mihirhirave/entity_extraction_ade_v2_with_validation

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Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.	[ { "ade": "Fulminant hepatic failure", "drug": "disulfiram" } ]
METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.	[ { "ade": "verrucous plaque", "drug": "imiquimod" } ]
Flaccid quadriparesis was noted after discontinuation of vecuronium.	[ { "ade": "Flaccid quadriparesis", "drug": "vecuronium" } ]
A new type of minocycline-induced cutaneous hyperpigmentation.	[ { "ade": "cutaneous hyperpigmentation", "drug": "minocycline" } ]
Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.	[ { "ade": "Severe hepatotoxicity", "drug": "phenobarbital" } ]
Albendazole-induced pseudomembranous colitis.	[ { "ade": "pseudomembranous colitis", "drug": "Albendazole" } ]
In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.	[ { "ade": "dyspnea", "drug": "lenalidomide" }, { "ade": "hypoxia", "drug": "lenalidomide" }, { "ade": "fever", "drug": "lenalidomide" }, { "ade": "diffuse pulmonary infiltrates", "drug": "lenalidomide" } ]
He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.	[ { "ade": "weakness", "drug": "trimethoprim" }, { "ade": "itching on the trunk", "drug": "trimethoprim" }, { "ade": "itching on the trunk", "drug": "sulfamethoxazole" }, { "ade": "maculopapular rash", "drug": "sulfamethoxazole" }, { "ade": "maculopapular rash", "drug": "trimethoprim" }, { "ade": "headaches", "drug": "sulfamethoxazole" }, { "ade": "difficulty with speech", "drug": "sulfamethoxazole" }, { "ade": "weakness", "drug": "sulfamethoxazole" }, { "ade": "dizziness", "drug": "sulfamethoxazole" }, { "ade": "dizziness", "drug": "trimethoprim" }, { "ade": "difficulty with speech", "drug": "trimethoprim" }, { "ade": "headaches", "drug": "trimethoprim" } ]
The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.	[ { "ade": "agranulocytosis", "drug": "methimazole" } ]
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.	[ { "ade": "acute hemorrhagic gastritis", "drug": "AZ" }, { "ade": "AZ intoxication", "drug": "AZ" } ]
However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.	[ { "ade": "photosensitivity", "drug": "mequitazine" } ]
Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.	[ { "ade": "prolapse of the urethral mucosa", "drug": "calcium hydroxylapatite" } ]
Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.	[ { "ade": "vomiting", "drug": "cyclophosphamide" }, { "ade": "nausea", "drug": "cyclophosphamide" }, { "ade": "Alopecia", "drug": "cyclophosphamide" } ]
METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.	[ { "ade": "vomiting", "drug": "Viokase" }, { "ade": "vomiting", "drug": "Pancrease MT 16" } ]
Gemcitabine-associated hemolytic-uremic syndrome.	[ { "ade": "hemolytic-uremic syndrome", "drug": "Gemcitabine" } ]
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.	[ { "ade": "Malignant mixed mullerian tumor of the uterus", "drug": "raloxifene" } ]
The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.	[ { "ade": "liver dysfunction", "drug": "Lp-TAE" }, { "ade": "low-grade fever", "drug": "Lp-TAE" }, { "ade": "localized pain", "drug": "Lp-TAE" }, { "ade": "myelo-suppression", "drug": "Lp-TAE" } ]
Angioedema and maculopapular eruptions associated with carbamazepine administration.	[ { "ade": "maculopapular eruptions", "drug": "carbamazepine" }, { "ade": "Angioedema", "drug": "carbamazepine" } ]
Anisocoria from transdermal scopolamine.	[ { "ade": "Anisocoria", "drug": "scopolamine" } ]
In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.	[ { "ade": "dyskinesias", "drug": "apomorphine" } ]
Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.	[ { "ade": "Hyperpigmentation", "drug": "interferon-alpha" } ]
Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.	[ { "ade": "rhabdomyolysis", "drug": "cerivastatin" } ]
Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.	[ { "ade": "neutropenic fever", "drug": "cilastatin" }, { "ade": "neutropenic fever", "drug": "imipenem" } ]
Cephalosporins are most likely associated with Vitamin K deficiency.	[ { "ade": "Vitamin K deficiency", "drug": "Cephalosporins" } ]
CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.	[ { "ade": "corneal ulcers", "drug": "moxifloxacin" } ]
Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.	[ { "ade": "Paradoxical precipitation of tonic seizures", "drug": "lorazepam" } ]
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.	[ { "ade": "acute coronary ischemia", "drug": "cis-diamine-dichloroplatinum II" }, { "ade": "infarction", "drug": "cisplatin" }, { "ade": "infarction", "drug": "cis-diamine-dichloroplatinum II" }, { "ade": "acute coronary ischemia", "drug": "cisplatin" } ]
Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.	[ { "ade": "tubular dysfunction", "drug": "Amikacin" } ]
Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.	[ { "ade": "contact dermatitis", "drug": "sodium bisulfite" }, { "ade": "eruption", "drug": "sodium bisulfite" } ]
CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.	[ { "ade": "hypercalcemia", "drug": "rhGH" } ]
Nephropathy caused by methicillin therapy for staphylococcal septicemia.	[ { "ade": "Nephropathy", "drug": "methicillin" } ]
