mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.	[ { "ade": "Hypersensitivity pneumonitis-like syndrome", "drug": "lenalidomide" } ]
An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.	[ { "ade": "athelia", "drug": "propranolol" }, { "ade": "mental retardation", "drug": "methimazole" }, { "ade": "choanal atresia", "drug": "propranolol" }, { "ade": "choanal atresia", "drug": "methimazole" }, { "ade": "athelia", "drug": "methimazole" }, { "ade": "mental retardation", "drug": "propranolol" } ]
An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.	[ { "ade": "renal colicky pain", "drug": "indinavir" } ]
The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.	[ { "ade": "corneal ulcers refractory to conventional treatment", "drug": "colchicine" } ]
OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.	[ { "ade": "seizure", "drug": "amphotericin B" } ]
Vortex keratopathy associated with atovaquone.	[ { "ade": "Vortex keratopathy", "drug": "atovaquone" } ]
A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.	[ { "ade": "malaise", "drug": "salazosulfapyridine" }, { "ade": "diffuse erythema", "drug": "salazosulfapyridine" }, { "ade": "fever up to 39 degrees C", "drug": "salazosulfapyridine" }, { "ade": "pustules", "drug": "salazosulfapyridine" } ]
Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.	[ { "ade": "Lichen planus", "drug": "hepatitis B vaccination" } ]
The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.	[ { "ade": "increase in the theophylline level", "drug": "zafirlukast" }, { "ade": "increase in the theophylline level", "drug": "theophylline" } ]
Acute sensorineural hearing loss following intravenous ketoralac administration.	[ { "ade": "Acute sensorineural hearing loss", "drug": "ketoralac" } ]
Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.	[ { "ade": "endoscopic lesions", "drug": "meloxicam" } ]
Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.	[ { "ade": "Hypoglycemia", "drug": "somatostatin" } ]
We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.	[ { "ade": "stroke", "drug": "PPA" } ]
Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.	[ { "ade": "magnesium toxicosis", "drug": "magnesium" } ]
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.	[ { "ade": "field defects", "drug": "vigabatrin" } ]
Quinine-induced hearing loss.	[ { "ade": "hearing loss", "drug": "Quinine" } ]
Physicians should be aware of the potentially lethal side effects of dapsone.	[ { "ade": "lethal", "drug": "dapsone" } ]
The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.	[ { "ade": "irreversible liver injury", "drug": "troglitazone" } ]
However, cyclosporine dependency is associated with the risk of nephrotoxicity.	[ { "ade": "nephrotoxicity", "drug": "cyclosporine" } ]
A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.	[ { "ade": "angioedema", "drug": "oxcarbazepine" } ]
Nonconvulsive status epilepticus due to ifosfamide.	[ { "ade": "Nonconvulsive status epilepticus", "drug": "ifosfamide" } ]
A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.	[ { "ade": "pulmonary fibrosis", "drug": "nabumetone" } ]
Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.	[ { "ade": "restless legs syndrome", "drug": "levodopa" } ]
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.	[ { "ade": "interstitial pulmonary disease", "drug": "ticlopidine" }, { "ade": "lymphocytic colitis", "drug": "ticlopidine" } ]
A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.	[ { "ade": "15-kg weight gain", "drug": "ibuprofen" } ]
The cases of CBZ-induced SLE reported in the literature were reviewed.	[ { "ade": "SLE", "drug": "CBZ" } ]
We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.	[ { "ade": "interstitial pneumonitis", "drug": "bicalutamide" }, { "ade": "interstitial pneumonitis", "drug": "leuprorelin acetate" } ]
Trazodone-induced transient hypomanic symptoms and their management.	[ { "ade": "transient hypomanic symptoms", "drug": "Trazodone" } ]
After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.	[ { "ade": "loss of glomerular filtration rate", "drug": "cyclosporine A" }, { "ade": "effective renal plasma flow", "drug": "cyclosporine A" } ]
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.	[ { "ade": "hypotension", "drug": "valproate" } ]
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.	[ { "ade": "Gynecomastia", "drug": "phenobarbital" }, { "ade": "Gynecomastia", "drug": "fluoresone" }, { "ade": "Gynecomastia", "drug": "phenytoin" } ]
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.	[ { "ade": "hypoxia", "drug": "indomethacin" }, { "ade": "ductal closure", "drug": "indomethacin" } ]
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.	[ { "ade": "CD", "drug": "etanercept" } ]
CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.	[ { "ade": "anaemia", "drug": "Zidovudine" } ]
