siddharthtumre/Revised-JNLPBA · Datasets at Hugging Face

id stringlengths 1 5	tokens sequence	ner_tags sequence
11001	[ "Higher", "concentrations", "of", "A", "beta", "(", "25-35", ")", "were", "effective", "by", "themselves", "in", "inducing", "NF-kappa", "B", "activation", ",", "both", "in", "the", "N9", "microglial", "cell", "line", "and", "in", "rat", "primary", "microglia", ",", "as", "well", "as", "in", "human", "monocytes", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 7, 8, 0 ]
11002	[ "For", "purposes", "of", "comparison", ",", "microglia", "were", "also", "stimulated", "with", "bacterial", "LPS", ",", "a", "known", "NF-kappa", "B", "inducer", "." ]	[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
11003	[ "As", "expected", ",", "LPS", "strongly", "induced", "the", "formation", "of", "two", "NF-kappa", "B", "DNA-binding", "activities", ",", "one", "of", "which", "was", "identified", "as", "RelA/p50", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11004	[ "The", "LPS", "response", "was", "also", "more", "rapid", ",", "as", "it", "was", "already", "evident", "by", "40", "min", "and", "remained", "sustained", "for", "up", "to", "3", "h", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11005	[ "Collectively", ",", "these", "findings", "indicate", "that", "NF-kappa", "B", "activation", "might", "constitute", "one", "of", "the", "mechanisms", "underlying", "the", "inducible", "expression", "of", "kappa", "B-dependent", "genes", "in", "microglia", "stimulated", "by", "A", "beta", "peptides", "and", "IFN", "gamma", ",", "or", "by", "LPS", "." ]	[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 7, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
11006	[ "Glucocorticoid-mediated", "repression", "of", "cytokine", "gene", "transcription", "in", "human", "arteritis-SCID", "chimeras", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11007	[ "Giant", "cell", "arteritis", "(", "GCA", ")", "is", "a", "vasculitic", "syndrome", "that", "preferentially", "affects", "medium", "and", "large-sized", "arteries", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11008	[ "Glucocorticoid", "therapy", "resolves", "clinical", "symptoms", "within", "hours", "to", "days", ",", "but", "therapy", "has", "to", "be", "continued", "over", "several", "years", "to", "prevent", "disease", "relapses", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11009	[ "It", "is", "not", "known", "whether", "and", "how", "glucocorticoids", "affect", "the", "function", "of", "the", "inflammatory", "infiltrate", "or", "why", "the", "disease", "persists", "subclinically", "despite", "chronic", "treatment", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11010	[ "GCA", "is", "self-sustained", "in", "temporal", "arteries", "engrafted", "into", "SCID", "mice", ",", "providing", "a", "model", "in", "which", "the", "mechanisms", "of", "action", "and", "limitations", "of", "glucocorticoid", "therapy", "can", "be", "examined", "in", "vivo", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11011	[ "Administration", "of", "dexamethasone", "to", "temporal", "artery-SCID", "chimeras", "for", "1", "wk", "induced", "a", "partial", "suppression", "of", "T", "cell", "and", "macrophage", "function", "as", "indicated", "by", "the", "reduced", "tissue", "concentrations", "of", "IL-2", ",", "IL-1beta", ",", "and", "IL-6", "mRNA", ",", "and", "by", "the", "diminished", "expression", "of", "inducible", "NO", "synthase", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
11012	[ "In", "contrast", ",", "synthesis", "of", "IFN-gamma", "mRNA", "was", "only", "slightly", "decreased", ",", "and", "expression", "of", "TGF-beta1", "was", "unaffected", "." ]	[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
11013	[ "These", "findings", "correlated", "with", "activation", "of", "the", "IkappaBalpha", "gene", "and", "blockade", "of", "the", "nuclear", "translocation", "of", "NFkappaB", "in", "the", "xenotransplanted", "tissue", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
11014	[ "Dose-response", "experiments", "suggested", "that", "steroid", "doses", "currently", "used", "in", "clinical", "medicine", "are", "suboptimal", "in", "repressing", "NFkappaB", "-mediated", "cytokine", "production", "in", "the", "inflammatory", "lesions", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
11015	[ "Chronic", "steroid", "therapy", "was", "able", "to", "deplete", "the", "T", "cell", "products", "IL-2", "and", "IFN-gamma", ",", "whereas", "the", "activation", "of", "tissue-infiltrating", "macrophages", "was", "only", "partially", "affected", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
11016	[ "IL-1beta", "transcription", "was", "abrogated", ";", "in", "contrast", ",", "TGF-beta1", "mRNA", "synthesis", "was", "steroid", "resistant", "." ]	[ 9, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]
