Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
10901
[ "EBF", "and", "E47", "collaborate", "to", "induce", "expression", "of", "the", "endogenous", "immunoglobulin", "surrogate", "light", "chain", "genes", "." ]
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10902
[ "Early", "B", "cell", "factor", "(", "EBF", ")", "and", "E47", "participate", "in", "the", "transcriptional", "control", "of", "early", "B", "lymphocyte", "differentiation", "." ]
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10903
[ "With", "the", "aim", "of", "identifying", "genetic", "targets", "for", "these", "transcription", "factors", ",", "we", "stably", "transfected", "cDNAs", "encoding", "EBF", "or", "a", "covalent", "homodimer", "of", "E47", ",", "individually", "or", "together", ",", "into", "immature", "hematopoietic", "Ba/F3", "cells", ",", "which", "lack", "both", "factors", "." ]
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10904
[ "In", "combination", ",", "EBF", "and", "E47", "induce", "efficient", "expression", "of", "the", "endogenous", "immunoglobulin", "surrogate", "light", "chain", "genes", ",", "lambda5", "and", "VpreB", ",", "whereas", "other", "pre-B", "cell-specific", "genes", "remain", "silent", "." ]
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10905
[ "Multiple", "functionally", "important", "EBF", "and", "E47", "binding", "sites", "were", "identified", "in", "the", "lambda5", "promoter/enhancer", "region", ",", "indicating", "that", "lambda5", "is", "a", "direct", "genetic", "target", "for", "these", "transcription", "factors", "." ]
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10906
[ "Taken", "together", ",", "these", "data", "suggest", "that", "EBF", "and", "E47", "synergize", "to", "activate", "expression", "of", "a", "subset", "of", "genes", "that", "define", "an", "early", "stage", "of", "the", "B", "cell", "lineage", "." ]
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10907
[ "Cytokines", ":", "shared", "receptors", ",", "distinct", "functions", "." ]
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10908
[ "That", "the", "signal", "transduction", "pathways", "used", "by", "the", "cytokines", "IL-2", "and", "IL-15", "are", "identical", "would", "suggest", "that", "these", "cytokines", "have", "redundant", "roles", "in", "lymphoid", "development", ";", "instead", ",", "IL-2", "is", "the", "guardian", "of", "thymus-derived", "T-cell", "homeostasis", ",", "while", "interleukin-15", "promotes", "extrathymic", "development", "of", "T", "and", "NK", "cells", "." ]
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10909
[ "The", "IL-4", "receptor", "alpha-chain", "cytoplasmic", "domain", "is", "sufficient", "for", "activation", "of", "JAK-1", "and", "STAT6", "and", "the", "induction", "of", "IL-4", "-specific", "gene", "expression", "." ]
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10910
[ "The", "common", "gamma-chain", "(", "gamma", "(", "c", ")", ")", "is", "a", "functional", "component", "of", "the", "IL-4R", ",", "yet", "cells", "lacking", "gamma", "(", "c", ")", "are", "able", "to", "respond", "to", "IL-4", "." ]
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10911
[ "This", "has", "led", "to", "the", "suggestion", "that", "a", "surrogate", "gamma'-chain", ",", "which", "can", "interact", "with", "the", "IL-4R", "alpha", "chain", "to", "mediate", "signaling", ",", "is", "expressed", "on", "cells", "lacking", "gamma", "(", "c", ")", "." ]
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10912
[ "An", "alternative", "possibility", "is", "that", "in", "the", "absence", "of", "gamma", "(", "c", ")", ",", "the", "IL-4R", "alpha", "chain", "is", "able", "to", "transduce", "signals", "by", "homodimerization", "." ]
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10913
[ "To", "test", "this", "latter", "possibility", ",", "a", "chimeric", "receptor", "containing", "the", "extracellular", "domain", "of", "c-kit", "(", "the", "stem", "cell", "factor", "(", "SCF", ")", "receptor", ")", "and", "the", "cytoplasmic", "and", "transmembrane", "domains", "of", "the", "IL-4R", "alpha", "chain", "was", "generated", "." ]
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10914
[ "Treatment", "of", "cells", "expressing", "the", "chimeric", "receptor", "kit/IL-4R", "alpha", "with", "SCF", "induces", "activation", "of", "the", "IL-4R", "alpha-associated", "kinase", "JAK-1", "and", "the", "transcription", "factor", "STAT6", "." ]
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10915
[ "However", ",", "tyrosine", "phosphorylation", "of", "JAK-3", ",", "which", "associates", "with", "gamma", "(", "c", ")", ",", "is", "not", "induced", "by", "SCF", "in", "these", "cells", "." ]
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10916
[ "SCF", "-mediated", "ligation", "of", "kit/IL-4R", "alpha", "is", "sufficient", "to", "elicit", "IL-4", "-specific", "gene", "expression", ",", "including", "up-regulation", "of", "CD23", "and", "synthesis", "of", "germ-line", "epsilon", "transcripts", "." ]
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10917
[ "In", "the", "T", "cell", "line", "CTLL2", ",", "ligation", "of", "kit/IL-4R", "alpha", "induces", "cellular", "proliferation", "." ]
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10918
[ "Finally", ",", "in", "JAK-1-deficient", "HeLa", "cells", ",", "STAT6", "activation", "by", "IL-4", "is", "completely", "abolished", "." ]
