Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
10701
[ "ZEBRA", "activation", "can", "be", "replaced", "by", "a", "heterologous", "acidic", ",", "proline-rich", ",", "or", "glutamine-rich", "activation", "domain", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10702
[ "ZEBRA", "activation", "domain", "swap", "constructs", "retain", "ZEBRA", "'s", "native", "abilities", "to", "activate", "specific", "EBV", "promoters", ",", "to", "disrupt", "EBV", "latency", ",", "and", "to", "stimulate", "replication", "at", "the", "EBV", "lytic", "origin", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10703
[ "Additional", "work", ",", "employing", "sequential", "and", "internal", "deletions", "of", "ZEBRA", "'s", "N-terminal", "activation", "domain", ",", "indicates", "that", "its", "separate", "activities", "are", "not", "attributable", "to", "specific", "subdomains", "but", "are", "spread", "throughout", "its", "N", "terminus", "and", "therefore", "can", "not", "be", "inactivated", "by", "deleting", "localized", "regions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10704
[ "CholecystokininB", "receptor", "from", "human", "Jurkat", "lymphoblastic", "T", "cells", "is", "involved", "in", "activator", "protein-1", "-responsive", "gene", "activation", "." ]
[ 9, 10, 0, 5, 6, 6, 6, 6, 0, 0, 0, 1, 2, 2, 2, 0, 0 ]
10705
[ "The", "aim", "of", "this", "study", "was", "to", "analyze", "the", "role", "of", "cholecystokinin", "(", "CCK", "(", "B", ")", ")", "receptor", "in", "human", "lymphoblastic", "Jurkat", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 9, 0, 5, 6, 6, 6, 6, 0 ]
10706
[ "We", "investigated", "the", "trophic", "effect", "resulting", "from", "activation", "of", "such", "a", "receptor", "by", "using", "the", "reporter", "gene", "strategy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10707
[ "For", "this", "purpose", ",", "we", "transiently", "transfected", "Jurkat", "T", "cells", "with", "the", "reporter", "plasmid", "p", "[", "(", "TRE", ")", "3-tk-Luc", "]", "and", "found", "that", "CCK-8", "was", "able", "to", "dose-dependently", "induce", "luciferase", "expression", "related", "to", "activator", "protein-1", "(", "AP-1", ")", "activation", "with", "a", "maximal", "response", "identical", "to", "that", "obtained", "with", "compounds", "known", "to", "activate", "AP-1", "complex", "(", "quantitatively", ",", "the", "same", "level", "of", "induction", "was", "obtained", "with", "1", "nM", "12-O-tetradecanoylphorbol-13-acetate", ",", "100", "microM", "diacylglycerol", ",", "or", "4", "nM", "epidermal", "growth", "factor", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10708
[ "The", "involvement", "of", "the", "CCK", "(", "B", ")", "receptor", "in", "such", "a", "stimulation", "was", "demonstrated", "by", "the", "inhibiting", "effect", "of", "the", "selective", "CCK", "(", "B", ")", "receptor", "antagonist", "PD-135", ",", "158", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0 ]
10709
[ "This", "effect", "was", "confirmed", "in", "COS-7", "cells", "transfected", "with", "the", "cDNA", "of", "CCK", "(", "B", ")", "receptor", "cloned", "from", "Jurkat", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 5, 6, 6, 0 ]
10710
[ "To", "better", "understand", "the", "AP-1", "-dependent", "luciferase", "expression", "in", "Jurkat", "T", "cells", ",", "we", "tested", "two", "specific", "inhibitors", "of", "serine/threonine", "phosphatases-1", "and", "-2A", ":", "okadaic", "acid", "and", "calyculin", "A", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
10711
[ "These", "compounds", "strongly", "increased", "the", "phorbol-12-myristate-13-acetate", "response", ",", "whereas", "we", "have", "not", "observed", "a", "contribution", "of", "phosphatase", "inhibitors", "on", "a", "CCK-8-induced", "luciferase", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
10712
