mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.	[ { "ade": "skin necrosis", "drug": "low-molecular weight heparin" } ]
Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.	[ { "ade": "Cutaneous seeding", "drug": "ethanol injection" } ]
We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.	[ { "ade": "hepatic angiosarcoma", "drug": "cyclophosphamide" } ]
The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.	[ { "ade": "cardiac arrhythmias", "drug": "chloral hydrate" } ]
A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.	[ { "ade": "febrile agranulocytosis", "drug": "ticlopidine" } ]
Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.	[ { "ade": "Extrapyramidal symptoms", "drug": "haloperidol" } ]
Methotrexate-induced diffuse interstitial pulmonary fibrosis.	[ { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "Methotrexate" } ]
We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).	[ { "ade": "GPP", "drug": "Molipaxin" }, { "ade": "generalized pustular psoriasis", "drug": "Molipaxin" }, { "ade": "GPP", "drug": "trazodone hydrochloride" }, { "ade": "generalized pustular psoriasis", "drug": "trazodone hydrochloride" } ]
Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.	[ { "ade": "systemic lupus erythematosus", "drug": "interferon-gamma" } ]
Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.	[ { "ade": "periods of crying", "drug": "risperidone" }, { "ade": "depression", "drug": "risperidone" }, { "ade": "feelings of agitation", "drug": "risperidone" }, { "ade": "insomnia", "drug": "risperidone" }, { "ade": "intolerable affect", "drug": "risperidone" } ]
Inappropriate antidiuretic hormone secretion after high dose vinblastine.	[ { "ade": "Inappropriate antidiuretic hormone secretion", "drug": "vinblastine" } ]
2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.	[ { "ade": "immunodeficiency", "drug": "2-CdA" }, { "ade": "secondary neoplasms", "drug": "2-CdA" } ]
Bowel perforation associated with intraperitoneal chromic phosphate instillation.	[ { "ade": "Bowel perforation", "drug": "chromic phosphate" } ]
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.	[ { "ade": "unilateral gingival hyperplasia", "drug": "phenytoin" } ]
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.	[ { "ade": "increased libido", "drug": "fluvoxamine" } ]
We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.	[ { "ade": "hepatic adenomas", "drug": "danazol" } ]
Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.	[ { "ade": "balanced translocation", "drug": "chlorambucil" } ]
Ampicillin may aggravate clinical and experimental myasthenia gravis.	[ { "ade": "myasthenia gravis", "drug": "Ampicillin" } ]
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.	[ { "ade": "sudden bilateral, sequential visual loss", "drug": "interferon alfa" } ]
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).	[ { "ade": "hepatic dysfunction", "drug": "Pexid" }, { "ade": "hepatic dysfunction", "drug": "perhexiline maleate" }, { "ade": "Papilloedema", "drug": "perhexiline maleate" }, { "ade": "Papilloedema", "drug": "Pexid" } ]
Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.	[ { "ade": "Raynaud's phenomenon", "drug": "bleomycin" }, { "ade": "acral necrosis", "drug": "bleomycin" } ]
Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.	[ { "ade": "HUS", "drug": "gemcitabine" } ]
We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.	[ { "ade": "transient anuria", "drug": "captopril" }, { "ade": "acute renal impairment", "drug": "captopril" } ]
Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.	[ { "ade": "Intracranial haemorrhage", "drug": "aspirin" } ]
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.	[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]
A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.	[ { "ade": "erythroderma", "drug": "phenytoin" }, { "ade": "pinhead-sized facial pustules", "drug": "phenytoin" }, { "ade": "abnormal liver function tests", "drug": "phenytoin" }, { "ade": "phenytoin hypersensitivity syndrome", "drug": "phenytoin" }, { "ade": "tibial and facial oedema", "drug": "phenytoin" }, { "ade": "fever", "drug": "phenytoin" } ]
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.	[ { "ade": "Worsening of neurologic syndrome", "drug": "penicillamine" } ]
An amiodarone optic neuropathy has been described.	[ { "ade": "optic neuropathy", "drug": "amiodarone" } ]
We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.	[ { "ade": "drug-seeking behavior", "drug": "diphenhydramine" }, { "ade": "anticholinergic symptoms", "drug": "diphenhydramine" } ]
An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.	[ { "ade": "acute ischaemic event", "drug": "venlafaxine" } ]
The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.	[ { "ade": "pain", "drug": "GSTM" }, { "ade": "mild nitritoid symptoms", "drug": "gold sodium thiomalate" }, { "ade": "T10-T12 dermatomes", "drug": "gold sodium thiomalate" }, { "ade": "pain", "drug": "gold sodium thiomalate" }, { "ade": "T10-T12 dermatomes", "drug": "GSTM" }, { "ade": "mild nitritoid symptoms", "drug": "GSTM" } ]
Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.	[ { "ade": "Progressive anemia", "drug": "interferon-alpha" }, { "ade": "Progressive anemia", "drug": "interleukin-2" } ]
Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?	[ { "ade": "Subfulminant hepatitis B", "drug": "infliximab" } ]
Cephalosporin-induced leukopenia following rechallenge with cefoxitin.	[ { "ade": "leukopenia", "drug": "Cephalosporin" } ]
We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.	[ { "ade": "fulminant hepatic failure", "drug": "didanosine" } ]
Fulminant hepatic failure associated with bicalutamide.	[ { "ade": "Fulminant hepatic failure", "drug": "bicalutamide" } ]
We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.	[ { "ade": "cytotoxic edema", "drug": "methotrexate" } ]
BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.	[ { "ade": "haemorrhagic side-effects", "drug": "warfarin" } ]
Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.	[ { "ade": "renal tubular acidosis", "drug": "foscarnet" }, { "ade": "nephrogenic diabetes insipidus", "drug": "foscarnet" } ]
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.	[ { "ade": "Stuttering priapism", "drug": "warfarin" } ]
Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.	[ { "ade": "withdrawal syndrome", "drug": "Chlormadinone acetate" } ]
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.	[ { "ade": "lethargy", "drug": "lithium" } ]
She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.	[ { "ade": "died", "drug": "doxorubicin" }, { "ade": "Adriamycin toxicity", "drug": "doxorubicin" }, { "ade": "Adriamycin toxicity", "drug": "Adriamycin" }, { "ade": "died", "drug": "Adriamycin" } ]
Tamoxifen retinopathy.	[ { "ade": "retinopathy", "drug": "Tamoxifen" } ]
In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.	[ { "ade": "serum triglyceride levels increased", "drug": "clozapine" } ]
Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.	[ { "ade": "pseudomembranous colitis", "drug": "clindamycin" } ]
Troglitazone-induced fulminant hepatic failure.	[ { "ade": "fulminant hepatic failure", "drug": "Troglitazone" } ]
It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.	[ { "ade": "VBDS", "drug": "ciprofloxacin" } ]
This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.	[ { "ade": "Schneiderian first-rank symptoms", "drug": "fluvoxamine" } ]
In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.	[ { "ade": "DIAN", "drug": "cefuroxime" } ]
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.	[ { "ade": "arrhythmia", "drug": "disopyramide" }, { "ade": "torsade de pointes", "drug": "amiodarone" }, { "ade": "Atypical ventricular tachycardia", "drug": "amiodarone" }, { "ade": "arrhythmia", "drug": "quinidine" } ]
We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.	[ { "ade": "CLS", "drug": "granulocyte colony-stimulating factor" } ]
OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.	[ { "ade": "squamous metaplasia within endometrial glands", "drug": "progestin" } ]
Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.	[ { "ade": "thrombocytopenia", "drug": "quinine" } ]
OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.	[ { "ade": "aggravation and spreading of a psoriatic plaque", "drug": "imiquimod" } ]
Naproxen-associated sudden sensorineural hearing loss.	[ { "ade": "sudden sensorineural hearing loss", "drug": "Naproxen" } ]
Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.	[ { "ade": "cerebral infarctions", "drug": "Thrombin" } ]
A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.	[ { "ade": "sensori-neural hearing loss", "drug": "vincristine" } ]
RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.	[ { "ade": "fixed drug eruption", "drug": "tadalafil" }, { "ade": "fixed drug eruption", "drug": "Cialis" } ]
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.	[ { "ade": "decrease in serum Na+", "drug": "lorcainide" } ]
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.	[ { "ade": "Intracranial hemorrhage", "drug": "L-asparaginase" }, { "ade": "focal seizures", "drug": "L-asparaginase" } ]
None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.	[ { "ade": "cardiac arrest", "drug": "doxorubicin" } ]
The patient was initially treated with hydration and furosemide but developed congestive heart failure.	[ { "ade": "congestive heart failure", "drug": "furosemide" } ]
We present a case of hypereosinophilia related to zafirlukast therapy.	[ { "ade": "hypereosinophilia", "drug": "zafirlukast" } ]
Phenytoin-induced hypersensitivity reactions.	[ { "ade": "hypersensitivity reactions", "drug": "Phenytoin" } ]
We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.	[ { "ade": "NEH", "drug": "mitoxantrone" }, { "ade": "NEH", "drug": "cytarabine" } ]
Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.	[ { "ade": "Symptomatic hypocalcaemia", "drug": "bisphosphonate" }, { "ade": "renal impairment", "drug": "bisphosphonate" } ]
We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.	[ { "ade": "rupture of a cerebral arterial aneurysm", "drug": "nifedipine" } ]
