mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.	[ { "ade": "bitemporal visual field defects", "drug": "ethambutol" }, { "ade": "decreased visual acuity", "drug": "ethambutol" } ]
No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.	[ { "ade": "nephrogenic diabetes insipidus", "drug": "foscarnet" } ]
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.	[ { "ade": "behavioural side effects", "drug": "gabapentin" }, { "ade": "behavioural side effects", "drug": "GBP" } ]
We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).	[ { "ade": "severe AVP", "drug": "infliximab" } ]
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.	[ { "ade": "anemia", "drug": "ribavirin" }, { "ade": "anemia", "drug": "pegylated interferon alpha-2a" }, { "ade": "progressive malaise", "drug": "pegylated interferon alpha-2a" }, { "ade": "progressive malaise", "drug": "ribavirin" } ]
Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.	[ { "ade": "hemorrhagic vasculitis", "drug": "ciprofloxacin" } ]
Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.	[ { "ade": "Acute pulmonary reactions", "drug": "nitrofurantoin" }, { "ade": "pulmonary dysfunction", "drug": "nitrofurantoin" } ]
A case of mania associated with fluoxetine.	[ { "ade": "mania", "drug": "fluoxetine" } ]
Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.	[ { "ade": "Anaphylaxis", "drug": "isoniazid" } ]
Piritrexim-induced pulmonary toxicity.	[ { "ade": "pulmonary toxicity", "drug": "Piritrexim" } ]
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.	[ { "ade": "SJS", "drug": "nevirapine" } ]
Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.	[ { "ade": "wide QRS complex dysrhythmia", "drug": "Propoxyphene" } ]
Edema associated with ibuprofen therapy.	[ { "ade": "Edema", "drug": "ibuprofen" } ]
Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.	[ { "ade": "fall of the filtration fraction", "drug": "cyclosporine A" }, { "ade": "nephrotoxicity", "drug": "cyclosporine A" }, { "ade": "rise in the relative clearance of 99Tc-dimercaptosuccinic acid", "drug": "cyclosporine A" }, { "ade": "increase in proteinuria", "drug": "cyclosporine A" } ]
Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.	[ { "ade": "Fatal eosinophilia myalgia syndrome", "drug": "tryptophan" } ]
The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.	[ { "ade": "transient intraoperative hypertension", "drug": "epinephrine" } ]
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.	[ { "ade": "Fatal acute encephalomyelitis", "drug": "methotrexate" } ]
The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).	[ { "ade": "status migrainosus", "drug": "carbamazepine" }, { "ade": "status migrainosus", "drug": "oxcarbazepine" }, { "ade": "status migrainosus", "drug": "OXC" }, { "ade": "status migrainosus", "drug": "CBZ" } ]
Cardiac arrest associated with sulprostone use during caesarean section.	[ { "ade": "Cardiac arrest", "drug": "sulprostone" } ]
A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.	[ { "ade": "normotensive scleroderma renal crisis", "drug": "methylprednisolone" } ]
An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.	[ { "ade": "red blood cell anemia", "drug": "prednisone" }, { "ade": "red blood cell anemia", "drug": "MMF" } ]
We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.	[ { "ade": "hyponatremia", "drug": "carbamazepine" } ]
We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.	[ { "ade": "acute myocardial ischaemia", "drug": "venlafaxine" } ]
Successful desensitization to high-dose methotrexate after systemic anaphylaxis.	[ { "ade": "systemic anaphylaxis", "drug": "methotrexate" } ]
The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.	[ { "ade": "systemic iron toxicity", "drug": "iron sucrose" } ]
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.	[ { "ade": "brain lesions", "drug": "penicillamine" } ]
We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.	[ { "ade": "mucositis", "drug": "doxorubicin" }, { "ade": "gastritis", "drug": "dexamethasone" } ]
Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.	[ { "ade": "Anaphylaxis", "drug": "cyclosporine" } ]
Gigantomastia induced by bucillamine.	[ { "ade": "Gigantomastia", "drug": "bucillamine" } ]
It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.	[ { "ade": "serositis", "drug": "sulfasalazine" }, { "ade": "pulmonary parenchymal involvement", "drug": "sulfasalazine" }, { "ade": "lupus", "drug": "sulfasalazine" } ]
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.	[ { "ade": "skin pigmentation", "drug": "sulfasalazine" }, { "ade": "Pulmonary infiltrates", "drug": "sulfasalazine" } ]
The elicitation of a movement disorder by trazodone: case report.	[ { "ade": "movement disorder", "drug": "trazodone" } ]
Gabapentin withdrawal presenting as status epilepticus.	[ { "ade": "status epilepticus", "drug": "Gabapentin" } ]
