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Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.
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We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.
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Chemotherapy for the malignant lymphoma was done after withdrawal of cyclosporine A and mizoribine, and thyroidectomy was performed for thyroid carcinoma.
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Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.
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One not so well documented consequence of this treatment is avascular necrosis or osteonecrosis of the underlying bone.
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Development of rickets in association with parenteral nutrition is described in four premature infants having gestational ages of 26-31 wk.
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Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation.
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Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy.
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Acute isoniazid neurotoxicity in an urban hospital.
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Heparin-induced hyperkalemia.
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In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.
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Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.
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A case of severe hyperlipidemia caused by long-term tube feedings.
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We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.
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Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.
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DATA: A 16-year-old girl was treated with risperidone for mood lability and impulsivity at a community hospital.
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A scan of fetal neck region is recommended in patients with current or previous history of thyroid disease, or if neck extension is noted on routine examination of fetal spine.
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The authors describe a 65-year-old man who, after 7 years of complete remission from lung cancer, was found on routine oncologic follow imaging to have lesions on several vertebral bodies.
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Clinical manifestations range from asymptomatic to fulminant in nature.
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Liver abscess caused by an infected ventriculoperitoneal shunt.
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Although free of disease, the patient has a subcortical dementia and is unable to work.
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Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.
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A conjunctival biopsy revealed invasive squamous cell carcinoma, with orbital invasion on computed tomography scan.
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Several clinical parameters indicate a remarkable improvement in the clinical courses of those patients in recent years: weaning time, extubation rate, and improvement of additional organ failures were all significantly better in patients treated after the emergence of new antimycotic agents, resulting in prolonged overall survival.
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Erosion of psoriatic plaques: an early sign of methotrexate toxicity.
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Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.
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When the treatment was completed, her depression substantially improved and her posture became completely upright.
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Diagnostic procedures did not reveal any liver, kidney, splenic, or pancreatic abnormalities.
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Possible causes and difficulties in diagnosis were reviewed.
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PURPOSE: To describe a patient with iatrogenically induced central retinal vein occlusions secondary to serum hyperviscosity from intravenous immunoglobulin administration.
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CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.
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Venous thrombosis and congenital absence of inferior vena cava in a patient with menorrhagia and pelvic pain.
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He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.
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We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.
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Long lasting recurrent familiar transient global amnesia after betablocker treatment withdrawal: case report.
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The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.
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Only one prior case has been reported in a patient receiving aggressive chemotherapy for a hematologic malignancy.
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CASE: In reviewing the literature of intraperitoneal catheter complications, there is no other cited case of a peritoneal catheter erosion into intestine presenting as an enterovaginal fistula.
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All her symptoms gradually subsided over the next few hours.
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Magnetic resonance imaging revealed focal abnormalities, predominantly in the cortex, that on light and electron microscopic examination were demonstrated to be highly localized areas of neuronal loss, gliosis, and secondary Wallerian degeneration with paramyxovirus inclusions in the oligodendrocytes and surviving neurons.
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He was initially managed as a suspected case of pulmonary embolism.
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Although cortisol has a distinct circadian rhythm, patients with adrenal insufficiency usually receive diurnal hydrocortisone replacement therapy (HRT), disregarding possible consequences for sleep quality.
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Epidural spinal lipomatosis with acute onset of paraplegia in an HIV-positive patient treated with corticosteroids and protease inhibitor: case report.
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Reinstitution of the chemotherapeutic regimen once again led to an increase in INR.
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The following is a case report of a 32-year-old man who experienced refractory bronchospasm upon emergence from general anesthesia.
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All the patients recovered after an appropriate treatment for 83 days.
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Clozapine has proven effective in reducing morbidity and suicidality in chronic non-remitting patients with schizophrenia.
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OBJECTIVE: Pancreatic enzyme is essential in the treatment of cystic fibrosis (CF), but intolerance to it occasionally occurs.
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Aspergillus terreus was isolated from her biliary fluid obtained at percutaneous transhepatic cholangiography.
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Education of employees and physicians should result in the prevention of unnecessary tissue destruction and pain for those inadvertently exposed to hydrofluoric acid.
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Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.