[ "To", "confirm", "that", "CCK", "(", "B", ")", "receptors", "are", "involved", "in", "AP-1", "response", ",", "we", "investigated", "the", "CCK-8", "effect", "on", "interleukin-2", "expression", ",", "a", "natural", "endogenous", "gene", "regulated", "by", "several", "factors", ",", "including", "AP-1", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
10713
[ "In", "Jurkat", "T", "cells", "activated", "by", "phorbol-12-myristate-13-acetate", "and", "phytohemagglutinin", ",", "CCK-8", "induced", "IL-2", "expression", "." ]
[ 0, 5, 6, 6, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0 ]
10714
[ "This", "induction", "was", "abolished", "by", "PD-135", ",", "158", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10715
[ "Our", "results", "indicate", "that", "CCK-8", "exerts", "a", "trophic", "effect", "in", "Jurkat", "T", "cells", "through", "stimulation", "of", "CCK", "(", "B", ")", "receptors", "by", "modulation", "of", "expression", "of", "AP-1-regulated", "genes", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 1, 2, 0 ]
10716
[ "A", "conserved", "tissue-specific", "structure", "at", "a", "human", "T-cell", "receptor", "beta-chain", "core", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
10717
[ "The", "T-cell", "receptor", "(", "TCR", ")", "beta-chain", "promoters", "have", "been", "characterized", "as", "nonstructured", "basal", "promoters", "that", "carry", "a", "single", "conserved", "ubiquitous", "cyclic", "AMP-responsive", "element", "." ]
[ 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
10718
[ "Our", "investigation", "of", "the", "human", "TCR", "beta", "gene", "uncovers", "a", "surprisingly", "complex", "and", "tissue-specific", "structure", "at", "the", "TCR", "Vbeta", "8.1", "promoter", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
10719
[ "The", "core", "of", "the", "promoter", "(", "positions", "-42", "to", "+11", ")", "is", "recognized", "by", "the", "lymphoid", "cell-specific", "transcription", "factors", "Ets-1", ",", "LEF1", ",", "and", "AML1", "as", "well", "as", "by", "CREB/ATF-1", ",", "as", "is", "demonstrated", "in", "gel", "shift", "and", "footprinting", "experiments", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10720
[ "With", "the", "exception", "of", "LEF1", ",", "these", "factors", "activate", "transcription", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
10721
[ "Binding", "sites", "at", "the", "core", "region", "show", "little", "conservation", "with", "consensus", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10722
[ "Nonetheless", ",", "CREB", ",", "Ets-1", ",", "and", "AML1", "bind", "and", "activate", "cooperatively", "and", "very", "efficiently", "through", "the", "nonconsensus", "binding", "sites", "at", "the", "core", "promoter", "region", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10723
[ "Moderate", "ubiquitous", "activation", "is", "further", "induced", "by", "CREB/ATF", "and", "Sp1", "factors", "through", "proximal", "upstream", "elements", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0 ]
10724
[ "The", "tissue-specific", "core", "promoter", "structure", "is", "apparently", "conserved", "in", "other", "T-cell-specifically", "expressed", "genes", "such", "as", "the", "CD4", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
10725
[ "Our", "observations", "suggest", "that", "both", "the", "enhancer", "and", "the", "promoter", "have", "a", "complex", "tissue-specific", "structure", "whose", "functional", "interplay", "potentiates", "T-cell-specific", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10726
[ "The", "cytoplasmic", "domain", "of", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "receptor", "alpha", "subunit", "is", "essential", "for", "both", "GM-CSF", "-mediated", "growth", "and", "differentiation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
10727
[ "Granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "regulates", "differentiation", ",", "survival", ",", "and", "proliferation", "of", "colony-forming", "unit-granulocyte-macrophage", "progenitor", "cells", "." ]