The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.	[ { "ade": "agranulocytosis", "drug": "clozapine" } ]
METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.	[ { "ade": "hallucinations", "drug": "interferon" }, { "ade": "hallucinations", "drug": "ribavirin" } ]
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.	[ { "ade": "spasm", "drug": "ergonovine" } ]
We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.	[ { "ade": "ifosfamide-induced encephalopathy", "drug": "ifosfamide" } ]
Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.	[ { "ade": "onycholysis", "drug": "clofazimine" }, { "ade": "discoloration of nail plate", "drug": "clofazimine" }, { "ade": "subungual hyperkeratosis", "drug": "clofazimine" } ]
Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.	[ { "ade": "dry mouth", "drug": "clonidine" }, { "ade": "bradycardia", "drug": "clonidine" }, { "ade": "constipation", "drug": "clonidine" }, { "ade": "hypotension", "drug": "clonidine" } ]
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.	[ { "ade": "Arrhythmias", "drug": "amphotericin B" }, { "ade": "cardiac arrest", "drug": "amphotericin B" } ]
Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.	[ { "ade": "cardiovascular collapse", "drug": "Flecainide" } ]
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.	[ { "ade": "hepatic dysfunction", "drug": "perhexiline maleate" }, { "ade": "papilloedema", "drug": "perhexiline maleate" } ]
Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.	[ { "ade": "scleroderma", "drug": "bleomycin" } ]
Captopril-induced acute reversible renal failure.	[ { "ade": "acute reversible renal failure", "drug": "Captopril" } ]
Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.	[ { "ade": "Thrombocytopenia", "drug": "quinine" }, { "ade": "TTP/HUS", "drug": "quinine" } ]
Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.	[ { "ade": "seizures", "drug": "methylprednisolone" }, { "ade": "transient blindness", "drug": "methylprednisolone" } ]
We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.	[ { "ade": "severe motor neuropathy", "drug": "vincristine" } ]
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.	[ { "ade": "posterior leukoencephalopathy", "drug": "methotrexate" }, { "ade": "Balint syndrome", "drug": "cytarabine" }, { "ade": "Balint syndrome", "drug": "methotrexate" }, { "ade": "posterior leukoencephalopathy", "drug": "cytarabine" } ]
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.	[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]
Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.	[ { "ade": "diarrhea", "drug": "Flucytosine" } ]
In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.	[ { "ade": "blood pressure decreased", "drug": "isosorbide dinitrate" }, { "ade": "sudden decrease in pulse rate", "drug": "isosorbide dinitrate" }, { "ade": "syncope", "drug": "isosorbide dinitrate" } ]
Progressive hypokalemia developed during phosphate treatment.	[ { "ade": "Progressive hypokalemia", "drug": "phosphate" } ]
Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.	[ { "ade": "hypoglycaemia", "drug": "Para-aminosalicylic acid" } ]
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.	[ { "ade": "Hepatocellular damage", "drug": "iron sucrose" } ]
Ticlopidine-induced interstitial pulmonary disease: a case report.	[ { "ade": "interstitial pulmonary disease", "drug": "Ticlopidine" } ]
A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.	[ { "ade": "CML", "drug": "hydroxyurea" }, { "ade": "chronic myeloid leukaemia", "drug": "hydroxyurea" } ]
Vincristine induced cranial polyneuropathy.	[ { "ade": "cranial polyneuropathy", "drug": "Vincristine" } ]
Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.	[ { "ade": "adrenal insufficiency", "drug": "Rifampicin" } ]
Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.	[ { "ade": "Mucosal pigmentation", "drug": "tacrolimus" } ]
However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.	[ { "ade": "interstitial pneumonia", "drug": "sorafenib" } ]
Asterixis induced by carbamazepine therapy.	[ { "ade": "Asterixis", "drug": "carbamazepine" } ]
Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.	[ { "ade": "rhabdomyolysis", "drug": "Sertraline" } ]
Psoriasis induced by interferon-alpha.	[ { "ade": "Psoriasis", "drug": "interferon-alpha" } ]
These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.	[ { "ade": "intrahepatic cholestasis", "drug": "chlorpropamide" } ]
Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.	[ { "ade": "Skin rash", "drug": "phenobarbital" }, { "ade": "hepatocellular failure", "drug": "phenobarbital" } ]
Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.	[ { "ade": "Reversible MR imaging and MR spectroscopy abnormalities", "drug": "metronidazole" } ]
We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.	[ { "ade": "agranulocytosis", "drug": "vancomycin" } ]
A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.	[ { "ade": "grand mal seizures", "drug": "vinblastine" }, { "ade": "grand mal seizures", "drug": "cisplatin" }, { "ade": "grand mal seizures", "drug": "bleomycin" } ]
