mihirhirave/entity_extraction_ade_v2_with_validation

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Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.	[ { "ade": "autoimmune hepatitis", "drug": "Minocycline" } ]
Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.	[ { "ade": "Schneiderian first-rank symptoms", "drug": "fluvoxamine" } ]
over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.	[ { "ade": "uveitis", "drug": "rifabutin" } ]
After four months, while receiving RH, he developed painful bilateral gynaecomastia.	[ { "ade": "bilateral gynaecomastia", "drug": "RH" } ]
However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.	[ { "ade": "cardiac effects", "drug": "halofantrine" }, { "ade": "sudden death", "drug": "halofantrine" } ]
Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.	[ { "ade": "bilateral pulmonary infiltrates", "drug": "methotrexate" }, { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "methotrexate" } ]
The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.	[ { "ade": "first-rank symptoms", "drug": "fluvoxamine" } ]
OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).	[ { "ade": "pain syndrome", "drug": "calcineurin" } ]
Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.	[ { "ade": "lithium toxicity", "drug": "lithium" }, { "ade": "lithium toxicity", "drug": "acyclovir" } ]
Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.	[ { "ade": "Atrioventricular block", "drug": "amiodarone" }, { "ade": "hypothyroidism", "drug": "amiodarone" } ]
Pulmonary toxicity with mefloquine.	[ { "ade": "Pulmonary toxicity", "drug": "mefloquine" } ]
Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.	[ { "ade": "encephalopathy", "drug": "risperidone" }, { "ade": "worsened motorically", "drug": "risperidone" } ]
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.	[ { "ade": "tremor", "drug": "lithium carbonate" } ]
A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).	[ { "ade": "fever", "drug": "fludarabine" }, { "ade": "cough", "drug": "fludarabine" } ]
We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.	[ { "ade": "ileus", "drug": "nimodipine" } ]
Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.	[ { "ade": "Posthypoglycemic hyperglycemia", "drug": "insulin" }, { "ade": "rebound hyperglycemia", "drug": "insulin" } ]
In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.	[ { "ade": "ulcers", "drug": "piroxicam" } ]
DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.	[ { "ade": "cardiomyopathy", "drug": "Interferon alpha-2b" } ]
Psychotic disorder associated with isoniazid.	[ { "ade": "Psychotic disorder", "drug": "isoniazid" } ]
OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.	[ { "ade": "psychosis", "drug": "ciprofloxacin" } ]
The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.	[ { "ade": "anterior ischemic optic neuropathy", "drug": "interferon alfa" }, { "ade": "vascular retinopathy", "drug": "interferon" } ]
The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.	[ { "ade": "pulmonary fibrosis", "drug": "CCNU" } ]
In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.	[ { "ade": "blast crisis", "drug": "imatinib" } ]
We describe a case of prolonged terbinafine-induced cholestatic liver disease.	[ { "ade": "cholestatic liver disease", "drug": "terbinafine" } ]
Acute coronary syndrome induced by capecitabine therapy.	[ { "ade": "Acute coronary syndrome", "drug": "capecitabine" } ]
Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.	[ { "ade": "pulmonary toxicity", "drug": "etoposide" } ]
Nail staining from hydroquinone cream.	[ { "ade": "Nail staining", "drug": "hydroquinone" } ]
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.	[ { "ade": "hypersensitivity", "drug": "carboplatin" }, { "ade": "hypersensitivity", "drug": "CBDCA" }, { "ade": "hypersensitivity", "drug": "paclitaxel" } ]
Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.	[ { "ade": "hypersensitivity", "drug": "sulfadiazine" } ]
After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.	[ { "ade": "skin lesions", "drug": "rifampicin" } ]
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.	[ { "ade": "Ischaemia", "drug": "diamorphine" }, { "ade": "Ischaemia", "drug": "methylphenidate" } ]
A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.	[ { "ade": "one patient became unconscious", "drug": "cotrimoxazole" }, { "ade": "hyperkalaemia", "drug": "cotrimoxazole" }, { "ade": "increased urinary N-acetyl glucosaminase", "drug": "cotrimoxazole" }, { "ade": "elevation of serum creatinine and blood urea", "drug": "cotrimoxazole" } ]
Spindle coma in benzodiazepine toxicity: case report.	[ { "ade": "Spindle coma", "drug": "benzodiazepine" } ]
Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.	[ { "ade": "hypocalcaemia", "drug": "folinic acid" }, { "ade": "hyperkalaemia", "drug": "methotrexate" }, { "ade": "hyperphosphataemia", "drug": "folinic acid" }, { "ade": "tetany", "drug": "methotrexate" }, { "ade": "acute renal impairment", "drug": "folinic acid" }, { "ade": "tetany", "drug": "folinic acid" }, { "ade": "hyper-uricaemia", "drug": "methotrexate" }, { "ade": "hyperkalaemia", "drug": "folinic acid" }, { "ade": "phosphate shower syndrome", "drug": "folinic acid" }, { "ade": "hyperphosphataemia", "drug": "methotrexate" }, { "ade": "hyper-uricaemia", "drug": "folinic acid" }, { "ade": "hypocalcaemia", "drug": "methotrexate" }, { "ade": "metabolic acidosis", "drug": "folinic acid" }, { "ade": "acute renal impairment", "drug": "methotrexate" }, { "ade": "metabolic acidosis", "drug": "methotrexate" }, { "ade": "phosphate shower syndrome", "drug": "methotrexate" } ]
