mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.	[ { "ade": "meningitis", "drug": "ibuprofen" } ]
How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.	[ { "ade": "mucocutaneous reactions", "drug": "gold" } ]
Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.	[ { "ade": "prolonged hypoglycemia", "drug": "octreotide" } ]
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.	[ { "ade": "grand mal seizure", "drug": "propranolol" }, { "ade": "photosensitivity", "drug": "propranolol" }, { "ade": "delirium", "drug": "propranolol" } ]
Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.	[ { "ade": "severe visual loss", "drug": "vincristine" } ]
The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.	[ { "ade": "bile stasis", "drug": "methimazole" }, { "ade": "cholestasis", "drug": "methimazole" }, { "ade": "fatty liver parenchyma degeneration", "drug": "methimazole" }, { "ade": "leucopenia", "drug": "methimazole" }, { "ade": "granulocytic portal infiltration", "drug": "methimazole" } ]
This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.	[ { "ade": "hepatic decompensation", "drug": "MTX" } ]
After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.	[ { "ade": "neurological manifestations", "drug": "interferon alpha" } ]
A review of the literature showed no previous description of this pattern in benzodiazepine coma.	[ { "ade": "coma", "drug": "benzodiazepine" } ]
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.	[ { "ade": "Thrombo-embolic complication", "drug": "streptokinase" } ]
In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.	[ { "ade": "QT interval was prolonged", "drug": "halofantrine" } ]
We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.	[ { "ade": "SJS", "drug": "prednisolone" } ]
This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.	[ { "ade": "catatonic syndrome", "drug": "disulfiram" } ]
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.	[ { "ade": "retinal toxicity", "drug": "hydroxychloroquine" } ]
Allergic and irritant contact dermatitis to calcipotriol.	[ { "ade": "irritant contact dermatitis", "drug": "calcipotriol" } ]
Delusional parasitosis associated with phenelzine.	[ { "ade": "Delusional parasitosis", "drug": "phenelzine" } ]
Methotrexate-induced papular eruption following treatment of psoriasis.	[ { "ade": "papular eruption", "drug": "Methotrexate" } ]
Acute renal failure in a patient receiving treatment with suramin.	[ { "ade": "Acute renal failure", "drug": "suramin" } ]
There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.	[ { "ade": "decrease in both lumbar spine", "drug": "anastrozole" }, { "ade": "increase in the incidence of all bone fractures", "drug": "anastrozole" }, { "ade": "increase in the cholesterol level", "drug": "anastrozole" }, { "ade": "joint disorders", "drug": "anastrozole" } ]
Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.	[ { "ade": "autoimmune disorders", "drug": "IFN-beta" } ]
Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.	[ { "ade": "colitis", "drug": "cisplatin" } ]
Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.	[ { "ade": "Carbamazepine toxicity", "drug": "clarithromycin" }, { "ade": "Carbamazepine toxicity", "drug": "Carbamazepine" } ]
CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.	[ { "ade": "Optic neuritis", "drug": "interferon alpha" }, { "ade": "neurological signs", "drug": "interferon alpha" } ]
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.	[ { "ade": "anaphylaxis", "drug": "cisplatin" } ]
However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.	[ { "ade": "liver failure", "drug": "MTX" }, { "ade": "death", "drug": "MTX" } ]
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.	[ { "ade": "Progressive interstitial fibrosis", "drug": "methotrexate" } ]
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.	[ { "ade": "hepatitis", "drug": "pegvisomant" }, { "ade": "hepatitis", "drug": "octreotide" } ]
When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.	[ { "ade": "DAT became positive with anti-IgG and anti-C3d antiglobulins", "drug": "fludarabine" } ]
Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.	[ { "ade": "Reversible posterior leukoencephalopathy syndrome", "drug": "cyclosporine" } ]
CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.	[ { "ade": "neurologic symptoms", "drug": "vancomycin" } ]
We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.	[ { "ade": "ejaculation without orgasm", "drug": "desipramine" }, { "ade": "anhedonic ejaculation", "drug": "desipramine" } ]
Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.	[ { "ade": "pulmonary toxicity", "drug": "Gemcitabine" } ]
We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.	[ { "ade": "supravenous hyperpigmentation", "drug": "CHOP" } ]
Severe vancomycin-induced anaphylactic reaction.	[ { "ade": "anaphylactic reaction", "drug": "vancomycin" } ]
METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.	[ { "ade": "HUS", "drug": "gemcitabine" } ]
Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.	[ { "ade": "progressive paraparesis", "drug": "methotrexate" } ]
DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.	[ { "ade": "C. difficile toxin in stool", "drug": "clindamycin" }, { "ade": "diarrhea", "drug": "clindamycin" } ]
Biomicroscopy revealed amiodarone corneal deposits.	[ { "ade": "corneal deposits", "drug": "amiodarone" } ]
Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.	[ { "ade": "hyperglycemia", "drug": "insulin" } ]
This eruption appears to be a distinct cutaneous toxicity of PLD.	[ { "ade": "eruption", "drug": "PLD" } ]
Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.	[ { "ade": "Nephrotic syndrome", "drug": "interferon-beta-1b" } ]
When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.	[ { "ade": "thrombosis", "drug": "heparin" } ]
Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.	[ { "ade": "superinfection", "drug": "DCF" }, { "ade": "immunosuppression", "drug": "DCF" } ]
This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.	[ { "ade": "seizure exacerbation", "drug": "valproic acid" }, { "ade": "seizure exacerbation", "drug": "paradoxical" } ]
We report a case of RTA secondary to FK506 administration in liver transplantation.	[ { "ade": "RTA", "drug": "FK506" } ]
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.	[ { "ade": "ventricular tachycardia", "drug": "bretylium" } ]
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.	[ { "ade": "multiple myeloma", "drug": "diphenylhydantoin" }, { "ade": "Monoclonal gammopathy", "drug": "diphenylhydantoin" } ]
Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.	[ { "ade": "temporary amnesia", "drug": "propranolol" }, { "ade": "disorientation", "drug": "propranolol" } ]
Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.	[ { "ade": "eosinophilia-myalgia syndrome", "drug": "L-tryptophan" } ]
We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.	[ { "ade": "vomiting", "drug": "voglibose" }, { "ade": "nausea", "drug": "voglibose" }, { "ade": "intolerable dizziness", "drug": "voglibose" } ]
Bleomycin pneumonitis potentiated by oxygen administration.	[ { "ade": "pneumonitis", "drug": "Bleomycin" } ]
Acute renal failure should be recognized as a potential complication of suramin treatment.	[ { "ade": "renal failure", "drug": "suramin" } ]
Radiation recall related to gemcitabine has been reported in lung and breast cancer.	[ { "ade": "Radiation recall", "drug": "gemcitabine" } ]
Ciprofloxacin-induced renal insufficiency in cystic fibrosis.	[ { "ade": "renal insufficiency", "drug": "Ciprofloxacin" } ]
CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.	[ { "ade": "insomnia", "drug": "grepafloxacin" }, { "ade": "headache", "drug": "sparfloxacin" }, { "ade": "insomnia", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "grepafloxacin" }, { "ade": "insomnia", "drug": "sparfloxacin" }, { "ade": "headache", "drug": "grepafloxacin" }, { "ade": "dizziness", "drug": "gatifloxacin" }, { "ade": "headache", "drug": "gatifloxacin" }, { "ade": "insomnia", "drug": "trovafloxacin" }, { "ade": "headache", "drug": "levofloxacin" }, { "ade": "headache", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "sparfloxacin" }, { "ade": "headache", "drug": "trovafloxacin" }, { "ade": "dizziness", "drug": "trovafloxacin" }, { "ade": "insomnia", "drug": "levofloxacin" }, { "ade": "dizziness", "drug": "levofloxacin" }, { "ade": "insomnia", "drug": "gatifloxacin" } ]
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.	[ { "ade": "myocardial ischemia", "drug": "BCNU" } ]
Scleritis complicating zoledronic acid infusion.	[ { "ade": "Scleritis", "drug": "zoledronic acid" } ]
After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.	[ { "ade": "general malaise", "drug": "pantoprazole" } ]
We report here a rare case of pleuropericarditis due to methotrexate.	[ { "ade": "pleuropericarditis", "drug": "methotrexate" } ]
Alprazolam-induced mania: two clinical cases.	[ { "ade": "mania", "drug": "Alprazolam" } ]
Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.	[ { "ade": "Agranulocytosis", "drug": "vancomycin" } ]
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).	[ { "ade": "TEN", "drug": "cytosine arabinoside" }, { "ade": "TEN", "drug": "ARA-C" }, { "ade": "toxic epidermal necrolysis", "drug": "ARA-C" }, { "ade": "toxic epidermal necrolysis", "drug": "cytosine arabinoside" } ]
Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.	[ { "ade": "acute pancreatitis", "drug": "tigecycline" } ]
Liver transplantation for fulminant hepatitis related to nevirapine therapy.	[ { "ade": "fulminant hepatitis", "drug": "nevirapine" } ]
The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.	[ { "ade": "UI", "drug": "venlafaxine" }, { "ade": "urinary incontinence", "drug": "venlafaxine" } ]
We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.	[ { "ade": "Nocardia Asteroides brain abscess", "drug": "cyclosporine" }, { "ade": "Nocardia Asteroides brain abscess", "drug": "prednisone" } ]
