mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
In all the patients, pellagra symptoms appeared during isoniazid therapy.	[ { "ade": "pellagra", "drug": "isoniazid" } ]
Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.	[ { "ade": "gangrene of the extremities", "drug": "ergot" }, { "ade": "arteriospasm", "drug": "ergot" } ]
Neurotoxicity of intrathecal administration of amphotericin B.	[ { "ade": "Neurotoxicity", "drug": "amphotericin B" } ]
The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.	[ { "ade": "multifocal leukoencephalopathy", "drug": "capecitabine" } ]
The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.	[ { "ade": "irritant type of reaction", "drug": "calcipotriol" } ]
To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.	[ { "ade": "cataract", "drug": "Propecia" } ]
Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.	[ { "ade": "Optic neuropathy", "drug": "D-penicillamine" } ]
Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.	[ { "ade": "neoplastic seeding", "drug": "ethanol" } ]
This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.	[ { "ade": "toxic epidermal necrolysis", "drug": "ofloxacin" } ]
The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.	[ { "ade": "hyponatremia", "drug": "caffeine" }, { "ade": "delirium", "drug": "caffeine" }, { "ade": "rhabdomyolysis", "drug": "caffeine" } ]
Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.	[ { "ade": "hypogammaglobulinemia", "drug": "gold" } ]
Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.	[ { "ade": "Esophageal candidiasis", "drug": "omeprazole" } ]
We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.	[ { "ade": "pericarditis", "drug": "mesalazine" } ]
We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.	[ { "ade": "CDI", "drug": "lithium" } ]
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.	[ { "ade": "calcium phosphate nephrolithiasis", "drug": "acetazolamide" } ]
Introduction of etanercept was also clinically effective but followed by development of severe heart failure.	[ { "ade": "severe heart failure", "drug": "etanercept" } ]
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.	[ { "ade": "bronchospasm", "drug": "propranolol" } ]
Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.	[ { "ade": "cardiotoxicity", "drug": "diphenhydramine" } ]
Acute interstitial nephritis due to pantoprazole.	[ { "ade": "Acute interstitial nephritis", "drug": "pantoprazole" } ]
BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.	[ { "ade": "teratogenic", "drug": "Accutane" } ]
CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.	[ { "ade": "increased serum thyroid-stimulating hormone", "drug": "levothyroxine" } ]
DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.	[ { "ade": "severe psychosis", "drug": "ciprofloxacin" } ]
Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.	[ { "ade": "hyperpigmentation", "drug": "bleomycin" } ]
Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.	[ { "ade": "Decreased plasma cortisol level", "drug": "alprazolam" } ]
These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.	[ { "ade": "production of granulocyte and neutrophil autoantibodies", "drug": "infliximab" }, { "ade": "autoimmune agranulocytosis", "drug": "infliximab" } ]
In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.	[ { "ade": "aortic wall in this case was damaged", "drug": "Bleomycin" } ]
Renal failure associated with acetazolamide therapy for glaucoma.	[ { "ade": "Renal failure", "drug": "acetazolamide" } ]
The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.	[ { "ade": "fatigue", "drug": "sunitinib" }, { "ade": "hypertension", "drug": "sunitinib" } ]
A syndrome of increased affect in response to risperidone among patients with schizophrenia.	[ { "ade": "syndrome of increased affect", "drug": "risperidone" } ]
On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.	[ { "ade": "edema", "drug": "magnesium sulfate" }, { "ade": "edema", "drug": "terbutaline" }, { "ade": "edema", "drug": "nifedipine" }, { "ade": "edema", "drug": "betamethasone" } ]
Poorly controlled hypertension in a painter with chronic lead toxicity.	[ { "ade": "lead toxicity", "drug": "lead" } ]
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.	[ { "ade": "prolonged QT", "drug": "methadone" } ]
Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).	[ { "ade": "gastroenteritis", "drug": "leflunomide" }, { "ade": "abdominal sepsis", "drug": "leflunomide" }, { "ade": "infection", "drug": "leflunomide" }, { "ade": "lower respiratory tract infections", "drug": "leflunomide" }, { "ade": "cellulitis", "drug": "leflunomide" }, { "ade": "mycotic aneurysm", "drug": "leflunomide" }, { "ade": "disseminated herpes zoster", "drug": "leflunomide" }, { "ade": "TB liver", "drug": "leflunomide" } ]