This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.	[ { "ade": "pulmonary signs and symptoms with alveolar infiltrates", "drug": "etanercept" } ]
In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.	[ { "ade": "severe hepatotoxicity", "drug": "hycanthone" } ]
Gabapentin toxicity in renal failure: the importance of dose adjustment.	[ { "ade": "renal failure", "drug": "Gabapentin" } ]
Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.	[ { "ade": "Reye syndrome", "drug": "aspirin" }, { "ade": "RS", "drug": "aspirin" } ]
The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.	[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]
Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.	[ { "ade": "Cushing's syndrome", "drug": "TCA" } ]
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.	[ { "ade": "marrow aplasia", "drug": "ticlopidine" } ]
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.	[ { "ade": "hematopoietic toxicity", "drug": "MTX" }, { "ade": "immunosuppression", "drug": "MTX" }, { "ade": "EBV-associated lymphoproliferative disease", "drug": "MTX" } ]
We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.	[ { "ade": "PSA continued to decrease", "drug": "flutamide" } ]
Valproate-induced hyperammonemia as a cause of altered mental status.	[ { "ade": "hyperammonemia", "drug": "Valproate" }, { "ade": "altered mental status", "drug": "Valproate" } ]
METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.	[ { "ade": "contact dermatitis", "drug": "budesonide" } ]
We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.	[ { "ade": "leukoencephalopathy", "drug": "methotrexate" }, { "ade": "hydrocephalus", "drug": "methotrexate" } ]
Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.	[ { "ade": "alveolar hemorrhage", "drug": "rituximab" }, { "ade": "Interstitial pneumonitis", "drug": "rituximab" } ]
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.	[ { "ade": "angle closure glaucoma", "drug": "topiramate" }, { "ade": "acute-onset myopia", "drug": "topiramate" } ]
It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.	[ { "ade": "salt and water retention", "drug": "indomethacin" }, { "ade": "salt and water retention", "drug": "ibuprofen" }, { "ade": "salt and water retention", "drug": "phenylbutazone" } ]
Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.	[ { "ade": "systemic lupus erythematosus", "drug": "griseofulvin" }, { "ade": "Nephrotic syndrome", "drug": "griseofulvin" } ]
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).	[ { "ade": "Intra-neural ceroid-like pigment", "drug": "B663" }, { "ade": "Intra-neural ceroid-like pigment", "drug": "Lamprene" }, { "ade": "Intra-neural ceroid-like pigment", "drug": "clofazimine" } ]
The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.	[ { "ade": "TEN", "drug": "phenolphthalein" }, { "ade": "rash", "drug": "phenolphthalein" } ]
Graft versus host-like illness in a child with phenobarbital hypersensitivity.	[ { "ade": "hypersensitivity", "drug": "phenobarbital" }, { "ade": "Graft versus host-like illness", "drug": "phenobarbital" } ]
These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.	[ { "ade": "bitemporal visual field defects", "drug": "ethambutol" }, { "ade": "mfERG abnormalities", "drug": "ethambutol" } ]
Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.	[ { "ade": "Allergic contact dermatitis", "drug": "4-chloro-7-nitrobenzofurazan" } ]
Vancomycin-induced vasculitis.	[ { "ade": "vasculitis", "drug": "Vancomycin" } ]
To our knowledge, this case is the first published report of levofloxacin-induced TEN.	[ { "ade": "TEN", "drug": "levofloxacin" } ]
Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.	[ { "ade": "arrhythmia", "drug": "adenosine" } ]
We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.	[ { "ade": "codeine intoxication", "drug": "codeine" } ]
DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.	[ { "ade": "stomatitis", "drug": "5-FU" }, { "ade": "mucositis", "drug": "5-FU" }, { "ade": "neurotoxicity", "drug": "5-FU" }, { "ade": "diarrhea", "drug": "5-FU" }, { "ade": "myelosuppression", "drug": "5-FU" } ]
CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.	[ { "ade": "acute hepatitis", "drug": "itraconazole" } ]
High-dose methotrexate-associated acute renal failure may be an avoidable complication.	[ { "ade": "acute renal failure", "drug": "methotrexate" } ]
A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.	[ { "ade": "PCNSL", "drug": "natalizumab" }, { "ade": "primary central nervous system lymphoma", "drug": "natalizumab" } ]
Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.	[ { "ade": "hemorrhagic vasculitis", "drug": "Ciprofloxacin" } ]
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.	[ { "ade": "Multifocal inflammatory leukoencephalopathy", "drug": "levamisole" } ]
Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.	[ { "ade": "primary and secondary perforation of the bladder", "drug": "epirubicin" } ]
Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.	[ { "ade": "Mobitz type I", "drug": "ritodrine" }, { "ade": "Wenckebach AV block", "drug": "ritodrine" }, { "ade": "Type I second-degree AV block", "drug": "ritodrine" } ]
Rupture of a cerebral aneurysm associated with nifedipine treatment.	[ { "ade": "Rupture of a cerebral aneurysm", "drug": "nifedipine" } ]
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.	[ { "ade": "Agranulocytosis", "drug": "vancomycin" } ]
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.	[ { "ade": "nephrotoxicity", "drug": "Tenofovir" } ]
Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.	[ { "ade": "haematoma", "drug": "warfarin" }, { "ade": "discomfort", "drug": "warfarin" }, { "ade": "diplopia", "drug": "warfarin" }, { "ade": "lagophthalmos", "drug": "warfarin" } ]
We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.	[ { "ade": "SJS", "drug": "ciprofloxacin" }, { "ade": "VBDS", "drug": "ciprofloxacin" } ]
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.	[ { "ade": "hypoglycaemia", "drug": "mefloquine" } ]
Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.	[ { "ade": "Pulmonary edema", "drug": "terbutaline" }, { "ade": "Pulmonary edema", "drug": "ritodrine" } ]
We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.	[ { "ade": "benign intracranial hypertension", "drug": "minocycline" } ]
A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.	[ { "ade": "hepatitis", "drug": "dapsone" }, { "ade": "lymphadenopathy", "drug": "dapsone" }, { "ade": "vomiting", "drug": "dapsone" }, { "ade": "nausea", "drug": "dapsone" }, { "ade": "leukopenia", "drug": "dapsone" }, { "ade": "fever", "drug": "dapsone" }, { "ade": "mononucleosis", "drug": "dapsone" }, { "ade": "headache", "drug": "dapsone" }, { "ade": "hemolysis", "drug": "dapsone" }, { "ade": "hypersensitivity syndrome", "drug": "dapsone" } ]
We also describe a case of timolol-induced ocular pemphigoid.	[ { "ade": "ocular pemphigoid", "drug": "timolol" } ]
A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.	[ { "ade": "gradual stiffness", "drug": "pentazocine" }, { "ade": "weakness of the lower extremities", "drug": "pentazocine" } ]
In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.	[ { "ade": "parasympathetic dysfunction of the visual system", "drug": "BTX-B" } ]
Life-threatening hyperkalemia induced by arginine.	[ { "ade": "hyperkalemia", "drug": "arginine" } ]
This is the first report of a disulfiram-like reaction with cefmenoxime.	[ { "ade": "disulfiram-like reaction", "drug": "cefmenoxime" } ]
We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.	[ { "ade": "dapsone reaction", "drug": "dapsone" }, { "ade": "fatal", "drug": "dapsone" } ]
The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.	[ { "ade": "hyperinsulinaemia", "drug": "insulin" }, { "ade": "insulin insensitivity", "drug": "insulin" } ]
Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.	[ { "ade": "Acute pancreatitis", "drug": "5-aminosalicylic acid" } ]
Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.	[ { "ade": "fatal intracerebral haemorrhage", "drug": "heparin" } ]
Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.	[ { "ade": "Visual hallucinations", "drug": "bevacizumab" } ]
Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.	[ { "ade": "Vogt-Koyanagi-Harada disease", "drug": "interferon alpha" } ]
Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.	[ { "ade": "headache", "drug": "fluoxetine" } ]
Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.	[ { "ade": "Hashimoto's disease", "drug": "interferon-alpha" } ]
A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.	[ { "ade": "fatal interaction", "drug": "minoxidil" } ]
Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.	[ { "ade": "methemoglobinemia", "drug": "Benzocaine" } ]
After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.	[ { "ade": "SaO2 dips", "drug": "infliximab" }, { "ade": "increase in the number of apneic events", "drug": "infliximab" } ]
Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.	[ { "ade": "Gestational diabetes", "drug": "norethisterone" } ]
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.	[ { "ade": "carbamazepine toxicity", "drug": "saquinavir" }, { "ade": "progressive ataxia", "drug": "ritonavir" }, { "ade": "carbamazepine toxicity", "drug": "carbamazepine" }, { "ade": "progressive ataxia", "drug": "carbamazepine" }, { "ade": "carbamazepine toxicity", "drug": "ritonavir" }, { "ade": "progressive ataxia", "drug": "saquinavir" } ]
Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.	[ { "ade": "lung fibrosis", "drug": "paclitaxel" }, { "ade": "pneumonitis", "drug": "paclitaxel" } ]
Tetany in a child with AIDS receiving intravenous tobramycin.	[ { "ade": "Tetany", "drug": "tobramycin" } ]
Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?	[ { "ade": "hypersensitivity", "drug": "carboplatin" } ]
Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.	[ { "ade": "multiple abscesses", "drug": "CHOP" } ]
Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.	[ { "ade": "paresthesias", "drug": "Ara-C" } ]
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.	[ { "ade": "TRAb/TBII without thyroid-stimulating activity", "drug": "amiodarone" }, { "ade": "thyroiditis", "drug": "amiodarone" }, { "ade": "destructive thyroiditis", "drug": "amiodarone" } ]

Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.

[ { "ade": "autoimmune hepatitis", "drug": "Minocycline" } ]

Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.

[ { "ade": "Schneiderian first-rank symptoms", "drug": "fluvoxamine" } ]

over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.

[ { "ade": "uveitis", "drug": "rifabutin" } ]

After four months, while receiving RH, he developed painful bilateral gynaecomastia.

[ { "ade": "bilateral gynaecomastia", "drug": "RH" } ]

However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.

[ { "ade": "cardiac effects", "drug": "halofantrine" }, { "ade": "sudden death", "drug": "halofantrine" } ]

Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.

[ { "ade": "bilateral pulmonary infiltrates", "drug": "methotrexate" }, { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "methotrexate" } ]

The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.

[ { "ade": "first-rank symptoms", "drug": "fluvoxamine" } ]

OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).

[ { "ade": "pain syndrome", "drug": "calcineurin" } ]

Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.

[ { "ade": "lithium toxicity", "drug": "lithium" }, { "ade": "lithium toxicity", "drug": "acyclovir" } ]

Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.

[ { "ade": "Atrioventricular block", "drug": "amiodarone" }, { "ade": "hypothyroidism", "drug": "amiodarone" } ]

Pulmonary toxicity with mefloquine.

[ { "ade": "Pulmonary toxicity", "drug": "mefloquine" } ]

Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.

[ { "ade": "encephalopathy", "drug": "risperidone" }, { "ade": "worsened motorically", "drug": "risperidone" } ]

Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.

[ { "ade": "tremor", "drug": "lithium carbonate" } ]

A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).

[ { "ade": "fever", "drug": "fludarabine" }, { "ade": "cough", "drug": "fludarabine" } ]

We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.

[ { "ade": "ileus", "drug": "nimodipine" } ]

Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.

[ { "ade": "Posthypoglycemic hyperglycemia", "drug": "insulin" }, { "ade": "rebound hyperglycemia", "drug": "insulin" } ]

In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.

[ { "ade": "ulcers", "drug": "piroxicam" } ]

DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.

[ { "ade": "cardiomyopathy", "drug": "Interferon alpha-2b" } ]

Psychotic disorder associated with isoniazid.