Epsilon-aminocaproic acid and renal complications: case report and review of the literature.	[ { "ade": "renal complications", "drug": "Epsilon-aminocaproic acid" } ]
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.	[ { "ade": "Acute myocardial ischemia", "drug": "epinephrine" } ]
Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.	[ { "ade": "Toxic epidermal necrolysis", "drug": "5-fluorocytosine" }, { "ade": "Toxic epidermal necrolysis", "drug": "amphotericin B" } ]
Severe symptomatic hyponatremia during sibutramine therapy: a case report.	[ { "ade": "Severe symptomatic hyponatremia", "drug": "sibutramine" } ]
A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.	[ { "ade": "erosion of a psoriatic plaque", "drug": "methotrexate" } ]
We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.	[ { "ade": "endometrial cancer", "drug": "tamoxifen" } ]
Treatment of lithium tremor with metoprolol.	[ { "ade": "tremor", "drug": "lithium" } ]
The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.	[ { "ade": "transient global amnesia", "drug": "clioquinol" }, { "ade": "retrograde amnesia", "drug": "clioquinol" } ]
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.	[ { "ade": "thrombosis", "drug": "Heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "Heparin" }, { "ade": "thrombosis", "drug": "heparin" } ]
One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.	[ { "ade": "neurotoxicity", "drug": "cyclosporin" }, { "ade": "MRI T2 abnormalities", "drug": "cyclosporin" } ]
It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.	[ { "ade": "allergic reaction", "drug": "capecitabine" } ]
Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).	[ { "ade": "Severe diffuse interstitial pneumonitis", "drug": "BCNU" }, { "ade": "Severe diffuse interstitial pneumonitis", "drug": "carmustine" } ]
Case report: acute renal failure after administering intravenous immunoglobulin.	[ { "ade": "acute renal failure", "drug": "immunoglobulin" } ]
Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.	[ { "ade": "severe arterial thrombotic events", "drug": "thrombin" } ]
OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.	[ { "ade": "neurotoxicity", "drug": "INH" }, { "ade": "neurotoxicity", "drug": "isoniazid" } ]
Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.	[ { "ade": "dementia", "drug": "valproic acid" } ]
We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.	[ { "ade": "decline in glomerular filtration rate", "drug": "rofecoxib" } ]
Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.	[ { "ade": "minor dizziness", "drug": "ciprofloxacin" }, { "ade": "mild headache", "drug": "ciprofloxacin" }, { "ade": "seizures", "drug": "ciprofloxacin" }, { "ade": "hallucinations", "drug": "ciprofloxacin" } ]
A case of noncardiogenic pulmonary edema by ethanolamine oleate.	[ { "ade": "noncardiogenic pulmonary edema", "drug": "ethanolamine oleate" } ]
The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.	[ { "ade": "hyperpyrexia", "drug": "lithium" }, { "ade": "hyperpyrexia", "drug": "haloperidol" }, { "ade": "irreversible tardive dyskinesia", "drug": "lithium" }, { "ade": "mutism", "drug": "haloperidol" }, { "ade": "irreversible tardive dyskinesia", "drug": "haloperidol" }, { "ade": "mutism", "drug": "lithium" }, { "ade": "severe rigidity", "drug": "haloperidol" }, { "ade": "severe rigidity", "drug": "lithium" } ]
Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.	[ { "ade": "interstitial pneumonitis", "drug": "sirolimus" } ]
This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.	[ { "ade": "polyuria", "drug": "lithium" } ]
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.	[ { "ade": "lung toxicity", "drug": "bleomycin" } ]
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.	[ { "ade": "multiple myeloma", "drug": "DILANTIN" }, { "ade": "multiple myeloma", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "DILANTIN" } ]
CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.	[ { "ade": "intracerebral hemorrhage", "drug": "pseudoephedrine" } ]
We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.	[ { "ade": "severe aplastic anemia", "drug": "lenalidomide" }, { "ade": "AA", "drug": "lenalidomide" } ]
Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.	[ { "ade": "infectious mononucleosis-like syndrome", "drug": "salazosulfapyridine" } ]
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.	[ { "ade": "Cardiac complications", "drug": "amphotericin B" } ]
Anaphylactic reaction to recombinant insulin-like growth factor-I.	[ { "ade": "Anaphylactic reaction", "drug": "recombinant insulin-like growth factor-I" } ]
Thalidomide neuropathy in childhood.	[ { "ade": "neuropathy", "drug": "Thalidomide" } ]
We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.	[ { "ade": "methemoglobinemia", "drug": "bupivacaine" }, { "ade": "methemoglobinemia", "drug": "lidocaine" } ]
PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.	[ { "ade": "reproductive endocrine disorder", "drug": "valproate" } ]