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10919
[ "Together", ",", "these", "data", "demonstrate", "that", "the", "IL-4R", "alpha", "cytoplasmic", "domain", "is", "sufficient", "to", "activate", "JAK-1", "and", "STAT6", "and", "to", "induce", "expression", "of", "IL-4", "target", "genes", ",", "thus", "identifying", "a", "mechanism", "by", "which", "IL-4", "signaling", "can", "proceed", "in", "the", "absence", "of", "JAK-3", "and", "gamma", "(", "c", ")", "." ]
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10920
[ "Histamine", "modulates", "the", "expression", "of", "c-fos", "through", "cyclic", "AMP", "production", "via", "the", "H2", "receptor", "in", "the", "human", "promonocytic", "cell", "line", "U937", "." ]
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10921
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10922
[ "Histamine", "transiently", "increased", "cAMP", "and", "c-fos", "expression", "through", "H2", "receptors", "." ]
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10923
[ "Dibutyryl", "cAMP", "also", "increased", "c-fos", "mRNA", "and", "protein", ",", "and", "levels", "remained", "elevated", "even", "after", "12", "hr", "of", "treatment", "." ]
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10924
[ "Dose-dependence", "studies", "using", "histamine", "and", "dimaprit", "showed", "that", "the", "EC50", "values", "for", "cAMP", "production", "and", "c-fos", "increase", "were", "similar", ",", "suggesting", "that", "cAMP", "might", "be", "involved", "in", "c-fos", "induction", "via", "H2", "receptors", "." ]
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10925
[ "Furthermore", ",", "studies", "carried", "out", "using", "H7", ",", "a", "protein", "kinase", "A/protein", "kinase", "C", "inhibitor", ",", "blocked", "c-fos", "induction", ",", "whereas", "no", "effect", "was", "observed", "with", "bisindolylmaleimide", ",", "a", "specific", "protein", "kinase", "C", "inhibitor", "." ]
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10926
[ "No", "modification", "of", "c-myc", "expression", "could", "be", "detected", "on", "treatment", "with", "histamine", "or", "its", "analogues", "." ]
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10927
[ "Nevertheless", ",", "dibutyryl", "cAMP", "induced", "a", "down-regulation", "of", "the", "levels", "of", "this", "proto-oncogene", "." ]
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10928
[ "In", "addition", ",", "dibutyryl", "cAMP", "inhibited", "cell", "growth", "in", "a", "dose-dependent", "manner", ",", "whereas", "histamine", "failed", "to", "affect", "proliferation", "and", "differentiation", "of", "U937", "cells", "." ]
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10929
[ "Cells", "pretreated", "with", "dimaprit", "showed", "a", "decrease", "in", "the", "cAMP", "response", "to", "subsequent", "addition", "of", "H2", "agonists", ",", "whereas", "the", "cAMP", "response", "to", "prostaglandin", "E2", "remained", "unaltered", "." ]
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10930
[ "This", "homologous", "mechanism", "of", "H2", "receptor", "desensitization", "was", "time", "dependent", "." ]
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10931
[ "These", "results", "indicate", "that", "histamine", "activates", "several", "mechanisms", "involved", "in", "the", "induction", "of", "differentiation", ",", "such", "as", "cAMP", "and", "c-fos", "production", ",", "but", "fails", "to", "promote", "differentiation", "of", "U937", "cells", ",", "apparently", "due", "to", "the", "rapid", "desensitization", "of", "H2", "receptors", "." ]
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10932
[ "Induction", "of", "cytokine", "expression", "in", "leukocytes", "by", "binding", "of", "thrombin-stimulated", "platelets", "." ]
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10933
[ "BACKGROUND", ":", "Activated", "platelets", "tether", "and", "activate", "myeloid", "leukocytes", "." ]
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10934
[ "To", "investigate", "the", "potential", "relevance", "of", "this", "mechanism", "in", "acute", "myocardial", "infarction", "(", "AMI", ")", ",", "we", "examined", "cytokine", "induction", "by", "leukocyte-platelet", "adhesion", "and", "the", "occurrence", "of", "leukocyte-platelet", "conjugates", "in", "patients", "with", "AMI", "." ]
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10935
[ "METHODS", "AND", "RESULTS", ":", "We", "obtained", "peripheral", "venous", "blood", "samples", "in", "20", "patients", "with", "AMI", "before", "and", "daily", "for", "5", "days", "after", "direct", "percutaneous", "transluminal", "coronary", "angioplasty", "(", "PTCA", ")", "and", "in", "20", "patients", "undergoing", "elective", "PTCA", "." ]
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10936
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10937
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10938
[ "Within", "2", "hours", ",", "this", "resulted", "in", "increased", "mRNA", "for", "interleukin", "(", "IL", ")", ",", "1", "beta", ",", "IL-8", ",", "and", "monocyte", "chemoattractant", "protein", "(", "MCP", ")", "-1", "in", "unfractionated", "leukocytes", "." ]
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10939
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10940
[ "Addition", "of", "activated", "platelets", "to", "adherent", "monocytes", "had", "a", "similar", "effect", "and", "was", "associated", "with", "nuclear", "factor-kappa", "B", "activation", "." ]
