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Here, a rare case of a patient with Type I GD who developed adenocarcinoma of the lung that was treated with chemotherapy, radiotherapy and biological agents inhibiting receptor tyrosine kinases is presented.
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Overall, they are the single largest cost to the healthcare system.
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Serological studies were carried out using flow cytometry (FCM).
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ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.
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Although opiates can provide patients with relief from pain and the discomfort of cough, the routine prescription of these drugs for infants demands caution and concern.
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The ratio of M-23 to M-1 in her serum was much lower than that of control persons (0.64 vs. 2.08).
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Affected persons usually are on chronic steroid treatment and in the fifth to seventh decades of life.
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The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.
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Histological analysis of a lung biopsy showed a diffuse infiltration with pigmented macrophages without granulomas, which particularly involved the pulmonary arterial and venular walls.
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BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.
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In a dose titration study we tested the efficacy and tolerance of recombinant human erythropoietin (rhEPO) in 10 patients with myelodysplasia (MDS) and 2 patients with idiopathic myelofibrosis.
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Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.
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To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.
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Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.
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A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.
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Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias.
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Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.
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A case is described in which non-convulsive status epilepticus (NCSE) prompted further investigation leading to the diagnosis of Lafora body disease (LBD).
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It has also been seen in people with gastrointestinal diseases with malabsorption.
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No life-threatening situations occurred and the patient fully recovered.
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This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.
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Other measures including attention to factors that contribute to falls should also be considered, necessitating a multi-disciplinary approach.
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Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.
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He developed necrotizing pancreatitis, possibly due to regurgitation of the chemotherapeutic agents to the pancreas.
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Disseminated Trichosporon infection.
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Epsilon-aminocaproic acid and renal complications: case report and review of the literature.
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Homozygous loss of TSC1 was identified in one PEComa.
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In vitro studies using 3H-thymidine uptake and dual parameter flow-cytometric analysis of DNA and proliferating cell nuclear antigen showed that leukemic blast cells in S phase were increased after incubation with G-CSF.
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The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.
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A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.
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Although trimethoprim-sulfamethoxazol (TMP/SMX) prophylaxis has been shown to prevent almost all P. carinii infections, 1%-2% of patients may still experience this complication.
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Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.
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The generalized dystonia improved in the following 3 months and 3 years respectively in 2 patients.
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Disseminated histoplasmosis has not been described previously as a complication of bone marrow transplantation.
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Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.
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Normal endometrial cells in the Pap smear test were the only signs associated with this cancer.
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Elimination rates for Staphylococcus aureus and Haemophilus influenzae were similar; adverse reactions did not differ in both arms.
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Neither patient has developed evidence of hepatotoxicity.
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The patient's condition improved after halothane was administered; treatment with this inhalational anaesthetic lasted 7 h, and the beneficial effect was obtained by employing concentrations between 0.5 and 2%.
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The role of antiemetics is invaluable in allowing cancer patients to complete otherwise potentially intolerable chemotherapy.
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Two illustrative cases are reported.
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There may be a synergistic effect when corticosteroids are used in combination with chemotherapy and radiation treatment.
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We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.
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The objective of this study was to retrospectively evaluate the clinical outcome of newborns treated with recombinant activated factor VII for intractable bleeding or severe coagulation disturbances, resistant to conventional hemostatic therapy.
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Polyacrylamide gel may have favorable properties for facial tissue augmentation, but a severe granulomatous inflammatory response induced by injection of polyacrylamide gel may occur.
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Relevant reports to the national Pharmacovigilance Centre were also examined.
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Follicular cell carcinoma (FCC) of the thyroid is rarely found during childhood.
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Postoperative assessment of intraocular pressure is essential in patients presenting with flap inflammation.
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In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.
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Lacosamide intoxication in attempted suicide.
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Chronic vulval ulceration--another immune reconstitution inflammatory syndrome?
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The other 2 eyes experienced regression of the myopia and astigmatism and had a BCVA of 20/25(-1) or better.
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INVESTIGATIONS: Blood tests, peripheral blood smear, bone-marrow biopsy and aspirate, Holter electrocardiogram.
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During this same time period, 537 patients were admitted with MI, 41 of whom died; the study's 4 patients were compared with these 41.
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Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.
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DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.
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An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.