We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.

[ { "ade": "skin necrosis", "drug": "low-molecular weight heparin" } ]

Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.

[ { "ade": "Cutaneous seeding", "drug": "ethanol injection" } ]

We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.

[ { "ade": "hepatic angiosarcoma", "drug": "cyclophosphamide" } ]

The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.

[ { "ade": "cardiac arrhythmias", "drug": "chloral hydrate" } ]

A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.

[ { "ade": "febrile agranulocytosis", "drug": "ticlopidine" } ]

Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.

[ { "ade": "Extrapyramidal symptoms", "drug": "haloperidol" } ]

Methotrexate-induced diffuse interstitial pulmonary fibrosis.

[ { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "Methotrexate" } ]

We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).

[ { "ade": "GPP", "drug": "Molipaxin" }, { "ade": "generalized pustular psoriasis", "drug": "Molipaxin" }, { "ade": "GPP", "drug": "trazodone hydrochloride" }, { "ade": "generalized pustular psoriasis", "drug": "trazodone hydrochloride" } ]

Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

[ { "ade": "systemic lupus erythematosus", "drug": "interferon-gamma" } ]

Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.

[ { "ade": "periods of crying", "drug": "risperidone" }, { "ade": "depression", "drug": "risperidone" }, { "ade": "feelings of agitation", "drug": "risperidone" }, { "ade": "insomnia", "drug": "risperidone" }, { "ade": "intolerable affect", "drug": "risperidone" } ]

Inappropriate antidiuretic hormone secretion after high dose vinblastine.

[ { "ade": "Inappropriate antidiuretic hormone secretion", "drug": "vinblastine" } ]

2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.

[ { "ade": "immunodeficiency", "drug": "2-CdA" }, { "ade": "secondary neoplasms", "drug": "2-CdA" } ]

Bowel perforation associated with intraperitoneal chromic phosphate instillation.

[ { "ade": "Bowel perforation", "drug": "chromic phosphate" } ]

A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.

[ { "ade": "unilateral gingival hyperplasia", "drug": "phenytoin" } ]

OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.

