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Prompt treatment with intravenous antibiotics usually leads to full recovery.
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New serologic tests show promise.
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Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.
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We report a case of acute popliteal artery occlusion after arthroscopic posterior cruciate ligament reconstruction.
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Lower extremity arterial insufficiency after long-term methysergide maleate therapy.
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Giant cell lichenoid dermatitis in a patient with baboon syndrome.
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Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.
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A chorio-retinal shunt was demonstrated.
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The patient was treated with triple tuberculostatic drug therapy, followed by two-drug therapy, while receiving maintenance chemotherapy for AML, including thioguanine and cytarabine.
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CT scan revealed infarction in the territory of the right middle cerebral artery.
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METHOD: We identified 101 patients at Yanbian Socio-Mental Hospital and Yanbian Brain Hospital in China who had received clozapine as a primary antipsychotic drug since their first episode of illness and evaluated the prevalence rate, type, and severity of TD using the Extrapyramidal Symptoms Rating Scale (ESRS).
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Specimens were evaluated by light and electron microscopy.
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Itraconazole withdrawal was followed by rapid improvement, with neurologic examination returning to normal within 6 weeks.
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Common hair care practices are a frequent cause of alopecia in black women.
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A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.
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An aggressive dose escalation (0.15, 0.2, 0.25 mg/kg/hr for 6 hrs) was done over the next 5 days in an attempt to avoid open-heart surgery.
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RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.
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The premature infant liver may be deficient in its ability to carry out this step of metabolism, and in normal intrauterine existence the fetus may receive 1,25-DHCC, the active metabolite, from the mother.
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To our knowledge, this report describes the first cases of C. striatum causing infection of exist sites of central venous catheters, thrombophlebitis associated with central venous catheters, conjunctivitis, and chorioamnionitis as well as a possible pathogen contributing to peritonitis and pyogenic granuloma.
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Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.
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The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.
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We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.
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Spinal meningiomas predominantly arise in the fourth to sixth decades of life and are more common in women.
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After 2 weeks, visual acuity was better and improvement was evident on topography, pachymetry, and slitlamp photography.
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The pupil dilated more widely following this procedure, resulting in an improvement in the patient's visual field.
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BACKGROUND: Although 5-aminosalicylic acid (5-ASA) preparations used to treat inflammatory bowel disease are reported to have fewer side effects than sulphasalazine, increased clinical use of these compounds has resulted in increased reports of significant side effects.
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Cholestyramine enabled the use of very low doses of sc vitamin K1 (2 mg total) with subsequent attainment of a therapeutic International Normalized Ratio in 39 h.
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During chemotherapy suggested pathogenetic factors were monitored without observing any significant abnormality.
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Magnetic resonance imaging and angiography showed right internal carotid artery stenosis with ulceration.
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Therapy-related myelodysplastic syndrome (t-MDS) was suspected approximately 2 years later; in addition, complex karyotypic abnormalities including 5q deletion, monosomy 7, and der(17)t(12;17)(q13;p13) were found repeatedly in the patient's chromosome studies.
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We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.
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She subsequently developed microbial keratitis at 1 o'clock adjacent to the limbus.
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In December 1983, symptoms of Parkinson disease developed in a 55-year-old man with no history of pulmonary disease, smoking, or asbestos exposure.
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METHODS: Retrospective chart review was performed.
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CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
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Biopsies revealed an interface dermatitis with epidermal dysmaturation.
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The level of ferritin in serum was elevated to 1192 ng/mL.
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Eight patients had elevated alkaline phosphatase, 4 elevated IgG and one elevated IgA.
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Acetylcholine receptor and anti-skeletal muscle antibody titers were positive in both patients.
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Another aqueous humor sample was taken and sent for microscopic examination of sputum for acid-fast bacilli and culture, both of which were positive for MT.
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Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.
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Rapid manifestation of cervical vertebral osteomyelitis.
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We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).
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Inappropriate antidiuretic hormone secretion after high dose vinblastine.
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Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism.
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We present and exemplify our routine test protocol for monitoring drug introduction and treatment regimen of cholinergic drugs in LEMS.
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The total amount received was 27 gm.
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We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.
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CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors.
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In-vitro rechallenge of the patient's lymphocytes with cytochrome P-450 generated metabolites of phenobarbital showed extensive cytotoxicity compared to control.
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His recovery was uneventful.