This was accepted as evidence for propranolol being the cause of this conduction disorder.	[ { "ade": "conduction disorder", "drug": "propranolol" } ]
Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.	[ { "ade": "cicatricial entropion", "drug": "dipivefrin" } ]
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.	[ { "ade": "bilateral pulmonary infiltrates", "drug": "methotrexate" } ]
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.	[ { "ade": "reversible granulocytopenia", "drug": "procainamide" } ]
Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.	[ { "ade": "nephrotoxicity", "drug": "lithium" }, { "ade": "renal failure", "drug": "lithium" } ]
A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.	[ { "ade": "pruritic bullous eruption", "drug": "prednisone" } ]
A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.	[ { "ade": "pulmonary fibrosis", "drug": "nitrofurantoin" } ]
OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.	[ { "ade": "rhabdomyolysis", "drug": "lovastatin" }, { "ade": "rhabdomyolysis", "drug": "clarithromycin" }, { "ade": "rhabdomyolysis", "drug": "azithromycin" } ]
Nail-changes induced by penicillamine.	[ { "ade": "Nail-changes", "drug": "penicillamine" } ]
In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.	[ { "ade": "symptoms of toxicity", "drug": "lamotrigine" }, { "ade": "doubling of the lamotrigine blood level", "drug": "sertraline" }, { "ade": "doubling of the lamotrigine blood level", "drug": "desmethylsertraline" }, { "ade": "doubling of the lamotrigine blood level", "drug": "lamotrigine" }, { "ade": "symptoms of toxicity", "drug": "desmethylsertraline" }, { "ade": "symptoms of toxicity", "drug": "sertraline" } ]
In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.	[ { "ade": "hepatic veno-occlusive disease", "drug": "busulfan" }, { "ade": "thrombosis", "drug": "busulfan" }, { "ade": "HVOD", "drug": "busulfan" } ]
Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.	[ { "ade": "hyponatremia", "drug": "desmopressin" }, { "ade": "Seizure", "drug": "desmopressin" } ]
Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).	[ { "ade": "elevated hepatic enzymes", "drug": "propylthiouracil" }, { "ade": "elevated hepatic enzymes", "drug": "PTU" } ]
OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).	[ { "ade": "extrapyramidal symptoms", "drug": "Clozapine" } ]
We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.	[ { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]
We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.	[ { "ade": "glaucoma", "drug": "doxetaxel" } ]
Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.	[ { "ade": "Leiomyosarcoma", "drug": "cyclophosphamide" } ]
Nodular scleritis following alendronate therapy.	[ { "ade": "Nodular scleritis", "drug": "alendronate" } ]
We report a case of pediatric bupropion ingestion resulting in multiple seizures.	[ { "ade": "multiple seizures", "drug": "bupropion" } ]
Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.	[ { "ade": "cardiotoxicity", "drug": "Doxorubicin" } ]
CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.	[ { "ade": "CD20-negative T-cell-rich B-cell lymphoma", "drug": "rituximab" } ]
Hepatotoxicity induced by cyproterone acetate: a report of three cases.	[ { "ade": "Hepatotoxicity", "drug": "cyproterone acetate" } ]
We report four cases of severe corneal ulceration in methamphetamine abusers.	[ { "ade": "severe corneal ulceration", "drug": "methamphetamine" } ]
AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.	[ { "ade": "stroke", "drug": "bevacizumab" }, { "ade": "acute retinal ischemic change", "drug": "bevacizumab" } ]
We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.	[ { "ade": "hypoglycemia", "drug": "glyburide" } ]
We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.	[ { "ade": "WES", "drug": "haloperidol" } ]
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.	[ { "ade": "thrombocytosis", "drug": "tazobactam" }, { "ade": "thrombocytosis", "drug": "piperacillin" }, { "ade": "thrombocytosis", "drug": "ciprofloxacin" } ]
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.	[ { "ade": "angio-oedema", "drug": "irbesartan" }, { "ade": "hypotensive shock", "drug": "irbesartan" } ]
So far, few cases of pulmonary side effects caused by ticlopidine have been reported.	[ { "ade": "pulmonary side effects", "drug": "ticlopidine" } ]
As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.	[ { "ade": "hematologic side effects", "drug": "linezolid" } ]
Regression of thyrotoxic ophthalmopathy following lithium withdrawal.	[ { "ade": "thyrotoxic ophthalmopathy", "drug": "lithium" } ]
Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.	[ { "ade": "hypertension", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "Rapamycin" }, { "ade": "myelosuppression", "drug": "SR" }, { "ade": "hypertension", "drug": "Rapamycin" }, { "ade": "infection", "drug": "SR" }, { "ade": "hypertension", "drug": "SR" }, { "ade": "infection", "drug": "Rapammune" }, { "ade": "myelosuppression", "drug": "Rapamycin" }, { "ade": "hypertension", "drug": "Rapammune" }, { "ade": "infection", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "Rapammune" }, { "ade": "infection", "drug": "Rapamycin" }, { "ade": "myelosuppression", "drug": "Rapammune" }, { "ade": "hyperlipidemia", "drug": "SR" }, { "ade": "myelosuppression", "drug": "sirolimus" } ]
Case studies in heparin-induced thrombocytopenia.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.	[ { "ade": "TTP", "drug": "penicillamine" }, { "ade": "Thrombotic thrombocytopenic purpura", "drug": "penicillamine" } ]
Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.	[ { "ade": "potential hazards", "drug": "mineral oil" } ]
The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.	[ { "ade": "pulmonary fibrosis", "drug": "bleomycin" } ]
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.	[ { "ade": "generalized tonic-clonic seizure", "drug": "naloxone" } ]
RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.	[ { "ade": "vortex keratopathy", "drug": "atovaquone" } ]
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.	[ { "ade": "ulcer", "drug": "ATRA" } ]
Phenylpropanolamine-induced psychosis.	[ { "ade": "psychosis", "drug": "Phenylpropanolamine" } ]
Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.	[ { "ade": "Stevens-Johnson syndrome", "drug": "prednisolone" } ]
Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.	[ { "ade": "allergic reactions", "drug": "Calcipotriol" }, { "ade": "irritation of the skin", "drug": "Calcipotriol" } ]
However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.	[ { "ade": "hemodynamic decompensation", "drug": "verapamil" } ]
Acute valproate ingestion induces symptomatic methemoglobinemia.	[ { "ade": "symptomatic methemoglobinemia", "drug": "valproate" } ]
Syncope induced by propranolol in hypertrophic cardiomyopathy.	[ { "ade": "Syncope", "drug": "propranolol" } ]
However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.	[ { "ade": "myopathy", "drug": "clofibrate" } ]
These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.	[ { "ade": "hepatic injury", "drug": "propylthiouracil" }, { "ade": "submassive hepatic necrosis", "drug": "propylthiouracil" } ]
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.	[ { "ade": "tongue lesions", "drug": "IFN" }, { "ade": "hyperpigmented skin", "drug": "ribavirin" }, { "ade": "hyperpigmented skin", "drug": "IFN" }, { "ade": "tongue lesions", "drug": "ribavirin" } ]
A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.	[ { "ade": "pleuropulmonary abnormalities", "drug": "bromocriptine" }, { "ade": "pleuropulmonary abnormalities", "drug": "cabergoline" } ]
A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.	[ { "ade": "overwhelming hepatic necrosis", "drug": "MTX" } ]
Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.	[ { "ade": "hemolytic uremic syndrome", "drug": "Mitomycin-C" } ]
PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.	[ { "ade": "spontaneous choroidal hemorrhage", "drug": "tissue plasminogen activator" } ]
Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.	[ { "ade": "SIADH", "drug": "CDDP" } ]
We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.	[ { "ade": "photosensitivity reaction", "drug": "mequitazine" } ]
Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.	[ { "ade": "interstitial pneumonitis", "drug": "Rituximab-CHOP" } ]
RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.	[ { "ade": "long-term immunosuppression", "drug": "Copaxone" }, { "ade": "Crohn's disease", "drug": "Copaxone" } ]
Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.	[ { "ade": "Accelerated nodulosis", "drug": "methotrexate" } ]
Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.	[ { "ade": "Myelodysplasia", "drug": "2-deoxycoformycin" }, { "ade": "acute myeloid leukemia", "drug": "2-deoxycoformycin" } ]
Colchicine-induced myopathy in renal failure.	[ { "ade": "myopathy", "drug": "Colchicine" } ]
Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.	[ { "ade": "nephropathy", "drug": "Methotrexate" } ]
The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.	[ { "ade": "exacerbation of psoriasis", "drug": "imiquimod" } ]
The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.	[ { "ade": "gastric mucosa foveolar hyperplasia", "drug": "PGE1" } ]
DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.	[ { "ade": "ectropion", "drug": "5-FU" }, { "ade": "tender, red, scaled lids", "drug": "5-FU" } ]
CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.	[ { "ade": "agranulocytosis", "drug": "quetiapine" } ]
In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.	[ { "ade": "SIADH", "drug": "mizoribin" } ]

Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.

[ { "ade": "Hypersensitivity pneumonitis-like syndrome", "drug": "lenalidomide" } ]

An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.

[ { "ade": "athelia", "drug": "propranolol" }, { "ade": "mental retardation", "drug": "methimazole" }, { "ade": "choanal atresia", "drug": "propranolol" }, { "ade": "choanal atresia", "drug": "methimazole" }, { "ade": "athelia", "drug": "methimazole" }, { "ade": "mental retardation", "drug": "propranolol" } ]

An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.

[ { "ade": "renal colicky pain", "drug": "indinavir" } ]

The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.

[ { "ade": "corneal ulcers refractory to conventional treatment", "drug": "colchicine" } ]

OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.

[ { "ade": "seizure", "drug": "amphotericin B" } ]

Vortex keratopathy associated with atovaquone.

[ { "ade": "Vortex keratopathy", "drug": "atovaquone" } ]

A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.

[ { "ade": "malaise", "drug": "salazosulfapyridine" }, { "ade": "diffuse erythema", "drug": "salazosulfapyridine" }, { "ade": "fever up to 39 degrees C", "drug": "salazosulfapyridine" }, { "ade": "pustules", "drug": "salazosulfapyridine" } ]

Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.

[ { "ade": "Lichen planus", "drug": "hepatitis B vaccination" } ]

The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.

[ { "ade": "increase in the theophylline level", "drug": "zafirlukast" }, { "ade": "increase in the theophylline level", "drug": "theophylline" } ]

Acute sensorineural hearing loss following intravenous ketoralac administration.

[ { "ade": "Acute sensorineural hearing loss", "drug": "ketoralac" } ]

Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.

[ { "ade": "endoscopic lesions", "drug": "meloxicam" } ]

Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.

[ { "ade": "Hypoglycemia", "drug": "somatostatin" } ]

We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.

[ { "ade": "stroke", "drug": "PPA" } ]

Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.

[ { "ade": "magnesium toxicosis", "drug": "magnesium" } ]

The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.

