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He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.
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CONCLUSIONS: This case describes the original development of a desensitization protocol to high-dose MTX.
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At least three of these patients developed acute myelogenous leukemia (AML).
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A 24-year-old woman with ALL developed severe epigastric pain 168 days after CBSCT, followed by blistering eruptions 2 days later.
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Use of St.
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Hypercoagulopathy induced by chemotherapy in a patient with lung cancer.
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Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.
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It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.
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Their use on the face in severe atopic eczema is relatively common.
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Gemcitabine-induced rectus abdominus radiation recall.
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Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.
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The case of a myasthenia-like syndrome induced by cardiovascular drugs is reported.
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In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.
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We describe a patient with respiratory failure due to Wegener's granulomatosis (WG) who obtained a dramatic and sustained response to pulse intravenous methylprednisolone and cyclophosphamide.
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Cluster headache (CH) is a well characterized primary headache disorder.
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We propose a classification of cutaneous minocycline pigmentation based on clinico-pathological criteria.
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Range orders should, for example, take into consideration the patient's age, pain intensity, and comorbidities; avoid frequency ranges; and prescribe a maximum dose that is at least two times but no more than four times the minimum dose in the range.
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He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.
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Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.
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Tamoxifen treatment is a proven therapy for breast cancer that produces a survival advantage when used as an adjuvant, and reduces the incidence of recurrences and controlateral tumor evolution.
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A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.
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If troglitazone is used, frequent monitoring of serum aminotransferases and symptoms is mandatory.
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Vasopressors were required to support blood pressure for approximately five hours.
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While our patient's second malignancy may have been a chance association, his and other cases of pancreatic carcinoma in young survivors of hematologic neoplasia suggest that the cytotoxic treatment may have had a role in the pathogenesis of the pancreatic carcinoma.
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Primary Hodgkin's disease of the CNS in an immunocompetent patient: a case study and review of the literature.
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It is rewarding to have the option to offer a medication that improves patients' status and enhances outcomes.
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The patient was resuscitated, and subsequent serial cardiac enzymes indicated myocardial infarction.
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Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.
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Increased awareness of this rapidly progressive and potentially fatal disease leads to accurate diagnosis and the prompt treatment that can decrease morbidity and mortality.
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RESULTS: Complete clinical response was obtained in both patients.
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Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.
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She was discharged with oral levofloxacin to complete an additional 3 days of treatment as an outpatient.
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Electroconvulsive therapy and antibiotics: a case report.
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She had Crohn's disease since age 9 years and was on chronic TPN.
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In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.
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Other explanations for an exaggerated and delayed response to opioids include co-administration of other respiratory depressant drugs such as magnesium sulphate, co-morbidity such as renal impairment and genetic variability in the metabolism of morphine.
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Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.
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These studies indicate that gastrointestinal absorption of aluminum can lead to aluminum intoxication in children with azotemia, and that infants may be particularly susceptible to this complication of therapy.
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Computed tomography and magnetic resonance imaging of the brain showed acute infarctions bilaterally in the cerebellum.
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The patient developed cardiac arrhythmias, acute renal failure, and anemia.
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Blastoschizomyces capitatus infection in acute leukemia patients.
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DCF appears valuable as a second-line treatment in non-Hodgkin's lymphomas and as initial treatment in T-cell chronic lymphocytic leukaemia and mycosis fungoides.
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Drug-induced psychosis is a serious late complication of Parkinson's disease (PD) that requires aggressive treatment.
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After treatment with steroids there was gradual clinical improvement and disappearance of infiltrates.
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We report a case of type III left anterior descending artery (LAD) perforation which was managed successfully with cyanoacrylate glue.
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We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.
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Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.
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We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.
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A recently recognized entity associated with the treatment of acute promyelocytic leukemia: the retinoic acid syndrome.
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We describe our modified technique for custom-made articulating spacers.
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METHODS: This was a prospective, open-label study.
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A MEDLINE search did not identify any citation describing the possibility of an interaction between the drugs.
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Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature.
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Severe complications following thrombolytic therapy of an acute thrombosis of a prosthetic mitral valve.
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Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.
