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Chemotherapy induced reversible posterior leukoencephalopathy syndrome.
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This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.
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A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.
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Pancreatic carcinoma in a ten-year survivor of acute myeloblastic leukemia.
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An antibiotic lock technique was created using a flush solution of vancomycin 1 mg/ml with 100 unit heparin/ml.
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Propecia-associated bilateral cataract.
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A case of presumed anaphylactic shock highlights early detection and review, rapid mobilization of the effector arm, and identification of implications for quality improvement.
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The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.
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Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.
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At three years progression free survival was 24% for the radiotherapy arm and 69% for the chemoradiotherapy group (P < 0.001), and three-year survival was 47% for the radiotherapy arm compared with 78% for the combined arm (P = 0.005).
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We identified high numbers of PDCs in psoriatic skin lesions (up to 16% of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123.
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Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.
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Preoperative chemotherapy for locally advanced breast carcinoma (stage IIIA,B) is increasingly utilized demonstrating a 70 to 95% objective response and 15 to 35% complete response.
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Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.
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No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations.
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Massive subchorionic hematomas following thrombolytic therapy in pregnancy.
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Symphysitis following transrectal biopsy of the prostate.
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Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.
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METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.
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Ethambutol is commonly used for the treatment of tuberculous and atypical mycobacterial infection.
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It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.
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This report describes SIADH that developed in an elderly woman with single dermatomal herpes varicella zoster ophthalmicus without evidence of varicella zoster encephalitis or dissemination.
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A pure osteogenic sarcoma of endometrial stromal origin developed in a 28-year-old woman with gonadal dysgenesis (Turner's syndrome) who had received estrogens for 18 years.
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Malignant osteopetrosis generally begins in utero and often results in stillbirth.
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All-trans-retinoic acid is an effective induction treatment for acute promyelocytic leukemia.
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Her hearing gradually, then completely returned 2-3 months after the vincristine therapy was discontinued.
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Investigations disclosed severe deficiency of all four vitamin K-dependent factors and a functional defect of platelets.
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The cases raise a number of issues, including the need for clinicians to routinely ask patients about alternative medicine use, to learn more about these treatments, and to discuss these approaches objectively with patients.
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Heparin was administered on the initial one and a half days.
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DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.
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The neurological status of the patient has only slightly improved to the present.
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Itraconazole can be administered as continuous dosing, 200 mg per day for 3 months, or in the form of pulse therapy, 200 mg twice a day for 1 week per month for 3 consecutive months.
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A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.
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The exacerbation of a co-existing autoimmune disease is often a concern for physicians who use immunomodulating agents for the treatment of a concomitant process.
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Both were suffering from acute and chronic GVHD and treated with heavy immunosuppression including steroids and cyclosporine.
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The treatment continued with follow-ups every 15 days.
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This patient's anemia resolved after discontinuation of the drug; he subsequently underwent an uncomplicated orthotopic heart transplant with no recurrence of anemia.
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Theophylline plasma concentration should be determined whenever drugs affecting theophylline clearance are administered simultaneously.
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This adverse effect has not been previously described for this agent.
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Extensive necrosis of normal tissues was a prominent feature and it is suggested that the action of radiation in combination with cytostatic therapy on normal tissues need further investigation.
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Bone scan showed multiple areas of increased uptake consistent with osteomalacia and microfractures.
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A brief discussion of thyroid myopathy, thionamide drug reactions, and polymyositis is included.
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Cardiovascular deterioration after seizures in tricyclic overdose has long been suspected.
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PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
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We describe a patient who developed intractable chronic vulval ulceration that we believe was related to immune reconstitution following treatment of HIV infection with highly active antiretroviral treatment (HAART).
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We describe a case of catheter-associated aortoiliac thrombosis in a newborn who was successfully treated by urokinase infusion.
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It is critical to differentiate this from other potential causes of hemorrhage, such as an acute bleed from an anastomotic false aneurysm which is a surgical emergency.
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A 2-day-old newborn was treated with tolazoline for persistent pulmonary hypertension due to meconium aspiration syndrome.
