Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
10501
[ "Three", "3rd", "base", "substitution", "polymorphisms", "were", "also", "detected", "during", "direct", "sequencing", "of", "PCR", "products", "." ]
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10502
[ "Confirmed", "mutations", "were", "identified", "in", "28", "%", "of", "the", "families", "studied", "and", "on", "the", "assumption", "that", "half", "of", "the", "sporadic", "cases", "should", "have", "TSC2", "mutations", ",", "a", "crude", "estimate", "of", "the", "detection", "rate", "would", "be", "60", "%", "." ]
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10503
[ "This", "compares", "favourably", "with", "other", "screening", "methods", "used", "for", "TSC2", ",", "notably", "SSCP", ",", "and", "since", "PTT", "involves", "much", "less", "work", "it", "may", "be", "the", "method", "of", "choice", "." ]
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10504
[ "alpha-Tocopheryl", "succinate", "inhibits", "monocytic", "cell", "adhesion", "to", "endothelial", "cells", "by", "suppressing", "NF-kappa", "B", "mobilization", "." ]
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10505
[ "The", "adherence", "of", "monocytes", "to", "activated", "endothelium", "is", "an", "early", "event", "in", "atherogenesis", "." ]
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10506
[ "Because", "antioxidants", "have", "been", "considered", "to", "be", "of", "antiatherosclerotic", "potential", ",", "we", "investigated", "the", "effects", "of", "alpha-tocopherol", "(", "TCP", ")", "and", "its", "acetate", "and", "succinate", "esters", "on", "monocyte", "adhesion", "to", "cytokine-stimulated", "human", "umbilical", "vein", "endothelial", "cells", "(", "HUVEC", ")", "." ]
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10507
[ "Endothelial", "cells", "were", "treated", "with", "TCP", ",", "alpha-tocopherol", "acetate", "(", "TCP", "acetate", ")", ",", "or", "alpha-tocopheryl", "succinate", "(", "TCP", "succinate", ")", "before", "stimulation", "with", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ";", "10", "U/ml", ",", "6", "h", ")", "or", "interleukin-1", "beta", "(", "IL-1", "beta", ";", "10", "U/ml", ",", "6", "h", ")", "." ]
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10508
[ "Cytokine-stimulated", "cell", "surface", "expression", "of", "vascular", "cell", "adhesion", "molecule-1", "(", "VCAM-1", ",", "CD106", ")", "and", "E-selectin", "(", "ELAM-1", ",", "CD62E", ")", ",", "but", "not", "of", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ",", "CD54", ")", ",", "was", "time-", "and", "dose-dependently", "inhibited", "by", "TCP", "succinate", "but", "not", "by", "TCP", "or", "TCP", "acetate", "." ]
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10509
[ "TCP", "succinate", "(", "200", "microM", ",", "24", "h", ")", "reduced", "TNF-induced", "VCAM-1", "and", "E-selectin", "expression", "from", "a", "specific", "mean", "fluorescence", "intensity", "of", "151", "+/-", "28", "to", "12", "+/-", "4", "channels", "and", "from", "225", "+/-", "38", "to", "79", "+/-", "21", "channels", ",", "respectively", "." ]
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10510
[ "Succinate", "alone", "had", "no", "effect", "." ]
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10511
[ "Decreased", "adhesion", "molecule", "expression", "was", "associated", "with", "a", "reduction", "of", "monocytic", "cell", "adhesion", "." ]
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10512
[ "TCP", "succinate", "(", "20", "microM", ",", "72", "h", ")", ",", "but", "not", "TCP", "(", "200", "microM", ",", "72", "h", ")", ",", "reduced", "U-937", "cell", "adhesion", "to", "TNF-alpha-stimulated", "(", "10", "U/ml", ",", "6", "h", ")", "HUVEC", "by", "30", "%", "(", "P", "<", "0.025", ")", "and", "to", "IL-1", "beta-stimulated", "HUVEC", "by", "56", "%", "(", "P", "<", "0.010", ")", "." ]
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10513
[ "Electrophoretic", "mobility-shift", "assays", "of", "HUVEC", "nuclear", "proteins", "revealed", "a", "decrease", "in", "TNF-alpha-stimulated", "nuclear", "factor-kappa", "B", "(", "NF-kappa", "B", ")", "activation", "after", "pretreatment", "of", "HUVEC", "with", "TCP", "succinate", "but", "not", "with", "TCP", ",", "TCP", "acetate", ",", "or", "succinate", "alone", "." ]
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10514
[ "In", "conclusion", ",", "we", "demonstrate", "that", "the", "vitamin", "E", "derivative", "TCP", "succinate", "prevents", "monocytic", "cell", "adhesion", "to", "cytokine-stimulated", "endothelial", "cells", "by", "inhibiting", "the", "activation", "of", "NF-kappa", "B", ",", "further", "emphasizing", "the", "antiatherosclerotic", "potential", "of", "lipid", "soluble", "antioxidants", "." ]
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10515
[ "The", "product", "of", "the", "murine", "homolog", "of", "the", "Drosophila", "extra", "sex", "combs", "gene", "displays", "transcriptional", "repressor", "activity", "." ]
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10516
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10517
[ "Using", "a", "fragment", "of", "K", "protein", "as", "bait", "in", "the", "yeast", "two-hybrid", "screen", ",", "we", "isolated", "a", "cDNA", "that", "encodes", "a", "protein", "whose", "primary", "structure", "has", "extensive", "similarity", "to", "the", "Drosophila", "melanogaster", "extra", "sex", "combs", "(", "esc", ")", "gene", "product", ",", "Esc", ",", "a", "putative", "silencer", "of", "homeotic", "genes", "." ]
