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Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets. | [
{
"ade": "Acute ischaemia of the leg",
"drug": "flunitrazepam"
}
]
|
Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent. | [
{
"ade": "movement disorder",
"drug": "trazodone"
}
]
|
Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas. | [
{
"ade": "HBV reactivations",
"drug": "rituximab"
}
]
|
Human insulin-induced lipoatrophy. | [
{
"ade": "lipoatrophy",
"drug": "Human insulin"
}
]
|
We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine. | [
{
"ade": "angioedema",
"drug": "oxcarbazepine"
}
]
|
During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself. | [
{
"ade": "visual loss",
"drug": "ethambutol"
}
]
|
Pemphigus foliaceus induced by rifampicin. | [
{
"ade": "Pemphigus foliaceus",
"drug": "rifampicin"
}
]
|
Losartan-induced angioedema. | [
{
"ade": "angioedema",
"drug": "Losartan"
}
]
|
We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T. | [
{
"ade": "psychosis",
"drug": "efavirenz"
}
]
|
Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. | [
{
"ade": "Renal failure",
"drug": "methotrexate"
}
]
|
This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients. | [
{
"ade": "Schneiderian first-rank symptoms",
"drug": "fluvoxamine"
}
]
|
CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide. | [
{
"ade": "weight loss",
"drug": "leflunomide"
}
]
|
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies. | [
{
"ade": "weight loss",
"drug": "leflunomide"
}
]
|
Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma. | [
{
"ade": "Diarrhoea",
"drug": "oxaliplatinum"
},
{
"ade": "Diarrhoea",
"drug": "5-fluorouracil"
},
{
"ade": "T-CD4+ lymphopenia",
"drug": "5-fluorouracil"
},
{
"ade": "T-CD4+ lymphopenia",
"drug": "oxaliplatinum"
},
{
"ade": "bilateral patchy pulmonary infiltrates",
"drug": "oxaliplatinum"
},
{
"ade": "bilateral patchy pulmonary infiltrates",
"drug": "5-fluorouracil"
}
]
|
Ischaemic colitis in a patient taking meloxicam. | [
{
"ade": "Ischaemic colitis",
"drug": "meloxicam"
}
]
|
Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX. | [
{
"ade": "subacute neurotoxicity",
"drug": "MTX"
}
]
|
AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin). | [
{
"ade": "skin necrosis",
"drug": "Glypressin"
},
{
"ade": "skin necrosis",
"drug": "terlipressin"
}
]
|
Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred. | [
{
"ade": "gastrointestinal bleeding",
"drug": "tolazoline"
}
]
|
Sotalol-induced bradycardia reversed by glucagon. | [
{
"ade": "bradycardia",
"drug": "Sotalol"
}
]
|
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. | [
{
"ade": "coma",
"drug": "valproic acid"
}
]
|
The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin. | [
{
"ade": "vasculitis",
"drug": "vancomycin"
},
{
"ade": "lupus-like syndrome",
"drug": "vancomycin"
}
]
|
In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy. | [
{
"ade": "immediate erythema",
"drug": "mequitazine"
},
{
"ade": "erythematous macule",
"drug": "mequitazine"
}
]
|
Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone. | [
{
"ade": "acute pancreatitis",
"drug": "amiodarone"
}
]
|
We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months. | [
{
"ade": "hemorrhage",
"drug": "aspirin"
}
]
|
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation. | [
{
"ade": "hyperglycemia",
"drug": "asparaginase"
}
]
|
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described. | [
{
"ade": "nail-changes",
"drug": "penicillamine"
}
]
|
Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis. | [
{
"ade": "C. difficile colitis",
"drug": "cisplatin"
}
]
|
We describe a case of EGE manifested as an allergy to gemfibrozil. | [
{
"ade": "EGE",
"drug": "gemfibrozil"
}
]
|
The gynecomastia regressed when the theophylline was discontinued. | [