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Further control studies assessing the efficacy and safety of antiandrogen agents are recommended.
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A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented.
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In the seven patients, the mean plasma concentration of carbamazepine, but not of carbamazepine-10,11-epoxide, after clarithromycin coadministration was significantly (p < 0.01) higher than those at 1 and 4 weeks after its discontinuation.
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Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.
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Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.
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Biperiden was transiently effective in the acute akathisia, while the more persistent akathisia was alleviated by mianserin.
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Histopathologic examination revealed adenomyosis with cyst formation and an unusual thick capsule.
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To date, with a total of 1,103 patient-months of follow-up study, seven episodes of small intestinal obstruction have developed of which two were definitely and five possibly related to chemotherapy induced adhesion formation.
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In lieu of an effective regimen, interleukin-2 (IL-2) and interferon alfa are considered drugs of choice to treat this cancer.
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The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance).
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Despite antibiotic therapy, his pulmonary function deteriorated and 100 percent oxygen was required to maintain adequate oxygenation.
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Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.
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In-hospital management of adults who have community-acquired pneumonia.
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She was otherwise healthy and did not complain of hyperhidrosis.
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Role of Stellate ganglion block in post CABG sympathetically mediated chest pain.
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The nephrotic syndrome cleared without steroid therapy and has not recurred 18 months later in one patient.
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Here we describe two cases in postpneumonectomy patients in which expandable esophageal stent placement resulted in respiratory compromise requiring reintervention due to airway compression.
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The patient was already on sodium valproate, and levetiracetam was given as add on therapy.
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Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence.
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A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.
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Nitrofurantoin-induced acute liver damage in pregnancy.
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DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.
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Lithium and ECT--concurrent use still demands attention: three case reports.
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Amisulpride and sertraline were discontinued.
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Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia.
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Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.
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Afterwards the thrombocyte count continuously decreased to normal values.
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In the other patient, APL was diagnosed 46 months after liver transplantation for congenital biliary atresia.
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Baseline laboratory studies to evaluate infertility had revealed normal hormonal levels.
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L-asparaginase-provoked seizures as singular expression of central nervous toxicity.
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Also, it appears that these patients may be more susceptible to complications with future disulfiram usage and should be strongly counseled to seek alternative therapies for their alcohol problems in the future.
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Treatment with diuretics and catecholamine products showed almost complete recovery from CHF in 3 weeks.
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We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.
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However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.
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Tests for thyroid autoantibodies, as well as inhibitory and stimulatory antibodies, were negative, and fine needle aspiration biopsy revealed an adenomatous goiter.
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Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.
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On day 12, the patient complained of dyspnea and cough.
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The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.
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IFN-alpha was continued in only one patient.
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A 52-year-old man with neither congenital heart disease nor history of drug abuse had a spiking fever after dental treatment and was diagnosed with pneumonia at a local clinic.
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INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection.
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TREATMENT AND OUTCOME: Exploratory surgery of the coelomic cavity was performed and the neoplasm was excised.
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The acyclovir levels measured by radioimmunoassay were related to the level of consciousness.
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Radiation was continued without chemotherapy.
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These observations support the view of an increase in both the severity and incidence of PCP in patients without human immunodeficiency virus infection and question the need for a primary prophylaxis in patients with connective tissue diseases receiving high-dose corticosteroid therapy.
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At laparotomy, the mass was located in the right broad ligament with a fibrous stalk connecting to the uterus.
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In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.
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We analyze a case of neutropenic enterocolitis which occurred in a patient with acute myeloid leukemia during chemotherapy and we suggest that, as well as intestinal wall thickness, hemodynamic worsening should be considered an indication for surgery.
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We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.
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FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.
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Mycophenolate mofetil is a non-nephrotoxic alternative which should be considered to rescue cyclosporine-dependent, severe myasthenia gravis sufferers with renal impairment from progression to end-stage renal failure.
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rEpo was administered by i.v. injection three times a week for at least four weeks.
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