11017	[ "The", "persistence", "of", "TGF-beta1-transcribing", "macrophages", ",", "despite", "paralysis", "of", "T", "cell", "function", ",", "may", "provide", "an", "explanation", "for", "the", "chronicity", "of", "the", "disease", ",", "and", "may", "identify", "a", "novel", "therapeutic", "target", "in", "this", "inflammatory", "vasculopathy", "." ]	[ 0, 0, 0, 0, 7, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11018	[ "Defective", "survival", "and", "activation", "of", "thymocytes", "in", "transgenic", "mice", "expressing", "a", "catalytically", "inactive", "form", "of", "Ca2+/calmodulin-dependent", "protein", "kinase", "IV", "." ]	[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
11019	[ "We", "have", "generated", "transgenic", "mice", "that", "express", "a", "catalytically", "inactive", "form", "of", "Ca2+/calmodulin-dependent", "protein", "kinase", "IV", "(", "CaMKIV", ")", "specifically", "in", "thymic", "T", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 7, 8, 8, 0 ]
11020	[ "The", "presence", "of", "this", "protein", "results", "in", "a", "markedly", "reduced", "thymic", "cellularity", ",", "although", "the", "distribution", "of", "the", "remaining", "cells", "is", "normal", "based", "on", "evaluation", "of", "the", "CD4", "and", "CD8", "cell", "surface", "antigens", "that", "are", "used", "to", "gauge", "T", "cell", "development", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
11021	[ "Isolated", "thymic", "T", "cells", "from", "the", "transgenic", "mice", "also", "show", "a", "dramatically", "decreased", "survival", "rate", "when", "evaluated", "in", "culture", "under", "conditions", "that", "do", "not", "favor", "activation", "." ]	[ 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11022	[ "When", "challenged", "with", "an", "activating", "stimulus", "such", "as", "alpha-CD3", "or", "a", "combination", "of", "phorbol", "ester", "plus", "ionophore", ",", "the", "cells", "are", "severely", "compromised", "in", "their", "ability", "to", "produce", "the", "cytokine", "interleukin-2", "(", "IL-2", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]
11023	[ "Reduction", "of", "IL-2", "production", "is", "secondary", "to", "the", "inability", "to", "phosphorylate", "the", "cAMP", "response", "element", "binding", "protein", ",", "CREB", ",", "and", "induce", "expression", "of", "the", "immediate", "early", "genes", "such", "as", "Fos", "B", "that", "are", "required", "to", "transactivate", "the", "IL-2", "promoter", "." ]	[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
11024	[ "Because", "transgene", "expression", "was", "regulated", "by", "the", "proximal", "promoter", "of", "the", "murine", "lck", "gene", "and", "this", "promoter", "is", "inactivated", "in", "T", "cells", "that", "exit", "the", "thymus", ",", "the", "mutant", "hCaMKIV", "is", "not", "present", "in", "peripheral", "T", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0 ]
11025	[ "Consequently", ",", "T", "lymphocytes", "present", "in", "the", "spleen", "can", "be", "activated", "normally", "in", "response", "to", "either", "stimulus", "mentioned", "above", ",", "demonstrating", "that", "the", "effects", "of", "the", "inactive", "CaMKIV", "on", "activation", "are", "reversible", "." ]	[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
11026	[ "Our", "results", "suggest", "that", "CaMKIV", "may", "represent", "a", "physiologically", "relevant", "CREB", "kinase", "in", "T", "cells", "and", "that", "the", "enzyme", "is", "also", "required", "to", "ensure", "normal", "expansion", "of", "T", "cells", "in", "the", "thymus", "." ]	[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
11027	[ "Whereas", "the", "pathway", "responsible", "for", "this", "latter", "role", "is", "yet", "to", "be", "elucidated", ",", "it", "is", "unlikely", "to", "include", "CREB", "phosphorylation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11028	[ "A", "new", "mouse", "gene", ",", "SRG3", ",", "related", "to", "the", "SWI3", "of", "Saccharomyces", "cerevisiae", ",", "is", "required", "for", "apoptosis", "induced", "by", "glucocorticoids", "in", "a", "thymoma", "cell", "line", "." ]	[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
11029	[ "We", "isolated", "a", "new", "mouse", "gene", "that", "is", "highly", "expressed", "in", "thymocytes", ",", "testis", ",", "and", "brain", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]
11030	[ "This", "gene", ",", "SRG3", ",", "showed", "a", "significant", "sequence", "homology", "to", "SWI3", ",", "a", "yeast", "transcriptional", "activator", ",", "and", "its", "human", "homolog", "BAF155", "." ]	[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
11031	[ "SRG3", "encodes", "1", ",", "100", "amino", "acids", "and", "has", "33-47", "%", "identity", "with", "SWI3", "protein", "over", "three", "regions", "." ]	[ 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
11032	[ "The", "SRG3", "protein", "contains", "an", "acidic", "NH2", "terminus", ",", "a", "myb-like", "DNA", "binding", "domain", ",", "a", "leucine-zipper", "motif", ",", "and", "a", "proline-", "and", "glutamine-rich", "region", "at", "its", "COOH", "terminus", "." ]	[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11033	[ "Rabbit", "antiserum", "raised", "against", "a", "COOH-terminal", "polypeptide", "of", "the", "SRG3", "recognized", "a", "protein", "with", "an", "apparent", "molecular", "mass", "of", "155", "kD", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11034	[ "The", "serum", "also", "detected", "a", "170-kD", "protein", "that", "seems", "to", "be", "a", "mouse", "homologue", "of", "human", "BAF170", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
