mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?	[ { "ade": "acute interstitial nephritis", "drug": "sunitinib" } ]
Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.	[ { "ade": "reduce the gastrointestinal absorption of orally administered levothyroxine sodium", "drug": "ferrous sulfate" } ]
We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.	[ { "ade": "skin and hepatic toxicity", "drug": "nevirapine" }, { "ade": "leukopenia", "drug": "nevirapine" } ]
Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.	[ { "ade": "Severe aphthous stomatitis", "drug": "calcineurin" } ]
Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.	[ { "ade": "pseudocyst of the pancreas", "drug": "L-asparaginase" } ]
Intravenous diazepam exacerbated the seizures.	[ { "ade": "seizures", "drug": "diazepam" } ]
Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.	[ { "ade": "pulmonary toxicity", "drug": "amiodarone" } ]
After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.	[ { "ade": "lethargy", "drug": "cholestyramine II" }, { "ade": "confusion", "drug": "cholestyramine II" }, { "ade": "drowsiness", "drug": "cholestyramine II" } ]
Chloroquine-induced bilateral ptosis.	[ { "ade": "bilateral ptosis", "drug": "Chloroquine" } ]
Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.	[ { "ade": "nephrotoxicity", "drug": "cisplatinum" }, { "ade": "cardiotoxicity", "drug": "adriamycin" } ]
The most common complication of warfarin use is adverse bleeding.	[ { "ade": "bleeding", "drug": "warfarin" } ]
CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.	[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]
Tacrolimus (FK506)-induced mutism after liver transplant.	[ { "ade": "mutism", "drug": "FK506" }, { "ade": "mutism", "drug": "Tacrolimus" } ]
It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.	[ { "ade": "hypersensitivity syndrome", "drug": "dapsone" } ]
We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.	[ { "ade": "systemic allergic contact dermatitis", "drug": "8-MOP" } ]
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.	[ { "ade": "ampicillin rash", "drug": "ampicillin" } ]
Pulmonary hypertension during lithium therapy: clinical case study.	[ { "ade": "Pulmonary hypertension", "drug": "lithium" } ]
A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.	[ { "ade": "reversible toxic liver damage", "drug": "disulfiram" } ]
A possible case of carbamazepine induced pancreatitis.	[ { "ade": "pancreatitis", "drug": "carbamazepine" } ]
Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.	[ { "ade": "Massive pulmonary embolism", "drug": "streptokinase" } ]
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.	[ { "ade": "psychiatric side effects", "drug": "interferon alpha" }, { "ade": "psychiatric side effects", "drug": "IFN-alpha" } ]
We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.	[ { "ade": "negative myoclonus", "drug": "pregabalin" } ]
We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.	[ { "ade": "elevation of serum transaminases", "drug": "6-TG" } ]
Acute coronary syndromes can be associated with the infusion of rituximab.	[ { "ade": "Acute coronary syndromes", "drug": "rituximab" } ]
Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.	[ { "ade": "thrombocythemia", "drug": "interferon alfa" }, { "ade": "thrombocythemia", "drug": "pentostatin" } ]
Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.	[ { "ade": "pulmonary disease", "drug": "calcium stearate" } ]
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.	[ { "ade": "Papilledema", "drug": "perhexiline maleate" } ]
We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.	[ { "ade": "psoriasis", "drug": "interferon-alpha" } ]
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.	[ { "ade": "Bronchiolitis obliterans organising pneumonia", "drug": "nitrofurantoin" } ]
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.	[ { "ade": "Leukopenia", "drug": "azathioprine" } ]
We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.	[ { "ade": "sarcoidosis", "drug": "interferon alfa" }, { "ade": "sarcoidosis", "drug": "ribavirin" } ]
Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.	[ { "ade": "granulomas", "drug": "methotrexate" }, { "ade": "pneumonitis", "drug": "methotrexate" }, { "ade": "Pulmonary eosinophilia", "drug": "methotrexate" } ]
Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.	[ { "ade": "pellagra", "drug": "Isoniazid" } ]
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.	[ { "ade": "postprandial hyperglycemia", "drug": "betamethasone valerate" } ]
The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.	[ { "ade": "akathisia", "drug": "interferon-alpha" }, { "ade": "neurotoxicity", "drug": "interferon-alpha" } ]