A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.	[ { "ade": "disabling neurotoxicity", "drug": "paclitaxel" } ]
CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.	[ { "ade": "papular eruption", "drug": "methotrexate" } ]
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.	[ { "ade": "tremulous", "drug": "clozapine" }, { "ade": "shivering", "drug": "clozapine" }, { "ade": "shivering", "drug": "clomipramine" }, { "ade": "tremulous", "drug": "clomipramine" }, { "ade": "agitated", "drug": "clozapine" }, { "ade": "behaving oddly", "drug": "clozapine" }, { "ade": "behaving oddly", "drug": "clomipramine" }, { "ade": "confused", "drug": "clomipramine" }, { "ade": "sweating profusely", "drug": "clozapine" }, { "ade": "sweating profusely", "drug": "clomipramine" }, { "ade": "agitated", "drug": "clomipramine" }, { "ade": "confused", "drug": "clozapine" } ]
Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.	[ { "ade": "LPD", "drug": "MTX" } ]
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.	[ { "ade": "Pigmentary disorders", "drug": "minocycline" } ]
Primary CNS lymphoma regressed on withdrawal of MM.	[ { "ade": "CNS lymphoma", "drug": "MM" } ]
We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.	[ { "ade": "anaphylactic/anaphylactoid reaction", "drug": "methotrexate" } ]
The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.	[ { "ade": "liver damage", "drug": "methimazole" } ]
The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.	[ { "ade": "hypersensitivity myocarditis", "drug": "clozapine" } ]
We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.	[ { "ade": "neurotoxicity", "drug": "acyclovir" } ]
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.	[ { "ade": "visual field defects", "drug": "triamcinolone" }, { "ade": "severe vision loss", "drug": "triamcinolone" } ]
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.	[ { "ade": "proximal muscle weakness", "drug": "colchicine" } ]
This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.	[ { "ade": "localized purpura", "drug": "lamotrigine" } ]
Paradoxical seizures in phenytoin toxicity.	[ { "ade": "seizures", "drug": "phenytoin" } ]
Torsade de pointes during loading with amiodarone.	[ { "ade": "Torsade de pointes", "drug": "amiodarone" } ]
Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.	[ { "ade": "impaired tissue perfusion", "drug": "vasopressin" }, { "ade": "vasodilation", "drug": "vasopressin" } ]
A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.	[ { "ade": "tardive dyskinesia", "drug": "deanol" } ]
Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.	[ { "ade": "Mycobacterium marinum infection", "drug": "infliximab" } ]
Severe hepatocellular dysfunction following cyproterone acetate therapy.	[ { "ade": "Severe hepatocellular dysfunction", "drug": "cyproterone acetate" } ]
Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.	[ { "ade": "palmar-plantar erythrodysaesthesia", "drug": "cytarabine" } ]
Cholestyramine induced hyperchloremic metabolic acidosis.	[ { "ade": "hyperchloremic metabolic acidosis", "drug": "Cholestyramine" } ]
We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.	[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]
Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.	[ { "ade": "tubular and interstitial lesions", "drug": "rifampin" } ]
In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).	[ { "ade": "gestational diabetes", "drug": "norethisterone" } ]
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.	[ { "ade": "poor night vision", "drug": "isotretinoin" }, { "ade": "excessive glare sensitivity", "drug": "isotretinoin" } ]
As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.	[ { "ade": "acute hemorrhagic gastritis", "drug": "AZ" }, { "ade": "AZ intoxication", "drug": "AZ" } ]
We report a case of sustained hypotension after administration of parenteral verapamil.	[ { "ade": "sustained hypotension", "drug": "verapamil" } ]
Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.	[ { "ade": "acute renal failure", "drug": "acetazolamide" } ]
He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.	[ { "ade": "fever", "drug": "Pentasa" }, { "ade": "nausea", "drug": "Pentasa" }, { "ade": "diarrhea", "drug": "Pentasa" }, { "ade": "malaise", "drug": "Pentasa" } ]
To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.	[ { "ade": "thrombocytopenia", "drug": "lansoprazole" } ]
These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.	[ { "ade": "RS", "drug": "aspirin" } ]
Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.	[ { "ade": "parkinsonism", "drug": "Metoclopramide" } ]
BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.	[ { "ade": "retinal hemorrhages", "drug": "Interferon" }, { "ade": "cotton wool spots", "drug": "Interferon" }, { "ade": "cotton wool spots", "drug": "IFN" }, { "ade": "retinopathy", "drug": "Interferon" }, { "ade": "retinal hemorrhages", "drug": "IFN" }, { "ade": "retinopathy", "drug": "IFN" } ]
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.	[ { "ade": "interstitial pneumopathy", "drug": "amiodarone" } ]