11035	[ "Immunoprecipitation", "of", "cell", "extract", "with", "the", "antiserum", "against", "the", "mouse", "SRG3", "also", "brought", "down", "a", "195-kD", "protein", "that", "could", "be", "recognized", "by", "an", "antiserum", "raised", "against", "human", "SWI2", "protein", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
11036	[ "The", "results", "suggest", "that", "the", "SRG3", "protein", "associates", "with", "a", "mouse", "SWI2", "." ]	[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0 ]
11037	[ "The", "SRG3", "protein", "is", "expressed", "about", "three", "times", "higher", "in", "thymocytes", "than", "in", "peripheral", "lymphocytes", "." ]	[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0 ]
11038	[ "The", "expression", "of", "anti-sense", "RNA", "to", "SRG3", "mRNA", "in", "a", "thymoma", "cell", "line", ",", "S49.1", ",", "reduced", "the", "expression", "level", "of", "the", "SRG3", "protein", ",", "and", "decreased", "the", "apoptotic", "cell", "death", "induced", "by", "glucocorticoids", "." ]	[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11039	[ "These", "results", "suggest", "that", "the", "SRG3", "protein", "is", "involved", "in", "the", "glucocorticoid-induced", "apoptosis", "in", "the", "thymoma", "cell", "line", "." ]	[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
11040	[ "This", "implicates", "that", "the", "SRG3", "may", "play", "an", "important", "regulatory", "role", "during", "T", "cell", "development", "in", "thymus", "." ]	[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
11041	[ "Transcriptional", "induction", "of", "collagenase-1", "in", "differentiated", "monocyte-like", "(", "U937", ")", "cells", "is", "regulated", "by", "AP-1", "and", "an", "upstream", "C/EBP-beta", "site", "." ]	[ 0, 0, 0, 9, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0 ]
11042	[ "In", "this", "report", ",", "we", "demonstrate", "that", "the", "AP-1", "site", "and", "a", "distal", "promoter", "element", "regulate", "transcriptional", "induction", "of", "collagenase-1", "during", "monocytic", "differentiation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
11043	[ "Chloramphenicol", "acetyltransferase", "expression", "constructs", "containing", "regions", "of", "the", "human", "collagenase-1", "promoter", "were", "stably", "or", "transiently", "transfected", "into", "U937", "cells", ",", "and", "reporter", "activity", "was", "assessed", "at", "various", "times", "after", "the", "onset", "of", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "-mediated", "differentiation", "." ]	[ 1, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11044	[ "Rapid", "and", "strong", "induction", "of", "promoter", "activity", "was", "lost", "in", "constructs", "with", "a", "mutant", "AP-1", "element", ";", "however", ",", "at", "16-96", "h", "post-PMA", ",", "the", "mutant", "collagenase-1", "promoter", "displayed", "AP-1", "independent", "PMA-mediated", "transactivation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 0, 0, 0 ]
11045	[ "The", "AP-1", "mutant", "constructs", "also", "showed", "delayed", "transcriptional", "activation", "in", "PMA-treated", "fibroblasts", "." ]	[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
11046	[ "Western", "and", "supershift", "analyses", "indicated", "that", "functional", "Jun", "and", "Fos", "proteins", "were", "present", "in", "nuclear", "extracts", "of", "PMA-differentiated", "U937", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
11047	[ "Promoter", "deletion", "constructs", "demonstrated", "the", "potential", "role", "of", "distal", "promoter", "sequences", "in", "regulating", "collagenase-1", "transcription", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11048	[ "In", "particular", ",", "Western", ",", "supershift", ",", "and", "promoter", "deletion", "analyses", "suggested", "a", "role", "for", "CCAAT/enhancer-binding", "protein-beta", "(", "C/EBP-beta", ")", "binding", "site", "between", "-2010", "and", "-1954", "in", "regulating", "transcription", "of", "collagenase-1", "in", "monocytic", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
11049	[ "Our", "findings", "suggest", "that", "distinct", "regulatory", "elements", ",", "acting", "somewhat", "independently", "of", "each", "other", ",", "control", "expression", "of", "collagenase-1", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11050	[ "In", "addition", ",", "our", "data", "suggests", "that", "the", "rapid", "PMA-mediated", "induction", "of", "collagenase-1", "transcription", "is", "controlled", "by", "a", "mechanism", "distinct", "from", "that", "regulating", "the", "sustained", "expression", "of", "this", "proteinase", "in", "activated", "macrophages", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0 ]
11051	[ "Quantification", "of", "vitamin", "D", "receptor", "mRNA", "by", "competitive", "polymerase", "chain", "reaction", "in", "PBMC", ":", "lack", "of", "correspondence", "with", "common", "allelic", "variants", "." ]	[ 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
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11001