[ 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
10728
[ "The", "biologic", "actions", "of", "GM-CSF", "are", "mediated", "by", "binding", "to", "a", "specific", "receptor", "consisting", "of", "two", "chains", "designated", "as", "alpha", "and", "beta", "subunits", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10729
[ "We", "have", "demonstrated", "that", "the", "murine", "FDC-P1-derived", "cell", "line", "WT-19", "transfected", "with", "the", "human", "GM-CSF", "receptor", "alpha", "and", "beta", "subunits", "(", "GM-CSFRalpha", "and", "beta", ")", "can", "be", "induced", "to", "differentiate", "by", "the", "addition", "of", "human", "GM-CSF", "(", "hGM-CSF", ")", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]
10730
[ "By", "expressing", "a", "series", "of", "GM-CSFRalpha", "mutants", "in", "WT19", "cells", ",", "we", "have", "determined", "the", "amino", "acid", "domains", "of", "the", "GM-CSFRalpha", "cytoplasmic", "domain", "that", "regulate", "cell", "differentiation", ",", "proliferation", ",", "and", "survival", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10731
[ "We", "found", "that", "the", "membrane", "proximal", "proline-rich", "domain", "and", "adjacent", "16", "residues", "are", "essential", "for", "both", "hGM-CSF", "-dependent", "cell", "proliferation", "and", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
10732
[ "In", "contrast", ",", "the", "C-terminal", "region", "of", "the", "GM-CSFRalpha", "cytoplasmic", "domain", "was", "not", "necessary", "for", "cell", "differentiation", "mediated", "by", "hGM-CSF", ",", "but", "the", "removal", "of", "this", "region", "severely", "impaired", "the", "ability", "of", "hGM-CSF", "to", "support", "cell", "survival", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
10733
[ "While", "the", "activation", "of", "JAK2", ",", "Shc", ",", "Erk", ",", "and", "STAT5", "proteins", "correlated", "with", "hGM-CSF", "-mediated", "cell", "growth", ",", "cellular", "differentiation", "occurred", "in", "the", "absence", "of", "activation", "of", "these", "signal", "transduction", "pathways", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10734
[ "gamma-Interferon", "-induced", "resistance", "to", "1", ",", "25-", "(", "OH", ")", "2", "D3", "in", "human", "monocytes", "and", "macrophages", ":", "a", "mechanism", "for", "the", "hypercalcemia", "of", "various", "granulomatoses", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10735
[ "The", "hypercalcemia", "of", "various", "granulomatoses", "is", "caused", "by", "endogenous", "1", ",", "25-dihydroxyvitamin", "D", "[", "1", ",", "25-", "(", "OH", ")", "2D3", "]", "overproduction", "by", "disease-activated", "macrophages", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
10736
[ "The", "inability", "of", "1", ",", "25", "(", "OH", ")", "2D3", "to", "suppress", "its", "synthesis", "in", "macrophages", "contrasts", "with", "the", "tight", "control", "of", "its", "production", "in", "macrophage", "precursors", ",", "peripheral", "blood", "monocytes", "(", "PBM", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 8, 0, 7, 0, 0 ]
10737
[ "We", "examined", "whether", "1", ",", "25", "(", "OH", ")", "2D3", "resistance", "develops", "as", "PBM", "differentiate", "to", "macrophages", "or", "with", "macrophage", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 0, 0, 7, 0, 0 ]
10738
[ "Normal", "human", "pulmonary", "alveolar", "macrophages", "(", "PAM", ")", "are", "less", "sensitive", "to", "1", ",", "25", "(", "OH", ")", "2D3", "than", "PBM", ",", "despite", "similar", "vitamin", "D", "receptor", "content", ";", "however", ",", "both", "PBM", "and", "PAM", "respond", "to", "exogenous", "1", ",", "25-", "(", "OH", ")", "2D3", "by", "inhibiting", "1", ",", "25", "(", "OH", ")", "2D3", "synthesis", "and", "inducing", "1", ",", "25", "(", "OH", ")", "2D3", "degradation", "through", "enhancement", "of", "24-hydroxylase", "mRNA", "levels", "and", "activity", "." ]