A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.	[ { "ade": "massive proteinuria", "drug": "methicillin" }, { "ade": "acute nephritic syndrome", "drug": "methicillin" } ]
We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.	[ { "ade": "myocardial infarction", "drug": "glucocorticoids" } ]
Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.	[ { "ade": "Eye movement disorders", "drug": "ganciclovir" }, { "ade": "Eye movement disorders", "drug": "cyclosporin" } ]
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.	[ { "ade": "Multicentric hepatocellular carcinoma", "drug": "phosphate diethylstilbestrol" } ]
Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.	[ { "ade": "exacerbate psoriasis or trigger off its onset", "drug": "Recombinant human interferon-alpha" } ]
We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.	[ { "ade": "acute myocardial ischemia", "drug": "epinephrine" }, { "ade": "severe allergic reaction", "drug": "epinephrine" } ]
Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.	[ { "ade": "severe hepatocellular necrosis", "drug": "tacrolimus" }, { "ade": "progressive liver failure", "drug": "tacrolimus" } ]
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.	[ { "ade": "brainstem herniation", "drug": "methotrexate" }, { "ade": "fatal cerebral edema", "drug": "methotrexate" } ]
Mycophenolate mofetil-induced neutropenia in liver transplantation.	[ { "ade": "neutropenia", "drug": "Mycophenolate mofetil" } ]
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.	[ { "ade": "cardiovascular collapse", "drug": "flecainide" } ]
Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.	[ { "ade": "hyperhidrosis", "drug": "Morphine" }, { "ade": "facial flushing", "drug": "Morphine" } ]
We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.	[ { "ade": "sustained monomorphic ventricular tachycardia", "drug": "adenosine" } ]
A 61 year-old male patient developed gynecomastia after starting theophylline.	[ { "ade": "gynecomastia", "drug": "theophylline" } ]
After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.	[ { "ade": "heart rate had decreased", "drug": "pentamidine" } ]
OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.	[ { "ade": "splenomegaly", "drug": "adalimumab" }, { "ade": "fever", "drug": "adalimumab" }, { "ade": "pancytopenia", "drug": "adalimumab" }, { "ade": "extreme hyperferritinemia", "drug": "adalimumab" } ]
Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.	[ { "ade": "symptomatic cerebral vasospasm", "drug": "sumatriptan" } ]
Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.	[ { "ade": "subacute combined degeneration of the spinal cord", "drug": "nitrous oxide" } ]
Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.	[ { "ade": "RPLS", "drug": "cisplatin" }, { "ade": "RPLS", "drug": "tacrolimus" }, { "ade": "RPLS", "drug": "cyclosporine" }, { "ade": "RPLS", "drug": "interferon-alpha" } ]
This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.	[ { "ade": "extramedullary relapse", "drug": "ATRA" } ]
To our knowledge, this is the first report of an angio-oedema associated with VRC.	[ { "ade": "angio-oedema", "drug": "VRC" } ]
Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.	[ { "ade": "significant abnormalities", "drug": "disulfiram" } ]
A case of colchicine-induced rhabdomyolysis is reported.	[ { "ade": "rhabdomyolysis", "drug": "colchicine" } ]
Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.	[ { "ade": "Fatal ventricular fibrillation", "drug": "digoxin" } ]
A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.	[ { "ade": "circumferential subglottic stenosis", "drug": "cyclophosphamide" } ]
The authors describe a case of the catatonia syndrome associated with disulfiram therapy.	[ { "ade": "catatonia syndrome", "drug": "disulfiram" } ]
Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.	[ { "ade": "pigmentation", "drug": "prostaglandin" }, { "ade": "Increased lash length", "drug": "prostaglandin" } ]
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.	[ { "ade": "DRESS", "drug": "Linezolid" }, { "ade": "drug rash with eosinophilia and systemic symptoms", "drug": "Linezolid" }, { "ade": "acute interstitial nephritis", "drug": "Linezolid" } ]
Exacerbation of schizophrenia associated with amantadine.	[ { "ade": "schizophrenia", "drug": "amantadine" } ]
Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.	[ { "ade": "Pemphigus foliaceus", "drug": "rifampicin" } ]
Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.	[ { "ade": "allergic reactions", "drug": "Capecitabine" } ]
However, an association of Ritalin with glaucoma has been reported.	[ { "ade": "glaucoma", "drug": "Ritalin" } ]
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.	[ { "ade": "Acute erythroid leukemia", "drug": "cyclophosphamide" } ]
CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.	[ { "ade": "Spontaneous hemothorax", "drug": "LMWH" } ]
The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.	[ { "ade": "cutaneous vasculitis", "drug": "propylthiouracil" } ]
Suxamethonium apnoea terminated with commercial serumcholinesterase.	[ { "ade": "apnoea", "drug": "Suxamethonium" } ]
We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.	[ { "ade": "intoxication", "drug": "mirtazapine" } ]
There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.	[ { "ade": "increases urate excretion", "drug": "losartan" } ]
A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.	[ { "ade": "focal neurological deficit", "drug": "phenytoin" } ]
We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.	[ { "ade": "death", "drug": "fluoxetine" }, { "ade": "neurological and cardiovascular toxicity", "drug": "fluoxetine" } ]
Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.	[ { "ade": "tardive dyskinesia", "drug": "Clozapine" } ]
Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.	[ { "ade": "antinuclear antibodies", "drug": "infliximab" }, { "ade": "increase of autoantibodies", "drug": "infliximab" }, { "ade": "anti-double-stranded DNA", "drug": "infliximab" } ]
Stupor from lamotrigine toxicity.	[ { "ade": "Stupor", "drug": "lamotrigine" } ]
ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.	[ { "ade": "ARDS", "drug": "gemtuzumab ozogamicin" }, { "ade": "ARDS", "drug": "OKT3" }, { "ade": "ARDS", "drug": "infliximab" } ]
We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).	[ { "ade": "severe akathisia", "drug": "olanzapine" } ]
Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.	[ { "ade": "Graves' hyperthyroidism", "drug": "IFN-alpha" }, { "ade": "thyrotoxicosis", "drug": "IFN-alpha" } ]
BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.	[ { "ade": "Reproductive endocrine disorders", "drug": "sodium valproate" }, { "ade": "polycystic ovaries", "drug": "sodium valproate" }, { "ade": "hyperandrogenism", "drug": "sodium valproate" }, { "ade": "menstrual disorders", "drug": "sodium valproate" } ]
Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.	[ { "ade": "thalamic and brainstem lesions", "drug": "penicillamine" }, { "ade": "Acute dystonia", "drug": "penicillamine" } ]
However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.	[ { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]
Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.	[ { "ade": "completely bald", "drug": "levodopa" } ]
She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.	[ { "ade": "Epstein-Barr virus-associated polymorphic lymphoproliferative disorder", "drug": "MTX" }, { "ade": "immunodeficiency", "drug": "MTX" }, { "ade": "LPD", "drug": "MTX" } ]
2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.	[ { "ade": "non-Hodgkin's lymphoma", "drug": "2-Chloro-deoxyadenosine" } ]
Case study: adverse response to clonidine.	[ { "ade": "adverse response", "drug": "clonidine" } ]
One patient had severe temporary weakness after an ampicillin sodium challenge.	[ { "ade": "severe temporary weakness", "drug": "ampicillin sodium" } ]
However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).	[ { "ade": "PD", "drug": "colchicine" } ]
Reversible cardiomyopathy caused by administration of interferon alpha.	[ { "ade": "Reversible cardiomyopathy", "drug": "interferon alpha" } ]
In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.	[ { "ade": "acute onset tetraparesia", "drug": "hepatitis B vaccination" } ]
When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.	[ { "ade": "histamine reaction", "drug": "isoniazid" } ]
A further case of anaphylactoid reaction to methylprednisolone is reported.	[ { "ade": "anaphylactoid reaction", "drug": "methylprednisolone" } ]
A fatal case of pancytopenia due to levomepromazine.	[ { "ade": "fatal case of pancytopenia", "drug": "levomepromazine" } ]
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.	[ { "ade": "unusual weight fluctuation", "drug": "aripiprazole" }, { "ade": "unusual weight fluctuation", "drug": "mianserin" } ]
Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.	[ { "ade": "hypersensitivity syndrome", "drug": "Carbamazepine" } ]
L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.	[ { "ade": "daytime sleepiness", "drug": "L-DOPA" } ]
Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.	[ { "ade": "precipitating psychosis", "drug": "amantadine" } ]
We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.	[ { "ade": "contact dermatitis", "drug": "sodium bisulfite" } ]
We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.	[ { "ade": "eye irritation and dryness", "drug": "docetaxel" } ]

Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?

[ { "ade": "acute interstitial nephritis", "drug": "sunitinib" } ]

Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.

[ { "ade": "reduce the gastrointestinal absorption of orally administered levothyroxine sodium", "drug": "ferrous sulfate" } ]

We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.

[ { "ade": "skin and hepatic toxicity", "drug": "nevirapine" }, { "ade": "leukopenia", "drug": "nevirapine" } ]

Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.

[ { "ade": "Severe aphthous stomatitis", "drug": "calcineurin" } ]

Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.

[ { "ade": "pseudocyst of the pancreas", "drug": "L-asparaginase" } ]

Intravenous diazepam exacerbated the seizures.

[ { "ade": "seizures", "drug": "diazepam" } ]

Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.

[ { "ade": "pulmonary toxicity", "drug": "amiodarone" } ]

After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.

[ { "ade": "lethargy", "drug": "cholestyramine II" }, { "ade": "confusion", "drug": "cholestyramine II" }, { "ade": "drowsiness", "drug": "cholestyramine II" } ]

Chloroquine-induced bilateral ptosis.

[ { "ade": "bilateral ptosis", "drug": "Chloroquine" } ]

Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.

[ { "ade": "nephrotoxicity", "drug": "cisplatinum" }, { "ade": "cardiotoxicity", "drug": "adriamycin" } ]

The most common complication of warfarin use is adverse bleeding.

[ { "ade": "bleeding", "drug": "warfarin" } ]

CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.

[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]

Tacrolimus (FK506)-induced mutism after liver transplant.

[ { "ade": "mutism", "drug": "FK506" }, { "ade": "mutism", "drug": "Tacrolimus" } ]

It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.

[ { "ade": "hypersensitivity syndrome", "drug": "dapsone" } ]

We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.

[ { "ade": "systemic allergic contact dermatitis", "drug": "8-MOP" } ]

The ampicillin rash occurring in cases of infectious mononucleosis is well documented.

[ { "ade": "ampicillin rash", "drug": "ampicillin" } ]

Pulmonary hypertension during lithium therapy: clinical case study.

[ { "ade": "Pulmonary hypertension", "drug": "lithium" } ]

A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.

[ { "ade": "reversible toxic liver damage", "drug": "disulfiram" } ]

A possible case of carbamazepine induced pancreatitis.

[ { "ade": "pancreatitis", "drug": "carbamazepine" } ]

Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.

[ { "ade": "Massive pulmonary embolism", "drug": "streptokinase" } ]

Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.

[ { "ade": "psychiatric side effects", "drug": "interferon alpha" }, { "ade": "psychiatric side effects", "drug": "IFN-alpha" } ]

We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.

[ { "ade": "negative myoclonus", "drug": "pregabalin" } ]

We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.

[ { "ade": "elevation of serum transaminases", "drug": "6-TG" } ]

Acute coronary syndromes can be associated with the infusion of rituximab.

[ { "ade": "Acute coronary syndromes", "drug": "rituximab" } ]

Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.

[ { "ade": "thrombocythemia", "drug": "interferon alfa" }, { "ade": "thrombocythemia", "drug": "pentostatin" } ]

Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.

[ { "ade": "pulmonary disease", "drug": "calcium stearate" } ]

Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.

[ { "ade": "Papilledema", "drug": "perhexiline maleate" } ]

We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.

[ { "ade": "psoriasis", "drug": "interferon-alpha" } ]

Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

[ { "ade": "Bronchiolitis obliterans organising pneumonia", "drug": "nitrofurantoin" } ]

Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.

[ { "ade": "Leukopenia", "drug": "azathioprine" } ]

We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.

[ { "ade": "sarcoidosis", "drug": "interferon alfa" }, { "ade": "sarcoidosis", "drug": "ribavirin" } ]

Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.

[ { "ade": "granulomas", "drug": "methotrexate" }, { "ade": "pneumonitis", "drug": "methotrexate" }, { "ade": "Pulmonary eosinophilia", "drug": "methotrexate" } ]

Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.

[ { "ade": "pellagra", "drug": "Isoniazid" } ]

A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.

[ { "ade": "postprandial hyperglycemia", "drug": "betamethasone valerate" } ]

The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.

[ { "ade": "akathisia", "drug": "interferon-alpha" }, { "ade": "neurotoxicity", "drug": "interferon-alpha" } ]

A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.