[ { "ade": "increased libido", "drug": "fluvoxamine" } ]

We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.

[ { "ade": "hepatic adenomas", "drug": "danazol" } ]

Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.

[ { "ade": "balanced translocation", "drug": "chlorambucil" } ]

Ampicillin may aggravate clinical and experimental myasthenia gravis.

[ { "ade": "myasthenia gravis", "drug": "Ampicillin" } ]

PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.

[ { "ade": "sudden bilateral, sequential visual loss", "drug": "interferon alfa" } ]

Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).

[ { "ade": "hepatic dysfunction", "drug": "Pexid" }, { "ade": "hepatic dysfunction", "drug": "perhexiline maleate" }, { "ade": "Papilloedema", "drug": "perhexiline maleate" }, { "ade": "Papilloedema", "drug": "Pexid" } ]

Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.

[ { "ade": "Raynaud's phenomenon", "drug": "bleomycin" }, { "ade": "acral necrosis", "drug": "bleomycin" } ]

Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.

[ { "ade": "HUS", "drug": "gemcitabine" } ]

We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.

[ { "ade": "transient anuria", "drug": "captopril" }, { "ade": "acute renal impairment", "drug": "captopril" } ]

Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.

[ { "ade": "Intracranial haemorrhage", "drug": "aspirin" } ]

CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.

[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]

A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.

[ { "ade": "erythroderma", "drug": "phenytoin" }, { "ade": "pinhead-sized facial pustules", "drug": "phenytoin" }, { "ade": "abnormal liver function tests", "drug": "phenytoin" }, { "ade": "phenytoin hypersensitivity syndrome", "drug": "phenytoin" }, { "ade": "tibial and facial oedema", "drug": "phenytoin" }, { "ade": "fever", "drug": "phenytoin" } ]

Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.

[ { "ade": "Worsening of neurologic syndrome", "drug": "penicillamine" } ]

An amiodarone optic neuropathy has been described.

[ { "ade": "optic neuropathy", "drug": "amiodarone" } ]

We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.

[ { "ade": "drug-seeking behavior", "drug": "diphenhydramine" }, { "ade": "anticholinergic symptoms", "drug": "diphenhydramine" } ]

An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.

[ { "ade": "acute ischaemic event", "drug": "venlafaxine" } ]

The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.

[ { "ade": "pain", "drug": "GSTM" }, { "ade": "mild nitritoid symptoms", "drug": "gold sodium thiomalate" }, { "ade": "T10-T12 dermatomes", "drug": "gold sodium thiomalate" }, { "ade": "pain", "drug": "gold sodium thiomalate" }, { "ade": "T10-T12 dermatomes", "drug": "GSTM" }, { "ade": "mild nitritoid symptoms", "drug": "GSTM" } ]

Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.

[ { "ade": "Progressive anemia", "drug": "interferon-alpha" }, { "ade": "Progressive anemia", "drug": "interleukin-2" } ]

Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?

[ { "ade": "Subfulminant hepatitis B", "drug": "infliximab" } ]

Cephalosporin-induced leukopenia following rechallenge with cefoxitin.

[ { "ade": "leukopenia", "drug": "Cephalosporin" } ]

We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.

[ { "ade": "fulminant hepatic failure", "drug": "didanosine" } ]

Fulminant hepatic failure associated with bicalutamide.

[ { "ade": "Fulminant hepatic failure", "drug": "bicalutamide" } ]

We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.

[ { "ade": "cytotoxic edema", "drug": "methotrexate" } ]

BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.

[ { "ade": "haemorrhagic side-effects", "drug": "warfarin" } ]

Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.

[ { "ade": "renal tubular acidosis", "drug": "foscarnet" }, { "ade": "nephrogenic diabetes insipidus", "drug": "foscarnet" } ]

Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.

[ { "ade": "Stuttering priapism", "drug": "warfarin" } ]

Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.

[ { "ade": "withdrawal syndrome", "drug": "Chlormadinone acetate" } ]

The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.

[ { "ade": "lethargy", "drug": "lithium" } ]

She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.