{
"ade": "gynecomastia",
"drug": "theophylline"
}
]
|
We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day. | [
{
"ade": "pancytopenia",
"drug": "5-aminosalicylic acid"
},
{
"ade": "pancytopenia",
"drug": "Pentasa"
}
]
|
Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity. | [
{
"ade": "central nervous system toxicity",
"drug": "cytarabine"
},
{
"ade": "central nervous system toxicity",
"drug": "methotrexate"
}
]
|
Renal injury due to anastrozole has not been published in the English literature. | [
{
"ade": "Renal injury",
"drug": "anastrozole"
}
]
|
Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy. | [
{
"ade": "cholangiopathy",
"drug": "itraconazole"
},
{
"ade": "ductopenia",
"drug": "itraconazole"
}
]
|
A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy. | [
{
"ade": "shocks",
"drug": "procainamide"
}
]
|
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%). | [
{
"ade": "fat embolism",
"drug": "Intralipid"
}
]
|
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate. | [
{
"ade": "Hepatitis",
"drug": "methotrexate"
},
{
"ade": "bridging fibrosis",
"drug": "methotrexate"
},
{
"ade": "reversible hepatic insufficiency",
"drug": "methotrexate"
}
]
|
We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia. | [
{
"ade": "DRESS syndrome",
"drug": "chlorambucil"
}
]
|
Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide. | [
{
"ade": "Acute intravascular hemolysis",
"drug": "glyburide"
},
{
"ade": "Acute intravascular hemolysis",
"drug": "chlorpropamide"
}
]
|
A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day). | [
{
"ade": "raised creatine phosphokinase",
"drug": "propylthiouracil"
},
{
"ade": "severe proximal muscle weakness",
"drug": "propylthiouracil"
},
{
"ade": "hyperthyroidism",
"drug": "propylthiouracil"
}
]
|
Anaphylactic reaction to oral prednisone: a case report and review of the literature. | [
{
"ade": "Anaphylactic reaction",
"drug": "prednisone"
}
]
|
MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate. | [
{
"ade": "MI",
"drug": "PCCs"
}
]
|
Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia. | [
{
"ade": "hyperammonemia",
"drug": "valproic acid"
}
]
|
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment. | [
{
"ade": "Masculinization of a female fetus",
"drug": "norethisterone"
},
{
"ade": "clitoral hypertrophy",
"drug": "norethisterone"
}
]
|
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. | [
{
"ade": "Diffuse alveolar hemorrhage",
"drug": "leflunomide"
}
]
|
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity. | [
{
"ade": "sub-acute neurotoxicity",
"drug": "methotrexate"
}
]
|
The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen. | [
{
"ade": "abnormal rhythm",
"drug": "propranolol"
}
]
|
There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication. | [
{
"ade": "hyperglycemia",
"drug": "olanzapine"
}
]
|
Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test. | [
{
"ade": "Acute generalized exanthematous pustulosis",
"drug": "morphine"
}
]
|
This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine. | [
{
"ade": "hemophagocytic syndrome",
"drug": "sulfasalazine"
}
]
|
This is the second report of lactic acidosis in a patient on stavudine and lamivudine. | [
{
"ade": "lactic acidosis",
"drug": "stavudine"
},
{
"ade": "lactic acidosis",
"drug": "lamivudine"
}
]
|
Localized dyskeratotic plaque with milia associated with sorafenib. | [
{
"ade": "milia",
"drug": "sorafenib"
},
{
"ade": "Localized dyskeratotic plaque",
"drug": "sorafenib"
}
]
|
Atypical neuroleptic malignant syndrome associated with olanzapine. | [
{
"ade": "neuroleptic malignant syndrome",
"drug": "olanzapine"
}
]
|
A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis. | [
{
"ade": "fatal massive pulmonary embolus",
"drug": "streptokinase"
}
]
|
Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline. | [
{
"ade": "Pleuropulmonary changes",
"drug": "cabergoline"
}
]
|
We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman. | [
{
"ade": "arterial thrombosis",
"drug": "thrombin"
}
]
|
Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review. | [
{
"ade": "angioneurotic edema",
"drug": "oxcarbazepine"
}
]
|
Generalized lichen nitidus with involvement of the palms following interferon alpha treatment. | [
{
"ade": "Generalized lichen nitidus",
"drug": "interferon alpha"
}
]
|
One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant. | [
{
"ade": "lower average mean blood pressure",
"drug": "propranolol"
},
{
"ade": "lower average heart rate",
"drug": "propranolol"
}
]
|
Tegaserod-associated ischemic colitis. | [
{
"ade": "ischemic colitis",
"drug": "Tegaserod"
}
]
|
Large cerebral infarction during praziquantel therapy in neurocysticercosis. | [
{
"ade": "Large cerebral infarction",
"drug": "praziquantel"
}
]
|
It is concluded that SIADH is an important side effect of lorcainide therapy. | [
{
"ade": "SIADH",
"drug": "lorcainide"
}
]
|
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity. | [
{
"ade": "neurotoxicity",
"drug": "5-FU"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-FU"
},
{
"ade": "neurotoxicity",
"drug": "5-fluorouracil"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-fluorouracil"
}
]
|
Cardiopulmonary arrest following intravenous phenytoin loading. | [
{
"ade": "Cardiopulmonary arrest",
"drug": "phenytoin"
}
]
|
A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand. | [
{
"ade": "Creutzfeldt-Jakob disease",
"drug": "human growth hormone"
}
]
|
Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms. | [
{
"ade": "nephrotoxicity syndrome",
"drug": "mannitol"
}
]
|
Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome. | [
{
"ade": "death",
"drug": "quinidine"
},
{
"ade": "apnea",
"drug": "quinidine"
},
{
"ade": "bradycardia",
"drug": "verapamil"
},
{
"ade": "sudden death",
"drug": "verapamil"
},
{
"ade": "atrial flutter",
"drug": "verapamil"
},
{
"ade": "long QT interval syndrome",
"drug": "quinidine"
},
{
"ade": "apnea",
"drug": "verapamil"
},
{
"ade": "hypotension",
"drug": "verapamil"
}
]
|
A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment. | [
{
"ade": "systemic lupus erythematosus",
"drug": "carbamazepine"
},
{
"ade": "SLE",
"drug": "carbamazepine"
}
]
|
When co-trimoxazole was stopped the red cell aplasia resolved. | [
{
"ade": "red cell aplasia",
"drug": "co-trimoxazole"
}
]
|
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment. | [
{
"ade": "multiple skin cancers",
"drug": "hydroxyurea"
},
{
"ade": "longitudinal melanonychia",
"drug": "hydroxyurea"
}
]
|
We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess. | [
{
"ade": "reversible deafness",
"drug": "metronidazole"
},
{
"ade": "tinnitus",
"drug": "metronidazole"
},
{
"ade": "ataxia",
"drug": "metronidazole"
},
{
"ade": "liver abscess",
"drug": "metronidazole"
},
{
"ade": "splenic abscess",
"drug": "metronidazole"
}
]
|
A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine. | [
{
"ade": "myoclonic jerks",
"drug": "quetiapine"
}
]
|
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction. | [
{
"ade": "early chronic cardiomyopathy",
"drug": "anthracycline"
}
]
|
Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops. | [
{
"ade": "bilateral granulomatous anterior uveitis",
"drug": "metripranolol"
}
]
|
Acute pancreatitis associated with danazol treatment for endometriosis. | [
{
"ade": "Acute pancreatitis",
"drug": "danazol"
}
]
|
After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication. | [
{
"ade": "Carbamazepine intoxication",
"drug": "Dantrolene"
},
{
"ade": "Carbamazepine intoxication",
"drug": "Carbamazepine"
},
{
"ade": "Carbamazepine intoxication",