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.	[ { "ade": "radiation recall reactions", "drug": "gemcitabine" } ]
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.	[ { "ade": "synovitis", "drug": "All-trans retinoic acid" }, { "ade": "mononeuritis", "drug": "All-trans retinoic acid" }, { "ade": "focal myositis", "drug": "All-trans retinoic acid" } ]
Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.	[ { "ade": "Skin necrosis", "drug": "vasopressin" } ]
Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.	[ { "ade": "angle-closure glaucoma", "drug": "topiramate" }, { "ade": "angle-closure glaucoma", "drug": "methylprednisolone" }, { "ade": "angle-closure glaucoma", "drug": "mannitol" } ]
Clozapine-induced akathisia in children with schizophrenia.	[ { "ade": "akathisia", "drug": "Clozapine" } ]
In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.	[ { "ade": "acute megaloblastic anaemia", "drug": "methotrexate" }, { "ade": "pneumonitis", "drug": "methotrexate" } ]
Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.	[ { "ade": "Transient anuria", "drug": "SQ 14225" } ]
CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.	[ { "ade": "headaches", "drug": "capecitabine" }, { "ade": "headaches", "drug": "5-FU" } ]
Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.	[ { "ade": "Anterior spinal artery syndrome", "drug": "phenol" } ]
We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.	[ { "ade": "acute oliguric renal failure", "drug": "PI" } ]
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.	[ { "ade": "Myoglobinuria", "drug": "vasopressin" }, { "ade": "acute renal failure", "drug": "vasopressin" } ]
A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.	[ { "ade": "acute respiratory failure", "drug": "adalimumab" } ]
A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.	[ { "ade": "optic neuropathy", "drug": "ethambutol" }, { "ade": "ocular toxicity", "drug": "isoniazid" } ]
a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.	[ { "ade": "Creutzfeldt-Jakob like syndrome", "drug": "lithium carbonate" } ]
CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.	[ { "ade": "CBS", "drug": "Avastin" }, { "ade": "Charles-Bonnet syndrome", "drug": "Avastin" } ]
In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.	[ { "ade": "intense burn", "drug": "8-methoxypsoralen" } ]
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.	[ { "ade": "polymorphic ventricular tachycardia", "drug": "Levofloxacin" } ]
Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.	[ { "ade": "Minor electrocardiographical changes", "drug": "ouabain" } ]
CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.	[ { "ade": "serotonin syndrome", "drug": "fentanyl" } ]
Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.	[ { "ade": "Lupus-like syndrome", "drug": "5-aminosalicylic acid" } ]
After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.	[ { "ade": "high blood lead level", "drug": "lead" } ]
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.	[ { "ade": "myelotoxicity", "drug": "chloramphenicol" }, { "ade": "dyserythropoietic anaemia", "drug": "linezolid" } ]
OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.	[ { "ade": "diffuse papular eruption", "drug": "methotrexate" } ]
Nephrotic syndrome associated with lithium therapy.	[ { "ade": "Nephrotic syndrome", "drug": "lithium" } ]
Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.	[ { "ade": "magnesium toxicosis", "drug": "magnesium" }, { "ade": "magnesium toxicosis", "drug": "magnesium sulfate" } ]
We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.	[ { "ade": "hypoglycemia", "drug": "doxycycline" } ]
The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.	[ { "ade": "electrophysiologic effect", "drug": "procainamide" } ]
Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.	[ { "ade": "swelling of the face and legs", "drug": "phenytoin" }, { "ade": "pruritus", "drug": "phenytoin" } ]
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).	[ { "ade": "unilateral gingival hyperplasia", "drug": "phenytoin" }, { "ade": "unilateral gingival hyperplasia", "drug": "PHT" } ]
PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.	[ { "ade": "bilateral optic neuritis", "drug": "interferon alpha" } ]
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.	[ { "ade": "acute renal failure", "drug": "acyclovir" } ]
Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.	[ { "ade": "Rhabdomyolysis", "drug": "clozapine" } ]
We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.	[ { "ade": "hiccups", "drug": "aripiprazole" } ]
Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.	[ { "ade": "Hypertension", "drug": "prednisone" }, { "ade": "Hypertension", "drug": "cyclosporine" } ]
The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.	[ { "ade": "oral lesions of PV", "drug": "glibenclamide" } ]
Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.	[ { "ade": "lupus syndrome", "drug": "sulfasalazine" } ]
Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.	[ { "ade": "pneumonitis", "drug": "amiodarone" } ]
However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.	[ { "ade": "vitreous hemorrhage", "drug": "tPA" } ]
A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.	[ { "ade": "generalized erythema", "drug": "trimethoprim" }, { "ade": "generalized erythema", "drug": "sulfamethoxazole" } ]
Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.	[ { "ade": "fever", "drug": "diltiazem" } ]
Fulminant hepatitis associated with disulfiram.	[ { "ade": "Fulminant hepatitis", "drug": "disulfiram" } ]
This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.	[ { "ade": "agranulocytosis", "drug": "methazolamide" }, { "ade": "aplastic anemia", "drug": "methazolamide" } ]
Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.	[ { "ade": "refractory seizures", "drug": "INH" } ]
We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.	[ { "ade": "mild parkinsonian signs", "drug": "olanzapine" }, { "ade": "camptocormia", "drug": "olanzapine" } ]
A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.	[ { "ade": "malignant neuroleptic syndrome", "drug": "haloperidol" } ]
CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.	[ { "ade": "protamine allergy", "drug": "insulin" } ]
We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.	[ { "ade": "acute weakness", "drug": "colchicine" }, { "ade": "acute weakness", "drug": "simvastatin" }, { "ade": "mild chronic renal insufficiency", "drug": "simvastatin" } ]
Hypercalcemia in an AIDS patient treated with growth hormone.	[ { "ade": "Hypercalcemia", "drug": "growth hormone" } ]
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.	[ { "ade": "Sagittal sinus thrombosis", "drug": "L-asparaginase" }, { "ade": "transient free protein S deficiency", "drug": "L-asparaginase" } ]
Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.	[ { "ade": "ulcerative colitis", "drug": "Sulfasalazine" }, { "ade": "ulcerative colitis", "drug": "sulfasalazine" }, { "ade": "lung disorder", "drug": "Sulfasalazine" } ]
When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.	[ { "ade": "intense anxiety", "drug": "lithium" }, { "ade": "neurotoxicity", "drug": "lithium" }, { "ade": "psychotic symptoms", "drug": "lithium" } ]
It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.	[ { "ade": "fatal stroke", "drug": "ergotamine" }, { "ade": "arterial spasm", "drug": "ergotamine" } ]
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.	[ { "ade": "severe restrictive ventilatory defect", "drug": "cyclophosphamide" } ]
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.	[ { "ade": "interstitial nephritis", "drug": "indinavir" }, { "ade": "nephrolithiasis", "drug": "indinavir" } ]
Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.	[ { "ade": "CD", "drug": "etanercept" } ]
The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.	[ { "ade": "nodular sclerosing Hodgkin's lymphoma", "drug": "infliximab" } ]
The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.	[ { "ade": "phenytoin toxicity", "drug": "phenytoin" } ]
Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.	[ { "ade": "Polyarthritis", "drug": "rifampicin" }, { "ade": "Polyarthritis", "drug": "ethambutol" }, { "ade": "anti-native DNA antibodies", "drug": "ethambutol" }, { "ade": "hepatitis", "drug": "ethambutol" }, { "ade": "hepatitis", "drug": "rifampicin" }, { "ade": "anti-native DNA antibodies", "drug": "rifampicin" } ]
Bradycardia and congestive heart failure associated with ocular timolol maleate.	[ { "ade": "congestive heart failure", "drug": "timolol maleate" }, { "ade": "Bradycardia", "drug": "timolol maleate" } ]
Both patients suddenly became hypotensive after injection of chymopapain into a disk.	[ { "ade": "hypotensive", "drug": "chymopapain" } ]
A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.	[ { "ade": "toxic hepatitis", "drug": "methotrexate" }, { "ade": "toxic hepatitis", "drug": "etretinate" } ]
Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.	[ { "ade": "Scleromyxedema", "drug": "interferon beta-1a" } ]
Dose-dependent olanzapine-associated leukopenia: three case reports.	[ { "ade": "leukopenia", "drug": "olanzapine" } ]
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.	[ { "ade": "severe hypersensitivity", "drug": "carboplatin" } ]
A case of acute cardiomyopathy and pericarditis associated with methylphenidate.	[ { "ade": "pericarditis", "drug": "methylphenidate" }, { "ade": "acute cardiomyopathy", "drug": "methylphenidate" } ]
We report three cases of amiodarone-induced torsades de pointe.	[ { "ade": "torsades de pointe", "drug": "amiodarone" } ]