[ { "ade": "Psychotic disorder", "drug": "isoniazid" } ]

OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.

[ { "ade": "psychosis", "drug": "ciprofloxacin" } ]

The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.

[ { "ade": "anterior ischemic optic neuropathy", "drug": "interferon alfa" }, { "ade": "vascular retinopathy", "drug": "interferon" } ]

The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.

[ { "ade": "pulmonary fibrosis", "drug": "CCNU" } ]

In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.

[ { "ade": "blast crisis", "drug": "imatinib" } ]

We describe a case of prolonged terbinafine-induced cholestatic liver disease.

[ { "ade": "cholestatic liver disease", "drug": "terbinafine" } ]

Acute coronary syndrome induced by capecitabine therapy.

[ { "ade": "Acute coronary syndrome", "drug": "capecitabine" } ]

Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.

[ { "ade": "pulmonary toxicity", "drug": "etoposide" } ]

Nail staining from hydroquinone cream.

[ { "ade": "Nail staining", "drug": "hydroquinone" } ]

We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.

[ { "ade": "hypersensitivity", "drug": "carboplatin" }, { "ade": "hypersensitivity", "drug": "CBDCA" }, { "ade": "hypersensitivity", "drug": "paclitaxel" } ]

Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.

[ { "ade": "hypersensitivity", "drug": "sulfadiazine" } ]

After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.

[ { "ade": "skin lesions", "drug": "rifampicin" } ]

Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.

[ { "ade": "Ischaemia", "drug": "diamorphine" }, { "ade": "Ischaemia", "drug": "methylphenidate" } ]

A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.

[ { "ade": "one patient became unconscious", "drug": "cotrimoxazole" }, { "ade": "hyperkalaemia", "drug": "cotrimoxazole" }, { "ade": "increased urinary N-acetyl glucosaminase", "drug": "cotrimoxazole" }, { "ade": "elevation of serum creatinine and blood urea", "drug": "cotrimoxazole" } ]

Spindle coma in benzodiazepine toxicity: case report.

[ { "ade": "Spindle coma", "drug": "benzodiazepine" } ]

Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.

[ { "ade": "hypocalcaemia", "drug": "folinic acid" }, { "ade": "hyperkalaemia", "drug": "methotrexate" }, { "ade": "hyperphosphataemia", "drug": "folinic acid" }, { "ade": "tetany", "drug": "methotrexate" }, { "ade": "acute renal impairment", "drug": "folinic acid" }, { "ade": "tetany", "drug": "folinic acid" }, { "ade": "hyper-uricaemia", "drug": "methotrexate" }, { "ade": "hyperkalaemia", "drug": "folinic acid" }, { "ade": "phosphate shower syndrome", "drug": "folinic acid" }, { "ade": "hyperphosphataemia", "drug": "methotrexate" }, { "ade": "hyper-uricaemia", "drug": "folinic acid" }, { "ade": "hypocalcaemia", "drug": "methotrexate" }, { "ade": "metabolic acidosis", "drug": "folinic acid" }, { "ade": "acute renal impairment", "drug": "methotrexate" }, { "ade": "metabolic acidosis", "drug": "methotrexate" }, { "ade": "phosphate shower syndrome", "drug": "methotrexate" } ]

This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.

[ { "ade": "pulmonary signs and symptoms with alveolar infiltrates", "drug": "etanercept" } ]

In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.

[ { "ade": "severe hepatotoxicity", "drug": "hycanthone" } ]

Gabapentin toxicity in renal failure: the importance of dose adjustment.

[ { "ade": "renal failure", "drug": "Gabapentin" } ]

Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.

[ { "ade": "Reye syndrome", "drug": "aspirin" }, { "ade": "RS", "drug": "aspirin" } ]

The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.

[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]

Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.

[ { "ade": "Cushing's syndrome", "drug": "TCA" } ]

There is no consensus on the treatment of ticlopidine-induced marrow aplasia.

[ { "ade": "marrow aplasia", "drug": "ticlopidine" } ]

We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.

[ { "ade": "hematopoietic toxicity", "drug": "MTX" }, { "ade": "immunosuppression", "drug": "MTX" }, { "ade": "EBV-associated lymphoproliferative disease", "drug": "MTX" } ]

We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.

[ { "ade": "PSA continued to decrease", "drug": "flutamide" } ]

Valproate-induced hyperammonemia as a cause of altered mental status.