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.	[ { "ade": "leukoencephalopathy", "drug": "methotrexate" } ]
Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.	[ { "ade": "peripheral neuropathy", "drug": "linezolid" }, { "ade": "bone marrow depression", "drug": "linezolid" } ]
Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.	[ { "ade": "anaphylaxis", "drug": "methotrexate" } ]
This report describes a case of bilateral ptosis induced by chloroquine.	[ { "ade": "bilateral ptosis", "drug": "chloroquine" } ]
Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.	[ { "ade": "abnormal liver function tests", "drug": "cyproterone acetate" } ]
Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.	[ { "ade": "Severe Raynaud's phenomenon", "drug": "yohimbine" } ]
She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.	[ { "ade": "asthma", "drug": "verapamil" } ]
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.	[ { "ade": "acute hemoglobinemia", "drug": "anti-D IGIV" }, { "ade": "hemoglobinuria", "drug": "anti-D IGIV" }, { "ade": "DIC", "drug": "anti-D IGIV" } ]
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.	[ { "ade": "obsessive-compulsive symptoms", "drug": "Quetiapine" }, { "ade": "OCS", "drug": "Quetiapine" } ]
Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.	[ { "ade": "Posterior leukoencephalopathy", "drug": "vinblastine" }, { "ade": "Posterior leukoencephalopathy", "drug": "cisplatin" }, { "ade": "Posterior leukoencephalopathy", "drug": "bleomycin" } ]
Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.	[ { "ade": "seizures", "drug": "CBZ" } ]
METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.	[ { "ade": "acute myopia", "drug": "topiramate" } ]
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.	[ { "ade": "ocular toxicity", "drug": "ethambutol" } ]
A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.	[ { "ade": "erythematous papular eruption", "drug": "G-CSF" } ]
In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.	[ { "ade": "decrease in blood lactate levels", "drug": "DCA" } ]
Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.	[ { "ade": "syncope", "drug": "oxymetazoline" } ]
We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.	[ { "ade": "headache", "drug": "cyclosporine" }, { "ade": "seizure", "drug": "cyclosporine" }, { "ade": "severe perspiration", "drug": "cyclosporine" } ]
After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.	[ { "ade": "acute liver toxicity", "drug": "TMP-SMX" }, { "ade": "liver toxicity", "drug": "TMP-SMX" } ]
We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.	[ { "ade": "hepatotoxicity", "drug": "benzarone" }, { "ade": "severe chronic active hepatitis", "drug": "benzarone" } ]
Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.	[ { "ade": "neurological symptoms", "drug": "zonisamide" }, { "ade": "oligohidrosis", "drug": "zonisamide" } ]
Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.	[ { "ade": "Herpes simplex esophagitis", "drug": "cyclosporine A" } ]
During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.	[ { "ade": "decrease in the D-dimers", "drug": "arsenic trioxide" }, { "ade": "slight decrease in peripheral blood leukocytes", "drug": "arsenic trioxide" } ]
Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.	[ { "ade": "cerebrospinal fluid eosinophilia", "drug": "vancomycin" } ]
Serious adverse events experienced by patients with chronic heart failure taking spironolactone.	[ { "ade": "Serious adverse events", "drug": "spironolactone" } ]
METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.	[ { "ade": "HUS", "drug": "gemcitabine" } ]
This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.	[ { "ade": "oro-pharyngeal dystonic reaction", "drug": "prochlorperazine" }, { "ade": "epiglottitis", "drug": "prochlorperazine" } ]
However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.	[ { "ade": "neuropathic side effects", "drug": "thalidomide" } ]
Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.	[ { "ade": "necrotizing fasciitis", "drug": "warfarin" } ]
Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.	[ { "ade": "lymphadenopathy", "drug": "minocycline" }, { "ade": "eosinophilia", "drug": "minocycline" }, { "ade": "dermatitis", "drug": "minocycline" }, { "ade": "lymphocytosis", "drug": "minocycline" }, { "ade": "Fever", "drug": "minocycline" }, { "ade": "hepatitis", "drug": "minocycline" } ]
We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.	[ { "ade": "Kaposi's sarcoma", "drug": "prednisolone" } ]
A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.	[ { "ade": "submassive hepatic necrosis", "drug": "barbiturate" } ]
A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.	[ { "ade": "transient tonic pupillary response", "drug": "quinine" }, { "ade": "abnormal visual-evoked potentials", "drug": "quinine" }, { "ade": "denervation supersensitivity", "drug": "quinine" } ]
Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.	[ { "ade": "aplastic anemia", "drug": "lenalidomide" } ]
Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?	[ { "ade": "athelia", "drug": "methimazole" }, { "ade": "Choanal atresia", "drug": "methimazole" }, { "ade": "teratogenicity", "drug": "methimazole" } ]

Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.

[ { "ade": "Fulminant hepatic failure", "drug": "disulfiram" } ]

METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.

[ { "ade": "verrucous plaque", "drug": "imiquimod" } ]

Flaccid quadriparesis was noted after discontinuation of vecuronium.

[ { "ade": "Flaccid quadriparesis", "drug": "vecuronium" } ]

A new type of minocycline-induced cutaneous hyperpigmentation.

[ { "ade": "cutaneous hyperpigmentation", "drug": "minocycline" } ]

Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

[ { "ade": "Severe hepatotoxicity", "drug": "phenobarbital" } ]

Albendazole-induced pseudomembranous colitis.

[ { "ade": "pseudomembranous colitis", "drug": "Albendazole" } ]

In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.

[ { "ade": "dyspnea", "drug": "lenalidomide" }, { "ade": "hypoxia", "drug": "lenalidomide" }, { "ade": "fever", "drug": "lenalidomide" }, { "ade": "diffuse pulmonary infiltrates", "drug": "lenalidomide" } ]

He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.

[ { "ade": "weakness", "drug": "trimethoprim" }, { "ade": "itching on the trunk", "drug": "trimethoprim" }, { "ade": "itching on the trunk", "drug": "sulfamethoxazole" }, { "ade": "maculopapular rash", "drug": "sulfamethoxazole" }, { "ade": "maculopapular rash", "drug": "trimethoprim" }, { "ade": "headaches", "drug": "sulfamethoxazole" }, { "ade": "difficulty with speech", "drug": "sulfamethoxazole" }, { "ade": "weakness", "drug": "sulfamethoxazole" }, { "ade": "dizziness", "drug": "sulfamethoxazole" }, { "ade": "dizziness", "drug": "trimethoprim" }, { "ade": "difficulty with speech", "drug": "trimethoprim" }, { "ade": "headaches", "drug": "trimethoprim" } ]

The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.

[ { "ade": "agranulocytosis", "drug": "methimazole" } ]

We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.