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Development of malignant breast microcalcifications after neoadjuvant chemotherapy in advanced breast cancer.
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With either discontinuation or decreased dosage of the drug the symptoms disappeared and did not recur.
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The safety of concurrent use has also to be balanced when lithium treatment is started within an ECT course.
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The patient had MRSA sepsis develop resistant to conventional therapy, which was successfully treated with daptomycin.
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We present a case report of endodontic overfilling involving the mandibular canal.
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With rapid recognition and treatment of the syndrome, the patient fully recovered.
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Familial Mediterranean fever at the millennium.
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The vacuum-assisted wound closure technique and device (the V.A.C.) has become a widely accepted technique in the management of chronic and difficult wounds.
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Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.
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One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.
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Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.
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A rare case of lumbosacral meningioma: nondural attachment and possible enlargement by orally administered sex steroid.
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Case examples illustrate problems of teacher compliance in filling out measures, supplying adequate placebos, and obtaining physician cooperation, and with the practical issue of providing adequate data without overwhelming the time and resources of participants.
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His current medication regimen was hydroxyurea (500 mg BID), iron (525 mg QD), and folic acid (15 mg QD) for the myeloproliferative disease and the associated anemia; spironolactone (25 mg BID) and furosemide (20 mg BID) for the complications of cirrhosis; allopurinol (100 mg QD) to treat gout; and theophylline (250 mg QD) for chronic bronchitis.
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The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.
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A trial of dexamethasone therapy normalized blood pressure, and plasma and urinary aldosterone decreased to low levels and renin levels increased.
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The occurrence of treatment-related hematologic malignancies after adjuvant therapy with alkylating agents for gastrointestinal cancers, ovarian carcinoma, and breast cancer and after treatment for Hodgkin's disease, non-Hodgkin's lymphoma, germ-cell tumors, and multiple myeloma has been well documented.
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A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.
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Early detection of ototoxicity is of vital importance in cases in which ototoxic drugs are administered.
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Laboratory investigations confirmed a metabolic acidosis (pH 7.15) and hyperchloremia.
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SCE analysis may provide a method for detecting patients at risk from oncogenic effects of cytotoxic drugs.
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OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.
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A 21-year-old woman with pars planitis was treated with a subtenon's depot corticosteroid injection that was complicated by the appearance of the corticosteroid suspension within the choroidal vasculature.
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The signs and symptoms of intracranial pathology in patients with dural puncture headache, in addition to their postural headache, are discussed.
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The second case occurred in a patient who developed renal failure while on daily therapy in the hospital.
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In none of these reports has radiologic or pathologic data been presented.
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These side effects may be inadvertently confused with other behavioral or psychiatric conditions, especially if exacerbation of existing challenging behavior occurs.
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Percutaneous endoscopic gastrostomy is a safe and easy method and carries a low mortality and complication rate.
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Ganciclovir-resistant cytomegalovirus (CMV) infection is an emerging problem in transplant recipients.
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Neurologic examination revealed right foot drop in Patient A and was unremarkable in Patient B.
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METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.
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Milnacipran was administered at 50 to 150 mg/day, and the dose at 12 weeks or at the time the drug was stopped was 85.0 +/- 31.3 mg/day.
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RESULTS: For this patient, clopidogrel (Plavix) therapy was the only risk factor related to SSEH.
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Vincristine (VCR) is commonly included in combinational chemotherapy regimens because of its synergy with a variety of other active agents, as well as its sparing of the hematopoietic system.
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Sensation of all modalities was intact.
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Seventeen had deposits of plasma proteins at the dermoepidermal junction, 16 had deposits in the vessel walls, and one had autofluorescence of the nuclei in the epidermis and vessel walls.
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Platelet count was within normal limits on admission and the patient developed no serious consequences because of the purpura.
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We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).
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Recombinant growth factors appear not to help in shortening the neutropenic period.
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E. coli was isolated from urine, blood cultures and later from bone biopsy.
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The administration of amyl nitrite and sodium thiosulfate led to a rapid improvement: the parameters reflecting oxygen metabolism improved and the plasma level of cyanide decreased.
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Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.
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Despite a preferential action on cerebral vessels, there is clinical and experimental evidence of effects on systemic vascular and intestinal smooth muscle cells.
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