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Methylphenidate (Ritalin)-associated cataract and glaucoma.
[ { "ade": "cataract", "drug": "Ritalin" }, { "ade": "glaucoma", "drug": "Methylphenidate" }, { "ade": "glaucoma", "drug": "Ritalin" }, { "ade": "cataract", "drug": "Methylphenidate" } ]
Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.
[ { "ade": "Dyspnea", "drug": "rituximab" }, { "ade": "pleuritic chest pain", "drug": "rituximab" }, { "ade": "hypoxemia", "drug": "rituximab" } ]
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.
[ { "ade": "serotonin syndrome", "drug": "citalopram" }, { "ade": "serotonin syndrome", "drug": "fentanyl" } ]
PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.
[ { "ade": "HVOD", "drug": "busulfan" }, { "ade": "PVT", "drug": "busulfan" } ]
We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).
[ { "ade": "bronchiolitis obliterans with organizing pneumonia", "drug": "rituximab" } ]
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).
[ { "ade": "severe skin rash", "drug": "methotrexate" }, { "ade": "bone marrow aplasia", "drug": "methotrexate" }, { "ade": "severe skin rash", "drug": "MTX" }, { "ade": "bone marrow aplasia", "drug": "MTX" } ]
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.
[ { "ade": "raised intracranial pressure", "drug": "valproic acid" } ]
A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.
[ { "ade": "recurrent arteriothromboses", "drug": "heparin" }, { "ade": "acute renal failure", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" }, { "ade": "HAT", "drug": "heparin" } ]
We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.
[ { "ade": "lymphoma", "drug": "infliximab" } ]
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.
[ { "ade": "hematochezia", "drug": "warfarin" } ]
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.
[ { "ade": "Laryngeal dyspnea", "drug": "acenocoumarol" }, { "ade": "Laryngeal dyspnea", "drug": "econazole" } ]
We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.
[ { "ade": "anaemia", "drug": "Zidovudine" }, { "ade": "bone marrow aplasia", "drug": "Zidovudine" } ]
Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).
[ { "ade": "Eosinophilia", "drug": "clozapine" } ]
A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.
[ { "ade": "hyponatremia", "drug": "desmopressin" }, { "ade": "altered mental status", "drug": "desmopressin" }, { "ade": "seizures", "drug": "desmopressin" } ]
Hypotension and sinus arrest with nifedipine in pulmonary hypertension.
[ { "ade": "Hypotension", "drug": "nifedipine" }, { "ade": "sinus arrest", "drug": "nifedipine" } ]
We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.
[ { "ade": "psoriasiform eruption", "drug": "carbamazepine" }, { "ade": "psoriasiform eruption", "drug": "sodium valproate" } ]
A paradoxical ocular effect of brimonidine.
[ { "ade": "paradoxical ocular effect", "drug": "brimonidine" } ]
A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.
[ { "ade": "basilar invagination", "drug": "phenytoin" } ]
A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.
[ { "ade": "acute icteric hepatitis-like illness", "drug": "gliclazide" } ]
Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.
[ { "ade": "sclerosing glomerulonephritis", "drug": "Anastrozole" } ]
Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.
[ { "ade": "hepatotoxicity", "drug": "6-MP" }, { "ade": "hepatotoxicity", "drug": "AZA" } ]
Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.
[ { "ade": "myocardial infarction", "drug": "methylprednisolone" }, { "ade": "severe hypertension", "drug": "methylprednisolone" } ]
It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.
[ { "ade": "hepatotoxicity", "drug": "troglitazone" } ]
Didanosine also has a potential for inducing seizures.
[ { "ade": "seizures", "drug": "Didanosine" } ]
A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.
[ { "ade": "tics", "drug": "CBZ" }, { "ade": "movement disorders", "drug": "CBZ" }, { "ade": "tics", "drug": "carbamazepine" }, { "ade": "movement disorders", "drug": "carbamazepine" } ]
These nail changes gradually disappeared when the dose of clofazimine was reduced.
[ { "ade": "nail changes", "drug": "clofazimine" } ]
METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.
[ { "ade": "diabetic ketoacidosis", "drug": "quetiapine" }, { "ade": "diabetic ketoacidosis", "drug": "risperidone" } ]
We describe a patient who became hypothyroid while taking ferrous sulfate.
[ { "ade": "hypothyroid", "drug": "ferrous sulfate" } ]
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.
[ { "ade": "increased serum lithium", "drug": "lithium" }, { "ade": "increased serum lithium", "drug": "acyclovir" } ]
It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.
[ { "ade": "anterior subcapsular opacity on the lens", "drug": "finasteride" } ]
Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.
[ { "ade": "thrombocytopenia", "drug": "quinine" } ]
Allergic contact dermatitis to compound tincture of benzoin.