[ 0, 7, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10739
[ "The", "human", "monocytic", "cell", "line", "THP-1", "mimics", "PAM", "in", "1", ",", "25", "(", "OH", ")", "2D3", "synthesis", "and", "sensitivity", "to", "exogenous", "1", ",", "25", "(", "OH", ")", "2D3", "." ]
[ 0, 5, 6, 6, 6, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10740
[ "We", "utilized", "THP-1", "cells", "to", "examine", "the", "response", "to", "1", ",", "25", "(", "OH", ")", "2D3", "with", "macrophage", "activation", "." ]
[ 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10741
[ "Activation", "of", "THP-1", "cells", "with", "gamma-interferon", "(", "gamma-IFN", ")", "enhances", "1", ",", "25", "(", "OH", ")", "2D3", "synthesis", "30-fold", ",", "blocks", "1", ",", "25-", "(", "OH", ")", "2D3", "suppression", "of", "its", "synthesis", ",", "and", "reduces", "by", "42.2", "%", "1", ",", "25-", "(", "OH", ")", "2D3", "induction", "of", "its", "degradation", "." ]
[ 0, 0, 5, 6, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10742
[ "The", "antagonistic", "effects", "of", "gamma-IFN", "are", "not", "merely", "restricted", "to", "enzymatic", "activities", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
10743
[ "In", "THP-1", "cells", "and", "in", "normal", "PBM", ",", "gamma-IFN", "inhibits", "1", ",", "25-", "(", "OH", ")", "2D3", "induction", "of", "24-hydroxylase", "mRNA", "levels", "without", "reducing", "mRNA", "stability", ",", "suggesting", "gamma-IFN", "inhibition", "of", "1", ",", "25", "(", "OH", ")", "2D3", "transactivating", "function", "." ]
[ 0, 5, 6, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10744
[ "These", "results", "explain", "1", ",", "25", "(", "OH", ")", "2D3", "overproduction", "in", "granulomatoses", "and", "demonstrate", "potent", "inhibition", "by", "gamma-IFN", "of", "1", ",", "25", "(", "OH", ")", "2D3", "action", "in", "immune", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10745
[ "Molecular", "cloning", "and", "characterization", "of", "a", "cDNA", ",", "CHEMR1", ",", "encoding", "a", "chemokine", "receptor", "with", "a", "homology", "to", "the", "human", "C-C", "chemokine", "receptor", ",", "CCR-4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
10746
[ "Chemokines", "refer", "to", "a", "rapidly", "expanding", "family", "of", "small", "cytokines", "whose", "primary", "function", "is", "recruitment", "of", "leukocytes", "to", "inflammatory", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
10747
[ "These", "are", "known", "to", "bind", "to", "seven-transmembrane-domain", "containing", "receptors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10748
[ "A", "cDNA", "clone", ",", "CHEMR1", ",", "resembling", "the", "typical", "G", "protein-coupled", "receptor", ",", "was", "isolated", "from", "a", "mouse", "cytotoxic", "T-lymphocyte", "(", "CTL", ")", "library", "." ]
[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0 ]
10749
[ "Northern", "blot", "analysis", "in", "mouse", "cell", "lines", "suggests", "that", "its", "expression", "is", "found", "in", "a", "variety", "of", "cells", ",", "including", "T", "cells", ",", "B", "cells", ",", "and", "macrophages", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 0, 7, 0 ]
10750
[ "The", "CHEMR1", "gene", "Scya3r2", "is", "a", "single-copy", "gene", "whose", "open", "reading", "frame", "may", "be", "in", "a", "single", "exon", "and", "maps", "to", "the", "distal", "region", "of", "mouse", "Chr", "9", "where", "the", "mouse", "macrophage", "inflammatory", "protein-1alpha", "(", "MIP-1alpha", ")", "receptor", "gene", "Scya3r", "and", "two", "related", "C-C", "chemokine", "receptor-like", "genes", "reside", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10751
[ "Amino", "acid", "sequence", "comparison", "shows", "that", "CHEMR1", "is", "84", "%", "identical", "to", "human", "CCR-4", ",", "indicating", "that", "CHEMR1", "is", "likely", "to", "be", "a", "mouse", "CCR-4", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 10, 0 ]