[ { "ade": "field defects", "drug": "vigabatrin" } ]

Quinine-induced hearing loss.

[ { "ade": "hearing loss", "drug": "Quinine" } ]

Physicians should be aware of the potentially lethal side effects of dapsone.

[ { "ade": "lethal", "drug": "dapsone" } ]

The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.

[ { "ade": "irreversible liver injury", "drug": "troglitazone" } ]

However, cyclosporine dependency is associated with the risk of nephrotoxicity.

[ { "ade": "nephrotoxicity", "drug": "cyclosporine" } ]

A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.

[ { "ade": "angioedema", "drug": "oxcarbazepine" } ]

Nonconvulsive status epilepticus due to ifosfamide.

[ { "ade": "Nonconvulsive status epilepticus", "drug": "ifosfamide" } ]

A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.

[ { "ade": "pulmonary fibrosis", "drug": "nabumetone" } ]

Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.

[ { "ade": "restless legs syndrome", "drug": "levodopa" } ]

We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.

[ { "ade": "interstitial pulmonary disease", "drug": "ticlopidine" }, { "ade": "lymphocytic colitis", "drug": "ticlopidine" } ]

A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.

[ { "ade": "15-kg weight gain", "drug": "ibuprofen" } ]

The cases of CBZ-induced SLE reported in the literature were reviewed.

[ { "ade": "SLE", "drug": "CBZ" } ]

We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.

[ { "ade": "interstitial pneumonitis", "drug": "bicalutamide" }, { "ade": "interstitial pneumonitis", "drug": "leuprorelin acetate" } ]

Trazodone-induced transient hypomanic symptoms and their management.

[ { "ade": "transient hypomanic symptoms", "drug": "Trazodone" } ]

After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.

[ { "ade": "loss of glomerular filtration rate", "drug": "cyclosporine A" }, { "ade": "effective renal plasma flow", "drug": "cyclosporine A" } ]

Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.

[ { "ade": "hypotension", "drug": "valproate" } ]

Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.

[ { "ade": "Gynecomastia", "drug": "phenobarbital" }, { "ade": "Gynecomastia", "drug": "fluoresone" }, { "ade": "Gynecomastia", "drug": "phenytoin" } ]

This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.

[ { "ade": "hypoxia", "drug": "indomethacin" }, { "ade": "ductal closure", "drug": "indomethacin" } ]

We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.

[ { "ade": "CD", "drug": "etanercept" } ]

CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.

[ { "ade": "anaemia", "drug": "Zidovudine" } ]

This was accepted as evidence for propranolol being the cause of this conduction disorder.

[ { "ade": "conduction disorder", "drug": "propranolol" } ]

Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.

[ { "ade": "cicatricial entropion", "drug": "dipivefrin" } ]

Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.

[ { "ade": "bilateral pulmonary infiltrates", "drug": "methotrexate" } ]

Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.

[ { "ade": "reversible granulocytopenia", "drug": "procainamide" } ]

Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.

[ { "ade": "nephrotoxicity", "drug": "lithium" }, { "ade": "renal failure", "drug": "lithium" } ]

A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.

[ { "ade": "pruritic bullous eruption", "drug": "prednisone" } ]

A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.

[ { "ade": "pulmonary fibrosis", "drug": "nitrofurantoin" } ]

OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.

[ { "ade": "rhabdomyolysis", "drug": "lovastatin" }, { "ade": "rhabdomyolysis", "drug": "clarithromycin" }, { "ade": "rhabdomyolysis", "drug": "azithromycin" } ]

Nail-changes induced by penicillamine.

[ { "ade": "Nail-changes", "drug": "penicillamine" } ]

In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.

[ { "ade": "symptoms of toxicity", "drug": "lamotrigine" }, { "ade": "doubling of the lamotrigine blood level", "drug": "sertraline" }, { "ade": "doubling of the lamotrigine blood level", "drug": "desmethylsertraline" }, { "ade": "doubling of the lamotrigine blood level", "drug": "lamotrigine" }, { "ade": "symptoms of toxicity", "drug": "desmethylsertraline" }, { "ade": "symptoms of toxicity", "drug": "sertraline" } ]

In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.