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Presence of hypertriglyceridemia, very high serum levels of ferritin and hemophagocytosis in a bone-marrow aspirate gave the diagnosis of HLH.
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After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.
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The pharmacist counseled the patient on the potential hazards of using herbal products with prescription medications.
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Spironolactone was continued, as serum creatinine and potassium levels were initially normal.
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Further research should be done to define the role of combination antidepressant therapy in the treatment of primary care patients with depression.
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DISCUSSION: Haloperidol is often used in the ICU for control of severe agitation, even in patients without a psychiatric history.
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She purchased cosmetic contact lenses via the Internet, and followed a contact lens care system irregularly, occasionally using tap water.
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A case report.
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CONCLUSIONS: Adrenal insufficiency should be suspected in all dialysis patients presenting with fever and atypical symptoms, but only after other potential causes are eliminated; since steroid administration may normalize fever regardless of the etiology, it may mask the signs and symptoms and delay the treatment of other (if any) underlying disorder(s).
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Intradermal tests with carboplatin were positive in all three patients and negative with cisplatin.
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Treatment is supportive; phenobarbital and carbamazepine may be used with caution as alternate anticonvulsant therapy.
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The patient treated with DBS developed severe dyskinesia a few days after discharge and began self medication with amantadine but showed no improvement.
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As patients survive longer, long-term therapy-related complications take on greater importance.
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Severe overdosage with the antiepileptic drug oxcarbazepine.
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Anxiety disorders are currently one of the most common health concerns in the United States.
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Drug discontinuation was followed by a complete resolution of the skin eruption.
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Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.
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CONCLUSIONS: Platinum-based therapies are vital to the treatment of primary peritoneal and ovarian carcinoma.
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Enterovirus was detected by the polymerase chain reaction (PCR) in two samples of pleural fluid that were obtained 21 days apart while he was alive.
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Most patients can be successfully managed when patient and physician expectations are realistic and aligned, the selection of preventive medications is individualised, and the initiation and titration strategy is appropriate and carefully followed.
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The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.
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We also found a severe decrease in her serum total carnitine level of 22 micromol/l (normal range 45-91 micromol/l) before changing the diet, suggesting secondary carnitine deficiency.
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Despite this experience, the patient continued to deny that quinine was the cause of his problem and that he had failed in his obligations to advise the dentist of his drug history.
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We present a case of methanol poisoning in a child in whom the use of fomepizole averted intravenous ethanol infusion and the attendant side effects of this therapy.
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Obstructive prosthetic atrioventricular valve thrombosis in a woman with congenitally corrected transposition of the great arteries during estrogen replacement therapy for pituitary dysfunction.
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CONCLUSIONS: Topical INF alpha 2-beta is a valid choice for the treatment of CIN in patients for whom surgery is not possible.
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CONCLUSIONS: Terbutaline therapy did not appear to be associated with any significant adverse effects and warrants further application and study in this setting.
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He became febrile and developed a productive cough and pulmonary infiltrates on postoperative day 4.
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Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.
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Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.
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DISCUSSION: Opioid dependence is generally considered synonymous with heroin dependence or dependence on prescribed opioid analgesics.
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Results of this study show milnacipran to be beneficial in patients with chronic pain.
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A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.
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Adjuvant chemotherapy was not indicated and anastrozole hormonotherapy was started.
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Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination.
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BACKGROUND: Large cerebral infarction is a rare complication of neurocysticercosis.
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Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.
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Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.
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This may be particularly useful in patients unable to tolerate an alternative class of antihypertensive agents.
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METHODS: Diagnostic aids included routine histology and direct immunofluorescence studies to rule out immunobullous diseases and to confirm the c-GVHD.
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Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.
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All patients were treated with ICD system explantation and antifungal therapy.
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Two patients were treated with bretylium tosylate for malignant ventricular arrhythmias after inadequate response to conventional agents.
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For one patient, the half-saturation constant was elevated 0.7 log units, suggesting reduction of retinal sensitivity, perhaps from decrease in retinal photopigment concentration.
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Ego-alien, suicidal ideas are an extremely rare form of adverse drug reaction.
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She also had been treated with oral conjugated equine estrogen (Premarin) because of congenital pituitary dysfunction.
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Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.
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Continuous EEG monitoring in a patient with massive carbamazepine overdose.
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A retrospective review of 4405 patients' charts identified 214 patients who initiated antimalarial therapy between January 1987 and April 1993 for different rheumatic disorders (mean duration of therapy of 17 months).
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