[ { "ade": "massive proteinuria", "drug": "methicillin" }, { "ade": "acute nephritic syndrome", "drug": "methicillin" } ]

We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.

[ { "ade": "myocardial infarction", "drug": "glucocorticoids" } ]

Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.

[ { "ade": "Eye movement disorders", "drug": "ganciclovir" }, { "ade": "Eye movement disorders", "drug": "cyclosporin" } ]

Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.

[ { "ade": "Multicentric hepatocellular carcinoma", "drug": "phosphate diethylstilbestrol" } ]

Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.

[ { "ade": "exacerbate psoriasis or trigger off its onset", "drug": "Recombinant human interferon-alpha" } ]

We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.

[ { "ade": "acute myocardial ischemia", "drug": "epinephrine" }, { "ade": "severe allergic reaction", "drug": "epinephrine" } ]

Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.

[ { "ade": "severe hepatocellular necrosis", "drug": "tacrolimus" }, { "ade": "progressive liver failure", "drug": "tacrolimus" } ]

A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.

[ { "ade": "brainstem herniation", "drug": "methotrexate" }, { "ade": "fatal cerebral edema", "drug": "methotrexate" } ]

Mycophenolate mofetil-induced neutropenia in liver transplantation.

[ { "ade": "neutropenia", "drug": "Mycophenolate mofetil" } ]

Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.

[ { "ade": "cardiovascular collapse", "drug": "flecainide" } ]

Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.

[ { "ade": "hyperhidrosis", "drug": "Morphine" }, { "ade": "facial flushing", "drug": "Morphine" } ]

We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.

[ { "ade": "sustained monomorphic ventricular tachycardia", "drug": "adenosine" } ]

A 61 year-old male patient developed gynecomastia after starting theophylline.

[ { "ade": "gynecomastia", "drug": "theophylline" } ]

After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.

[ { "ade": "heart rate had decreased", "drug": "pentamidine" } ]

OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.

[ { "ade": "splenomegaly", "drug": "adalimumab" }, { "ade": "fever", "drug": "adalimumab" }, { "ade": "pancytopenia", "drug": "adalimumab" }, { "ade": "extreme hyperferritinemia", "drug": "adalimumab" } ]

Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.

[ { "ade": "symptomatic cerebral vasospasm", "drug": "sumatriptan" } ]

Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.

[ { "ade": "subacute combined degeneration of the spinal cord", "drug": "nitrous oxide" } ]

Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.

[ { "ade": "RPLS", "drug": "cisplatin" }, { "ade": "RPLS", "drug": "tacrolimus" }, { "ade": "RPLS", "drug": "cyclosporine" }, { "ade": "RPLS", "drug": "interferon-alpha" } ]

This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.

[ { "ade": "extramedullary relapse", "drug": "ATRA" } ]

To our knowledge, this is the first report of an angio-oedema associated with VRC.

[ { "ade": "angio-oedema", "drug": "VRC" } ]

Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.

[ { "ade": "significant abnormalities", "drug": "disulfiram" } ]

A case of colchicine-induced rhabdomyolysis is reported.

[ { "ade": "rhabdomyolysis", "drug": "colchicine" } ]

Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.

[ { "ade": "Fatal ventricular fibrillation", "drug": "digoxin" } ]

A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.

[ { "ade": "circumferential subglottic stenosis", "drug": "cyclophosphamide" } ]

The authors describe a case of the catatonia syndrome associated with disulfiram therapy.

[ { "ade": "catatonia syndrome", "drug": "disulfiram" } ]

Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.

[ { "ade": "pigmentation", "drug": "prostaglandin" }, { "ade": "Increased lash length", "drug": "prostaglandin" } ]

Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.

[ { "ade": "DRESS", "drug": "Linezolid" }, { "ade": "drug rash with eosinophilia and systemic symptoms", "drug": "Linezolid" }, { "ade": "acute interstitial nephritis", "drug": "Linezolid" } ]

Exacerbation of schizophrenia associated with amantadine.

[ { "ade": "schizophrenia", "drug": "amantadine" } ]

Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.

[ { "ade": "Pemphigus foliaceus", "drug": "rifampicin" } ]

Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.

[ { "ade": "allergic reactions", "drug": "Capecitabine" } ]

However, an association of Ritalin with glaucoma has been reported.

[ { "ade": "glaucoma", "drug": "Ritalin" } ]

Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.