[ { "ade": "hepatic veno-occlusive disease", "drug": "busulfan" }, { "ade": "thrombosis", "drug": "busulfan" }, { "ade": "HVOD", "drug": "busulfan" } ]

Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.

[ { "ade": "hyponatremia", "drug": "desmopressin" }, { "ade": "Seizure", "drug": "desmopressin" } ]

Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).

[ { "ade": "elevated hepatic enzymes", "drug": "propylthiouracil" }, { "ade": "elevated hepatic enzymes", "drug": "PTU" } ]

OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).

[ { "ade": "extrapyramidal symptoms", "drug": "Clozapine" } ]

We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.

[ { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]

We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.

[ { "ade": "glaucoma", "drug": "doxetaxel" } ]

Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.

[ { "ade": "Leiomyosarcoma", "drug": "cyclophosphamide" } ]

Nodular scleritis following alendronate therapy.

[ { "ade": "Nodular scleritis", "drug": "alendronate" } ]

We report a case of pediatric bupropion ingestion resulting in multiple seizures.

[ { "ade": "multiple seizures", "drug": "bupropion" } ]

Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.

[ { "ade": "cardiotoxicity", "drug": "Doxorubicin" } ]

CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.

[ { "ade": "CD20-negative T-cell-rich B-cell lymphoma", "drug": "rituximab" } ]

Hepatotoxicity induced by cyproterone acetate: a report of three cases.

[ { "ade": "Hepatotoxicity", "drug": "cyproterone acetate" } ]

We report four cases of severe corneal ulceration in methamphetamine abusers.

[ { "ade": "severe corneal ulceration", "drug": "methamphetamine" } ]

AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.

[ { "ade": "stroke", "drug": "bevacizumab" }, { "ade": "acute retinal ischemic change", "drug": "bevacizumab" } ]

We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.

[ { "ade": "hypoglycemia", "drug": "glyburide" } ]

We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.

[ { "ade": "WES", "drug": "haloperidol" } ]

It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.

[ { "ade": "thrombocytosis", "drug": "tazobactam" }, { "ade": "thrombocytosis", "drug": "piperacillin" }, { "ade": "thrombocytosis", "drug": "ciprofloxacin" } ]

A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.

[ { "ade": "angio-oedema", "drug": "irbesartan" }, { "ade": "hypotensive shock", "drug": "irbesartan" } ]

So far, few cases of pulmonary side effects caused by ticlopidine have been reported.

[ { "ade": "pulmonary side effects", "drug": "ticlopidine" } ]

As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.

[ { "ade": "hematologic side effects", "drug": "linezolid" } ]

Regression of thyrotoxic ophthalmopathy following lithium withdrawal.

[ { "ade": "thyrotoxic ophthalmopathy", "drug": "lithium" } ]

Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.

[ { "ade": "hypertension", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "Rapamycin" }, { "ade": "myelosuppression", "drug": "SR" }, { "ade": "hypertension", "drug": "Rapamycin" }, { "ade": "infection", "drug": "SR" }, { "ade": "hypertension", "drug": "SR" }, { "ade": "infection", "drug": "Rapammune" }, { "ade": "myelosuppression", "drug": "Rapamycin" }, { "ade": "hypertension", "drug": "Rapammune" }, { "ade": "infection", "drug": "sirolimus" }, { "ade": "hyperlipidemia", "drug": "Rapammune" }, { "ade": "infection", "drug": "Rapamycin" }, { "ade": "myelosuppression", "drug": "Rapammune" }, { "ade": "hyperlipidemia", "drug": "SR" }, { "ade": "myelosuppression", "drug": "sirolimus" } ]

Case studies in heparin-induced thrombocytopenia.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.

