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Delirium after cessation of glucocorticoid therapy.
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In a patient without evidence of hypersensitivity (the lymphocytes did not react to the drug in vitro) fever was the sole manifestation of an adverse reaction to cimetidine that was confirmed by challenge with the drug.
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After a 8-year follow-up since transplantation, the patient is free from dyspnea, angina, and adverse cardiovascular events.
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BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.
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Other features of this adverse drug reaction were unremitting fever, leukocytosis with eosinophilia and atypical lymphocytosis, and proteinuria.
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Post resuscitation there was no myocardial infarction and she had complete neurological recovery.
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The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.
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Vitamin D toxicity is associated with enhanced resorption of bone in some patients.
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Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.
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Five hours after arrival, the patient reported a recurrence of severe chest pain.
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The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.
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The progressive appearance of squamous epitheliomas and other cutaneous adverse events, such as the ulcer, suggests that alternative chemotherapies should be considered for the treatment of myeloproliferative diseases.
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Initial plasma concentration of pyrimethamine was 6.22 micrograms/mL.
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This case illustrates the diagnostic challenges in the management of such a patient, as well as the need for greater vigilance in the monitoring of liver function tests for patients treated with imatinib.
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Finally, the patient had improvement in symptoms and oxygenation after withdrawing lenalidomide and recurrence of symptoms when the drug was restarted.
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We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.
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A 32 year-old healthy nullipara pregnant woman, with an uneventful past gynaecological history, was admitted in Hospital, with a severe depressive syndrome in a 18 weeks malformed pregnancy for thoraco-omphalopagus conjoined twins.
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A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery.
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Measurement of serum acyclovir levels substantiated the diagnosis in only a subset of patients.
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METHODS: Review of two patients.
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Final maintenance dose was 2 mg every 4 weeks in 1 patient, 2 mg weekly in 1, 3 mg weekly in 3, 5 mg monthly in 1, 10 mg every 3 weeks in 2, 10 mg every 4 weeks in 2, 10 mg every 6 weeks in 1, and 5 mg weekly in 2 patients.
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We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.
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Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.
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The clinical course and results of renal biopsy studies suggest multiple causes of the renal lesions in this patient.
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Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.
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RESULTS: Within the first 4 weeks after the injection, dense cataract developed necessitating cataract surgery.
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We report a 67-year-old man with Parkinson's disease for 9 years who developed compulsive use of levodopa.
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The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.
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The skin lesions healed over the next month.
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Drug eruption was diagnosed in a 4-year-old German Shepherd Dog being treated with sulfonamides for vertebral osteomyelitis due to infection with Nocardia spp.
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A double-blind challenge with nadolol and captopril decreased FEV1 by 3 and 12%, respectively.
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Major surgery for a gastric cancer in a haemophilic with high inhibitor titre successfully performed by the use of recombinant FVIIa.
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Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy.
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Reversible renal failure associated with angiotensin-converting enzyme inhibitors in polycystic kidney disease.
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Antibiotic irrigation of the capsular bag can resolve chronic, low-grade endophthalmitis in culture-positive patients unresponsive to the same drugs administered by other routes, including conventional intraocular injection.
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These symptoms abated 1 week after fluvoxamine treatment was discontinued and haloperidol was started.
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Severe complications are rarely seen.
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Hormonal, ultrasonographic, radioiodine scanning and fine needle aspiration findings were consistent with the diagnosis of Hashimoto's thyroiditis.
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PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.
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Sarcoma complicating therapy with cyclophosphamide.
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Intradermal testing with a wide range of steroid preparations gave positive results to prednisone.
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At the time of this writing (2 y), the patient has had no symptoms and has continued on the chemotherapy protocol as planned.
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We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.
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The medical and ophthalmic literature was reviewed for current use of these medications as well as for the reported incidence of visual side effects.
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We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.
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Case report.
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De novo inflammatory bowel disease after pediatric orthotopic liver transplant: a case report.
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Thrombocytopenia is one of the most frequent challenges faced in patients with chronic liver diseases.
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Occurrence in an immunosuppressed patient with chronic active hepatitis.
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Tardive dyskinesia in young adults.
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Rickets in low birth weight infants receiving total parenteral nutrition.
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This finding suggests that eosinophil infiltration may be associated with nasal polyp formation in AIA, and that activation of eosinophils plays an important role in accumulation of eosinophils and polyp formation beginning with the initial stage.
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Propafenone-induced ataxia: report of three cases.
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One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.
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Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.
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Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.
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However, a common source for these infections could not be demonstrated.
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Serum and salivary IgA were absent with high IgE serum total.
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BACKGROUND: Intracranial malignancies (primary and metastatic) are often complicated by seizure activity.
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It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.
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This case shows a combined mechanism of DME resolution by anti VEGF and PHD.
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METHODS: Prospective interventional case series of three patients with nonischaemic CRVO who were treated with L-CRA.
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The case emphasises that immune reconstitution can be an extremely aggressive complication of HAART.
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Seven cases of successfully treated Candida albicans cerebrospinal fluid shunt infections are reported.
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Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).
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Two days later, on hospital day 27, the patient spontaneously delivered two healthy, male infants.
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Poor bone vascularisation and reduced local defences prolong the defensive response.
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This lead to the hypothesis of a partially dialysable toxic metabolite of muzolimine.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.
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CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.
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RESULTS: A two-year-old boy was surgically treated for residual esotropia after two botulinum toxin A injections.
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These observations suggest that CPH82 has glucocorticoid receptor agonistic effects.
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Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms.
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Such a clinical association has not been previously described in the literature and might be due to the persistent expression of gp91phox at a very low level.
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RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.
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Aortic perforation complicating carcinoma of the oesophagus is extremely uncommon.
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Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.
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The patient had no history of trauma, lymphatic obstruction, venous obstruction or infection.
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Two days after completing this regimen, the patient developed a rash with blistering.
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Baseline and follow-up examinations should include: Snellen acuity, Farnsworth D-15 color testing, automated threshold perimetry and optic nerve head photography.
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Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.
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One was infected by PVB19-contaminated blood transfusion, whereas the other had become infected naturally.
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Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.
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Majocchi's granuloma is a condition with chronic erythematous and indurated plaques that is a result of the rupture of a dermatophyte-infected infundibulum as a result of trauma.
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A review of the relevant literature follows the case reports.
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Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).
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The effective valve area was 0.41 cm2.
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CONCLUSIONS: Caution should be exercised when using ciprofloxacin in the treatment of patients with personality abnormalities or symptoms of psychosis.
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Because the AKBR changes in relation to electron transport in liver mitochondria, it seems to be a logical parameter for evaluating the effect of potassium cyanide poisoning on electron transport.
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This case report describes a patient who ingested magnesium sulfate (MgSO4) for approximately four days as a treatment for pregnancy-induced hypertension.
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The treatment approach is described and the literature on the subject is reviewed.
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The resulting pneumonitis may be severe and irreversible.
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To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.
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Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.
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Brain metastasis was detected in one patient at 7 months after initial therapy and was treated with stereotactic radiotherapy combined with whole brain irradiation.
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Cell culture was performed on samples collected from a corneal scraping, the contact lenses and the storage cases.
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In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.
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MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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