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This rare adverse reaction to TMP-SMX has been reported in adults; however, to our knowledge, it has been reported in only five other children.
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Encephalopathy and seizures induced by intravesical alum irrigations.
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CONCLUSION: The use of HDR radiation in these patients eliminated radiation exposure to care-givers and permitted constant nursing care and interaction among the parents, nursing personnel, and child.
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Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.
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CONCLUSIONS: TEN is a rare disorder that can be fatal in up to 30% of patients.
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The vancomycin concentration was decreased from 101 mg/l to 16.59 mg/l at the end of the procedure.
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The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.
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A wide variety of clinical outcomes have been described after acute valproate ingestion.
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In the latter cases, it is commonly attributed to azathioprine and/or tacrolimus.
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This infection was successfully eradicated after neutrophil recovery by prolonged systemic administration of amphotericin B as well as aggressive local therapy including enucleation of the affected eye.
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To our knowledge, this is the first report of an angio-oedema associated with VRC.
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OBJECTIVES: The authors examined the efficacy of highly selective CDT in late salvage of free-flaps with vascular compromise.
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Recently, results of three open clinical trials on mycophenolate mofetil in myasthenia gravis have been reported.
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These features were initially ascribed to the veno-occlusive disease caused by pyrrolizidine alkaloids, radiotherapy and some therapeutic drugs but have not been described in detail as a complication of AMD therapy.
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Pulmonary thromboembolism after spinal instrumentation surgery.
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An upper gastrointestinal endoscopy revealed reflux esophagitis and the patient was given 20 mg b.i.d. omeprazole.
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We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.
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OBJECTIVE: The aim of this study was to evaluate the present status of surviving patients 10 years later, together with the latest clinical and histological data on patients who had died.
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Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.
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These cases emphasize the need for a high index of suspicion for tickborne illness in oncology patients, and the importance of a low threshold for starting empiric treatment before confirming the diagnosis.
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Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.
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A case of colchicine-induced rhabdomyolysis is reported.
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INTRODUCTION: Fever of unknown origin is a complex problem in dialysis patients with recently rejected renal allografts, due to the contribution of the newly withheld immunosuppressive agents to the immunosuppression of uremia, resulting in an atypical presentation of infections, a main cause of fever in these cases.
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RESULTS: Six preterm and 2 term patients were included in the study.
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The possible pathophysiologic mechanisms for the adverse reactions include a single-drug effect, a pharmacodynamic interaction, and a pharmacokinetic interaction.
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These cases demonstrate that CBZ can induce simple motor tics in children.
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There has been relatively good organ growth and function during this short follow-up period.
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We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.
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A diagnosis of lead poisoning was made and a course of chelating treatment started.
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The patient recovered completely with oral prednisolone.
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Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
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In most patients with catheter-related Rhodotorula fungemia, the condition has been treated with broadspectrum antibiotics.
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Significant systemic manifestations are rare.
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He recovered and could be discharged home after 36 days of hospitalization with normal blood counts and without severe sequelae.
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Our cases of monophasic, multiphasic and recurrent DEM, invoking possible causative triggers, point to the conclusion that DEM has to be regarded as a separate disease; its similarities with NMO raise the expectations that other specific autoantibodies will be identified to explain DEM and its variations.
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After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.
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Recovery was complete in two of three children.
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This theory was supported by disturbances in serine and glycine excretion found in all patients during psychotic episodes.
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INTRODUCTION: Tuberculosis is a rare but serious complication after transplantation.
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This observation highlights the need for hemodynamic monitoring when potent vasodilators are used in this disorder.
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The vasodilating action of calcium-channel blockers decreases the systemic pressure and in turn, may increase the pressure gradient and the left ventricular end-diastolic pressure.
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Donepezil may be a valuable alternative to psychostimulants in the treatment of opioid-induced sedation.
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A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.
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We report that perospirone may have had positive effects on the obesity of three patients with schizophrenia and on the fasting blood sugar (FBS) and HbA1C of two of them who had type 2 diabetes mellitus.
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The efficacy and safety of fluticasone has been established at recommended doses of 200 micrograms/day, but not at higher doses that are often used.
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