"drug": "Oxybutynin"
}
]
|
We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. | [
{
"ade": "hypersensitivity syndrome",
"drug": "dapsone"
}
]
|
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis. | [
{
"ade": "Insulin-dependent diabetes mellitus",
"drug": "danazol"
}
]
|
Gentamicin-associated acute renal failure. | [
{
"ade": "acute renal failure",
"drug": "Gentamicin"
}
]
|
A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis. | [
{
"ade": "methotrexate toxicity",
"drug": "methotrexate"
},
{
"ade": "macrophage activation syndrome",
"drug": "methotrexate"
}
]
|
METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine. | [
{
"ade": "haematological adverse effects",
"drug": "quetiapine"
}
]
|
This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS. | [
{
"ade": "renal toxicity",
"drug": "interferons"
}
]
|
In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness. | [
{
"ade": "exacerbation in myasthenic weakness",
"drug": "verapamil"
}
]
|
CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion. | [
{
"ade": "myoclonic muscle spasms",
"drug": "dobutamine"
}
]
|
Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency. | [
{
"ade": "pantothenic acid deficiency",
"drug": "calcium hopantenate"
},
{
"ade": "Reye-like syndrome",
"drug": "calcium hopantenate"
}
]
|
When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance. | [
{
"ade": "worsening of the dysesthesia",
"drug": "5-aminosalicylic acid"
},
{
"ade": "weakness",
"drug": "5-ASA"
},
{
"ade": "atrophy",
"drug": "5-ASA"
},
{
"ade": "weakness",
"drug": "5-aminosalicylic acid"
},
{
"ade": "gait disturbance",
"drug": "5-ASA"
},
{
"ade": "gait disturbance",
"drug": "5-aminosalicylic acid"
},
{
"ade": "worsening of the dysesthesia",
"drug": "5-ASA"
},
{
"ade": "atrophy",
"drug": "5-aminosalicylic acid"
}
]
|
Sulfadiazine crystalluria revisited. | [
{
"ade": "crystalluria",
"drug": "Sulfadiazine"
}
]
|
Catatonia associated with disulfiram therapy. | [
{
"ade": "Catatonia",
"drug": "disulfiram"
}
]
|
Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment. | [
{
"ade": "Telescoped digits of the hands and feet",
"drug": "allopurinol"
}
]
|
Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction. | [
{
"ade": "angioedema",
"drug": "aspirin"
},
{
"ade": "systemic anaphylactoid reaction",
"drug": "aspirin"
},
{
"ade": "urticaria",
"drug": "aspirin"
}
]
|
However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again. | [
{
"ade": "bilateral breast enlargement",
"drug": "sunitinib"
}
]
|
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. | [
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
]
|
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients. | [
{
"ade": "cholelithiasis",
"drug": "cyclosporin"
}
]
|
Delayed hypersensitivity to flurbiprofen. | [
{
"ade": "Delayed hypersensitivity",
"drug": "flurbiprofen"
}
]
|
An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment. | [
{
"ade": "menstrual cycle disturbances",
"drug": "valproate"
}
]
|
Mesalamine-induced hypersensitivity pneumonitis. | [
{
"ade": "hypersensitivity pneumonitis",
"drug": "Mesalamine"
}
]
|
Acute myocardial necrosis during administration of amsacrine. | [
{
"ade": "Acute myocardial necrosis",
"drug": "amsacrine"
}
]
|
CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin. | [
{
"ade": "severe myelopathy",
"drug": "doxorubicin"
}
]
|
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate. | [
{
"ade": "Growth and adrenal suppression",
"drug": "fluticasone propionate"
}
]
|
A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements. | [
{
"ade": "dyskinetic movements",
"drug": "risperidone"
}
]
|
Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations. | [
{
"ade": "acute exacerbations",
"drug": "ampicillin"
}
]
|
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