[ { "ade": "Allergic contact dermatitis", "drug": "benzoin" } ]
We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.
[ { "ade": "torsades de pointes", "drug": "amiodarone" } ]
Visceral herpesvirus infections in leukemic patients receiving cytarabine.
[ { "ade": "Visceral herpesvirus infections", "drug": "cytarabine" } ]
The observations suggest that testicular swelling and pain are side effects of desipramine.
[ { "ade": "testicular swelling", "drug": "desipramine" }, { "ade": "pain", "drug": "desipramine" } ]
Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).
[ { "ade": "tardive dyskinesia", "drug": "Ziprasidone" }, { "ade": "TD", "drug": "Ziprasidone" }, { "ade": "extrapyramidal symptoms", "drug": "Ziprasidone" } ]
Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.
[ { "ade": "Neurologic toxicity", "drug": "FUdR" } ]
CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.
[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]
We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.
[ { "ade": "acute myeloid leukaemia", "drug": "tamoxifen" }, { "ade": "AML", "drug": "tamoxifen" } ]
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.
[ { "ade": "dyserythropoiesis", "drug": "Linezolid" } ]
Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.
[ { "ade": "acute focal myositis", "drug": "all-trans retinoic acid" }, { "ade": "synovitis", "drug": "all-trans retinoic acid" }, { "ade": "possible vasculitis", "drug": "all-trans retinoic acid" } ]
We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.
[ { "ade": "nephrotic syndrome", "drug": "interferon-alpha" } ]
This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.
[ { "ade": "refractory coronary vasospasm", "drug": "cocaine" } ]
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.
[ { "ade": "thrombocytopenia", "drug": "heparin" }, { "ade": "Massive pulmonary embolism", "drug": "heparin" } ]
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.
[ { "ade": "AGEP", "drug": "nimesulide" }, { "ade": "acute generalized exanthematous pustulosis", "drug": "nimesulide" } ]
Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.
[ { "ade": "thrombocytopenia", "drug": "Rifampin" }, { "ade": "hemolytic anemia", "drug": "Rifampin" }, { "ade": "acute renal failure", "drug": "Rifampin" }, { "ade": "hepatitis", "drug": "Rifampin" } ]
Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.
[ { "ade": "neurotoxicity", "drug": "5-fluorouracil" } ]
In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.
[ { "ade": "visual loss", "drug": "ethambutol" } ]
Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.
[ { "ade": "HUS", "drug": "tacrolimus" }, { "ade": "ARF", "drug": "tacrolimus" } ]
Zolpidem tissue concentrations in a multiple drug related death involving Ambien.
[ { "ade": "death", "drug": "Ambien" }, { "ade": "death", "drug": "Zolpidem" } ]
This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.
[ { "ade": "cryptococcal meningitis", "drug": "prednisolone" }, { "ade": "cryptococcal meningitis", "drug": "azathioprine" } ]
Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.
[ { "ade": "skin toxicity", "drug": "aminoglutethimide" } ]
As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.
[ { "ade": "hypersensitivity response", "drug": "tuberculin" } ]
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.
[ { "ade": "ifosfamide-induced encephalopathy", "drug": "ifosfamide" } ]
We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.
[ { "ade": "eye movement abnormality", "drug": "cyclosporin" }, { "ade": "transient brain stem or neuromuscular dysfunction", "drug": "cyclosporin" }, { "ade": "eye movement abnormality", "drug": "ganciclovir" }, { "ade": "transient brain stem or neuromuscular dysfunction", "drug": "ganciclovir" } ]
Anhedonic ejaculation with desipramine.
[ { "ade": "Anhedonic ejaculation", "drug": "desipramine" } ]
CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.
[ { "ade": "impair sexual function", "drug": "baclofen" } ]
Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.
[ { "ade": "Paroxysmal supraventricular tachycardia", "drug": "etoposide" }, { "ade": "Paroxysmal supraventricular tachycardia", "drug": "cisplatin" } ]
Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.
[ { "ade": "akathisia", "drug": "interferon-alpha" } ]
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.
[ { "ade": "Acute pancreatitis", "drug": "5-aminosalicylic acid" } ]
De novo absence status of late onset following withdrawal of lorazepam: a case report.
[ { "ade": "De novo absence status", "drug": "lorazepam" } ]
This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.
[ { "ade": "atypical localized cutaneous eruption", "drug": "sorafenib" } ]
The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.
[ { "ade": "rapidly progressive glomerulonephritis", "drug": "D-penicillamine" } ]
We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.
[ { "ade": "neurological depression", "drug": "oxymetalzoline" } ]
Aminophylline hypersensitivity apparently due to ethylenediamine.
[ { "ade": "Aminophylline hypersensitivity", "drug": "Aminophylline" }, { "ade": "Aminophylline hypersensitivity", "drug": "ethylenediamine" } ]
Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.