[ { "ade": "died", "drug": "doxorubicin" }, { "ade": "Adriamycin toxicity", "drug": "doxorubicin" }, { "ade": "Adriamycin toxicity", "drug": "Adriamycin" }, { "ade": "died", "drug": "Adriamycin" } ]

Tamoxifen retinopathy.

[ { "ade": "retinopathy", "drug": "Tamoxifen" } ]

In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.

[ { "ade": "serum triglyceride levels increased", "drug": "clozapine" } ]

Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.

[ { "ade": "pseudomembranous colitis", "drug": "clindamycin" } ]

Troglitazone-induced fulminant hepatic failure.

[ { "ade": "fulminant hepatic failure", "drug": "Troglitazone" } ]

It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.

[ { "ade": "VBDS", "drug": "ciprofloxacin" } ]

This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.

[ { "ade": "Schneiderian first-rank symptoms", "drug": "fluvoxamine" } ]

In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.

[ { "ade": "DIAN", "drug": "cefuroxime" } ]

Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

[ { "ade": "arrhythmia", "drug": "disopyramide" }, { "ade": "torsade de pointes", "drug": "amiodarone" }, { "ade": "Atypical ventricular tachycardia", "drug": "amiodarone" }, { "ade": "arrhythmia", "drug": "quinidine" } ]

We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.

[ { "ade": "CLS", "drug": "granulocyte colony-stimulating factor" } ]

OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.

[ { "ade": "squamous metaplasia within endometrial glands", "drug": "progestin" } ]

Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.

[ { "ade": "thrombocytopenia", "drug": "quinine" } ]

OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.

[ { "ade": "aggravation and spreading of a psoriatic plaque", "drug": "imiquimod" } ]

Naproxen-associated sudden sensorineural hearing loss.

[ { "ade": "sudden sensorineural hearing loss", "drug": "Naproxen" } ]

Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.

[ { "ade": "cerebral infarctions", "drug": "Thrombin" } ]

A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.

[ { "ade": "sensori-neural hearing loss", "drug": "vincristine" } ]

RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.

[ { "ade": "fixed drug eruption", "drug": "tadalafil" }, { "ade": "fixed drug eruption", "drug": "Cialis" } ]

In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.

[ { "ade": "decrease in serum Na+", "drug": "lorcainide" } ]

Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.

[ { "ade": "Intracranial hemorrhage", "drug": "L-asparaginase" }, { "ade": "focal seizures", "drug": "L-asparaginase" } ]

None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.

[ { "ade": "cardiac arrest", "drug": "doxorubicin" } ]

The patient was initially treated with hydration and furosemide but developed congestive heart failure.

[ { "ade": "congestive heart failure", "drug": "furosemide" } ]

We present a case of hypereosinophilia related to zafirlukast therapy.

[ { "ade": "hypereosinophilia", "drug": "zafirlukast" } ]

Phenytoin-induced hypersensitivity reactions.

[ { "ade": "hypersensitivity reactions", "drug": "Phenytoin" } ]

We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.

[ { "ade": "NEH", "drug": "mitoxantrone" }, { "ade": "NEH", "drug": "cytarabine" } ]

Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.

[ { "ade": "Symptomatic hypocalcaemia", "drug": "bisphosphonate" }, { "ade": "renal impairment", "drug": "bisphosphonate" } ]

We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.

[ { "ade": "rupture of a cerebral arterial aneurysm", "drug": "nifedipine" } ]

Epsilon-aminocaproic acid and renal complications: case report and review of the literature.

[ { "ade": "renal complications", "drug": "Epsilon-aminocaproic acid" } ]

Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.

[ { "ade": "Acute myocardial ischemia", "drug": "epinephrine" } ]

Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.

[ { "ade": "Toxic epidermal necrolysis", "drug": "5-fluorocytosine" }, { "ade": "Toxic epidermal necrolysis", "drug": "amphotericin B" } ]

Severe symptomatic hyponatremia during sibutramine therapy: a case report.

[ { "ade": "Severe symptomatic hyponatremia", "drug": "sibutramine" } ]

A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.