In all the patients, pellagra symptoms appeared during isoniazid therapy.

[ { "ade": "pellagra", "drug": "isoniazid" } ]

Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.

[ { "ade": "gangrene of the extremities", "drug": "ergot" }, { "ade": "arteriospasm", "drug": "ergot" } ]

Neurotoxicity of intrathecal administration of amphotericin B.

[ { "ade": "Neurotoxicity", "drug": "amphotericin B" } ]

The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.

[ { "ade": "multifocal leukoencephalopathy", "drug": "capecitabine" } ]

The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.

[ { "ade": "irritant type of reaction", "drug": "calcipotriol" } ]

To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.

[ { "ade": "cataract", "drug": "Propecia" } ]

Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.

[ { "ade": "Optic neuropathy", "drug": "D-penicillamine" } ]

Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.

[ { "ade": "neoplastic seeding", "drug": "ethanol" } ]

This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.

[ { "ade": "toxic epidermal necrolysis", "drug": "ofloxacin" } ]

The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.

[ { "ade": "hyponatremia", "drug": "caffeine" }, { "ade": "delirium", "drug": "caffeine" }, { "ade": "rhabdomyolysis", "drug": "caffeine" } ]

Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.

[ { "ade": "hypogammaglobulinemia", "drug": "gold" } ]

Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.

[ { "ade": "Esophageal candidiasis", "drug": "omeprazole" } ]

We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.

[ { "ade": "pericarditis", "drug": "mesalazine" } ]

We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.

[ { "ade": "CDI", "drug": "lithium" } ]

This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.

[ { "ade": "calcium phosphate nephrolithiasis", "drug": "acetazolamide" } ]

Introduction of etanercept was also clinically effective but followed by development of severe heart failure.

[ { "ade": "severe heart failure", "drug": "etanercept" } ]

Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.

[ { "ade": "bronchospasm", "drug": "propranolol" } ]

Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.

[ { "ade": "cardiotoxicity", "drug": "diphenhydramine" } ]

Acute interstitial nephritis due to pantoprazole.

[ { "ade": "Acute interstitial nephritis", "drug": "pantoprazole" } ]

BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.

[ { "ade": "teratogenic", "drug": "Accutane" } ]

CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.

[ { "ade": "increased serum thyroid-stimulating hormone", "drug": "levothyroxine" } ]

DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.

[ { "ade": "severe psychosis", "drug": "ciprofloxacin" } ]

Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.

[ { "ade": "hyperpigmentation", "drug": "bleomycin" } ]

Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.

[ { "ade": "Decreased plasma cortisol level", "drug": "alprazolam" } ]

These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.

[ { "ade": "production of granulocyte and neutrophil autoantibodies", "drug": "infliximab" }, { "ade": "autoimmune agranulocytosis", "drug": "infliximab" } ]

In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.

[ { "ade": "aortic wall in this case was damaged", "drug": "Bleomycin" } ]

Renal failure associated with acetazolamide therapy for glaucoma.

[ { "ade": "Renal failure", "drug": "acetazolamide" } ]

The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.

[ { "ade": "fatigue", "drug": "sunitinib" }, { "ade": "hypertension", "drug": "sunitinib" } ]

A syndrome of increased affect in response to risperidone among patients with schizophrenia.

[ { "ade": "syndrome of increased affect", "drug": "risperidone" } ]

On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.

[ { "ade": "edema", "drug": "magnesium sulfate" }, { "ade": "edema", "drug": "terbutaline" }, { "ade": "edema", "drug": "nifedipine" }, { "ade": "edema", "drug": "betamethasone" } ]

Poorly controlled hypertension in a painter with chronic lead toxicity.

[ { "ade": "lead toxicity", "drug": "lead" } ]

We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.

[ { "ade": "prolonged QT", "drug": "methadone" } ]

Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).

[ { "ade": "gastroenteritis", "drug": "leflunomide" }, { "ade": "abdominal sepsis", "drug": "leflunomide" }, { "ade": "infection", "drug": "leflunomide" }, { "ade": "lower respiratory tract infections", "drug": "leflunomide" }, { "ade": "cellulitis", "drug": "leflunomide" }, { "ade": "mycotic aneurysm", "drug": "leflunomide" }, { "ade": "disseminated herpes zoster", "drug": "leflunomide" }, { "ade": "TB liver", "drug": "leflunomide" } ]

The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.

[ { "ade": "radiation recall reactions", "drug": "gemcitabine" } ]

All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.

