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Case studies in heparin-induced thrombocytopenia.
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Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.
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Patients were monitored for adverse treatment effects.
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One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.
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Patients receiving these agents are at risk of acute or subacute pulmonary damage.
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Antimicrobial treatment was changed to tigecycline and continued for suspected pleural space infection.
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Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.
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All-trans retinoic acid and short-time, high-dose cytarabine in two children with acute promyelocytic leukemia.
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Tardive seizure and antibiotics: case reports and review of the literature.
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Reduction of postoperative pain is an important goal in the perioperative management of tonsillectomy patients.
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Liver disease was diagnosed 12 +/- 4 years (range, 8-18) after initiation of antiretroviral therapy (ART).
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Reactivated herpetic keratitis following laser in situ keratomileusis.
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Furosemide, spironolactone, allopurinol, and hydroxyurea were considered possible causes of the reaction and were discontinued.
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DISCUSSION: Cutaneous IL-2 adverse effects are frequent, but generally mild and reversible.
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We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.
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We conclude, this novel mode of intra-operative local chemotherapy by spray application of fibrin glue containing antineoplastic agent is effective in the control of residual tumor progression and may also prevent local recurrence and hence suggests its possible role as an adjuvant therapy in the management of malignant gliomas.
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Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.
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Asthma and dental erosion.
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Cimetidine, an H2 blocker, may partially abolish the effect of tolazoline.
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We postulate that the patient's hearing loss was the result of ketoralac's direct and indirect ototoxic effects that were potentiated as a result of her underlying illness and medications.
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Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.
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Osteonecrosis of the maxilla as a complication to chemotherapy: a case report.
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Resistance to combined ganciclovir and foscarnet therapy in a liver transplant recipient with possible dual-strain cytomegalovirus coinfection.
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Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.
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Lamotrigine toxicity secondary to sertraline.
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Percutaneous drainage of the liver abscess and externalization of the VP shunt were performed.
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When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.
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Radiation recall resolved spontaneously with withdrawal of gemcitabine.
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Her response to a postural challenge test, without medication, was normal.
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Neutropenia is an uncommon but potentially serious complication of drug therapy.
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After stopping indapamide, glucose tolerance impairing may be reversed.
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Discontinuation of the ACE inhibitor results in rapid alleviation of the cough, although this is not always necessary, as most patients may experience a cessation or decrease in cough.
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A healthy 62-year-old woman was referred to our dermatology department with a 1-month history of a pruritic axillary eruption.
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Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.
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Long-term, controlled studies are required to specifically address this issue.
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After 3 h of hemodialysis, her post-dialysis acyclovir level was 1.9 micrograms/ml.
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Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.
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Four cycles of this protocol yielded a dramatic response on re-staging CT scan.
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Her acyclovir level was later found to have been 3.4 micrograms/ml (normal peak range 0.4-2 micrograms/ml) prior to dialysis.
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In vivo confocal micrographs showed the double-walled structure of the Acanthamoeba cyst and associated radial keratoneuritis (perineuritis).
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Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.
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Therefore, the possibility of an association by chance cannot be ruled out.
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This ubiquitous inhabitant of the sebaceous glands and hair follicles can cause acne vulgaris.
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The coexistence of acute myeloid leukemia (AML) and CLL in the same patient has been occasionally reported.
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CASE SUMMARY: An 85-year-old white man presented with an upper gastrointestinal hemorrhage from a gastric ulcer.
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Although leukemia after liver transplantation is generally thought of as a rare complication, increases in survival rate following liver transplantation is likely to lead to more such cases, and documentation of these cases is therefore of importance.
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CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.
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INTERVENTIONS: Patients were treated with 4 to 8mg of cyproheptadine by mouth every 6 to 8 hours, 5 to 10mg of diazepam by mouth every 6 to 12 hours, 10 to 20mg of baclofen by mouth every 6 hours, and ITB boluses in some cases.
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STUDY DESIGN: Case report.
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Crumley).
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The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.
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We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.
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Both premortem and postmortem bone marrow sampling revealed almost complete replacement of the marrow space by sheets of histiocytes demonstrating metachromatic cytoplasmic granules.
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This is the first report to describe this extremely rare occurrence.
