", "be", "pertinent", "to", "the", "oncogenic", "and", "neuropathogenic", "processes", "associated", "with", "HTLV-I", "infection", "in", "both", "the", "immune", "and", "nervous", "systems", "." ]

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11171

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11172

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11173

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11174

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11175

[ "HIV", "does", "not", "replicate", "in", "naive", "CD4", "T", "cells", "stimulated", "with", "CD3/CD28", "." ]

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11176

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11177

[ "In", "contrast", ",", "LAI", "replicates", "well", "in", "memory", "CD4", "T", "cells", "stimulated", "in", "the", "same", "way", "." ]

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11178

[ "Unlike", "this", "physiologically", "relevant", "stimulation", ",", "PHA", "stimulates", "productive", "LAI", "replication", "in", "both", "naive", "and", "memory", "T", "cells", "." ]

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11179

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11180

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11181

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11182

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11183

[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]

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11184

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11185

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11186

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11187

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11188

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11189

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11190

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11191

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11192

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11193

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11194

[ "DNA", "methylation", "changes", "are", "among", "the", "most", "common", "detectable", "abnormalities", "in", "human", "neoplasia", "." ]

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11195

[ "Hypermethylation", "within", "the", "promoters", "of", "selected", "genes", "appears", "to", "be", "especially", "common", "in", "all", "types", "of", "human", "hematopoietic", "neoplasms", ",", "and", "is", "usually", "associated", "with", "inactivation", "of", "the", "involved", "gene", "(", "s", ")", "." ]

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11196

[ "Such", "hypermethylation-associated", "silencing", "of", "gene", "expression", "has", "been", "shown", "for", "several", "genes", "regulating", "the", "growth", "and", "differentiation", "of", "hematopoietic", "cells", ",", "including", "the", "estrogen", "receptor", "(", "ER", ")", "gene", ",", "P15", ",", "P16", "and", "others", "." ]

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11197

[ "Hypermethylation", "within", "the", "promoters", "of", "some", "genes", "appear", "to", "be", "an", "early", "event", "in", "the", "pathogenesis", "of", "neoplasia", "(", "ER", ",", "P15", ")", ",", "while", "other", "genes", "seem", "to", "become", "methylated", "during", "the", "progression", "of", "leukemias", "(", "HIC1", ",", "c-abl", ")", "." ]

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11198

[ "The", "high", "prevalence", "of", "promoter", "methylation", "suggests", "that", "this", "molecular", "abnormality", "can", "be", "used", "to", "monitor", "disease", "activity", "during", "therapy", "." ]

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11199

[ "In", "addition", ",", "new", "technology", "allows", "the", "sensitive", "identification", "of", "gene", "hypermethylation", "in", "a", "background", "of", "normal", "cells", ",", "suggesting", "possible", "new", "strategies", "for", "the", "detection", "of", "minimal", "residual", "disease", "." ]

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11200

[ "Finally", ",", "reactivation", "of", "tumor-suppressor", "gene", "expression", "through", "pharmacologic", "inhibition", "of", "DNA", "methyltransferase", "and", "resultant", "DNA", "demethylation", "appears", "to", "be", "a", "promising", "new", "avenue", "of", "therapy", "in", "acute", "leukemia", "." ]

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