We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.

[ { "ade": "meningitis", "drug": "ibuprofen" } ]

How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.

[ { "ade": "mucocutaneous reactions", "drug": "gold" } ]

Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.

[ { "ade": "prolonged hypoglycemia", "drug": "octreotide" } ]

The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.

[ { "ade": "grand mal seizure", "drug": "propranolol" }, { "ade": "photosensitivity", "drug": "propranolol" }, { "ade": "delirium", "drug": "propranolol" } ]

Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.

[ { "ade": "severe visual loss", "drug": "vincristine" } ]

The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.

[ { "ade": "bile stasis", "drug": "methimazole" }, { "ade": "cholestasis", "drug": "methimazole" }, { "ade": "fatty liver parenchyma degeneration", "drug": "methimazole" }, { "ade": "leucopenia", "drug": "methimazole" }, { "ade": "granulocytic portal infiltration", "drug": "methimazole" } ]

This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.

[ { "ade": "hepatic decompensation", "drug": "MTX" } ]

After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.

[ { "ade": "neurological manifestations", "drug": "interferon alpha" } ]

A review of the literature showed no previous description of this pattern in benzodiazepine coma.

[ { "ade": "coma", "drug": "benzodiazepine" } ]

Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.

[ { "ade": "Thrombo-embolic complication", "drug": "streptokinase" } ]

In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.

[ { "ade": "QT interval was prolonged", "drug": "halofantrine" } ]

We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.

[ { "ade": "SJS", "drug": "prednisolone" } ]

This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.

[ { "ade": "catatonic syndrome", "drug": "disulfiram" } ]

Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.

[ { "ade": "retinal toxicity", "drug": "hydroxychloroquine" } ]

Allergic and irritant contact dermatitis to calcipotriol.

[ { "ade": "irritant contact dermatitis", "drug": "calcipotriol" } ]

Delusional parasitosis associated with phenelzine.

[ { "ade": "Delusional parasitosis", "drug": "phenelzine" } ]

Methotrexate-induced papular eruption following treatment of psoriasis.