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Myalgias were self-limited and lasted 4-10 days.
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Patients with PS-1 AD may be at substantially increased risk of neuroleptic-induced EPS.
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This rise was halved over the next 8 days.
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This can occur with combinations such as non-steroidal anti-inflammatory drugs (NSAIDs), phenytoin (Dilantin), carbamazepine (Tegretol), and valproic acid (Depakene) or when the albumin level is low.
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It is usually given in an outpatient setting.
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After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.
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Blastoschizomyces capitatus (BC), a filamentous fungus of genus Trichosporum, is as an important opportunistic pathogen in the compromised host.
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It can be used to increase the intracellular concentration of chemotherapeutic agents in tumor cells (electrochemotherapy; ECT).
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CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.
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Multiple sclerosis-like disease secondary to alpha interferon.
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Staphylococcal pyomyositis in a patient with non-Hodgkin's lymphoma.
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None of these patients were operated on.
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Conversion to another immunosuppressant seems to be an appropriate procedure in this condition.
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Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.
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They improved rapidly and over 6 months were able to stop taking analgesics and return to normal activities.
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Ichthyosiform erythrodermas and the 'half-baby syndrome' treated with an aromatic retinoid.
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Recently, we have employed fibrin glue as a vehicle for the sustained release of ACNU (nimustine hydrochloride) by spray application following subtotal tumor removal in two patients with recurrent malignant gliomas.
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Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.
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CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.
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To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.
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Successful elective lumbar spine surgery was performed 4 days post-myocardial infarction during perioperative beta-blockade, after cardiology evaluation recommended surgery without further evaluation.
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OBJECTIVE: To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand.
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This case indicates that large and presumably organised thrombi may be treated with anticoagulant therapy.
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CONCLUSIONS: Most cases of pseudoporphyria are drug-induced.
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Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon.
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It is suggested that, when drug induced pneumonitis is noted, careful screening of left ventricular function should be performed in order to diagnose myocardial fibrosis and subsequent cardiac failure.
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Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.
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Minimal evidence supports treatment with multiple antipsychotics, even when the agents have different mechanisms of action.
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Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.
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Allergic and irritant contact dermatitis to calcipotriol.
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Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient: a new treatment strategy.
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Five operations were performed in four patients: a nephrectomy for massive subcapsular hemorrhage with a prothrombin time that exceeded 100 seconds; arteriovenous graft complicated by post-operative bleeding associated with prolongation of the prothrombin time; elective femoral-popliteal bypass complicated by a prolonged prothrombin time, bleeding into the graft site, hypotension, and a subendocardial myocardial infarction; elective cholecystectomy complicated by a two unit bleed associated with a slightly prolonged prothrombin time, followed by elective femoral-popliteal bypass complicated by a fatal intercerebral bleed associated with a more than twice normal prothrombin time.
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Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.
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Two years after transplantation, nefazodone 50 mg twice/day orally was prescribed due to depression.
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The patient was regularly taking a mixture of herbal products, used as a laxative, for a number of years, with no alteration of blood chemistry until 6 months before the present observation.
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We report a case of a scleroderma-like reaction induced by long-term administration of UFT.
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OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.
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Herbal remedies generate more than 1.8 billion dollars in annual sales in the United States.
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The infection was arrested but not cured.
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He was successfully treated with albendazole and ivermectin, and immunosuppression was reduced.
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DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.
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He was started on intravenous Zoledronic acid for reduction of bone pain and prevention of skeletal complication from multiple bone metastases.
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The results of modeling studies have suggested and clinical investigations have confirmed a major pharmacokinetic advantage for exposure of the peritoneal cavity to certain chemotherapeutic agents compared with exposure of the systemic circulation when these drugs are delivered through the intraperitoneal route.
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The ECG showed atrial fibrillation with a rapid ventricular rate.
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The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.
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A fatal outcome has been described in all reported cases of Fusarium infection occurring after bone marrow transplantation.
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Symptoms and laboratory findings improved after zafirlukast was removed.
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Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.
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Six received intra-arterial alteplase and 1 underwent intracranial angioplasty; in a final patient, technical aspects prevented intra-arterial therapy.
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