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10518
[ "The", "cDNA", "that", "we", "isolated", "is", "identical", "to", "the", "cDNA", "of", "the", "recently", "positionally", "cloned", "mouse", "embryonic", "ectoderm", "development", "gene", ",", "eed", "." ]
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10519
[ "Like", "Esc", ",", "Eed", "contains", "six", "WD-40", "repeats", "in", "the", "C-terminal", "half", "of", "the", "protein", "and", "is", "thought", "to", "repress", "homeotic", "gene", "expression", "during", "mouse", "embryogenesis", "." ]
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10520
[ "Eed", "binds", "to", "K", "protein", "through", "a", "domain", "in", "its", "N", "terminus", ",", "but", "interestingly", ",", "this", "domain", "is", "not", "found", "in", "the", "Drosophila", "Esc", "." ]
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10521
[ "Gal4-Eed", "fusion", "protein", "represses", "transcription", "of", "a", "reporter", "gene", "driven", "by", "a", "promoter", "that", "contains", "Gal4-binding", "DNA", "elements", "." ]
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10522
[ "Eed", "also", "represses", "transcription", "when", "recruited", "to", "a", "target", "promoter", "by", "Gal4-K", "protein", "." ]
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10523
[ "Point", "mutations", "within", "the", "eed", "gene", "that", "are", "responsible", "for", "severe", "embryonic", "development", "abnormalities", "abolished", "the", "transcriptional", "repressor", "activity", "of", "Eed", "." ]
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10524
[ "Results", "of", "this", "study", "suggest", "that", "Eed", "-restricted", "homeotic", "gene", "expression", "during", "embryogenesis", "reflects", "the", "action", "of", "Eed", "as", "a", "transcriptional", "repressor", "." ]
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10525
[ "The", "Eed", "-mediated", "transcriptional", "effects", "are", "likely", "to", "reflect", "the", "interaction", "of", "Eed", "with", "multiple", "molecular", "partners", ",", "including", "K", "protein", "." ]
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10526
[ "Interferons", "up-regulate", "STAT1", ",", "STAT2", ",", "and", "IRF", "family", "transcription", "factor", "gene", "expression", "in", "human", "peripheral", "blood", "mononuclear", "cells", "and", "macrophages", "." ]
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10527
[ "IFN", "signaling", "is", "mediated", "by", "binding", "of", "IFNs", "to", "their", "receptors", "and", "subsequent", "activation", "of", "Janus", "tyrosine", "kinase", "(", "JAK", ")", "-", "STAT", "signaling", "pathway", "." ]
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10528
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10529
[ "IFN-gamma", "signaling", "is", "mediated", "by", "homodimeric", "STAT1", "protein", "." ]
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10530
[ "Although", "these", "signaling", "molecules", "are", "expressed", "constitutively", ",", "there", "is", "also", "evidence", "of", "transcriptional", "regulation", "by", "IFNs", "." ]
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10531
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10532
[ "We", "show", "that", "IFN-alpha", "and", "IFN-gamma", "rapidly", "and", "efficiently", "enhanced", "STAT1", ",", "STAT2", ",", "p48", ",", "and", "IRF-1", "gene", "expression", "." ]
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10533
[ "IFN-gamma", "induced", "IRF-1", "gene", "expression", "more", "strongly", "than", "IFN-alpha", "." ]
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10534
[ "Stimulation", "experiments", "in", "the", "presence", "of", "protein", "synthesis", "inhibitor", ",", "cycloheximide", ",", "suggested", "that", "these", "genes", "were", "activated", "directly", "by", "IFNs", "." ]
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10535
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10536
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10537
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10538
[ "The", "role", "of", "nuclear", "factor-kappa", "B", "in", "cytokine", "gene", "regulation", "." ]
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10539
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10540
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10541
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10542
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10543
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10544
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10545
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10546
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10547
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10548
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10549
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10550
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10551
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10552
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10553
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10554
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10555
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