[ { "ade": "papular eruption", "drug": "Methotrexate" } ]

Acute renal failure in a patient receiving treatment with suramin.

[ { "ade": "Acute renal failure", "drug": "suramin" } ]

There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.

[ { "ade": "decrease in both lumbar spine", "drug": "anastrozole" }, { "ade": "increase in the incidence of all bone fractures", "drug": "anastrozole" }, { "ade": "increase in the cholesterol level", "drug": "anastrozole" }, { "ade": "joint disorders", "drug": "anastrozole" } ]

Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.

[ { "ade": "autoimmune disorders", "drug": "IFN-beta" } ]

Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.

[ { "ade": "colitis", "drug": "cisplatin" } ]

Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.

[ { "ade": "Carbamazepine toxicity", "drug": "clarithromycin" }, { "ade": "Carbamazepine toxicity", "drug": "Carbamazepine" } ]

CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.

[ { "ade": "Optic neuritis", "drug": "interferon alpha" }, { "ade": "neurological signs", "drug": "interferon alpha" } ]

After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.

[ { "ade": "anaphylaxis", "drug": "cisplatin" } ]

However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.

[ { "ade": "liver failure", "drug": "MTX" }, { "ade": "death", "drug": "MTX" } ]

Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.

[ { "ade": "Progressive interstitial fibrosis", "drug": "methotrexate" } ]

Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.

[ { "ade": "hepatitis", "drug": "pegvisomant" }, { "ade": "hepatitis", "drug": "octreotide" } ]

When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.

[ { "ade": "DAT became positive with anti-IgG and anti-C3d antiglobulins", "drug": "fludarabine" } ]

Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.

[ { "ade": "Reversible posterior leukoencephalopathy syndrome", "drug": "cyclosporine" } ]

CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.

[ { "ade": "neurologic symptoms", "drug": "vancomycin" } ]

We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.

[ { "ade": "ejaculation without orgasm", "drug": "desipramine" }, { "ade": "anhedonic ejaculation", "drug": "desipramine" } ]

Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.

[ { "ade": "pulmonary toxicity", "drug": "Gemcitabine" } ]

We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.

[ { "ade": "supravenous hyperpigmentation", "drug": "CHOP" } ]

Severe vancomycin-induced anaphylactic reaction.

[ { "ade": "anaphylactic reaction", "drug": "vancomycin" } ]

METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.

[ { "ade": "HUS", "drug": "gemcitabine" } ]

Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.

[ { "ade": "progressive paraparesis", "drug": "methotrexate" } ]

DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.

[ { "ade": "C. difficile toxin in stool", "drug": "clindamycin" }, { "ade": "diarrhea", "drug": "clindamycin" } ]

Biomicroscopy revealed amiodarone corneal deposits.

[ { "ade": "corneal deposits", "drug": "amiodarone" } ]

Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.

[ { "ade": "hyperglycemia", "drug": "insulin" } ]

This eruption appears to be a distinct cutaneous toxicity of PLD.

[ { "ade": "eruption", "drug": "PLD" } ]

Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.

[ { "ade": "Nephrotic syndrome", "drug": "interferon-beta-1b" } ]

When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.

[ { "ade": "thrombosis", "drug": "heparin" } ]

Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.

[ { "ade": "superinfection", "drug": "DCF" }, { "ade": "immunosuppression", "drug": "DCF" } ]

This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.

[ { "ade": "seizure exacerbation", "drug": "valproic acid" }, { "ade": "seizure exacerbation", "drug": "paradoxical" } ]

We report a case of RTA secondary to FK506 administration in liver transplantation.

[ { "ade": "RTA", "drug": "FK506" } ]

In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.

[ { "ade": "ventricular tachycardia", "drug": "bretylium" } ]

Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.

[ { "ade": "multiple myeloma", "drug": "diphenylhydantoin" }, { "ade": "Monoclonal gammopathy", "drug": "diphenylhydantoin" } ]

Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.

[ { "ade": "temporary amnesia", "drug": "propranolol" }, { "ade": "disorientation", "drug": "propranolol" } ]

Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.

[ { "ade": "eosinophilia-myalgia syndrome", "drug": "L-tryptophan" } ]

We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.