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10941
[ "Inhibition", "of", "binding", "by", "anti-P", "selectin", "antibodies", "reduced", "the", "effect", "of", "activated", "platelets", "on", "cytokine", "production", "." ]
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10942
[ "CONCLUSIONS", ":", "In", "patients", "with", "AMI", ",", "leukocyte-platelet", "adhesion", "is", "increased", "." ]
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10943
[ "Binding", "of", "activated", "platelets", "induces", "IL-1", "beta", ",", "IL-8", ",", "and", "MCP-1", "in", "leukocytes", "." ]
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10944
[ "Our", "findings", "suggest", "that", "leukocyte-platelet", "adhesion", "contributes", "to", "the", "regulation", "of", "inflammatory", "responses", "in", "AMI", "." ]
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10945
[ "Immediate", "early", "and", "early", "lytic", "cycle", "proteins", "are", "frequent", "targets", "of", "the", "Epstein-Barr", "virus-induced", "cytotoxic", "T", "cell", "response", "." ]
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10946
[ "Epstein-Barr", "virus", "(", "EBV", ")", ",", "a", "human", "gamma-herpesvirus", ",", "can", "establish", "both", "nonproductive", "(", "latent", ")", "and", "productive", "(", "lytic", ")", "infections", "." ]
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10947
[ "Although", "the", "CD8+", "cytotoxic", "T", "lymphocyte", "(", "CTL", ")", "response", "to", "latently", "infected", "cells", "is", "well", "characterized", ",", "very", "little", "is", "known", "about", "T", "cell", "controls", "over", "lytic", "infection", ";", "this", "imbalance", "in", "our", "understanding", "belies", "the", "importance", "of", "virus-replicative", "lesions", "in", "several", "aspects", "of", "EBV", "disease", "pathogenesis", "." ]
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10948
[ "The", "present", "work", "shows", "that", "the", "primary", "CD8+", "CTL", "response", "to", "EBV", "in", "infectious", "mononucleosis", "patients", "contains", "multiple", "lytic", "antigen-specific", "reactivities", "at", "levels", "at", "least", "as", "high", "as", "those", "seen", "against", "latent", "antigens", ";", "similar", "reactivities", "are", "also", "detectable", "in", "CTL", "memory", "." ]
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10949
[ "Clonal", "analysis", "revealed", "individual", "responses", "to", "the", "two", "immediate", "early", "proteins", "BZLF1", "and", "BRLF1", ",", "and", "to", "three", "(", "BMLF1", ",", "BMRF1", ",", "and", "BALF2", ")", "of", "the", "six", "early", "proteins", "tested", "." ]
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10950
[ "In", "several", "cases", ",", "the", "peptide", "epitope", "and", "HLA-restricting", "determinant", "recognized", "by", "these", "CTLs", "has", "been", "defined", ",", "one", "unusual", "feature", "being", "the", "number", "of", "responses", "restricted", "through", "HLA-C", "alleles", "." ]
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10951
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10952
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10953
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10960
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10962
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10965
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10966
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10967
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10968
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10969
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10970
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10971
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10973
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10974
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10975
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10976
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10977
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10978
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10979
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10980
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10981
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10982
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10983
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10985
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10986
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10987
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10988
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10989
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10990
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10991
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10992
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10993
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10994
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10995
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10996
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10997
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10998
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10999
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11000
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