[ { "ade": "acute hemorrhagic gastritis", "drug": "AZ" }, { "ade": "AZ intoxication", "drug": "AZ" } ]

However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.

[ { "ade": "photosensitivity", "drug": "mequitazine" } ]

Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.

[ { "ade": "prolapse of the urethral mucosa", "drug": "calcium hydroxylapatite" } ]

Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.

[ { "ade": "vomiting", "drug": "cyclophosphamide" }, { "ade": "nausea", "drug": "cyclophosphamide" }, { "ade": "Alopecia", "drug": "cyclophosphamide" } ]

METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.

[ { "ade": "vomiting", "drug": "Viokase" }, { "ade": "vomiting", "drug": "Pancrease MT 16" } ]

Gemcitabine-associated hemolytic-uremic syndrome.

[ { "ade": "hemolytic-uremic syndrome", "drug": "Gemcitabine" } ]

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

[ { "ade": "Malignant mixed mullerian tumor of the uterus", "drug": "raloxifene" } ]

The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.

[ { "ade": "liver dysfunction", "drug": "Lp-TAE" }, { "ade": "low-grade fever", "drug": "Lp-TAE" }, { "ade": "localized pain", "drug": "Lp-TAE" }, { "ade": "myelo-suppression", "drug": "Lp-TAE" } ]

Angioedema and maculopapular eruptions associated with carbamazepine administration.

[ { "ade": "maculopapular eruptions", "drug": "carbamazepine" }, { "ade": "Angioedema", "drug": "carbamazepine" } ]

Anisocoria from transdermal scopolamine.

[ { "ade": "Anisocoria", "drug": "scopolamine" } ]

In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.

[ { "ade": "dyskinesias", "drug": "apomorphine" } ]

Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.

[ { "ade": "Hyperpigmentation", "drug": "interferon-alpha" } ]

Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.

[ { "ade": "rhabdomyolysis", "drug": "cerivastatin" } ]

Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.

[ { "ade": "neutropenic fever", "drug": "cilastatin" }, { "ade": "neutropenic fever", "drug": "imipenem" } ]

Cephalosporins are most likely associated with Vitamin K deficiency.

[ { "ade": "Vitamin K deficiency", "drug": "Cephalosporins" } ]

CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.

[ { "ade": "corneal ulcers", "drug": "moxifloxacin" } ]

Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.

[ { "ade": "Paradoxical precipitation of tonic seizures", "drug": "lorazepam" } ]

Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.

[ { "ade": "acute coronary ischemia", "drug": "cis-diamine-dichloroplatinum II" }, { "ade": "infarction", "drug": "cisplatin" }, { "ade": "infarction", "drug": "cis-diamine-dichloroplatinum II" }, { "ade": "acute coronary ischemia", "drug": "cisplatin" } ]

Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.

[ { "ade": "tubular dysfunction", "drug": "Amikacin" } ]

Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.

[ { "ade": "contact dermatitis", "drug": "sodium bisulfite" }, { "ade": "eruption", "drug": "sodium bisulfite" } ]

CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.

[ { "ade": "hypercalcemia", "drug": "rhGH" } ]

Nephropathy caused by methicillin therapy for staphylococcal septicemia.

[ { "ade": "Nephropathy", "drug": "methicillin" } ]

The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.

[ { "ade": "agranulocytosis", "drug": "clozapine" } ]

METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.

[ { "ade": "hallucinations", "drug": "interferon" }, { "ade": "hallucinations", "drug": "ribavirin" } ]

In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.

[ { "ade": "spasm", "drug": "ergonovine" } ]

We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.

[ { "ade": "ifosfamide-induced encephalopathy", "drug": "ifosfamide" } ]

Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.

[ { "ade": "onycholysis", "drug": "clofazimine" }, { "ade": "discoloration of nail plate", "drug": "clofazimine" }, { "ade": "subungual hyperkeratosis", "drug": "clofazimine" } ]

Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.

[ { "ade": "dry mouth", "drug": "clonidine" }, { "ade": "bradycardia", "drug": "clonidine" }, { "ade": "constipation", "drug": "clonidine" }, { "ade": "hypotension", "drug": "clonidine" } ]

Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.

[ { "ade": "Arrhythmias", "drug": "amphotericin B" }, { "ade": "cardiac arrest", "drug": "amphotericin B" } ]

Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.

