Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
10401
[ "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]
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10402
[ "Expression", "of", "the", "gene", "encoding", "human", "inosine-", "5'-monophosphate", "dehydrogenase", "(", "IMPDH", ")", "type", "II", ",", "an", "enzyme", "catalyzing", "the", "rate-limiting", "step", "in", "the", "generation", "of", "guanine", "nucleotides", ",", "is", "increased", "more", "than", "10-fold", "in", "activated", "peripheral", "blood", "T", "lymphocytes", "and", "is", "required", "for", "T", "cell", "activation", "." ]
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10403
[ "We", "have", "examined", "the", "5'-regulatory", "sequences", "that", "are", "important", "for", "the", "transcriptional", "regulation", "of", "this", "gene", "in", "T", "cells", "." ]
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10404
[ "DNase", "I", "mapping", "of", "genomic", "DNA", "identified", "a", "hypersensitive", "element", "near", "the", "transcription", "initiation", "site", "." ]
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10405
[ "Fine", "mapping", "by", "in", "vivo", "footprinting", "demonstrated", "five", "transcription", "factor", "binding", "sites", "that", "are", "occupied", "in", "both", "resting", "and", "activated", "peripheral", "blood", "T", "lymphocytes", ";", "these", "are", "tandem", "CRE", "motifs", ",", "a", "Sp1", "site", ",", "an", "overlapping", "Egr-1/Sp1", "site", ",", "and", "a", "novel", "palindromic", "octamer", "sequence", "(", "POS", ")", "." ]
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10406
[ "The", "tandem", "CRE", "and", "POS", "sites", "are", "of", "major", "functional", "importance", "as", "judged", "by", "mutational", "and", "electrophoretic", "mobility", "shift", "analyses", "." ]
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10407
[ "These", "data", "provide", "evidence", "that", "expression", "of", "the", "human", "IMPDH", "type", "II", "gene", "is", "predominantly", "regulated", "by", "the", "nuclear", "factors", "ATF-2", "and", "an", "as", "yet", "unidentified", "POS-binding", "protein", "." ]
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10408
[ "Additional", "major", "protein-DNA", "interactions", "do", "not", "occur", "within", "the", "promoter", "region", "after", "T", "lymphocyte", "activation", ",", "indicating", "a", "requirement", "for", "additional", "protein-protein", "interactions", "and/or", "post-translational", "modifications", "of", "pre-bound", "transcription", "factors", "to", "account", "for", "the", "observed", "increase", "in", "IMPDH", "type", "II", "gene", "expression", "." ]
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10409
[ "Distinct", "mechanisms", "for", "N-acetylcysteine", "inhibition", "of", "cytokine-induced", "E-selectin", "and", "VCAM-1", "expression", "." ]
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10410
[ "We", "have", "examined", "the", "effects", "of", "N-acetyl-L-cysteine", "(", "NAC", ")", ",", "a", "well-characterized", ",", "thiol-containing", "antioxidant", ",", "on", "agonist-induced", "monocytic", "cell", "adhesion", "to", "endothelial", "cells", "(", "EC", ")", "." ]
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10411
[ "NAC", "inhibited", "interleukin-1", "(", "IL-1", "beta", ")", "-induced", ",", "but", "not", "basal", ",", "adhesion", "with", "50", "%", "inhibition", "at", "approximately", "20", "mM", "." ]
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10412
[ "Monocytic", "cell", "adhesion", "to", "EC", "in", "response", "to", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", ",", "lipopolysaccharide", "(", "LPS", ")", ",", "alpha-thrombin", ",", "or", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "was", "similarly", "inhibited", "by", "NAC", "." ]
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10413
[ "Unlike", "published", "studies", "with", "pyrrolidinedithiocarbamate", ",", "which", "specifically", "inhibited", "vascular", "cell", "adhesion", "molecule", "1", "(", "VCAM-1", ")", ",", "NAC", "inhibited", "IL-1", "beta-induced", "mRNA", "and", "cell", "surface", "expression", "of", "both", "E-selectin", "and", "VCAM-1", "." ]
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10414
[ "NAC", "had", "no", "effect", "on", "the", "half-life", "of", "E-selectin", "or", "VCAM-1", "mRNA", "." ]
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10415
[ "Although", "NAC", "reduced", "nuclear", "factor-kappa", "B", "(", "NF-kappa", "B", ")", "activation", "in", "EC", "as", "measured", "by", "gel-shift", "assays", "using", "an", "oligonucleotide", "probe", "corresponding", "to", "the", "consensus", "NF-kappa", "B", "binding", "sites", "of", "the", "VCAM-1", "gene", "(", "VCAM-NF-kappa", "B", ")", ",", "the", "antioxidant", "had", "no", "appreciable", "effect", "when", "an", "oligomer", "corresponding", "to", "the", "consensus", "NF-kappa", "B", "binding", "site", "of", "the", "E-selectin", "gene", "(", "E-selectin", "-NF-kappa", "B", ")", "was", "used", "." ]
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10416
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10417
[ "NAC", "caused", "an", "expected", "dramatic", "increase", "in", "the", "reduced", "glutathione", "(", "GSH", ")", "levels", "in", "EC", "." ]
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10418
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10419
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10420
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10421
[ "Opposite", "effects", "of", "the", "acute", "promyelocytic", "leukemia", "PML-retinoic", "acid", "receptor", "alpha", "(", "RAR", "alpha", ")", "and", "PLZF-RAR", "alpha", "fusion", "proteins", "on", "retinoic", "acid", "signalling", "." ]
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10422
[ "Fusion", "proteins", "involving", "the", "retinoic", "acid", "receptor", "alpha", "(", "RAR", "alpha", ")", "and", "the", "PML", "or", "PLZF", "nuclear", "protein", "are", "the", "genetic", "markers", "of", "acute", "promyelocytic", "leukemias", "(", "APLs", ")", "." ]
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10423
[ "APLs", "with", "the", "PML-RAR", "alpha", "or", "the", "PLZF-RAR", "alpha", "fusion", "protein", "are", "phenotypically", "indistinguishable", "except", "that", "they", "differ", "in", "their", "sensitivity", "to", "retinoic", "acid", "(", "RA", ")", "-induced", "differentiation", ":", "PML-RAR", "alpha", "blasts", "are", "sensitive", "to", "RA", "and", "patients", "enter", "disease", "remission", "after", "RA", "treatment", ",", "while", "patients", "with", "PLZF-RAR", "alpha", "do", "not", "." ]
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10424
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10425
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10426
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10427
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10428
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10429
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10430
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10431
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10432
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10433
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10434
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10435
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10436
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10437
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10438
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10439
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10440
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10441
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10450
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10452
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10456
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10460
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10461
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10462
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10463
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10464
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10465
[ "Plasma", "sialyltransferase", "levels", "in", "psychiatric", "disorders", "as", "a", "possible", "indicator", "of", "HPA", "axis", "function", "." ]
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10466
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10467
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10468
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10469
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10470
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10472
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10473
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10475
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10477
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10479
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10480
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10482
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10486
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10487
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10488
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10489
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10490
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