Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12701
[ "GATA-3", "inhibits", "Th1", "cytokines", "by", "a", "cell-intrinsic", "mechanism", "that", "is", "not", "dependent", "on", "IL-4", "and", "that", "may", "involve", "repression", "of", "IL-12", "signaling", "." ]
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12702
[ "Thus", ",", "GATA-3", "expression", "and", "IL-12", "signaling", "are", "mutually", "antagonistic", ",", "which", "facilitates", "rapid", "dominance", "of", "one", "pathway", "during", "early", "Th", "development", ",", "producing", "a", "stable", "divergence", "in", "cytokine", "profiles", "." ]
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12703
[ "Conserved", "elements", "containing", "NF-E2", "and", "tandem", "GATA", "binding", "sites", "are", "required", "for", "erythroid-specific", "chromatin", "structure", "reorganization", "within", "the", "human", "beta-globin", "locus", "control", "region", "." ]
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12704
[ "Proper", "expression", "of", "the", "genes", "of", "the", "human", "beta-globin", "gene", "locus", "requires", "the", "associated", "locus", "control", "region", "(", "LCR", ")", "." ]
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12705
[ "Structurally", ",", "the", "LCR", "is", "defined", "by", "the", "presence", "of", "four", "domains", "of", "erythroid-specific", "chromatin", "structure", "." ]
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12706
[ "These", "domains", ",", "which", "have", "been", "characterized", "as", "DNase", "I", "hypersensitive", "sites", "(", "HSs", ")", ",", "comprise", "the", "active", "elements", "of", "the", "LCR", "." ]
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12707
[ "The", "major", "focus", "of", "this", "research", "is", "to", "define", "the", "cis", "-acting", "elements", "which", "are", "required", "for", "the", "formation", "of", "these", "domains", "of", "unique", "chromatin", "structure", "." ]
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12708
[ "Our", "previous", "investigations", "on", "the", "formation", "of", "LCR", "HS4", "demonstrated", "that", "NF-E2", "and", "tandem", ",", "inverted", "GATA", "binding", "sites", "are", "required", "for", "the", "formation", "of", "the", "native", "HS", "." ]
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12709
[ "Similarly", "arranged", "NF-E2", "and", "tandem", "GATA", "sites", "are", "present", "within", "the", "core", "regions", "of", "the", "other", "human", "LCR", "HSs", "and", "are", "evolutionarily", "conserved", "." ]
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12710
[ "Using", "site-directed", "mutagenesis", "of", "human", "HSs", "2", "and", "3", "we", "have", "tested", "the", "hypothesis", "that", "these", "NF-E2", "and", "GATA", "sites", "are", "common", "requirements", "for", "the", "formation", "of", "all", "LCR", "HSs", "." ]
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12711
[ "We", "find", "that", "mutation", "of", "these", "elements", ",", "and", "particularly", "the", "GATA", "elements", ",", "results", "in", "a", "decrease", "or", "complete", "loss", "of", "DNase", "I", "hypersensitivity", "." ]
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12712
[ "These", "data", "imply", "the", "presence", "of", "common", "structural", "elements", "within", "the", "core", "of", "each", "LCR", "HS", "which", "are", "required", "for", "erythroid-specific", "chromatin", "structure", "reorganization", "." ]
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12713
[ "Cloning", "of", "ARE-containing", "genes", "by", "AU-motif-directed", "display", "." ]
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12714
[ "A", "procedure", "suitable", "for", "cloning", "labile", "mRNAs", "that", "contain", "AU", "motifs", "is", "presented", "(", "AU-DD", ")", "." ]
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12715
[ "These", "motifs", "are", "regulatory", "sequences", "within", "the", "so-called", "AU-rich", "elements", "(", "AREs", ")", "often", "found", "in", "3", "'", "untranslated", "regions", "of", "genes", "such", "as", "cytokines", ",", "proto-oncogenes", ",", "and", "transcription", "factors", "." ]
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12716
[ "AU-DD", "is", "an", "AU-motif-directed", "differential", "display", "that", "permits", "the", "identification", "of", "ARE-containing", "genes", "differentially", "expressed", "after", "cell", "activation", "." ]
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12717
[ "It", "has", "been", "applied", "to", "peripheral", "blood", "monocytes", "and", "a", "T", "cell", "clone", "to", "isolate", "59", "cDNA", "fragments", "associated", "to", "activation", "." ]
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12718
[ "Fourteen", "percent", "of", "isolated", "fragments", "belong", "to", "already", "known", "genes", "that", "certainly", "are", "cytokines", "and", "transduction/transcription", "factors", "." ]
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12719
[ "The", "remaining", "86", "%", "correspond", "to", "unknown", "genes", "of", "which", "92", "%", "have", "been", "confirmed", "to", "be", "differentially", "expressed", "." ]
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12720
[ "These", "data", "demonstrate", "the", "efficiency", "of", "the", "system", "and", "support", "the", "notion", "that", "numerous", "genes", "falling", "into", "those", "categories", "remain", "unidentified", "and", "that", "they", "can", "be", "cloned", "by", "this", "method", "." ]
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12721
[ "Copyright", "1998", "Academic", "Press", "." ]
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12722
[ "Transcription", "factor", "NF-kappaB", "regulation", "of", "renal", "fibrosis", "during", "ureteral", "obstruction", "." ]
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12723