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.	[ { "ade": "fever", "drug": "5-ASA" }, { "ade": "worsening respiratory distress", "drug": "prednisone" }, { "ade": "worsening respiratory distress", "drug": "5-ASA" }, { "ade": "fever", "drug": "prednisone" }, { "ade": "fever", "drug": "mesalamine" }, { "ade": "worsening respiratory distress", "drug": "mesalamine" } ]
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.	[ { "ade": "aplastic anemia", "drug": "gold" } ]
Magnesium tocolysis as the cause of urinary calculus during pregnancy.	[ { "ade": "urinary calculus", "drug": "Magnesium" } ]
The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.	[ { "ade": "hepatic enzyme disturbances", "drug": "pegvisomant" } ]
This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.	[ { "ade": "hypothyroidism", "drug": "amiodarone" } ]
It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.	[ { "ade": "cholestasis", "drug": "azathioprine" } ]
The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.	[ { "ade": "ovarian endometrioid carcinoma", "drug": "tamoxifen" } ]
Pemphigus vulgaris precipitated by glibenclamide therapy.	[ { "ade": "Pemphigus vulgaris", "drug": "glibenclamide" } ]
This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.	[ { "ade": "hypothermia", "drug": "risperidone" } ]
A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.	[ { "ade": "interstitial pneumonitis", "drug": "pranlukast" }, { "ade": "high fever", "drug": "pranlukast" } ]
We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.	[ { "ade": "aseptic meningitis", "drug": "TMP" }, { "ade": "aseptic meningitis", "drug": "SMX" } ]
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.	[ { "ade": "hypoadrenalism", "drug": "o,p'-DDD" } ]
In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.	[ { "ade": "tachycardia", "drug": "procainamide" } ]
Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.	[ { "ade": "pancreatitis", "drug": "Torsemide" } ]
OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.	[ { "ade": "psychosis", "drug": "interferon" } ]
High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.	[ { "ade": "High-grade endometrial stromal sarcoma", "drug": "tamoxifen" } ]
Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.	[ { "ade": "nephrotic syndrome", "drug": "IFN" } ]
A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.	[ { "ade": "apnoea", "drug": "suxamethonium" } ]
A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.	[ { "ade": "leukocytopenia", "drug": "sulfasalazine" }, { "ade": "fever", "drug": "sulfasalazine" }, { "ade": "thrombocytopenia", "drug": "sulfasalazine" }, { "ade": "skin eruptions", "drug": "sulfasalazine" } ]
Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.	[ { "ade": "coma", "drug": "Valproic acid" } ]
The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.	[ { "ade": "diabetic ketoacidosis", "drug": "perospirone hydrochloride" } ]
Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.	[ { "ade": "Autoimmune thyroid disease", "drug": "interferon-alpha" }, { "ade": "Autoimmune thyroid disease", "drug": "IFN-alpha" } ]
The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.	[ { "ade": "hypothermia", "drug": "risperidone" } ]
Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.	[ { "ade": "disseminated intravascular coagulation", "drug": "zomepirac" }, { "ade": "Anaphylactoid shock", "drug": "zomepirac" }, { "ade": "anuric renal failure", "drug": "zomepirac" } ]
In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.	[ { "ade": "incontinence", "drug": "venlafaxine" }, { "ade": "incontinence", "drug": "paroxetine" }, { "ade": "incontinence", "drug": "sertraline" } ]
The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.	[ { "ade": "delayed elimination", "drug": "methotrexate" }, { "ade": "toxicity", "drug": "ciprofloxacin" }, { "ade": "delayed elimination", "drug": "ciprofloxacin" } ]
Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.	[ { "ade": "secondary hyperparathyroidism", "drug": "calcitriol" }, { "ade": "vitamin D intoxication", "drug": "phosphate" }, { "ade": "potassium loss", "drug": "phosphate" }, { "ade": "vitamin D intoxication", "drug": "calcitriol" }, { "ade": "potassium loss", "drug": "calcitriol" }, { "ade": "secondary hyperparathyroidism", "drug": "phosphate" } ]
Mammary gigantism is a rare complication of D-penicillamine treatment.	[ { "ade": "Mammary gigantism", "drug": "D-penicillamine" } ]
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.	[ { "ade": "rapid mood cycling", "drug": "L-dopa" } ]
Two cases of mequitazine-induced photosensitivity reactions.	[ { "ade": "photosensitivity reactions", "drug": "mequitazine" } ]
The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.	[ { "ade": "FVS", "drug": "valproic acid" } ]
The role of Adriamycin in the production of cardiotoxicity is reviewed.	[ { "ade": "cardiotoxicity", "drug": "Adriamycin" } ]
Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.	[ { "ade": "diabetic coma", "drug": "thiazide" }, { "ade": "diabetic coma", "drug": "propranolol" } ]