[ { "ade": "TTP", "drug": "penicillamine" }, { "ade": "Thrombotic thrombocytopenic purpura", "drug": "penicillamine" } ]

Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.

[ { "ade": "potential hazards", "drug": "mineral oil" } ]

The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.

[ { "ade": "pulmonary fibrosis", "drug": "bleomycin" } ]

A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.

[ { "ade": "generalized tonic-clonic seizure", "drug": "naloxone" } ]

RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.

[ { "ade": "vortex keratopathy", "drug": "atovaquone" } ]

The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.

[ { "ade": "ulcer", "drug": "ATRA" } ]

Phenylpropanolamine-induced psychosis.

[ { "ade": "psychosis", "drug": "Phenylpropanolamine" } ]

Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.

[ { "ade": "Stevens-Johnson syndrome", "drug": "prednisolone" } ]

Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.

[ { "ade": "allergic reactions", "drug": "Calcipotriol" }, { "ade": "irritation of the skin", "drug": "Calcipotriol" } ]

However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.

[ { "ade": "hemodynamic decompensation", "drug": "verapamil" } ]

Acute valproate ingestion induces symptomatic methemoglobinemia.

[ { "ade": "symptomatic methemoglobinemia", "drug": "valproate" } ]

Syncope induced by propranolol in hypertrophic cardiomyopathy.

[ { "ade": "Syncope", "drug": "propranolol" } ]

However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.

[ { "ade": "myopathy", "drug": "clofibrate" } ]

These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.

[ { "ade": "hepatic injury", "drug": "propylthiouracil" }, { "ade": "submassive hepatic necrosis", "drug": "propylthiouracil" } ]

We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.

[ { "ade": "tongue lesions", "drug": "IFN" }, { "ade": "hyperpigmented skin", "drug": "ribavirin" }, { "ade": "hyperpigmented skin", "drug": "IFN" }, { "ade": "tongue lesions", "drug": "ribavirin" } ]

A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.

[ { "ade": "pleuropulmonary abnormalities", "drug": "bromocriptine" }, { "ade": "pleuropulmonary abnormalities", "drug": "cabergoline" } ]

A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.

[ { "ade": "overwhelming hepatic necrosis", "drug": "MTX" } ]

Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.

[ { "ade": "hemolytic uremic syndrome", "drug": "Mitomycin-C" } ]

PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.

[ { "ade": "spontaneous choroidal hemorrhage", "drug": "tissue plasminogen activator" } ]

Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.

[ { "ade": "SIADH", "drug": "CDDP" } ]

We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.

[ { "ade": "photosensitivity reaction", "drug": "mequitazine" } ]

Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.

[ { "ade": "interstitial pneumonitis", "drug": "Rituximab-CHOP" } ]

RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.

[ { "ade": "long-term immunosuppression", "drug": "Copaxone" }, { "ade": "Crohn's disease", "drug": "Copaxone" } ]

Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.

[ { "ade": "Accelerated nodulosis", "drug": "methotrexate" } ]

Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.

[ { "ade": "Myelodysplasia", "drug": "2-deoxycoformycin" }, { "ade": "acute myeloid leukemia", "drug": "2-deoxycoformycin" } ]

Colchicine-induced myopathy in renal failure.

[ { "ade": "myopathy", "drug": "Colchicine" } ]

Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

[ { "ade": "nephropathy", "drug": "Methotrexate" } ]

The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.

[ { "ade": "exacerbation of psoriasis", "drug": "imiquimod" } ]

The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.

[ { "ade": "gastric mucosa foveolar hyperplasia", "drug": "PGE1" } ]

DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.

[ { "ade": "ectropion", "drug": "5-FU" }, { "ade": "tender, red, scaled lids", "drug": "5-FU" } ]

CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.

[ { "ade": "agranulocytosis", "drug": "quetiapine" } ]

In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.

[ { "ade": "SIADH", "drug": "mizoribin" } ]