10752
[ "Binding", "assays", "using", "125I-labeled", "C-C", "chemokines", "in", "mammalian", "cells", "indicated", "that", "CHEMR1", "did", "not", "bind", "MIP-1alpha", ",", "RANTES", ",", "or", "MIP-1beta", ",", "whereas", "CCR-1", "binds", "MIP-1alpha", "and", "RANTES", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 9, 0, 9, 0, 9, 0 ]
10753
[ "Our", "result", "is", "different", "from", "the", "reported", "properties", "of", "human", "CCR-4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
10754
[ "This", "suggests", "that", "CHEMR1", "may", "be", "a", "receptor", "for", "unidentified", "C-C", "chemokine", "or", "a", "low-affinity", "receptor", "for", "MIP-1alpha", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
10755
[ "Transactivation", "by", "CIITA", ",", "the", "type", "II", "bare", "lymphocyte", "syndrome-associated", "factor", ",", "requires", "participation", "of", "multiple", "regions", "of", "the", "TATA", "box", "binding", "protein", "." ]
[ 0, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
10756
[ "CIITA", "is", "a", "positive", "regulator", "of", "class", "II", "major", "histocompatibility", "complex", "gene", "transcription", "that", "has", "been", "found", "to", "be", "defective", "in", "one", "of", "the", "five", "complementation", "groups", "of", "class", "II", "major", "histocompatibility", "complex-negative", "cell", "lines", "." ]
[ 9, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10757
[ "Its", "N-terminal", "region", "is", "capable", "of", "activating", "transcription", "from", "a", "reporter", "gene", "when", "fused", "to", "a", "DNA", "binding", "domain", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10758
[ "We", "have", "investigated", "the", "mechanism", "of", "transactivation", "mediated", "by", "the", "CIITA", "activation", "domain", "by", "studying", "its", "role", "in", "the", "process", "of", "transcription", "initiation", "and", "elongation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10759
[ "Specifically", "the", "altered", "specificity", "TBP", "(", "TATA", "box", "binding", "protein", ")", "assay", "has", "been", "used", "to", "analyze", "the", "response", "of", "the", "CIITA", "activation", "domain", "to", "mutations", "in", "TBP", "known", "to", "disrupt", "its", "interaction", "with", "its", "associated", "general", "factors", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10760
[ "Transactivation", "by", "CIITA", "was", "extremely", "sensitive", "to", "a", "mutation", "in", "TBP", "that", "in", "yeast", "is", "known", "to", "abolish", "VP16", "-mediated", "transcription", "but", "leaves", "basal", "transcription", "unaffected", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
10761
[ "A", "TBP", "mutant", "defective", "in", "interaction", "with", "TBP-associated", "factor", "TAFII250", "also", "failed", "to", "mediate", "transactivation", "through", "the", "CIITA", "activation", "domain", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
10762
[ "Certain", "interactions", "between", "TBP", "and", "general", "factors", "that", "are", "specifically", "required", "for", "acidic", "activation", "domains", "were", "also", "required", "for", "CIITA", "-mediated", "transactivation", "to", "reach", "its", "full", "potential", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
10763
[ "Finally", ",", "like", "VP16", ",", "CIITA", "was", "able", "to", "stimulate", "elongation", "of", "transcription", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
10764
[ "Overall", "the", "mechanism", "of", "transactivation", "by", "the", "human", "B-cell-specific", "CIITA", "is", "very", "similar", "to", "that", "mediated", "by", "the", "herpes", "virus", "transactivator", "VP16", "in", "the", "ways", "that", "have", "been", "tested", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