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.	[ { "ade": "serotonin syndrome", "drug": "venlafaxine" }, { "ade": "extrapyramidal movement disorders", "drug": "venlafaxine" }, { "ade": "extrapyramidal movement disorders", "drug": "sertraline" }, { "ade": "serotonin syndrome", "drug": "metoclopramide" }, { "ade": "extrapyramidal movement disorders", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "sertraline" } ]
We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.	[ { "ade": "sub-acute leukoencephalopathy", "drug": "methotrexate" } ]
A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.	[ { "ade": "fatal pulmonary fibrosis", "drug": "BCNU" } ]
A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.	[ { "ade": "nonconvulsive status epilepticus", "drug": "morphine" } ]
PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.	[ { "ade": "corneal endothelial deposits", "drug": "rifabutin" } ]
CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.	[ { "ade": "rhabdomyolysis", "drug": "sertraline" } ]
RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.	[ { "ade": "sexual dysfunction", "drug": "baclofen" } ]
The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.	[ { "ade": "soft-tissue injury", "drug": "phenytoin" }, { "ade": "purple glove syndrome", "drug": "phenytoin" } ]
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.	[ { "ade": "methanol poisoning", "drug": "methanol" } ]
DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.	[ { "ade": "liver enzyme elevation", "drug": "leflunomide" }, { "ade": "alopecia", "drug": "leflunomide" }, { "ade": "hypertension", "drug": "leflunomide" }, { "ade": "nausea", "drug": "leflunomide" }, { "ade": "allergic skin reactions", "drug": "leflunomide" }, { "ade": "diarrhea", "drug": "leflunomide" } ]
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.	[ { "ade": "stupor", "drug": "valproate" } ]
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.	[ { "ade": "interstitial lung disease", "drug": "sorafenib" } ]
Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.	[ { "ade": "tardive seizures", "drug": "piperacillin" }, { "ade": "tardive seizures", "drug": "cefotiam" } ]
Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.	[ { "ade": "Marked hyperkalemia", "drug": "arginine monohydrochloride" } ]
A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.	[ { "ade": "hepatic angiosarcoma", "drug": "vinyl chloride" }, { "ade": "hepatic angiosarcoma", "drug": "Thorotrast" }, { "ade": "hepatic angiosarcoma", "drug": "inorganic arsenic" } ]
Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.	[ { "ade": "Ataxia", "drug": "propafenone" } ]
He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.	[ { "ade": "serotonin syndrome", "drug": "clomipramine" } ]
CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.	[ { "ade": "seizures", "drug": "Amphotericin B" } ]
Transient phenytoin induced IgA deficiency and permanent IgE increase.	[ { "ade": "IgA deficiency", "drug": "phenytoin" }, { "ade": "IgE increase", "drug": "phenytoin" } ]
Two patients had ampicillin-associated seizures.	[ { "ade": "seizures", "drug": "ampicillin" } ]
OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.	[ { "ade": "rhabdomyolysis", "drug": "sertraline" } ]
CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.	[ { "ade": "hemorrhagic choroidal detachment", "drug": "tissue plasminogen activator" }, { "ade": "hemorrhage", "drug": "tissue plasminogen activator" } ]
Rifampin-associated thrombocytopenia secondary to poor compliance.	[ { "ade": "thrombocytopenia", "drug": "Rifampin" } ]
Priapism associated with zuclopenthixol.	[ { "ade": "Priapism", "drug": "zuclopenthixol" } ]
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.	[ { "ade": "acute renal failure", "drug": "enalapril" } ]
Syncope in a 65-year-old woman after nitrate ingestion.	[ { "ade": "Syncope", "drug": "nitrate" } ]
Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.	[ { "ade": "Abdominal wall ulceration", "drug": "recombinant human interferon-beta-1b" }, { "ade": "mucinosis", "drug": "recombinant human interferon-beta-1b" } ]
In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.	[ { "ade": "hypoglycaemic coma", "drug": "SP" } ]
We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.	[ { "ade": "worsening of Raynaud's phenomenon", "drug": "yohimbine" } ]
A case of oculogyric crisis induced by metoclopramide is described in this paper.	[ { "ade": "oculogyric crisis", "drug": "metoclopramide" } ]
Transient global amnesia after clioquinol: five personal observations from outside Japan.	[ { "ade": "Transient global amnesia", "drug": "clioquinol" } ]
Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.	[ { "ade": "vincristine neurotoxicity", "drug": "Itraconazole" }, { "ade": "vincristine neurotoxicity", "drug": "vincristine" } ]
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.	[ { "ade": "severe splenic hemorrhage and rupture", "drug": "tPA" } ]
Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.	[ { "ade": "delirious", "drug": "lithium" } ]

Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.

[ { "ade": "bitemporal visual field defects", "drug": "ethambutol" }, { "ade": "decreased visual acuity", "drug": "ethambutol" } ]

No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.

[ { "ade": "nephrogenic diabetes insipidus", "drug": "foscarnet" } ]

We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.

[ { "ade": "behavioural side effects", "drug": "gabapentin" }, { "ade": "behavioural side effects", "drug": "GBP" } ]

We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).

[ { "ade": "severe AVP", "drug": "infliximab" } ]

PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.

[ { "ade": "anemia", "drug": "ribavirin" }, { "ade": "anemia", "drug": "pegylated interferon alpha-2a" }, { "ade": "progressive malaise", "drug": "pegylated interferon alpha-2a" }, { "ade": "progressive malaise", "drug": "ribavirin" } ]

Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.

[ { "ade": "hemorrhagic vasculitis", "drug": "ciprofloxacin" } ]

Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.

[ { "ade": "Acute pulmonary reactions", "drug": "nitrofurantoin" }, { "ade": "pulmonary dysfunction", "drug": "nitrofurantoin" } ]

A case of mania associated with fluoxetine.

[ { "ade": "mania", "drug": "fluoxetine" } ]

Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.

[ { "ade": "Anaphylaxis", "drug": "isoniazid" } ]

Piritrexim-induced pulmonary toxicity.

[ { "ade": "pulmonary toxicity", "drug": "Piritrexim" } ]

We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.

[ { "ade": "SJS", "drug": "nevirapine" } ]

Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.

[ { "ade": "wide QRS complex dysrhythmia", "drug": "Propoxyphene" } ]

Edema associated with ibuprofen therapy.

[ { "ade": "Edema", "drug": "ibuprofen" } ]

Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.

[ { "ade": "fall of the filtration fraction", "drug": "cyclosporine A" }, { "ade": "nephrotoxicity", "drug": "cyclosporine A" }, { "ade": "rise in the relative clearance of 99Tc-dimercaptosuccinic acid", "drug": "cyclosporine A" }, { "ade": "increase in proteinuria", "drug": "cyclosporine A" } ]

Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.