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In general, it is good medical practice to avoid concomitant administration with centrally acting anticholinergic agents.
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We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.
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Both of the previous patients had therapy-related leukemias after exposure to topoisomerase II inhibitors, whereas our patient had received cytotoxic therapy that did not include a topoisomerase II inhibitor.
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Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.
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Treatment requires management of both the liver abscess and the infected shunt.
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Ten hours later, the patient developed myoclonus of his upper extremities and face.
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Five of nine cases developed in patients with significant gastrointestinal illnesses.
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A 40-year-old Hispanic man with acute lymphoblastic leukemia was treated with a single dose of intrathecal methotrexate 12 mg for prophylaxis against leptomeningeal spread of tumor.
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Shortly after mitral valve replacement she developed a severe hypercalcemia (serum calcium 5.95 mmol/l) during a febrile illness.
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Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.
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Alopecia is an adverse effect in those patients taking aromatic anti-convulsant drugs but is rarely reported after discontinuing such medications in the convalescent status of anti-convulsant hypersensitivity syndrome (AHS).
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She had taken no drug except for the IFN-beta-1b.
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Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels.
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Pathology evaluation of a specimen revealed a high-grade osteoblastic osteosarcoma.
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We also describe a case of timolol-induced ocular pemphigoid.
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Although it has been reported previously in patients being treated for lymphoma, it occurred in this case in a man under treatment for glomerulonephritis.
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Another explanation for the decreased drug levels might be an increased volume of distribution.
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Although guidelines for management have been developed, they may be predicated on data from a single institution or depend on diagnostic procedures and laboratory support that are not necessarily available to physicians in all locations.
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We present foreign body granulomas induced by activated charcoal from intraperitoneal chemotherapy and mimicked peritoneal metastases in the patients with gastric cancer.
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A case of superior sagittal sinus thrombosis associated with Evans' syndrome of immune haemolytic anaemia is reported.
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Drug-induced thrombocytopenia was also considered, and he was told to stop all of his medicines.
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This case report describes a non-cigarette smoking elderly woman who developed bronchial anthracostenosis and mediastinal fibrosis after long-term exposure to wood smoke.
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Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.
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Copaxone is a drug approved for the treatment of MS, and one that is very well tolerated with a high safety profile and relatively few side effects.
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Over 12 months, the patient received six rather than 12 CY treatments, half the cumulative dose that might have been administered.
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Pulmonary impairment in the HUS is rarely reported in the literature, and no reports of pulmonary hemorrhage, as a clinical feature of the HUS, have been documented.
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METHODS: We describe a patient with MG and a steroid-induced major depressive episode with psychotic features treated with ECT.
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This case report represents the successful usage of LS for weaning from cardiopulmonary bypass circulation after coronary artery bypass surgery.
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Severe abdominal colic because of lead poisoning is an uncommon condition in adults.
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A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.
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She recovered with shock therapy and intravenous administration of diphenhydramine and hydrocortisone.
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In patients with GI GVHD clinicians need to be aware of the potential for oral absorption and, in select cases, monitoring of levels may be appropriate.
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RESULTS: Six eyes had occult subfoveal CNV, and one eye had recurrent classic subfoveal CNV.
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Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.
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There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma.
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Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.
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In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.
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To our knowledge, AVP following therapy with TNF-alpha antagonists has not been reported in English literature.
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After 48 hours, improvement in the patient's respiratory symptoms allowed transfer to the ear, nose, and throat unit, where daily endoscopic examination was performed.
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Serum triglyceride levels of four patients with psychotic disorders were decreased after switching therapy from clozapine to risperidone.
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A 55-year-old woman who had been receiving treatment with amiodarone for recurrent supraventricular tachyarrhythmias became thyrotoxic after 30 months of treatment.
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After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.
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The episodes of ocular dystonia were associated with other dystonic movements and a number of psychiatric symptoms, with obsessional thoughts and hallucinations being the outstanding features in one patient each.
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There are few reports in the literature related to sulfonylurea-induced hepatotoxicity.
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The clinical monitoring was based on the serial registration of respiratory rate, cardiac rate, SaO2 and body temperature.
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Until this time, she was without any antidepressive medication.
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