[ "Irrespective", "of", "the", "etiology", ",", "many", "kidney", "diseases", "result", "in", "inflammation", "and", "fibrosis", "of", "the", "tubulointerstitium", ",", "with", "the", "subsequent", "loss", "of", "renal", "function", "." ]
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12724
[ "To", "initiate", "any", "disease", "process", "or", "for", "any", "disease", "process", "to", "progress", ",", "there", "must", "be", "changes", "in", "the", "transcription", "of", "genes", "within", "the", "affected", "tissue", "." ]
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12725
[ "The", "nuclear", "factor-kappa", "B", "(", "NF-kappaB", ")", "family", "of", "transcription", "factors", "regulates", "genes", "involved", "in", "inflammation", ",", "cell", "proliferation", ",", "and", "cell", "differentiation", "." ]
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12726
[ "This", "review", "discusses", "the", "NF-kappaB", "transcription", "factor", "family", "in", "general", "and", "the", "association", "of", "NF-kappaB", "activation", "with", "cellular/molecular", "events", "of", "renal", "inflammation", "and", "fibrosis" ]
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12727
[ "Expression", "of", "transcription", "factors", "during", "sodium", "phenylacetate", "induced", "erythroid", "differentiation", "in", "K562", "cells", "." ]
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12728
[ "During", "15", "days", "of", "treatment", "of", "K562", "cells", "with", "sodium", "phenylacetate", ",", "we", "observed", "an", "increase", "in", "the", "cellular", "hemoglobin", "concentration", "with", "a", "similar", "increase", "in", "the", "expression", "of", "gamma-globin", "mRNA", "." ]
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12729
[ "Morphological", "studies", "demonstrated", "characteristic", "features", "of", "erythroid", "differentiation", "and", "maturation", "." ]
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12730
[ "At", "the", "same", "time", "there", "was", "no", "change", "in", "the", "level", "of", "expression", "of", "the", "cell", "surface", "antigenes", "CD33", ",", "CD34", ",", "CD45", ",", "CD71", "and", "glycophorin", "A", "." ]
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12731
[ "Likewise", ",", "the", "level", "of", "expression", "of", "the", "erythroid", "transcription", "factors", "GATA-1", ",", "GATA-2", ",", "NF-E2", ",", "SCL", "and", "RBTN2", ",", "all", "expressed", "in", "untreated", "K562", "cells", ",", "did", "not", "increase", "during", "sodium", "phenylacetate", "induced", "erythroid", "differentiation", "." ]
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12732
[ "The", "expression", "of", "the", "nuclear", "factors", "Evi-1", "and", "c-myb", ",", "known", "to", "inhibit", "erythroid", "differentiation", ",", "did", "not", "decrease", "." ]
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12733
[ "We", "conclude", "that", "sodium", "phenylacetate", "treatment", "of", "K562", "cells", "increases", "gamma-globin", "mRNA", "and", "induces", "cell", "maturation", "as", "judged", "by", "morphology", "without", "affecting", "the", "expression", "of", "the", "erythroid", "transcription", "factors", ",", "some", "of", "which", "are", "known", "to", "be", "involved", "in", "the", "regulation", "of", "beta-like", "globin", "genes", "." ]
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12734
[ "Isolation", "of", "a", "B-cell-specific", "promoter", "for", "the", "human", "class", "II", "transactivator", "." ]
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12735
[ "The", "class", "II", "transactivator", "(", "CIITA", ")", "is", "essential", "for", "the", "expression", "of", "major", "histocompatibility", "complex", "(", "MHC", ")", "class", "II", "antigens", "." ]
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12736
[ "The", "tissular", "patterns", "of", "CIITA", "and", "MHC", "class", "II", "gene", "expression", "are", "tightly", "correlated", ":", "CIITA", "mRNA", "is", "highly", "expressed", "in", "B", "cells", ",", "and", "is", "induced", "by", "interferon", "gamma", "(", "IFN-gamma", ")", "in", "macrophage", "and", "epithelial", "cell", "lines", "." ]
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12737
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12738
[ "Subsequently", ",", "a", "1.8", "kilobase", "(", "kb", ")", "fragment", "of", "the", "CIITA", "promoter", "was", "isolated", "and", "sequenced", "." ]
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12739
[ "A", "motif", "presenting", "a", "strong", "similarity", "to", "an", "initiator", "was", "detected", ",", "as", "well", "as", "putative", "binding", "sites", "for", "Sp1", ",", "GATA-2", ",", "LyF-1", ",", "ets-1", ",", "AP1", ",", "and", "MZF1", "transcription", "factors", ",", "and", "two", "GAS", "motifs", "." ]
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12740
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12741
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12742
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12743
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12744
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12745
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12746
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12747
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12748
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12749
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12750
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12751
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12752
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12753
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12754
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12755
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12756
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