10765
[ "Relief", "of", "cyclin", "A", "gene", "transcriptional", "inhibition", "during", "activation", "of", "human", "primary", "T", "lymphocytes", "via", "CD2", "and", "CD28", "adhesion", "molecules", "." ]
[ 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 9, 0, 9, 10, 10, 0 ]
10766
[ "Cyclin", "A", "transcription", "is", "cell", "cycle", "regulated", "and", "induced", "by", "cell", "proliferative", "signals", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10767
[ "To", "understand", "the", "mechanisms", "underlined", "in", "this", "regulation", "in", "normal", "human", "cells", ",", "we", "have", "analysed", "in", "vivo", "protein-DNA", "interactions", "at", "the", "Cyclin", "A", "locus", "in", "primary", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 7, 8, 0 ]
10768
[ "Stimulation", "of", "purified", "T", "lymphocytes", "by", "a", "combination", "of", "monoclonal", "antibodies", "directed", "at", "CD2", "and", "CD28", "adhesion", "molecules", "gives", "rise", "to", "a", "long", "lasting", "proliferation", "in", "the", "absence", "of", "accessory", "cells", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10769
[ "Cyclin", "A", "was", "observed", "after", "4", "days", "of", "costimulation", "with", "anti", "CD2", "+", "CD28", "whereas", "stimulation", "by", "anti", "CD2", "or", "anti", "CD28", "alone", "was", "not", "effective", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0 ]
10770
[ "In", "vivo", "genomic", "DMS", "footprinting", "revealed", "upstream", "of", "the", "major", "transcription", "initiation", "sites", ",", "the", "presence", "of", "at", "least", "three", "protein", "binding", "sites", ",", "two", "of", "which", "were", "constitutively", "occupied", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10771
[ "They", "bind", "in", "vitro", "respectively", "ATF-1", "and", "NF-Y", "proteins", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]
10772
[ "The", "third", "site", "was", "occupied", "in", "quiescent", "cells", "or", "in", "cells", "stimulated", "by", "anti", "CD2", "or", "anti", "CD28", "alone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]
10773
[ "The", "mitogenic", "combination", "of", "anti", "CD2", "+", "anti", "CD28", "released", "the", "footprint", "as", "cells", "were", "committed", "to", "proliferation", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10774
[ "Consistent", "with", "theses", "results", ",", "nuclear", "extracts", "prepared", "from", "quiescent", "cells", "formed", "a", "specific", "complex", "with", "this", "element", ",", "whereas", "extracts", "prepared", "from", "cells", "treated", "with", "anti", "CD2", "+", "anti", "CD28", "failed", "to", "do", "so", "after", "cells", "entered", "a", "proliferative", "state", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10775
[ "An", "enhancer-blocking", "element", "between", "alpha", "and", "delta", "gene", "segments", "within", "the", "human", "T", "cell", "receptor", "alpha/delta", "locus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
10776
[ "T", "cell", "receptor", "(", "TCR", ")", "alpha", "and", "delta", "gene", "segments", "are", "organized", "within", "a", "single", "genetic", "locus", "but", "are", "differentially", "regulated", "during", "T", "cell", "development", "." ]
[ 1, 2, 2, 2, 2, 2, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
10777
[ "An", "enhancer-blocking", "element", "(", "BEAD-1", ",", "for", "blocking", "element", "alpha/delta", "1", ")", "was", "localized", "to", "a", "2.0-kb", "region", "3", "'", "of", "TCR", "delta", "gene", "segments", "and", "5", "'", "of", "TCR", "alpha", "joining", "gene", "segments", "within", "this", "locus", "." ]
[ 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
10778
[ "BEAD-1", "blocked", "the", "ability", "of", "the", "TCR", "delta", "enhancer", "(", "Edelta", ")", "to", "activate", "a", "promoter", "when", "located", "between", "the", "two", "in", "a", "chromatin-integrated", "construct", "." ]
