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In all cases, response to corticosteroids was unsatisfactory and three of these patients ultimately died from complications that ensued from prolonged immunosuppressive therapy.
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METHODS: The number of reports received, age and sex of the reporters, characteristics of the most frequently reported drugs and characteristics of the ADRs (most frequently reported ADRs, seriousness, outcome) in a 3-year period (April 2004-April 2007) were compared between patient reports and reports from healthcare professionals.
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Inflammatory mononuclear cells and granulocytes typically seen in patients with diffuse lamellar keratitis (DLK) were absent.
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With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.
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The patient considered C&C caused him less discomfort and disruption.
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Late onset subgaleal hemorrhage infection with Streptococcus pneumoniae?
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The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.
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Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation-- successful treatment with high-dose methylprednisolone and defibrotide.
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Current trends toward intensive insulin therapy for rapid near-normalization of blood glucose levels will increase the recognition of this entity.
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A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.
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Case report: role of granulocyte colony stimulating factor in radiotherapy.
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No adverse effects of joint toxicity were detected.
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For this reason, olanzapine was considered strongly associated with this patient's apparent NMS episode.
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The patient underwent treatment with corticosteroids, and after 2 months, the clinical examination revealed an improved clinical situation with a disappearance of the hypoesthesia but with a persistence of the pain.
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Interstrain differences in the development of pyometra after estrogen treatment of rats.
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Administration of hydrocortisone reversed the mental status changes seen in this patient.
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The authors describe a 6-year-old boy who developed pulmonary tuberculosis during intensive chemotherapy for acute myeloblastic leukemia (AML).
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Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 mg/day) than in normal age matched children.
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Further studies should be encouraged to evaluate the usefulness of CITB for other patients with severe and otherwise untreatable tardive dystonia.
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PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.
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Mitomycin C is a powerful antineoplastic agent.
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Further histologic documentation in other cases is necessary to strengthen our current findings.
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Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome.
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When the therapy was discontinued, the frequency and amplitude of the myoclonus increased, and synchronous and weak myoclonus also was observed in the left abdomen.
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Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.
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No side effects were observed and improvement was sustained during a mean of 7 months (range 3-12 months) follow up.
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Thirteen bacteremias and 25 nonbacteremic infections caused by Pseudomonas spp. occurred in 22 of 236 children with human immunodeficiency virus infection with a rate of infection of 0.098 (bacteremia, 0.030) per patient year.
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Essential thrombocythemia (ET) is an uncommon myeloproliferative disorder, which is thought to develop from a multipotent stem cell.
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Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.
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The occurrence of this reaction in a mother and daughter on ingestion of tuna fish is reported.
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Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.
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The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.
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18 perfusions were performed on 15 patients with stage II disease, that is with tumor growth restricted to an extremity including possible regional node metastases.
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Met-Hgb should be suspected in patients with cyanosis that does not respond to administration of oxygen and who have a discrepancy in oxygen saturation measured by pulse oximetry compared with the arterial partial pressure of oxygen (PaO2) determined by blood gas analysis.
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PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.
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Intrauterine contraceptive device-associated pelvic actinomycosis caused by Actinomyces urogenitalis.
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The first patient, who received gemcitabine for treatment of a carcinoma of the pancreas, required hemodialysis for 6 months.
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A transdermal scopolamine patch is an effective medication for relieving motion sickness, treating nausea and vomiting from chemotherapy and decreasing withdrawal side-effects from wearing off opioids.
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After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.
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These findings mean that the effect of the MP pulse therapy on renal function depends on the clinical state of the patient and that renal deterioration after the pulse therapy may be more marked in patients who are more nephrotic and more impaired in renal function and suggest that increasing sodium and water retention during an MP therapy and the associated renal interstitial edema, proposed as one of the mechanisms of acute renal failure occurring in patients with minimal-change nephrotic syndrome, may be responsible for the MP-induced transient renal failure.
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Stage 4 diffuse lamellar keratitis after laser in situ keratomileusis Clinical, topographical, and pachymetry resolution 5 years later.
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Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.
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We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.
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We conclude that after an accidental overdose in this patient, body TCA disappearance was strongly prolonged due to a very slow (absorption) half-life of the drug in comparison to a therapeutic dose.
