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Magnesium toxicosis in two horses.
[ { "ade": "Magnesium toxicosis", "drug": "Magnesium" } ]
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.
[ { "ade": "vancomycin toxicity", "drug": "vancomycin" } ]
We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.
[ { "ade": "severe hypocalcaemia", "drug": "bisphosphonate" } ]
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
[ { "ade": "extrapyramidal symptoms", "drug": "clomipramine" }, { "ade": "Seizures", "drug": "clomipramine" }, { "ade": "extrapyramidal symptoms", "drug": "interferon beta-1a" }, { "ade": "Seizures", "drug": "interferon beta-1a" } ]
A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.
[ { "ade": "acute subdural haematoma", "drug": "aspirin" } ]
This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.
[ { "ade": "panic anxiety", "drug": "mianserin" } ]
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).
[ { "ade": "acute encephalopathy", "drug": "HOPA" }, { "ade": "acute encephalopathy", "drug": "calcium hopantenate" } ]
A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.
[ { "ade": "dyspnea", "drug": "homochlorcyclizine hydrochloride" } ]
Isotretinoin teratogenicity.
[ { "ade": "teratogenicity", "drug": "Isotretinoin" } ]
Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.
[ { "ade": "coronary vasoconstriction", "drug": "dopamine" } ]
After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.
[ { "ade": "hepatitis", "drug": "pegvisomant" }, { "ade": "hepatic enzyme disturbances", "drug": "pegvisomant" } ]
Rhabdomyolysis following clarithromycin monotherapy.
[ { "ade": "Rhabdomyolysis", "drug": "clarithromycin" } ]
The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.
[ { "ade": "encephalopathy", "drug": "methotrexate" } ]
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.
[ { "ade": "hypernatraemia", "drug": "Kayexalate" } ]
Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.
[ { "ade": "fatal pulmonary fibrosis", "drug": "CCNU" } ]
DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.
[ { "ade": "SS", "drug": "mirtazapine" } ]
In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.
[ { "ade": "rippling phenomena worsened", "drug": "pyridostigmine" } ]
A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.
[ { "ade": "muscle weakness", "drug": "cerivastatin" }, { "ade": "muscle pain", "drug": "cerivastatin" } ]
PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.
[ { "ade": "myoclonus", "drug": "dobutamine" } ]
Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.
[ { "ade": "severe angioedematous reaction", "drug": "BP" } ]
Intrahepatic cholestasis and sicca complex after thiabendazole.
[ { "ade": "Intrahepatic cholestasis", "drug": "thiabendazole" }, { "ade": "sicca complex", "drug": "thiabendazole" } ]
We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.
[ { "ade": "cutaneous necrosis", "drug": "interferon alfa" }, { "ade": "cutaneous necrosis", "drug": "pegylated interferon alfa-2b" } ]
Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.
[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
Careful follow-up of so-called "self-limited" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.
[ { "ade": "edema", "drug": "insulin" } ]
CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.
[ { "ade": "thrombocytopenia", "drug": "lansoprazole" } ]
Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.
[ { "ade": "teratogenic effect", "drug": "ATRA" } ]
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
[ { "ade": "Methemoglobinemia", "drug": "bupivacaine" }, { "ade": "Methemoglobinemia", "drug": "lidocaine" } ]
BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.
[ { "ade": "delated cutaneous reactions", "drug": "captopril" } ]
CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.
[ { "ade": "angle-closure glaucoma", "drug": "Topiramate" }, { "ade": "anterior chamber shallowing", "drug": "Topiramate" }, { "ade": "displacement of the lens-iris diaphragm", "drug": "Topiramate" }, { "ade": "acute myopia", "drug": "Topiramate" }, { "ade": "ciliochoroidal effusion", "drug": "Topiramate" } ]
Occult quinine-induced thrombocytopenia.
[ { "ade": "thrombocytopenia", "drug": "quinine" } ]
A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.
[ { "ade": "galactorrhea", "drug": "amoxapine" }, { "ade": "galactorrhea", "drug": "dibenzoxazepine" } ]
Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.
[ { "ade": "cutaneous vasculitis", "drug": "diltiazem" } ]
Juvenile absence epilepsy exacerbated by valproic acid.
[ { "ade": "Juvenile absence epilepsy", "drug": "valproic acid" } ]
During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.
[ { "ade": "peripheral neuropathy", "drug": "CAP" } ]
A case of recall pneumonitis induced by gemcitabine is reported.
[ { "ade": "recall pneumonitis", "drug": "gemcitabine" } ]
Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.
[ { "ade": "HIT", "drug": "heparin" } ]
Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.
[ { "ade": "renal dysfunction", "drug": "interferon alpha" }, { "ade": "renal dysfunction", "drug": "IFNalpha" } ]
We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.
[ { "ade": "human teratogen", "drug": "cyclophosphamide" } ]
A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).
[ { "ade": "acute allergic contact dermatitis", "drug": "NBD-Cl" }, { "ade": "acute allergic contact dermatitis", "drug": "4-chloro-7-nitrobenzofurazan" } ]
DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.