[ { "ade": "pancreatitis", "drug": "ezetimibe" } ]
The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.
[ { "ade": "brain injury", "drug": "IL-2" }, { "ade": "disability", "drug": "IL-2" } ]
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
[ { "ade": "mid-line skeletal abnormalities", "drug": "phenytoin" }, { "ade": "Basilar invagination", "drug": "phenytoin" } ]
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.
[ { "ade": "toxic epidermal necrolysis", "drug": "ofloxacin" } ]
Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.
[ { "ade": "Pleuropulmonary fibrosis", "drug": "pergolide" } ]
However, recurrent staphylococcus aureus sepsis developed during CyA therapy.
[ { "ade": "staphylococcus aureus sepsis", "drug": "CyA" } ]
Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.
[ { "ade": "Anaphylaxis", "drug": "cisplatin" } ]
PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.
[ { "ade": "traumatic flap dehiscence", "drug": "LASIK" }, { "ade": "Enterobacter keratitis", "drug": "LASIK" } ]
In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.
[ { "ade": "prolonged ECT seizure", "drug": "ciprofloxacin" } ]
We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.
[ { "ade": "acute hepatitis B and C", "drug": "naltrexone" } ]
The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.
[ { "ade": "proarrhythmic", "drug": "amiodarone" } ]
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.
[ { "ade": "agranulocytosis", "drug": "clozapine" }, { "ade": "Neutropenia", "drug": "phenothiazines" }, { "ade": "agranulocytosis", "drug": "phenothiazines" }, { "ade": "Neutropenia", "drug": "clozapine" } ]
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.
[ { "ade": "fatal case of acute interstitial pneumonitis", "drug": "carmustine" }, { "ade": "fatal case of acute interstitial pneumonitis", "drug": "BCNU" } ]
Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.
[ { "ade": "Fulminant hepatitis", "drug": "propylthiouracil" } ]
Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.
[ { "ade": "nephrotic syndrome", "drug": "macrophage-colony-stimulating factor" } ]
This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.
[ { "ade": "intracerebral hemorrhage", "drug": "pseudoephedrine" } ]
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
[ { "ade": "sudden cutaneous reaction", "drug": "tacrolimus" } ]
During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.
[ { "ade": "peripheral edema", "drug": "omeprazole" }, { "ade": "peripheral edema", "drug": "pantoprazole" } ]
A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.
[ { "ade": "hepatitis", "drug": "halothane" } ]
Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.
[ { "ade": "transient renal impairment", "drug": "Quinapril" }, { "ade": "prolonged hypotension", "drug": "Quinapril" } ]
The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.
[ { "ade": "Clostridium difficile colitis", "drug": "cisplatin" } ]
DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.
[ { "ade": "neuralgic amyotrophy", "drug": "tazobactam" }, { "ade": "neuralgic amyotrophy", "drug": "piperacillin" }, { "ade": "neuralgic amyotrophy", "drug": "vancomycin" }, { "ade": "neuralgic amyotrophy", "drug": "tobramycin" } ]
Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.
[ { "ade": "pulmonary damage", "drug": "oxygen" }, { "ade": "pulmonary damage", "drug": "bleomycin" } ]
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.
[ { "ade": "pulmonary toxicity", "drug": "fludarabine" }, { "ade": "Multiple pulmonary nodules", "drug": "fludarabine" } ]
Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.
[ { "ade": "leukopenia", "drug": "Ibopamine" } ]
Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.
[ { "ade": "Agranulocytosis", "drug": "ticlopidine" } ]
Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.
[ { "ade": "neurotoxicity", "drug": "CAP" } ]
To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.
[ { "ade": "pemphigus", "drug": "captopril" } ]
Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.
[ { "ade": "cutaneous vasculitis", "drug": "ramipril" } ]
We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.
[ { "ade": "hypercalcemia", "drug": "tacalcitol" }, { "ade": "hypercalciuria", "drug": "tacalcitol" }, { "ade": "hypercalcemia", "drug": "thiazide" }, { "ade": "hypercalciuria", "drug": "thiazide" } ]
Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.
[ { "ade": "neurologic toxic effects", "drug": "Sulindac" }, { "ade": "neurologic toxic effects", "drug": "Clinoril" } ]
This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.
[ { "ade": "lupus", "drug": "infliximab" } ]
Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.
[ { "ade": "hemorrhagic", "drug": "L-asparaginase" }, { "ade": "thrombotic cerebrovascular events", "drug": "L-asparaginase" } ]
We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.
[ { "ade": "bilateral vocal cord paralysis", "drug": "bupivacaine" } ]
Persisent ocular hypertension following intravitreal ranibizumab.
[ { "ade": "Persisent ocular hypertension", "drug": "ranibizumab" } ]