[ { "ade": "Fatal eosinophilia myalgia syndrome", "drug": "tryptophan" } ]

The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.

[ { "ade": "transient intraoperative hypertension", "drug": "epinephrine" } ]

Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.

[ { "ade": "Fatal acute encephalomyelitis", "drug": "methotrexate" } ]

The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).

[ { "ade": "status migrainosus", "drug": "carbamazepine" }, { "ade": "status migrainosus", "drug": "oxcarbazepine" }, { "ade": "status migrainosus", "drug": "OXC" }, { "ade": "status migrainosus", "drug": "CBZ" } ]

Cardiac arrest associated with sulprostone use during caesarean section.

[ { "ade": "Cardiac arrest", "drug": "sulprostone" } ]

A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.

[ { "ade": "normotensive scleroderma renal crisis", "drug": "methylprednisolone" } ]

An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.

[ { "ade": "red blood cell anemia", "drug": "prednisone" }, { "ade": "red blood cell anemia", "drug": "MMF" } ]

We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.

[ { "ade": "hyponatremia", "drug": "carbamazepine" } ]

We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.

[ { "ade": "acute myocardial ischaemia", "drug": "venlafaxine" } ]

Successful desensitization to high-dose methotrexate after systemic anaphylaxis.

[ { "ade": "systemic anaphylaxis", "drug": "methotrexate" } ]

The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.

[ { "ade": "systemic iron toxicity", "drug": "iron sucrose" } ]

Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.

[ { "ade": "brain lesions", "drug": "penicillamine" } ]

We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.

[ { "ade": "mucositis", "drug": "doxorubicin" }, { "ade": "gastritis", "drug": "dexamethasone" } ]

Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.

[ { "ade": "Anaphylaxis", "drug": "cyclosporine" } ]

Gigantomastia induced by bucillamine.

[ { "ade": "Gigantomastia", "drug": "bucillamine" } ]

It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.

[ { "ade": "serositis", "drug": "sulfasalazine" }, { "ade": "pulmonary parenchymal involvement", "drug": "sulfasalazine" }, { "ade": "lupus", "drug": "sulfasalazine" } ]

Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.

[ { "ade": "skin pigmentation", "drug": "sulfasalazine" }, { "ade": "Pulmonary infiltrates", "drug": "sulfasalazine" } ]

The elicitation of a movement disorder by trazodone: case report.

[ { "ade": "movement disorder", "drug": "trazodone" } ]

Gabapentin withdrawal presenting as status epilepticus.

[ { "ade": "status epilepticus", "drug": "Gabapentin" } ]

A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.

[ { "ade": "fever", "drug": "5-ASA" }, { "ade": "worsening respiratory distress", "drug": "prednisone" }, { "ade": "worsening respiratory distress", "drug": "5-ASA" }, { "ade": "fever", "drug": "prednisone" }, { "ade": "fever", "drug": "mesalamine" }, { "ade": "worsening respiratory distress", "drug": "mesalamine" } ]

Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.

[ { "ade": "aplastic anemia", "drug": "gold" } ]

Magnesium tocolysis as the cause of urinary calculus during pregnancy.

[ { "ade": "urinary calculus", "drug": "Magnesium" } ]

The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.

[ { "ade": "hepatic enzyme disturbances", "drug": "pegvisomant" } ]

This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.

[ { "ade": "hypothyroidism", "drug": "amiodarone" } ]

It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.

[ { "ade": "cholestasis", "drug": "azathioprine" } ]

The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.

[ { "ade": "ovarian endometrioid carcinoma", "drug": "tamoxifen" } ]

Pemphigus vulgaris precipitated by glibenclamide therapy.

[ { "ade": "Pemphigus vulgaris", "drug": "glibenclamide" } ]

This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.

[ { "ade": "hypothermia", "drug": "risperidone" } ]

A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.

[ { "ade": "interstitial pneumonitis", "drug": "pranlukast" }, { "ade": "high fever", "drug": "pranlukast" } ]

We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.