[ { "ade": "vomiting", "drug": "voglibose" }, { "ade": "nausea", "drug": "voglibose" }, { "ade": "intolerable dizziness", "drug": "voglibose" } ]

Bleomycin pneumonitis potentiated by oxygen administration.

[ { "ade": "pneumonitis", "drug": "Bleomycin" } ]

Acute renal failure should be recognized as a potential complication of suramin treatment.

[ { "ade": "renal failure", "drug": "suramin" } ]

Radiation recall related to gemcitabine has been reported in lung and breast cancer.

[ { "ade": "Radiation recall", "drug": "gemcitabine" } ]

Ciprofloxacin-induced renal insufficiency in cystic fibrosis.

[ { "ade": "renal insufficiency", "drug": "Ciprofloxacin" } ]

CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.

[ { "ade": "insomnia", "drug": "grepafloxacin" }, { "ade": "headache", "drug": "sparfloxacin" }, { "ade": "insomnia", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "grepafloxacin" }, { "ade": "insomnia", "drug": "sparfloxacin" }, { "ade": "headache", "drug": "grepafloxacin" }, { "ade": "dizziness", "drug": "gatifloxacin" }, { "ade": "headache", "drug": "gatifloxacin" }, { "ade": "insomnia", "drug": "trovafloxacin" }, { "ade": "headache", "drug": "levofloxacin" }, { "ade": "headache", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "moxifloxacin" }, { "ade": "dizziness", "drug": "sparfloxacin" }, { "ade": "headache", "drug": "trovafloxacin" }, { "ade": "dizziness", "drug": "trovafloxacin" }, { "ade": "insomnia", "drug": "levofloxacin" }, { "ade": "dizziness", "drug": "levofloxacin" }, { "ade": "insomnia", "drug": "gatifloxacin" } ]

Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.

[ { "ade": "myocardial ischemia", "drug": "BCNU" } ]

Scleritis complicating zoledronic acid infusion.

[ { "ade": "Scleritis", "drug": "zoledronic acid" } ]

After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.

[ { "ade": "general malaise", "drug": "pantoprazole" } ]

We report here a rare case of pleuropericarditis due to methotrexate.

[ { "ade": "pleuropericarditis", "drug": "methotrexate" } ]

Alprazolam-induced mania: two clinical cases.

[ { "ade": "mania", "drug": "Alprazolam" } ]

Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.

[ { "ade": "Agranulocytosis", "drug": "vancomycin" } ]

We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).

[ { "ade": "TEN", "drug": "cytosine arabinoside" }, { "ade": "TEN", "drug": "ARA-C" }, { "ade": "toxic epidermal necrolysis", "drug": "ARA-C" }, { "ade": "toxic epidermal necrolysis", "drug": "cytosine arabinoside" } ]

Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.

[ { "ade": "acute pancreatitis", "drug": "tigecycline" } ]

Liver transplantation for fulminant hepatitis related to nevirapine therapy.

[ { "ade": "fulminant hepatitis", "drug": "nevirapine" } ]

The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.

[ { "ade": "UI", "drug": "venlafaxine" }, { "ade": "urinary incontinence", "drug": "venlafaxine" } ]

We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.

[ { "ade": "Nocardia Asteroides brain abscess", "drug": "cyclosporine" }, { "ade": "Nocardia Asteroides brain abscess", "drug": "prednisone" } ]

A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.

[ { "ade": "disabling neurotoxicity", "drug": "paclitaxel" } ]

CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.

[ { "ade": "papular eruption", "drug": "methotrexate" } ]

The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.

[ { "ade": "tremulous", "drug": "clozapine" }, { "ade": "shivering", "drug": "clozapine" }, { "ade": "shivering", "drug": "clomipramine" }, { "ade": "tremulous", "drug": "clomipramine" }, { "ade": "agitated", "drug": "clozapine" }, { "ade": "behaving oddly", "drug": "clozapine" }, { "ade": "behaving oddly", "drug": "clomipramine" }, { "ade": "confused", "drug": "clomipramine" }, { "ade": "sweating profusely", "drug": "clozapine" }, { "ade": "sweating profusely", "drug": "clomipramine" }, { "ade": "agitated", "drug": "clomipramine" }, { "ade": "confused", "drug": "clozapine" } ]

Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.