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This toxic effect was attributed to lomustine and was not seen in patients treated with carmustine alone.
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Chloroquine-induced bilateral ptosis.
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Heparin therapy, adjusted according to the patient's clinical status and the results of coagulation studies, rapidly controlled the manifestations of DIC.
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BACKGROUND: Because of its unique mechanism of action and safety profile, imiquimod, a topical immune response modifier, is used for many benign and malignant dermatologic conditions.
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In this study, we report the development of severe autologous GVHD in five patients who underwent HPCT for multiple myeloma.
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Abnormal retinal function associated with isotretinoin therapy for acne.
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Nitric oxide, a potent smooth muscle relaxant, has been shown to be involved in the initiation and maintenance of erections; future research involving specific inhibitors of this chemical is indicated for the possible treatment of intraoperative penile erections.
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'Spontaneous' hypertensive episodes with monoamine oxidase inhibitors.
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We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.
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Fulminant hepatic failure associated with bicalutamide.
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She received chemotherapy according to the previously described modified St.
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A trial of combination chemotherapy using mitoxantrone-cyclophosphamide was started in 1983.
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Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.
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A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.
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The patient recovered completely following withdrawal of antacids and sucralfate and short-term treatment with phosphate.
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This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.
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This article discusses the reasons why this case may represent serotonin syndrome rather than clozapine withdrawal and the possible pharmacologic mechanisms involved.
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Adverse reactions to reserpine were studied in 231 hospitalized medical patients who received the drug.
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To our knowledge this is the third article presented in the literature so far.
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Bone marrow cytogenetic study confirmed the deletion of the long arm of chromosome 11, as reported in myeloid leukemia.
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Five hours later he developed a dramatic hypersensitivity reaction including high fever, pulmonary edema, cyanosis, and convulsions.
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The marked thrombocytosis was nonresponsive to hydroxyurea therapy.
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Salicylate intoxication was excluded, and theophylline was finally incriminated.
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We present a case report of a cytomegalovirus (CMV)-seronegative, 58-year-old male who received a CMV-seropositive donor liver transplant without CMV prophylaxis.
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Triazolam-induced nocturnal bingeing with amnesia.
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GVHD is a recognized complication of autologous hematopoietic progenitor cell transplantation (HPCT), but has typically been reported to respond well to primary therapy with corticosteroids.
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Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.
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The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.
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Mean duration of therapy was 5.5 yrs.
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An unusual cause of hypocalcaemia: magnesium induced inhibition of parathyroid hormone secretion in a patient with subarachnoid haemorrhage.
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We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.
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Thus, the risk appears to be confined to women over 50 because, in contrast, in women under 50 there was no statistically significant increase in the risk of endometrial carcinoma.
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Gemcitabine, a nucleotide analog, recently was implicated in several cases.
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Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.
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Based on these findings, the patient was diagnosed with DRESS/DIHS caused by zonisamide.
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Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.
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Both patients were in a state of neutropenia.
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We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.
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Dystonic symptoms began two to three weeks after introduction of therapy and subsided within three weeks after discontinuation.
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Endoscopic rinsing was performed, and multiple small yellowish microgranulations, less than 1 mm in diameter, were observed in the lateral ventricles and the third ventricle.
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Soon after, the SvO2 decreased progressively from 55 to 39%.
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All four patients in this study were treated with alcohol neurolysis of the superior cluneal nerves.
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Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
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Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.
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Early detection of this rare adverse reaction may prevent acute renal insufficiency.
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Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.
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In both, skin biopsy showed a cell-poor subepidermal vesicle with festooning of the dermal papillae.
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Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.
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Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.
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This case report shows an unusual complication of mandibular second premolar root canal overfilling.
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We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.
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The pharmacokinetics of antineoplastic drugs in obese patients are poorly understood and are not sufficient to create standards for rational dosing.
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In addition, there were findings suggesting a possibly immunologically mediated mechanism.
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The plasma concentrations of noradrenaline, adrenaline, and dopamine increased to 26.4, 1.8, and 36.2 micrograms/l, respectively.
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They recovered within three and four weeks, respectively, with complete remission of the radiologic abnormalities and had an uneventful follow-up after discharge.
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A case report with comment on the toxicity of mebendazole.
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