[ { "ade": "Acute erythroid leukemia", "drug": "cyclophosphamide" } ]

CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.

[ { "ade": "Spontaneous hemothorax", "drug": "LMWH" } ]

The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.

[ { "ade": "cutaneous vasculitis", "drug": "propylthiouracil" } ]

Suxamethonium apnoea terminated with commercial serumcholinesterase.

[ { "ade": "apnoea", "drug": "Suxamethonium" } ]

We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.

[ { "ade": "intoxication", "drug": "mirtazapine" } ]

There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.

[ { "ade": "increases urate excretion", "drug": "losartan" } ]

A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.

[ { "ade": "focal neurological deficit", "drug": "phenytoin" } ]

We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.

[ { "ade": "death", "drug": "fluoxetine" }, { "ade": "neurological and cardiovascular toxicity", "drug": "fluoxetine" } ]

Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.

[ { "ade": "tardive dyskinesia", "drug": "Clozapine" } ]

Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.

[ { "ade": "antinuclear antibodies", "drug": "infliximab" }, { "ade": "increase of autoantibodies", "drug": "infliximab" }, { "ade": "anti-double-stranded DNA", "drug": "infliximab" } ]

Stupor from lamotrigine toxicity.

[ { "ade": "Stupor", "drug": "lamotrigine" } ]

ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.

[ { "ade": "ARDS", "drug": "gemtuzumab ozogamicin" }, { "ade": "ARDS", "drug": "OKT3" }, { "ade": "ARDS", "drug": "infliximab" } ]

We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).

[ { "ade": "severe akathisia", "drug": "olanzapine" } ]

Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.

[ { "ade": "Graves' hyperthyroidism", "drug": "IFN-alpha" }, { "ade": "thyrotoxicosis", "drug": "IFN-alpha" } ]

BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.

[ { "ade": "Reproductive endocrine disorders", "drug": "sodium valproate" }, { "ade": "polycystic ovaries", "drug": "sodium valproate" }, { "ade": "hyperandrogenism", "drug": "sodium valproate" }, { "ade": "menstrual disorders", "drug": "sodium valproate" } ]

Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.

[ { "ade": "thalamic and brainstem lesions", "drug": "penicillamine" }, { "ade": "Acute dystonia", "drug": "penicillamine" } ]

However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.

[ { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]

Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.

[ { "ade": "completely bald", "drug": "levodopa" } ]

She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.

[ { "ade": "Epstein-Barr virus-associated polymorphic lymphoproliferative disorder", "drug": "MTX" }, { "ade": "immunodeficiency", "drug": "MTX" }, { "ade": "LPD", "drug": "MTX" } ]

2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.

[ { "ade": "non-Hodgkin's lymphoma", "drug": "2-Chloro-deoxyadenosine" } ]

Case study: adverse response to clonidine.

[ { "ade": "adverse response", "drug": "clonidine" } ]

One patient had severe temporary weakness after an ampicillin sodium challenge.

[ { "ade": "severe temporary weakness", "drug": "ampicillin sodium" } ]

However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).

[ { "ade": "PD", "drug": "colchicine" } ]

Reversible cardiomyopathy caused by administration of interferon alpha.

[ { "ade": "Reversible cardiomyopathy", "drug": "interferon alpha" } ]

In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.

[ { "ade": "acute onset tetraparesia", "drug": "hepatitis B vaccination" } ]

When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.

[ { "ade": "histamine reaction", "drug": "isoniazid" } ]

A further case of anaphylactoid reaction to methylprednisolone is reported.

[ { "ade": "anaphylactoid reaction", "drug": "methylprednisolone" } ]

A fatal case of pancytopenia due to levomepromazine.

[ { "ade": "fatal case of pancytopenia", "drug": "levomepromazine" } ]

The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.

[ { "ade": "unusual weight fluctuation", "drug": "aripiprazole" }, { "ade": "unusual weight fluctuation", "drug": "mianserin" } ]

Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.

[ { "ade": "hypersensitivity syndrome", "drug": "Carbamazepine" } ]

L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.

[ { "ade": "daytime sleepiness", "drug": "L-DOPA" } ]

Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.

[ { "ade": "precipitating psychosis", "drug": "amantadine" } ]

We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.

[ { "ade": "contact dermatitis", "drug": "sodium bisulfite" } ]

We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.

[ { "ade": "eye irritation and dryness", "drug": "docetaxel" } ]