[ 1, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10779
[ "We", "propose", "that", "BEAD-1", "functions", "as", "a", "boundary", "that", "separates", "the", "TCR", "alpha/delta", "locus", "into", "distinct", "regulatory", "domains", "controlled", "by", "Edelta", "and", "the", "TCR", "alpha", "enhancer", ",", "and", "that", "it", "prevents", "Edelta", "from", "opening", "the", "chromatin", "of", "the", "TCR", "alpha", "joining", "gene", "segments", "for", "VDJ", "recombination", "at", "an", "early", "stage", "of", "T", "cell", "development", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
10780
[ "Uncoupling", "of", "cell", "cycle", "arrest", "from", "the", "expression", "of", "monocytic", "differentiation", "markers", "in", "HL60", "cell", "variants", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0 ]
10781
[ "Differentiation", "generally", "leads", "to", "cell", "cycle", "arrest", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
10782
[ "Human", "leukemia", "HL60", "cells", "respond", "to", "the", "presence", "of", "1", ",", "25-dihydroxyvitamin", "D3", "(", "1", ",", "25D3", ")", "by", "expressing", "a", "number", "of", "markers", "of", "the", "monocyte/macrophage", "phenotype", "and", "become", "arrested", "predominantly", "in", "the", "G1", "phase", "of", "the", "cell", "cycle", "." ]
[ 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10783
[ "We", "have", "recently", "reported", "a", "series", "(", "A", ")", "of", "1", ",", "25D3-resistant", "variants", "of", "HL60", "cells", "which", "proliferate", "in", "the", "presence", "of", "1", ",", "25D3", "and", "do", "not", "express", "differentiation", "markers", "(", "Exp.", "Cell", "Res.", "224", ",", "312", ",", "1996", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10784
[ "We", "now", "describe", "another", "series", "(", "B", ")", "of", "such", "variants", ",", "which", "differ", "from", "A", "series", "cells", "grown", "in", "similar", "concentrations", "of", "1", ",", "25D3", "in", "that", "they", "express", "the", "CD14", "antigen", "and", "nonspecific", "esterase", ",", "characteristic", "of", "the", "monocyte", ",", "while", "continuing", "to", "proliferate", "and", "they", "develop", "hypotetraploid", "DNA", "(", "4C", ")", "content", "at", "higher", "concentrations", "of", "ambient", "1", ",", "25D3", "than", "the", "A", "series", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10785
[ "Cells", "in", "the", "B", "series", "with", "4C", "DNA", "content", "(", "100B", "and", "200B", ")", "also", "differed", "from", "the", "A", "series", "4C", "cells", "by", "the", "absence", "of", "DNA", "binding", "by", "the", "full-length", "Sp1", "transcription", "factor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
10786
[ "However", ",", "B", "series", "cells", "resembled", "the", "A", "series", "cells", "in", "exhibiting", "faster", "growth", "rates", "than", "the", "parental", "HL60", "cells", "and", "showed", "high", "levels", "of", "vitamin", "D", "receptor", "and", "retinoid", "receptor", "X", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 10, 0 ]
10787
[ "These", "results", "show", "that", "the", "initial", "steps", "in", "the", "1", ",", "25D3", "signaling", "pathway", "are", "intact", "in", "B", "series", "resistant", "cells", "and", "lead", "to", "the", "appearance", "of", "early", "markers", "of", "monocytic", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10788
[ "However", ",", "the", "progression", "to", "subsequent", "events", "which", "comprise", "terminal", "differentiation", "and", "cell", "cycle", "arrest", "is", "halted", "during", "the", "adaptation", "to", "the", "presence", "of", "1", ",", "25D3", "in", "these", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10789
[ "Thus", ",", "the", "availability", "of", "these", "variant", "cells", "should", "provide", "a", "system", "for", "studying", "the", "link", "between", "differentiation", "and", "cell", "cycle", "arrest", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10790