[ { "ade": "cardiovascular collapse", "drug": "Flecainide" } ]

A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.

[ { "ade": "hepatic dysfunction", "drug": "perhexiline maleate" }, { "ade": "papilloedema", "drug": "perhexiline maleate" } ]

Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.

[ { "ade": "scleroderma", "drug": "bleomycin" } ]

Captopril-induced acute reversible renal failure.

[ { "ade": "acute reversible renal failure", "drug": "Captopril" } ]

Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.

[ { "ade": "Thrombocytopenia", "drug": "quinine" }, { "ade": "TTP/HUS", "drug": "quinine" } ]

Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.

[ { "ade": "seizures", "drug": "methylprednisolone" }, { "ade": "transient blindness", "drug": "methylprednisolone" } ]

We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.

[ { "ade": "severe motor neuropathy", "drug": "vincristine" } ]

The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.

[ { "ade": "posterior leukoencephalopathy", "drug": "methotrexate" }, { "ade": "Balint syndrome", "drug": "cytarabine" }, { "ade": "Balint syndrome", "drug": "methotrexate" }, { "ade": "posterior leukoencephalopathy", "drug": "cytarabine" } ]

Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.

[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]

Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.

[ { "ade": "diarrhea", "drug": "Flucytosine" } ]

In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.

[ { "ade": "blood pressure decreased", "drug": "isosorbide dinitrate" }, { "ade": "sudden decrease in pulse rate", "drug": "isosorbide dinitrate" }, { "ade": "syncope", "drug": "isosorbide dinitrate" } ]

Progressive hypokalemia developed during phosphate treatment.

[ { "ade": "Progressive hypokalemia", "drug": "phosphate" } ]

Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.

[ { "ade": "hypoglycaemia", "drug": "Para-aminosalicylic acid" } ]

Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.

[ { "ade": "Hepatocellular damage", "drug": "iron sucrose" } ]

Ticlopidine-induced interstitial pulmonary disease: a case report.

[ { "ade": "interstitial pulmonary disease", "drug": "Ticlopidine" } ]

A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.

[ { "ade": "CML", "drug": "hydroxyurea" }, { "ade": "chronic myeloid leukaemia", "drug": "hydroxyurea" } ]

Vincristine induced cranial polyneuropathy.

[ { "ade": "cranial polyneuropathy", "drug": "Vincristine" } ]

Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.

[ { "ade": "adrenal insufficiency", "drug": "Rifampicin" } ]

Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.

[ { "ade": "Mucosal pigmentation", "drug": "tacrolimus" } ]

However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.

[ { "ade": "interstitial pneumonia", "drug": "sorafenib" } ]

Asterixis induced by carbamazepine therapy.

[ { "ade": "Asterixis", "drug": "carbamazepine" } ]

Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

[ { "ade": "rhabdomyolysis", "drug": "Sertraline" } ]

Psoriasis induced by interferon-alpha.

[ { "ade": "Psoriasis", "drug": "interferon-alpha" } ]

These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.

[ { "ade": "intrahepatic cholestasis", "drug": "chlorpropamide" } ]

Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.

[ { "ade": "Skin rash", "drug": "phenobarbital" }, { "ade": "hepatocellular failure", "drug": "phenobarbital" } ]

Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.

[ { "ade": "Reversible MR imaging and MR spectroscopy abnormalities", "drug": "metronidazole" } ]

We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.

[ { "ade": "agranulocytosis", "drug": "vancomycin" } ]

A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.

[ { "ade": "grand mal seizures", "drug": "vinblastine" }, { "ade": "grand mal seizures", "drug": "cisplatin" }, { "ade": "grand mal seizures", "drug": "bleomycin" } ]

An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.

[ { "ade": "leukoencephalopathy", "drug": "methotrexate" } ]

Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.

[ { "ade": "peripheral neuropathy", "drug": "linezolid" }, { "ade": "bone marrow depression", "drug": "linezolid" } ]

Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.

[ { "ade": "anaphylaxis", "drug": "methotrexate" } ]

This report describes a case of bilateral ptosis induced by chloroquine.

[ { "ade": "bilateral ptosis", "drug": "chloroquine" } ]

Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.