[ { "ade": "allergy", "drug": "AZA" } ]
We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.
[ { "ade": "seizures", "drug": "L-asparaginase" }, { "ade": "altered sensorium", "drug": "L-asparaginase" } ]
Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.
[ { "ade": "CD8+ cutaneous lymphoproliferative disorders", "drug": "efalizumab" }, { "ade": "CD8+ cutaneous lymphoproliferative disorders", "drug": "infliximab" } ]
Rapidly developing hyperglycemia during treatment with olanzapine.
[ { "ade": "hyperglycemia", "drug": "olanzapine" } ]
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.
[ { "ade": "neurotoxicity", "drug": "valacyclovir" } ]
A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.
[ { "ade": "incessant orthodromic atrioventricular tachycardia", "drug": "procainamide" } ]
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
[ { "ade": "Severe hepatotoxicity", "drug": "benzarone" } ]
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.
[ { "ade": "Cryptococcus neoformans fatal sepsis", "drug": "alemtuzumab" } ]
We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.
[ { "ade": "acute interstitial nephritis", "drug": "Sunitinib" } ]
We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.
[ { "ade": "syndrome of inappropriate antidiuretic hormone", "drug": "cisplatin" }, { "ade": "SIADH", "drug": "cisplatin" } ]
A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.
[ { "ade": "lupus-like syndrome", "drug": "methotrexate" }, { "ade": "lupus-like syndrome", "drug": "infliximab" } ]
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.
[ { "ade": "generalized rigidity", "drug": "olanzapine" }, { "ade": "leukocytosis", "drug": "olanzapine" }, { "ade": "fever", "drug": "olanzapine" }, { "ade": "fever", "drug": "lithium" }, { "ade": "leukocytosis", "drug": "lithium" }, { "ade": "increased serum transaminase and creatine kinase", "drug": "lithium" }, { "ade": "increased serum transaminase and creatine kinase", "drug": "olanzapine" }, { "ade": "generalized rigidity", "drug": "lithium" } ]
A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.
[ { "ade": "visual impairment", "drug": "Decadron" }, { "ade": "bilateral posterior subcapsular cataracts", "drug": "Decadron" }, { "ade": "nausea", "drug": "cisplatin" } ]
Cis-retinoic acid (RA) may further increase the risk of developing BMTN.
[ { "ade": "BMTN", "drug": "Cis-retinoic acid" }, { "ade": "BMTN", "drug": "RA" } ]
Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.
[ { "ade": "Fatal pulmonary fibrosis", "drug": "BCNU" } ]
OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.
[ { "ade": "syndrome of inappropriate antidiuretic hormone", "drug": "vinorelbine" }, { "ade": "SIADH", "drug": "vinorelbine" } ]
There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.
[ { "ade": "organic brain syndromes", "drug": "lithium" } ]
She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.
[ { "ade": "vomiting", "drug": "Pancrease MT 16" } ]
Anaphylaxis to cisplatin following nine previous uncomplicated cycles.
[ { "ade": "Anaphylaxis", "drug": "cisplatin" } ]
He developed a late secondary infection in some sites treated with imiquimod.
[ { "ade": "secondary infection", "drug": "imiquimod" } ]
Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.
[ { "ade": "Acute delirium", "drug": "levofloxacin" } ]
This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.
[ { "ade": "hyperpigmentation", "drug": "minocycline" } ]
Captopril-induced lichen planus pemphigoides with pemphigus-like features.
[ { "ade": "lichen planus pemphigoides", "drug": "Captopril" } ]
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.
[ { "ade": "gastric LPD", "drug": "MTX" } ]
Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.
[ { "ade": "duct paucity", "drug": "ampicillin" }, { "ade": "cholestasis", "drug": "ampicillin" }, { "ade": "cholestatic hepatitis", "drug": "ampicillin" } ]
We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.
[ { "ade": "anaphylactic reaction", "drug": "prednisone" } ]
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.
[ { "ade": "Pheripheral edema", "drug": "lansoprazole" }, { "ade": "Pheripheral edema", "drug": "omeprazole" }, { "ade": "Pheripheral edema", "drug": "pantoprazole" } ]
This case report illustrates the neurotoxicity unique to HDARAC.
[ { "ade": "neurotoxicity", "drug": "HDARAC" } ]
CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.
[ { "ade": "liver cirrhosis", "drug": "MTX" } ]
Additionally, danazol produces hepatocellular damage in approximately 10% of women.
[ { "ade": "hepatocellular damage", "drug": "danazol" } ]
A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.
[ { "ade": "ECM", "drug": "glatiramer acetate" } ]
Cerebral and ocular toxicity induced by desferrioxamine.
[ { "ade": "Cerebral and ocular toxicity", "drug": "desferrioxamine" } ]
DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.
[ { "ade": "Anaphylactoid reactions", "drug": "cisplatin" } ]
PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.
[ { "ade": "bilateral corneal endothelial dysfunction", "drug": "amantadine" } ]
PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.