[ { "ade": "aseptic meningitis", "drug": "TMP" }, { "ade": "aseptic meningitis", "drug": "SMX" } ]

Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.

[ { "ade": "hypoadrenalism", "drug": "o,p'-DDD" } ]

In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.

[ { "ade": "tachycardia", "drug": "procainamide" } ]

Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.

[ { "ade": "pancreatitis", "drug": "Torsemide" } ]

OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.

[ { "ade": "psychosis", "drug": "interferon" } ]

High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.

[ { "ade": "High-grade endometrial stromal sarcoma", "drug": "tamoxifen" } ]

Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.

[ { "ade": "nephrotic syndrome", "drug": "IFN" } ]

A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.

[ { "ade": "apnoea", "drug": "suxamethonium" } ]

A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.

[ { "ade": "leukocytopenia", "drug": "sulfasalazine" }, { "ade": "fever", "drug": "sulfasalazine" }, { "ade": "thrombocytopenia", "drug": "sulfasalazine" }, { "ade": "skin eruptions", "drug": "sulfasalazine" } ]

Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.

[ { "ade": "coma", "drug": "Valproic acid" } ]

The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.

[ { "ade": "diabetic ketoacidosis", "drug": "perospirone hydrochloride" } ]

Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.

[ { "ade": "Autoimmune thyroid disease", "drug": "interferon-alpha" }, { "ade": "Autoimmune thyroid disease", "drug": "IFN-alpha" } ]

The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.

[ { "ade": "hypothermia", "drug": "risperidone" } ]

Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.

[ { "ade": "disseminated intravascular coagulation", "drug": "zomepirac" }, { "ade": "Anaphylactoid shock", "drug": "zomepirac" }, { "ade": "anuric renal failure", "drug": "zomepirac" } ]

In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.

[ { "ade": "incontinence", "drug": "venlafaxine" }, { "ade": "incontinence", "drug": "paroxetine" }, { "ade": "incontinence", "drug": "sertraline" } ]

The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

[ { "ade": "delayed elimination", "drug": "methotrexate" }, { "ade": "toxicity", "drug": "ciprofloxacin" }, { "ade": "delayed elimination", "drug": "ciprofloxacin" } ]

Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.

[ { "ade": "secondary hyperparathyroidism", "drug": "calcitriol" }, { "ade": "vitamin D intoxication", "drug": "phosphate" }, { "ade": "potassium loss", "drug": "phosphate" }, { "ade": "vitamin D intoxication", "drug": "calcitriol" }, { "ade": "potassium loss", "drug": "calcitriol" }, { "ade": "secondary hyperparathyroidism", "drug": "phosphate" } ]

Mammary gigantism is a rare complication of D-penicillamine treatment.

[ { "ade": "Mammary gigantism", "drug": "D-penicillamine" } ]

Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.

[ { "ade": "rapid mood cycling", "drug": "L-dopa" } ]

Two cases of mequitazine-induced photosensitivity reactions.

[ { "ade": "photosensitivity reactions", "drug": "mequitazine" } ]

The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.

[ { "ade": "FVS", "drug": "valproic acid" } ]

The role of Adriamycin in the production of cardiotoxicity is reviewed.

[ { "ade": "cardiotoxicity", "drug": "Adriamycin" } ]

Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.

[ { "ade": "diabetic coma", "drug": "thiazide" }, { "ade": "diabetic coma", "drug": "propranolol" } ]

OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.

[ { "ade": "serotonin syndrome", "drug": "venlafaxine" }, { "ade": "extrapyramidal movement disorders", "drug": "venlafaxine" }, { "ade": "extrapyramidal movement disorders", "drug": "sertraline" }, { "ade": "serotonin syndrome", "drug": "metoclopramide" }, { "ade": "extrapyramidal movement disorders", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "sertraline" } ]

We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.

[ { "ade": "sub-acute leukoencephalopathy", "drug": "methotrexate" } ]

A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.

[ { "ade": "fatal pulmonary fibrosis", "drug": "BCNU" } ]

A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.