[ { "ade": "hyperammonemia", "drug": "Valproate" }, { "ade": "altered mental status", "drug": "Valproate" } ]

METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.

[ { "ade": "contact dermatitis", "drug": "budesonide" } ]

We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.

[ { "ade": "leukoencephalopathy", "drug": "methotrexate" }, { "ade": "hydrocephalus", "drug": "methotrexate" } ]

Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.

[ { "ade": "alveolar hemorrhage", "drug": "rituximab" }, { "ade": "Interstitial pneumonitis", "drug": "rituximab" } ]

Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.

[ { "ade": "angle closure glaucoma", "drug": "topiramate" }, { "ade": "acute-onset myopia", "drug": "topiramate" } ]

It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.

[ { "ade": "salt and water retention", "drug": "indomethacin" }, { "ade": "salt and water retention", "drug": "ibuprofen" }, { "ade": "salt and water retention", "drug": "phenylbutazone" } ]

Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.

[ { "ade": "systemic lupus erythematosus", "drug": "griseofulvin" }, { "ade": "Nephrotic syndrome", "drug": "griseofulvin" } ]

Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).

[ { "ade": "Intra-neural ceroid-like pigment", "drug": "B663" }, { "ade": "Intra-neural ceroid-like pigment", "drug": "Lamprene" }, { "ade": "Intra-neural ceroid-like pigment", "drug": "clofazimine" } ]

The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.

[ { "ade": "TEN", "drug": "phenolphthalein" }, { "ade": "rash", "drug": "phenolphthalein" } ]

Graft versus host-like illness in a child with phenobarbital hypersensitivity.

[ { "ade": "hypersensitivity", "drug": "phenobarbital" }, { "ade": "Graft versus host-like illness", "drug": "phenobarbital" } ]

These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.

[ { "ade": "bitemporal visual field defects", "drug": "ethambutol" }, { "ade": "mfERG abnormalities", "drug": "ethambutol" } ]

Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.

[ { "ade": "Allergic contact dermatitis", "drug": "4-chloro-7-nitrobenzofurazan" } ]

Vancomycin-induced vasculitis.

[ { "ade": "vasculitis", "drug": "Vancomycin" } ]

To our knowledge, this case is the first published report of levofloxacin-induced TEN.

[ { "ade": "TEN", "drug": "levofloxacin" } ]

Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.

[ { "ade": "arrhythmia", "drug": "adenosine" } ]

We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.

[ { "ade": "codeine intoxication", "drug": "codeine" } ]

DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.

[ { "ade": "stomatitis", "drug": "5-FU" }, { "ade": "mucositis", "drug": "5-FU" }, { "ade": "neurotoxicity", "drug": "5-FU" }, { "ade": "diarrhea", "drug": "5-FU" }, { "ade": "myelosuppression", "drug": "5-FU" } ]

CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.

[ { "ade": "acute hepatitis", "drug": "itraconazole" } ]

High-dose methotrexate-associated acute renal failure may be an avoidable complication.

[ { "ade": "acute renal failure", "drug": "methotrexate" } ]

A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.

[ { "ade": "PCNSL", "drug": "natalizumab" }, { "ade": "primary central nervous system lymphoma", "drug": "natalizumab" } ]

Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.

[ { "ade": "hemorrhagic vasculitis", "drug": "Ciprofloxacin" } ]

Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.

[ { "ade": "Multifocal inflammatory leukoencephalopathy", "drug": "levamisole" } ]

Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.

[ { "ade": "primary and secondary perforation of the bladder", "drug": "epirubicin" } ]

Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.

[ { "ade": "Mobitz type I", "drug": "ritodrine" }, { "ade": "Wenckebach AV block", "drug": "ritodrine" }, { "ade": "Type I second-degree AV block", "drug": "ritodrine" } ]

Rupture of a cerebral aneurysm associated with nifedipine treatment.

[ { "ade": "Rupture of a cerebral aneurysm", "drug": "nifedipine" } ]

Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.

[ { "ade": "Agranulocytosis", "drug": "vancomycin" } ]

Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.

[ { "ade": "nephrotoxicity", "drug": "Tenofovir" } ]

Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.

[ { "ade": "haematoma", "drug": "warfarin" }, { "ade": "discomfort", "drug": "warfarin" }, { "ade": "diplopia", "drug": "warfarin" }, { "ade": "lagophthalmos", "drug": "warfarin" } ]

We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.