[ { "ade": "synovitis", "drug": "All-trans retinoic acid" }, { "ade": "mononeuritis", "drug": "All-trans retinoic acid" }, { "ade": "focal myositis", "drug": "All-trans retinoic acid" } ]

Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.

[ { "ade": "Skin necrosis", "drug": "vasopressin" } ]

Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.

[ { "ade": "angle-closure glaucoma", "drug": "topiramate" }, { "ade": "angle-closure glaucoma", "drug": "methylprednisolone" }, { "ade": "angle-closure glaucoma", "drug": "mannitol" } ]

Clozapine-induced akathisia in children with schizophrenia.

[ { "ade": "akathisia", "drug": "Clozapine" } ]

In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.

[ { "ade": "acute megaloblastic anaemia", "drug": "methotrexate" }, { "ade": "pneumonitis", "drug": "methotrexate" } ]

Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.

[ { "ade": "Transient anuria", "drug": "SQ 14225" } ]

CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.

[ { "ade": "headaches", "drug": "capecitabine" }, { "ade": "headaches", "drug": "5-FU" } ]

Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.

[ { "ade": "Anterior spinal artery syndrome", "drug": "phenol" } ]

We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.

[ { "ade": "acute oliguric renal failure", "drug": "PI" } ]

Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.

[ { "ade": "Myoglobinuria", "drug": "vasopressin" }, { "ade": "acute renal failure", "drug": "vasopressin" } ]

A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.

[ { "ade": "acute respiratory failure", "drug": "adalimumab" } ]

A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.

[ { "ade": "optic neuropathy", "drug": "ethambutol" }, { "ade": "ocular toxicity", "drug": "isoniazid" } ]

a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.

[ { "ade": "Creutzfeldt-Jakob like syndrome", "drug": "lithium carbonate" } ]

CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.

[ { "ade": "CBS", "drug": "Avastin" }, { "ade": "Charles-Bonnet syndrome", "drug": "Avastin" } ]

In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.

[ { "ade": "intense burn", "drug": "8-methoxypsoralen" } ]

Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.

[ { "ade": "polymorphic ventricular tachycardia", "drug": "Levofloxacin" } ]

Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.

[ { "ade": "Minor electrocardiographical changes", "drug": "ouabain" } ]

CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.

[ { "ade": "serotonin syndrome", "drug": "fentanyl" } ]

Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.

[ { "ade": "Lupus-like syndrome", "drug": "5-aminosalicylic acid" } ]

After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.

[ { "ade": "high blood lead level", "drug": "lead" } ]

We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.

[ { "ade": "myelotoxicity", "drug": "chloramphenicol" }, { "ade": "dyserythropoietic anaemia", "drug": "linezolid" } ]

OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.

[ { "ade": "diffuse papular eruption", "drug": "methotrexate" } ]

Nephrotic syndrome associated with lithium therapy.

[ { "ade": "Nephrotic syndrome", "drug": "lithium" } ]

Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.

[ { "ade": "magnesium toxicosis", "drug": "magnesium" }, { "ade": "magnesium toxicosis", "drug": "magnesium sulfate" } ]

We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.

[ { "ade": "hypoglycemia", "drug": "doxycycline" } ]

The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.

[ { "ade": "electrophysiologic effect", "drug": "procainamide" } ]

Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.

[ { "ade": "swelling of the face and legs", "drug": "phenytoin" }, { "ade": "pruritus", "drug": "phenytoin" } ]

INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).

[ { "ade": "unilateral gingival hyperplasia", "drug": "phenytoin" }, { "ade": "unilateral gingival hyperplasia", "drug": "PHT" } ]

PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.

[ { "ade": "bilateral optic neuritis", "drug": "interferon alpha" } ]

A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.

[ { "ade": "acute renal failure", "drug": "acyclovir" } ]

Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.

[ { "ade": "Rhabdomyolysis", "drug": "clozapine" } ]

We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.

[ { "ade": "hiccups", "drug": "aripiprazole" } ]

Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.

[ { "ade": "Hypertension", "drug": "prednisone" }, { "ade": "Hypertension", "drug": "cyclosporine" } ]

The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.

[ { "ade": "oral lesions of PV", "drug": "glibenclamide" } ]

Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.

[ { "ade": "lupus syndrome", "drug": "sulfasalazine" } ]

Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.

[ { "ade": "pneumonitis", "drug": "amiodarone" } ]

However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.