[ { "ade": "erosion of a psoriatic plaque", "drug": "methotrexate" } ]

We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.

[ { "ade": "endometrial cancer", "drug": "tamoxifen" } ]

Treatment of lithium tremor with metoprolol.

[ { "ade": "tremor", "drug": "lithium" } ]

The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.

[ { "ade": "transient global amnesia", "drug": "clioquinol" }, { "ade": "retrograde amnesia", "drug": "clioquinol" } ]

Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.

[ { "ade": "thrombosis", "drug": "Heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "Heparin" }, { "ade": "thrombosis", "drug": "heparin" } ]

One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.

[ { "ade": "neurotoxicity", "drug": "cyclosporin" }, { "ade": "MRI T2 abnormalities", "drug": "cyclosporin" } ]

It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.

[ { "ade": "allergic reaction", "drug": "capecitabine" } ]

Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).

[ { "ade": "Severe diffuse interstitial pneumonitis", "drug": "BCNU" }, { "ade": "Severe diffuse interstitial pneumonitis", "drug": "carmustine" } ]

Case report: acute renal failure after administering intravenous immunoglobulin.

[ { "ade": "acute renal failure", "drug": "immunoglobulin" } ]

Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.

[ { "ade": "severe arterial thrombotic events", "drug": "thrombin" } ]

OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.

[ { "ade": "neurotoxicity", "drug": "INH" }, { "ade": "neurotoxicity", "drug": "isoniazid" } ]

Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.

[ { "ade": "dementia", "drug": "valproic acid" } ]

We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.

[ { "ade": "decline in glomerular filtration rate", "drug": "rofecoxib" } ]

Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.

[ { "ade": "minor dizziness", "drug": "ciprofloxacin" }, { "ade": "mild headache", "drug": "ciprofloxacin" }, { "ade": "seizures", "drug": "ciprofloxacin" }, { "ade": "hallucinations", "drug": "ciprofloxacin" } ]

A case of noncardiogenic pulmonary edema by ethanolamine oleate.

[ { "ade": "noncardiogenic pulmonary edema", "drug": "ethanolamine oleate" } ]

The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.

[ { "ade": "hyperpyrexia", "drug": "lithium" }, { "ade": "hyperpyrexia", "drug": "haloperidol" }, { "ade": "irreversible tardive dyskinesia", "drug": "lithium" }, { "ade": "mutism", "drug": "haloperidol" }, { "ade": "irreversible tardive dyskinesia", "drug": "haloperidol" }, { "ade": "mutism", "drug": "lithium" }, { "ade": "severe rigidity", "drug": "haloperidol" }, { "ade": "severe rigidity", "drug": "lithium" } ]

Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.

[ { "ade": "interstitial pneumonitis", "drug": "sirolimus" } ]

This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.

[ { "ade": "polyuria", "drug": "lithium" } ]

This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.

[ { "ade": "lung toxicity", "drug": "bleomycin" } ]

The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.

[ { "ade": "multiple myeloma", "drug": "DILANTIN" }, { "ade": "multiple myeloma", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "DILANTIN" } ]

CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.

[ { "ade": "intracerebral hemorrhage", "drug": "pseudoephedrine" } ]

We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.

[ { "ade": "severe aplastic anemia", "drug": "lenalidomide" }, { "ade": "AA", "drug": "lenalidomide" } ]

Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.

[ { "ade": "infectious mononucleosis-like syndrome", "drug": "salazosulfapyridine" } ]

INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.

[ { "ade": "Cardiac complications", "drug": "amphotericin B" } ]

Anaphylactic reaction to recombinant insulin-like growth factor-I.

[ { "ade": "Anaphylactic reaction", "drug": "recombinant insulin-like growth factor-I" } ]

Thalidomide neuropathy in childhood.

[ { "ade": "neuropathy", "drug": "Thalidomide" } ]

We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.

[ { "ade": "methemoglobinemia", "drug": "bupivacaine" }, { "ade": "methemoglobinemia", "drug": "lidocaine" } ]

PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.

[ { "ade": "reproductive endocrine disorder", "drug": "valproate" } ]