[ { "ade": "SJS", "drug": "ciprofloxacin" }, { "ade": "VBDS", "drug": "ciprofloxacin" } ]

We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.

[ { "ade": "hypoglycaemia", "drug": "mefloquine" } ]

Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.

[ { "ade": "Pulmonary edema", "drug": "terbutaline" }, { "ade": "Pulmonary edema", "drug": "ritodrine" } ]

We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.

[ { "ade": "benign intracranial hypertension", "drug": "minocycline" } ]

A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.

[ { "ade": "hepatitis", "drug": "dapsone" }, { "ade": "lymphadenopathy", "drug": "dapsone" }, { "ade": "vomiting", "drug": "dapsone" }, { "ade": "nausea", "drug": "dapsone" }, { "ade": "leukopenia", "drug": "dapsone" }, { "ade": "fever", "drug": "dapsone" }, { "ade": "mononucleosis", "drug": "dapsone" }, { "ade": "headache", "drug": "dapsone" }, { "ade": "hemolysis", "drug": "dapsone" }, { "ade": "hypersensitivity syndrome", "drug": "dapsone" } ]

We also describe a case of timolol-induced ocular pemphigoid.

[ { "ade": "ocular pemphigoid", "drug": "timolol" } ]

A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.

[ { "ade": "gradual stiffness", "drug": "pentazocine" }, { "ade": "weakness of the lower extremities", "drug": "pentazocine" } ]

In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.

[ { "ade": "parasympathetic dysfunction of the visual system", "drug": "BTX-B" } ]

Life-threatening hyperkalemia induced by arginine.

[ { "ade": "hyperkalemia", "drug": "arginine" } ]

This is the first report of a disulfiram-like reaction with cefmenoxime.

[ { "ade": "disulfiram-like reaction", "drug": "cefmenoxime" } ]

We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.

[ { "ade": "dapsone reaction", "drug": "dapsone" }, { "ade": "fatal", "drug": "dapsone" } ]

The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.

[ { "ade": "hyperinsulinaemia", "drug": "insulin" }, { "ade": "insulin insensitivity", "drug": "insulin" } ]

Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.

[ { "ade": "Acute pancreatitis", "drug": "5-aminosalicylic acid" } ]

Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.

[ { "ade": "fatal intracerebral haemorrhage", "drug": "heparin" } ]

Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.

[ { "ade": "Visual hallucinations", "drug": "bevacizumab" } ]

Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.

[ { "ade": "Vogt-Koyanagi-Harada disease", "drug": "interferon alpha" } ]

Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.

[ { "ade": "headache", "drug": "fluoxetine" } ]

Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.

[ { "ade": "Hashimoto's disease", "drug": "interferon-alpha" } ]

A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.

[ { "ade": "fatal interaction", "drug": "minoxidil" } ]

Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.

[ { "ade": "methemoglobinemia", "drug": "Benzocaine" } ]

After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.

[ { "ade": "SaO2 dips", "drug": "infliximab" }, { "ade": "increase in the number of apneic events", "drug": "infliximab" } ]

Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.

[ { "ade": "Gestational diabetes", "drug": "norethisterone" } ]

Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.

[ { "ade": "carbamazepine toxicity", "drug": "saquinavir" }, { "ade": "progressive ataxia", "drug": "ritonavir" }, { "ade": "carbamazepine toxicity", "drug": "carbamazepine" }, { "ade": "progressive ataxia", "drug": "carbamazepine" }, { "ade": "carbamazepine toxicity", "drug": "ritonavir" }, { "ade": "progressive ataxia", "drug": "saquinavir" } ]

Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.

[ { "ade": "lung fibrosis", "drug": "paclitaxel" }, { "ade": "pneumonitis", "drug": "paclitaxel" } ]

Tetany in a child with AIDS receiving intravenous tobramycin.

[ { "ade": "Tetany", "drug": "tobramycin" } ]

Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?

[ { "ade": "hypersensitivity", "drug": "carboplatin" } ]

Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.

[ { "ade": "multiple abscesses", "drug": "CHOP" } ]

Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.

[ { "ade": "paresthesias", "drug": "Ara-C" } ]

These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.

[ { "ade": "TRAb/TBII without thyroid-stimulating activity", "drug": "amiodarone" }, { "ade": "thyroiditis", "drug": "amiodarone" }, { "ade": "destructive thyroiditis", "drug": "amiodarone" } ]