[ { "ade": "nonconvulsive status epilepticus", "drug": "morphine" } ]

PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.

[ { "ade": "corneal endothelial deposits", "drug": "rifabutin" } ]

CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.

[ { "ade": "rhabdomyolysis", "drug": "sertraline" } ]

RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.

[ { "ade": "sexual dysfunction", "drug": "baclofen" } ]

The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.

[ { "ade": "soft-tissue injury", "drug": "phenytoin" }, { "ade": "purple glove syndrome", "drug": "phenytoin" } ]

Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.

[ { "ade": "methanol poisoning", "drug": "methanol" } ]

DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.

[ { "ade": "liver enzyme elevation", "drug": "leflunomide" }, { "ade": "alopecia", "drug": "leflunomide" }, { "ade": "hypertension", "drug": "leflunomide" }, { "ade": "nausea", "drug": "leflunomide" }, { "ade": "allergic skin reactions", "drug": "leflunomide" }, { "ade": "diarrhea", "drug": "leflunomide" } ]

The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.

[ { "ade": "stupor", "drug": "valproate" } ]

Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.

[ { "ade": "interstitial lung disease", "drug": "sorafenib" } ]

Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.

[ { "ade": "tardive seizures", "drug": "piperacillin" }, { "ade": "tardive seizures", "drug": "cefotiam" } ]

Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.

[ { "ade": "Marked hyperkalemia", "drug": "arginine monohydrochloride" } ]

A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.

[ { "ade": "hepatic angiosarcoma", "drug": "vinyl chloride" }, { "ade": "hepatic angiosarcoma", "drug": "Thorotrast" }, { "ade": "hepatic angiosarcoma", "drug": "inorganic arsenic" } ]

Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.

[ { "ade": "Ataxia", "drug": "propafenone" } ]

He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.

[ { "ade": "serotonin syndrome", "drug": "clomipramine" } ]

CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.

[ { "ade": "seizures", "drug": "Amphotericin B" } ]

Transient phenytoin induced IgA deficiency and permanent IgE increase.

[ { "ade": "IgA deficiency", "drug": "phenytoin" }, { "ade": "IgE increase", "drug": "phenytoin" } ]

Two patients had ampicillin-associated seizures.

[ { "ade": "seizures", "drug": "ampicillin" } ]

OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

[ { "ade": "rhabdomyolysis", "drug": "sertraline" } ]

CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.

[ { "ade": "hemorrhagic choroidal detachment", "drug": "tissue plasminogen activator" }, { "ade": "hemorrhage", "drug": "tissue plasminogen activator" } ]

Rifampin-associated thrombocytopenia secondary to poor compliance.

[ { "ade": "thrombocytopenia", "drug": "Rifampin" } ]

Priapism associated with zuclopenthixol.

[ { "ade": "Priapism", "drug": "zuclopenthixol" } ]

A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.

[ { "ade": "acute renal failure", "drug": "enalapril" } ]

Syncope in a 65-year-old woman after nitrate ingestion.

[ { "ade": "Syncope", "drug": "nitrate" } ]

Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.

[ { "ade": "Abdominal wall ulceration", "drug": "recombinant human interferon-beta-1b" }, { "ade": "mucinosis", "drug": "recombinant human interferon-beta-1b" } ]

In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.

[ { "ade": "hypoglycaemic coma", "drug": "SP" } ]

We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.

[ { "ade": "worsening of Raynaud's phenomenon", "drug": "yohimbine" } ]

A case of oculogyric crisis induced by metoclopramide is described in this paper.

[ { "ade": "oculogyric crisis", "drug": "metoclopramide" } ]

Transient global amnesia after clioquinol: five personal observations from outside Japan.

[ { "ade": "Transient global amnesia", "drug": "clioquinol" } ]

Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.

[ { "ade": "vincristine neurotoxicity", "drug": "Itraconazole" }, { "ade": "vincristine neurotoxicity", "drug": "vincristine" } ]

A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.

[ { "ade": "severe splenic hemorrhage and rupture", "drug": "tPA" } ]

Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.

[ { "ade": "delirious", "drug": "lithium" } ]