[ { "ade": "LPD", "drug": "MTX" } ]

Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.

[ { "ade": "Pigmentary disorders", "drug": "minocycline" } ]

Primary CNS lymphoma regressed on withdrawal of MM.

[ { "ade": "CNS lymphoma", "drug": "MM" } ]

We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.

[ { "ade": "anaphylactic/anaphylactoid reaction", "drug": "methotrexate" } ]

The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.

[ { "ade": "liver damage", "drug": "methimazole" } ]

The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.

[ { "ade": "hypersensitivity myocarditis", "drug": "clozapine" } ]

We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.

[ { "ade": "neurotoxicity", "drug": "acyclovir" } ]

RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.

[ { "ade": "visual field defects", "drug": "triamcinolone" }, { "ade": "severe vision loss", "drug": "triamcinolone" } ]

A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.

[ { "ade": "proximal muscle weakness", "drug": "colchicine" } ]

This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.

[ { "ade": "localized purpura", "drug": "lamotrigine" } ]

Paradoxical seizures in phenytoin toxicity.

[ { "ade": "seizures", "drug": "phenytoin" } ]

Torsade de pointes during loading with amiodarone.

[ { "ade": "Torsade de pointes", "drug": "amiodarone" } ]

Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.

[ { "ade": "impaired tissue perfusion", "drug": "vasopressin" }, { "ade": "vasodilation", "drug": "vasopressin" } ]

A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.

[ { "ade": "tardive dyskinesia", "drug": "deanol" } ]

Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.

[ { "ade": "Mycobacterium marinum infection", "drug": "infliximab" } ]

Severe hepatocellular dysfunction following cyproterone acetate therapy.

[ { "ade": "Severe hepatocellular dysfunction", "drug": "cyproterone acetate" } ]

Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.

[ { "ade": "palmar-plantar erythrodysaesthesia", "drug": "cytarabine" } ]

Cholestyramine induced hyperchloremic metabolic acidosis.

[ { "ade": "hyperchloremic metabolic acidosis", "drug": "Cholestyramine" } ]

We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.

[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]

Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.

[ { "ade": "tubular and interstitial lesions", "drug": "rifampin" } ]

In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).

[ { "ade": "gestational diabetes", "drug": "norethisterone" } ]

Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.

[ { "ade": "poor night vision", "drug": "isotretinoin" }, { "ade": "excessive glare sensitivity", "drug": "isotretinoin" } ]

As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.

[ { "ade": "acute hemorrhagic gastritis", "drug": "AZ" }, { "ade": "AZ intoxication", "drug": "AZ" } ]

We report a case of sustained hypotension after administration of parenteral verapamil.

[ { "ade": "sustained hypotension", "drug": "verapamil" } ]

Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.

[ { "ade": "acute renal failure", "drug": "acetazolamide" } ]

He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.

[ { "ade": "fever", "drug": "Pentasa" }, { "ade": "nausea", "drug": "Pentasa" }, { "ade": "diarrhea", "drug": "Pentasa" }, { "ade": "malaise", "drug": "Pentasa" } ]

To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.

[ { "ade": "thrombocytopenia", "drug": "lansoprazole" } ]

These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.

[ { "ade": "RS", "drug": "aspirin" } ]

Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.

[ { "ade": "parkinsonism", "drug": "Metoclopramide" } ]

BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.

[ { "ade": "retinal hemorrhages", "drug": "Interferon" }, { "ade": "cotton wool spots", "drug": "Interferon" }, { "ade": "cotton wool spots", "drug": "IFN" }, { "ade": "retinopathy", "drug": "Interferon" }, { "ade": "retinal hemorrhages", "drug": "IFN" }, { "ade": "retinopathy", "drug": "IFN" } ]

In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.

[ { "ade": "interstitial pneumopathy", "drug": "amiodarone" } ]