[ { "ade": "vitreous hemorrhage", "drug": "tPA" } ]

A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.

[ { "ade": "generalized erythema", "drug": "trimethoprim" }, { "ade": "generalized erythema", "drug": "sulfamethoxazole" } ]

Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.

[ { "ade": "fever", "drug": "diltiazem" } ]

Fulminant hepatitis associated with disulfiram.

[ { "ade": "Fulminant hepatitis", "drug": "disulfiram" } ]

This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.

[ { "ade": "agranulocytosis", "drug": "methazolamide" }, { "ade": "aplastic anemia", "drug": "methazolamide" } ]

Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.

[ { "ade": "refractory seizures", "drug": "INH" } ]

We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.

[ { "ade": "mild parkinsonian signs", "drug": "olanzapine" }, { "ade": "camptocormia", "drug": "olanzapine" } ]

A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.

[ { "ade": "malignant neuroleptic syndrome", "drug": "haloperidol" } ]

CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.

[ { "ade": "protamine allergy", "drug": "insulin" } ]

We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.

[ { "ade": "acute weakness", "drug": "colchicine" }, { "ade": "acute weakness", "drug": "simvastatin" }, { "ade": "mild chronic renal insufficiency", "drug": "simvastatin" } ]

Hypercalcemia in an AIDS patient treated with growth hormone.

[ { "ade": "Hypercalcemia", "drug": "growth hormone" } ]

Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.

[ { "ade": "Sagittal sinus thrombosis", "drug": "L-asparaginase" }, { "ade": "transient free protein S deficiency", "drug": "L-asparaginase" } ]

Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.

[ { "ade": "ulcerative colitis", "drug": "Sulfasalazine" }, { "ade": "ulcerative colitis", "drug": "sulfasalazine" }, { "ade": "lung disorder", "drug": "Sulfasalazine" } ]

When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.

[ { "ade": "intense anxiety", "drug": "lithium" }, { "ade": "neurotoxicity", "drug": "lithium" }, { "ade": "psychotic symptoms", "drug": "lithium" } ]

It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.

[ { "ade": "fatal stroke", "drug": "ergotamine" }, { "ade": "arterial spasm", "drug": "ergotamine" } ]

The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.

[ { "ade": "severe restrictive ventilatory defect", "drug": "cyclophosphamide" } ]

The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.

[ { "ade": "interstitial nephritis", "drug": "indinavir" }, { "ade": "nephrolithiasis", "drug": "indinavir" } ]

Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.

[ { "ade": "CD", "drug": "etanercept" } ]

The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.

[ { "ade": "nodular sclerosing Hodgkin's lymphoma", "drug": "infliximab" } ]

The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.

[ { "ade": "phenytoin toxicity", "drug": "phenytoin" } ]

Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.

[ { "ade": "Polyarthritis", "drug": "rifampicin" }, { "ade": "Polyarthritis", "drug": "ethambutol" }, { "ade": "anti-native DNA antibodies", "drug": "ethambutol" }, { "ade": "hepatitis", "drug": "ethambutol" }, { "ade": "hepatitis", "drug": "rifampicin" }, { "ade": "anti-native DNA antibodies", "drug": "rifampicin" } ]

Bradycardia and congestive heart failure associated with ocular timolol maleate.

[ { "ade": "congestive heart failure", "drug": "timolol maleate" }, { "ade": "Bradycardia", "drug": "timolol maleate" } ]

Both patients suddenly became hypotensive after injection of chymopapain into a disk.

[ { "ade": "hypotensive", "drug": "chymopapain" } ]

A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.

[ { "ade": "toxic hepatitis", "drug": "methotrexate" }, { "ade": "toxic hepatitis", "drug": "etretinate" } ]

Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.

[ { "ade": "Scleromyxedema", "drug": "interferon beta-1a" } ]

Dose-dependent olanzapine-associated leukopenia: three case reports.

[ { "ade": "leukopenia", "drug": "olanzapine" } ]

Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.

[ { "ade": "severe hypersensitivity", "drug": "carboplatin" } ]

A case of acute cardiomyopathy and pericarditis associated with methylphenidate.

[ { "ade": "pericarditis", "drug": "methylphenidate" }, { "ade": "acute cardiomyopathy", "drug": "methylphenidate" } ]

We report three cases of amiodarone-induced torsades de pointe.

[ { "ade": "torsades de pointe", "drug": "amiodarone" } ]