[ "Inhibition", "of", "human", "immunodeficiency", "virus", "type", "1", "replication", "in", "vitro", "by", "a", "novel", "combination", "of", "anti-Tat", "single-chain", "intrabodies", "and", "NF-kappa", "B", "antagonists", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0 ]
10791
[ "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "Tat", ",", "an", "early", "regulatory", "protein", "that", "is", "critical", "for", "viral", "gene", "expression", "and", "replication", ",", "transactivates", "the", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "via", "its", "binding", "to", "the", "transactivation", "response", "element", "(", "TAR", ")", "and", ",", "along", "with", "other", "cellular", "factors", ",", "increases", "viral", "transcription", "initiation", "and", "elongation", "." ]
[ 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10792
[ "Tat", "also", "superactivates", "the", "HIV-1", "promoter", "through", "a", "TAR", "-independent", "mechanism", ",", "including", "tumor", "necrosis", "factor", "alpha-induced", "and", "protein", "kinase", "C", "(", "PKC", ")", "-dependent", "activation", "of", "NF-kappa", "B", ",", "and", "inhibitors", "of", "Tat", "and", "NF-kappa", "B", "cooperatively", "down-regulate", "this", "Tat", "-mediated", "LTR", "superactivation", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0 ]
10793
[ "In", "this", "study", ",", "a", "combined", "pharmacologic", "and", "genetic", "strategy", "using", "two", "PKC", "(", "NF-kappa", "B", ")", "inhibitors", ",", "pentoxifylline", "(", "PTX", ")", "and", "Go-6976", ",", "and", "a", "stably", "expressed", "anti-Tat", "single-chain", "intracellular", "antibody", "(", "sFv", "intrabody", ")", "was", "employed", "to", "obtain", "cooperative", "inhibition", "of", "both", "HIV-1", "LTR", "-driven", "gene", "expression", "and", "HIV-1", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
10794
[ "Treatment", "of", "cells", "with", "PTX", "and", "Go-6976", "resulted", "in", "cooperative", "inhibition", "of", "both", "HIV-1", "LTR", "-driven", "gene", "expression", "and", "HIV-1", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
10795
[ "In", "addition", ",", "the", "combined", "use", "of", "anti-Tat", "sFv", "intrabodies", "and", "the", "two", "NF-kappa", "B", "inhibitors", "retained", "the", "virus", "in", "the", "latent", "state", "for", "as", "long", "as", "45", "days", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10796
[ "The", "combined", "treatment", "resulted", "in", "more", "durable", "inhibition", "of", "HIV-1", "replication", "than", "was", "seen", "with", "the", "NF-kappa", "B", "inhibitors", "alone", "or", "the", "anti-", "Tat", "sFv", "intrabodies", "alone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
10797
[ "Together", ",", "these", "results", "suggest", "that", "in", "future", "clinical", "gene", "therapy", "trials", ",", "a", "combined", "pharmacologic", "and", "genetic", "strategy", "like", "the", "one", "reported", "here", "may", "improve", "the", "survival", "of", "transduced", "cells", "and", "prolong", "clinical", "benefit", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10798
[ "Transcription", "factors", "in", "immune-mediated", "disease", "." ]
[ 0, 0, 0, 0, 0, 0 ]
10799
[ "A", "large", "amount", "of", "detailed", "information", "about", "the", "intracellular", "proteins", "regulating", "NF-kappa", "B", "activation", "and", "the", "cellular", "response", "to", "NF-kappa", "B", "activation", "has", "emerged", "recently", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
10800
[ "Several", "small", "molecules", ",", "an", "antisense", "oligonucleotide", ",", "and", "gene", "therapeutic", "agents", "that", "inhibit", "NF-kappa", "b", "activation", "have", "been", "described", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]