[ "Higher", "concentrations", "of", "A", "beta", "(", "25-35", ")", "were", "effective", "by", "themselves", "in", "inducing", "NF-kappa", "B", "activation", ",", "both", "in", "the", "N9", "microglial", "cell", "line", "and", "in", "rat", "primary", "microglia", ",", "as", "well", "as", "in", "human", "monocytes", "." ]

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11002

[ "For", "purposes", "of", "comparison", ",", "microglia", "were", "also", "stimulated", "with", "bacterial", "LPS", ",", "a", "known", "NF-kappa", "B", "inducer", "." ]

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11003

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11004

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11005

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11006

[ "Glucocorticoid-mediated", "repression", "of", "cytokine", "gene", "transcription", "in", "human", "arteritis-SCID", "chimeras", "." ]

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11007

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11008

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11009

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11010

[ "GCA", "is", "self-sustained", "in", "temporal", "arteries", "engrafted", "into", "SCID", "mice", ",", "providing", "a", "model", "in", "which", "the", "mechanisms", "of", "action", "and", "limitations", "of", "glucocorticoid", "therapy", "can", "be", "examined", "in", "vivo", "." ]

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11011

[ "Administration", "of", "dexamethasone", "to", "temporal", "artery-SCID", "chimeras", "for", "1", "wk", "induced", "a", "partial", "suppression", "of", "T", "cell", "and", "macrophage", "function", "as", "indicated", "by", "the", "reduced", "tissue", "concentrations", "of", "IL-2", ",", "IL-1beta", ",", "and", "IL-6", "mRNA", ",", "and", "by", "the", "diminished", "expression", "of", "inducible", "NO", "synthase", "." ]

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11012

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11013

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11014

[ "Dose-response", "experiments", "suggested", "that", "steroid", "doses", "currently", "used", "in", "clinical", "medicine", "are", "suboptimal", "in", "repressing", "NFkappaB", "-mediated", "cytokine", "production", "in", "the", "inflammatory", "lesions", "." ]

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11015

[ "Chronic", "steroid", "therapy", "was", "able", "to", "deplete", "the", "T", "cell", "products", "IL-2", "and", "IFN-gamma", ",", "whereas", "the", "activation", "of", "tissue-infiltrating", "macrophages", "was", "only", "partially", "affected", "." ]

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11016

[ "IL-1beta", "transcription", "was", "abrogated", ";", "in", "contrast", ",", "TGF-beta1", "mRNA", "synthesis", "was", "steroid", "resistant", "." ]

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11017

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11018

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11019

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11020

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11021

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11022

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11023

[ "Reduction", "of", "IL-2", "production", "is", "secondary", "to", "the", "inability", "to", "phosphorylate", "the", "cAMP", "response", "element", "binding", "protein", ",", "CREB", ",", "and", "induce", "expression", "of", "the", "immediate", "early", "genes", "such", "as", "Fos", "B", "that", "are", "required", "to", "transactivate", "the", "IL-2", "promoter", "." ]

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11024

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11025

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11026

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11027

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11028

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11029

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11030

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11031

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11032

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11033

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11034

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11035

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11036

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11037

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11038

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11039

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11040

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11041

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11042

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11043

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11044

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11045

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11046

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11047

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11048

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11049

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11050

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11051

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11052

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11053

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11054

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11055

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11059

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11060

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11061

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11066

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11068

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11070

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11072

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11073

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11074

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11075

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11076

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11077

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11078

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11079

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11080

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11081

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11082

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11083

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11084

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11085

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11087

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11088

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11089

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11090

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11091

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11092

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11093

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11094

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11095

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11096

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11097

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11098

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11099

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