[ { "ade": "hyperammonemia", "drug": "carbamazepine" } ]
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).
[ { "ade": "AVT", "drug": "quinidine" }, { "ade": "AVT", "drug": "disopyramide" }, { "ade": "torsade de pointes", "drug": "quinidine" }, { "ade": "atypical ventricular tachycardia", "drug": "quinidine" }, { "ade": "AVT", "drug": "amiodarone" }, { "ade": "torsade de pointes", "drug": "amiodarone" }, { "ade": "atypical ventricular tachycardia", "drug": "disopyramide" }, { "ade": "atypical ventricular tachycardia", "drug": "amiodarone" }, { "ade": "torsade de pointes", "drug": "disopyramide" } ]
A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.
[ { "ade": "thrombocytopenia", "drug": "D-Pen" }, { "ade": "anemia", "drug": "D-penicillamine" }, { "ade": "anemia", "drug": "D-Pen" }, { "ade": "thrombocytopenia", "drug": "D-penicillamine" } ]
Ethambutol toxicity manifesting as acute onset psychosis.
[ { "ade": "acute onset psychosis", "drug": "Ethambutol" } ]
Diabetes Mellitus was observed in a patient given carbamazepine.
[ { "ade": "Diabetes Mellitus", "drug": "carbamazepine" } ]
Seizures associated with fluoxetine therapy are uncommon.
[ { "ade": "Seizures", "drug": "fluoxetine" } ]
Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.
[ { "ade": "hepatotoxicity", "drug": "TMP-SMX" } ]
A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.
[ { "ade": "icterus", "drug": "phenobarbital" }, { "ade": "protein-losing enteropathy", "drug": "phenobarbital" }, { "ade": "hypersensitivity", "drug": "phenobarbital" }, { "ade": "alopecia", "drug": "phenobarbital" }, { "ade": "a pruritic desquamating erythrodermic rash", "drug": "phenobarbital" }, { "ade": "fever", "drug": "phenobarbital" }, { "ade": "nephritis", "drug": "phenobarbital" }, { "ade": "myositis", "drug": "phenobarbital" } ]
We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.
[ { "ade": "severe hypertension", "drug": "phenylephrine" }, { "ade": "severe hypertension", "drug": "epinephrine" } ]
Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.
[ { "ade": "RTA", "drug": "FK506" } ]
The following is a report of 2 cases of rifampicin-induced renal insufficiency.
[ { "ade": "renal insufficiency", "drug": "rifampicin" } ]
The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.
[ { "ade": "visual acuity had decreased", "drug": "IFN" } ]
Two patients on long-term lithium therapy developed the nephrotic syndrome.
[ { "ade": "nephrotic syndrome", "drug": "lithium" } ]
An adverse reaction to IFN was strongly suspected as the cause of CHF.
[ { "ade": "CHF", "drug": "IFN" } ]
Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.
[ { "ade": "granulomatous anterior uveitis", "drug": "Metipranolol" } ]
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.
[ { "ade": "blood levels in the toxic range", "drug": "phenytoin" } ]
We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).
[ { "ade": "rhinitis", "drug": "calcitonin" }, { "ade": "perspiration", "drug": "calcitonin" }, { "ade": "conjunctivitis", "drug": "Calsynar" }, { "ade": "conjunctivitis", "drug": "calcitonin" }, { "ade": "rhinitis", "drug": "Calsynar" }, { "ade": "perspiration", "drug": "Calsynar" } ]
Amiodarone was discontinued, and thyrotoxicosis gradually abated.
[ { "ade": "thyrotoxicosis", "drug": "Amiodarone" } ]
Acute acoustic nerve palsy associated with vincristine therapy.
[ { "ade": "Acute acoustic nerve palsy", "drug": "vincristine" } ]
Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.
[ { "ade": "hepatotoxicity", "drug": "naltrexone" }, { "ade": "hepatotoxicity", "drug": "NTX" } ]
Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.
[ { "ade": "Massive subfascial hematoma", "drug": "alteplase" } ]
The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.
[ { "ade": "respiratory dyskinesia", "drug": "risperidone" }, { "ade": "orofacial dyskinesia", "drug": "risperidone" }, { "ade": "RD", "drug": "risperidone" }, { "ade": "limb dyskinesia", "drug": "risperidone" }, { "ade": "TD", "drug": "risperidone" } ]
Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.
[ { "ade": "Hypersensitivity", "drug": "carboplatin" }, { "ade": "hyperacute changes on ECG", "drug": "carboplatin" } ]
Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.
[ { "ade": "mortality rate <3", "drug": "IL-2" } ]
One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.
[ { "ade": "feeding gastrostomy", "drug": "risperidone" }, { "ade": "worsening parkinsonism", "drug": "risperidone" } ]
Gelofusine allergy--the need for identification jewellery.
[ { "ade": "Gelofusine allergy", "drug": "Gelofusine" } ]
The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.
[ { "ade": "focal segmental glomerulosclerosis", "drug": "IFNalpha" } ]