[ { "ade": "abnormal liver function tests", "drug": "cyproterone acetate" } ]

Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.

[ { "ade": "Severe Raynaud's phenomenon", "drug": "yohimbine" } ]

She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.

[ { "ade": "asthma", "drug": "verapamil" } ]

This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.

[ { "ade": "acute hemoglobinemia", "drug": "anti-D IGIV" }, { "ade": "hemoglobinuria", "drug": "anti-D IGIV" }, { "ade": "DIC", "drug": "anti-D IGIV" } ]

Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.

[ { "ade": "obsessive-compulsive symptoms", "drug": "Quetiapine" }, { "ade": "OCS", "drug": "Quetiapine" } ]

Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.

[ { "ade": "Posterior leukoencephalopathy", "drug": "vinblastine" }, { "ade": "Posterior leukoencephalopathy", "drug": "cisplatin" }, { "ade": "Posterior leukoencephalopathy", "drug": "bleomycin" } ]

Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.

[ { "ade": "seizures", "drug": "CBZ" } ]

METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.

[ { "ade": "acute myopia", "drug": "topiramate" } ]

There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.

[ { "ade": "ocular toxicity", "drug": "ethambutol" } ]

A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.

[ { "ade": "erythematous papular eruption", "drug": "G-CSF" } ]

In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.

[ { "ade": "decrease in blood lactate levels", "drug": "DCA" } ]

Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.

[ { "ade": "syncope", "drug": "oxymetazoline" } ]

We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.

[ { "ade": "headache", "drug": "cyclosporine" }, { "ade": "seizure", "drug": "cyclosporine" }, { "ade": "severe perspiration", "drug": "cyclosporine" } ]

After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.

[ { "ade": "acute liver toxicity", "drug": "TMP-SMX" }, { "ade": "liver toxicity", "drug": "TMP-SMX" } ]

We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.

[ { "ade": "hepatotoxicity", "drug": "benzarone" }, { "ade": "severe chronic active hepatitis", "drug": "benzarone" } ]

Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.

[ { "ade": "neurological symptoms", "drug": "zonisamide" }, { "ade": "oligohidrosis", "drug": "zonisamide" } ]

Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.

[ { "ade": "Herpes simplex esophagitis", "drug": "cyclosporine A" } ]

During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.

[ { "ade": "decrease in the D-dimers", "drug": "arsenic trioxide" }, { "ade": "slight decrease in peripheral blood leukocytes", "drug": "arsenic trioxide" } ]

Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.

[ { "ade": "cerebrospinal fluid eosinophilia", "drug": "vancomycin" } ]

Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

[ { "ade": "Serious adverse events", "drug": "spironolactone" } ]

METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.

[ { "ade": "HUS", "drug": "gemcitabine" } ]

This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.

[ { "ade": "oro-pharyngeal dystonic reaction", "drug": "prochlorperazine" }, { "ade": "epiglottitis", "drug": "prochlorperazine" } ]

However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.

[ { "ade": "neuropathic side effects", "drug": "thalidomide" } ]

Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.

[ { "ade": "necrotizing fasciitis", "drug": "warfarin" } ]

Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.

[ { "ade": "lymphadenopathy", "drug": "minocycline" }, { "ade": "eosinophilia", "drug": "minocycline" }, { "ade": "dermatitis", "drug": "minocycline" }, { "ade": "lymphocytosis", "drug": "minocycline" }, { "ade": "Fever", "drug": "minocycline" }, { "ade": "hepatitis", "drug": "minocycline" } ]

We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.

[ { "ade": "Kaposi's sarcoma", "drug": "prednisolone" } ]

A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.

[ { "ade": "submassive hepatic necrosis", "drug": "barbiturate" } ]

A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.

[ { "ade": "transient tonic pupillary response", "drug": "quinine" }, { "ade": "abnormal visual-evoked potentials", "drug": "quinine" }, { "ade": "denervation supersensitivity", "drug": "quinine" } ]

Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.

[ { "ade": "aplastic anemia", "drug": "lenalidomide" } ]

Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?

[ { "ade": "athelia", "drug": "methimazole" }, { "ade": "Choanal atresia", "drug": "methimazole" }, { "ade": "teratogenicity", "drug": "methimazole" } ]