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10601
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10602
[ "These", "results", "suggest", "a", "novel", "mechanism", "by", "which", "integrin", "-mediated", "cell", "adhesion", "can", "modulate", "the", "magnitude", "of", "cytokine", "-induced", "signal", "transduction", "pathways", ",", "thereby", "amplifying", "cellular", "events", "leading", "to", "monocyte", "activation", "and", "inflammation", "." ]
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10603
[ "Surfactant", "protein", "A", "activates", "NF-kappa", "B", "in", "the", "THP-1", "monocytic", "cell", "line", "." ]
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10604
[ "The", "expression", "of", "many", "genes", "for", "which", "products", "are", "involved", "in", "inflammation", "is", "controlled", "by", "the", "transcriptional", "regulator", "nuclear", "factor", "(", "NF", ")", "-kappa", "B", "." ]
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10605
[ "Because", "surfactant", "protein", "(", "SP", ")", "A", "is", "involved", "in", "local", "host", "defense", "in", "the", "lung", "and", "alters", "immune", "cell", "function", "by", "modulating", "the", "expression", "of", "proinflammatory", "cytokines", "as", "well", "as", "surface", "proteins", "involved", "in", "inflammation", ",", "we", "hypothesized", "that", "SP-A", "exerts", "its", "action", ",", "at", "least", "in", "part", ",", "via", "activation", "of", "NF-kappa", "B", "." ]
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10606
[ "We", "used", "gel", "shift", "assays", "to", "determine", "whether", "SP-A", "activated", "NF-kappa", "B", "in", "the", "THP-1", "cell", "line", ",", "a", "human", "monocytic", "cell", "line", "." ]
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10607
[ "Activation", "of", "NF-kappa", "B", "in", "THP-1", "cells", "by", "SP-A", "doses", "as", "low", "as", "1", "microgram/ml", "occurred", "within", "30", "min", "of", "SP-A", "treatment", ",", "peaked", "at", "60", "min", ",", "and", "then", "declined", "." ]
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10608
[ "This", "activation", "is", "inhibited", "by", "known", "inhibitors", "of", "NF-kappa", "B", "or", "by", "simultaneous", "treatment", "of", "the", "cells", "with", "surfactant", "lipids", "." ]
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10609
[ "Moreover", ",", "the", "NF-kappa", "B", "inhibitors", "blocked", "SP-A", "-dependent", "increases", "in", "tumor", "necrosis", "factor-alpha", "mRNA", "levels", "." ]
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10610
[ "These", "observations", "suggest", "a", "mechanism", "by", "which", "SP-A", "plays", "a", "role", "in", "the", "pathogenesis", "of", "some", "lung", "conditions", "and", "point", "to", "potential", "therapeutic", "measures", "that", "could", "be", "used", "to", "prevent", "SP-A", "induced", "inflammation", "in", "the", "lung", "." ]
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10611
[ "GABP", "factors", "bind", "to", "a", "distal", "interleukin", "2", "(", "IL-2", ")", "enhancer", "and", "contribute", "to", "c-Raf", "-mediated", "increase", "in", "IL-2", "induction", "." ]
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10612
[ "Triggering", "of", "the", "T-cell", "receptor-CD3", "complex", "activates", "two", "major", "signal", "cascades", "in", "T", "lymphocytes", ",", "(", "i", ")", "Ca2+-dependent", "signal", "cascades", "and", "(", "ii", ")", "protein", "kinase", "cascades", "." ]
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10613
[ "Both", "signal", "cascades", "contribute", "to", "the", "induction", "of", "the", "interleukin", "2", "(", "IL-2", ")", "gene", "during", "T-cell", "activation", "." ]
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10614
[ "Prominent", "protein", "kinase", "cascades", "are", "those", "that", "activate", "mitogen-activated", "protein", "(", "MAP", ")", "kinases", "." ]
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10615
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10616
[ "Induction", "of", "this", "distal", "IL-2", "enhancer", "differs", "from", "induction", "of", "the", "proximal", "IL-2", "promoter-enhancer", ",", "since", "it", "is", "induced", "by", "phorbol", "esters", "alone", "and", "independent", "from", "Ca2+", "signals", "." ]
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10617
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10618
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10619
[ "Overexpression", "of", "BXB", ",", "a", "constitutive", "active", "version", "of", "c-Raf", ",", "and", "of", "further", "members", "of", "the", "Ras", "-", "Raf", "-", "Erk", "signal", "cascade", "exerted", "an", "increase", "of", "GABP", "-mediated", "promoter-enhancer", "induction", "." ]
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10620
[ "In", "conjunction", "with", "previously", "published", "data", "on", "c-Raf", "-induced", "phosphorylation", "of", "GABP", "factors", "(", "E.Flory", ",", "A.", "Hoffmeyer", ",", "U.Smola", ",", "U.R.Rapp", ",", "and", "J.T.Bruder", ",", "J.Virol.70", ":", "2260-", "2268", ",", "1996", ")", ",", "these", "results", "indicate", "a", "contribution", "of", "GABP", "factors", "to", "the", "Raf", "-mediated", "enhancement", "of", "IL-2", "induction", "during", "T-cell", "activation", "." ]
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10621
[ "Lipopolysaccharide", "induction", "of", "the", "tumor", "necrosis", "factor-alpha", "promoter", "in", "human", "monocytic", "cells", "." ]
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10622
[ "Regulation", "by", "Egr-1", ",", "c-Jun", ",", "and", "NF-kappaB", "transcription", "factors", "." ]
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10623
[ "Biosynthesis", "of", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "is", "predominantly", "by", "cells", "of", "the", "monocytic", "lineage", "." ]
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10624
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10625
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10626
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10627
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10628
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10629
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10630
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10631
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10632
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10633
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10634
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10635
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10636
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10637
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10638
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10639
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10640
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10643
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10646
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10647
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10648
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10650
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10651
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10653
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10670
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10674
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10678
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10680
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