text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
these cell lines , except the hlec-1 cell line , produced the following human plasma proteins among those examined : albumin , prealbumin , alpha 1-antitrypsin , ceruloplasmin , fibrinogen , fibronectin , haptoglobin , hemopexin , beta-lipoprotein , alpha 2-macroglobulin , beta 2-microglobulin , transferrin , lipoprotein , alpha 2-macroglobulin , beta 2-microglobulin , transferrin , complement components 3 and 4 , and alpha 1-fetoprotein . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
78,
84
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
219,
228
]
} |
the hypothalamic lhrh content continued to increase throughout the entire experimental period and attained 140 % of the initial level . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
17,
21
]
} |
treatment of human fibroblast cells with human interferon ( inf-alpha , ifn-beta , or ifn-gamma ) resulted in the accumulation of at least four newly synthesized mrnas . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
19,
29
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
72,
80
]
} |
avian luteinizing hormone-releasing hormone ( lh-rh ) has been isolated from 249,000 chicken hypothalami and shown to differ structurally from mammalian hypothalamic lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
153,
165
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
166,
171
]
} |
these same inhibitors have been previously shown to block thrombin-induced platelet lectin activity and platelet thrombospondin lectin activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
75,
83
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
113,
127
]
} |
there was a weak correlation between the weight of the removed thyroid tissue and the maximally obtained tg concentration at the time of surgery , but no correlation with the levels before operation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
63,
70
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
105,
107
]
} |
a solid phase radioimmunoassay ( ria ) for human fibroblast-derived beta ( beta ) interferon is described using dinitrophenylated ( dnp ) igg from rabbit anti-interferon serum and quantitation of the antigen-bound antibodies by subsequently measuring the attachment of 125i-labeled anti-dnp . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
49,
59
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
75,
79
]
} |
hypothalamic-pituitary function in 62 women with amenorrhea syndrome was evaluated by comparing the response of gonadotropin to gnrh stimulation before and after clomiphene treatment . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
128,
132
]
} |
we have investigated the lh response to lh releasing hormone ( lh-rh ) in female hypogonadal ( hpg ) mice in which the hypothalamus contains no lh-rh and the pituitary gland contains significantly less lh than in normal mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
119,
131
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
144,
149
]
} |
one of the characteristic features of the so2-time curves of the red cell was the decrease in steepness at a high so2 range , which has been thought to occur due to the decrease in the oxygenation rate of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
65,
73
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
205,
215
]
} |
we concluded that the rat embryo-derived yolk sac carcinoma is a useful experimental system to study basement membranes and their components such as laminin , type iv collagen , and heparan sulfate . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
101,
119
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
159,
175
]
} |
in order to determine which component of the gbm is responsible for the binding of the gag we studied the linkage between basement membrane collagen type iv and laminin with the gag . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
122,
139
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
140,
156
]
} |
chromatographic fractionation of hypothalamic phospholipids and identification of an acth-trophic factor different from guillemin 's corticotrophin releasing factor ( crf ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
33,
45
]
} | {
"id": "C0010132",
"name": "corticotrophin releasing factor",
"pos": [
133,
164
]
} |
erythrocytic reduced glutathione ( gsh ) and glucose 6-phosphate dehydrogenase ( g-6-pd ) activty in thalassaemia trait and hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
0,
12
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
124,
126
]
} |
receptor identity was explored using antibodies to the leukocyte adhesive receptors mac-1 , lfa-1 , and p150.95 . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
55,
64
]
} | {
"id": "C0079785",
"name": "adhesive",
"pos": [
65,
73
]
} |
and also support the conclusion that the heterodimeric leukocyte adhesive receptor mac-1 functions as the specific receptor structure . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
55,
64
]
} | {
"id": "C0079785",
"name": "adhesive receptor mac-1",
"pos": [
65,
88
]
} |
of the basement membrane components , type iv collagen produces the greatest structural modification , generating thick fibrin fibers ; | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
7,
24
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
38,
54
]
} |
the information obtained here provide a foundation for studies of analyzing trans-acting placental and pituitary proteins to the defined cg beta promoter region . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
89,
98
]
} | {
"id": "C0106132",
"name": "cg beta",
"pos": [
137,
144
]
} |
in the same islet b-cell , gad immunoreactivity appeared predominantly in the extragranular cytoplasm , whereas insulin immunoreactivity was associated with the secretory granules . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
12,
17
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
natural porcine interferons ( poifns ) were obtained from : adherent peripheral blood leukocytes induced with newcastle disease virus ( ndv ) ( ifn-alpha ) , kidney fibroblasts induced with poly ( i : c ) ( ifn-beta ) and whole blood leukocytes induced with phytohemagglutinin ( ifn-gamma ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
165,
176
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
207,
215
]
} |
it is proposed that in pregnancies complicated by red cell isoimmunisation the severity of the disease should be assessed and treated on the basis of the deviation of the fetal haemoglobin from the normal mean for gestation into mild ( haemoglobin deficit less than 2 g/dl ) , moderate ( deficit 2-7 g/dl ) , and severe ( deficit greater than 7 g/dl ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
50,
58
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
236,
247
]
} |
numerous investigations have demonstrated that basement membranes ( bms ) are composed of type iv collagen , laminin , heparan sulfate proteoglycan , nidogen , and possibly fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
47,
65
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
90,
106
]
} |
following attachment to the basement membrane , the tumor cell next secretes proteases which may degrade type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
28,
45
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
105,
109
]
} |
differential counts of blood cells ( neutrophils , lymphocytes , red cells ) , renal tubule cells ( convoluted , collecting duct , necrotic ) , and casts ( i.e . hemoglobin , renal tubule cell ) were included in the sediment evaluation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
65,
74
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
162,
172
]
} |
responses to mycobacterium leprae by lymphocytes from new and old leprosy patients : role of exogenous lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
37,
48
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
103,
114
]
} |
by culture with ril-2 for five days , the lymphocytes were activated to generate lak activity , which was measured by chromium release assay . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
42,
53
]
} | {
"id": "C0024297",
"name": "lak",
"pos": [
81,
84
]
} |
compared with uncoated polyethylene , platelet deposition was increased after precoating with purified human von willebrand factor , fibrinogen or fibronectin , and decreased by preadsorbed immunoglobulin g , albumin or whole plasma . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
38,
46
]
} | {
"id": "C0795677",
"name": "human von willebrand factor",
"pos": [
103,
130
]
} |
serum thyroglobulin ( tg ) is often very elevated in patients with metastatic thyroid carcinoma and , in 18 out of 40 patients examined , serum tg was found to exceed 400 micrograms/l . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
78,
85
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
144,
146
]
} |
following decapitation and surgical isolation , poa-mbh explants were individually perifused with culture medium which was collected for radioimmunoassay of lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "poa-mbh",
"pos": [
48,
55
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
157,
162
]
} |
poa-mbh explants obtained from prepubertal female rats exhibited increased lh-rh release in response to the two pulses of ne and subsequent kcl pulse ( p less than 0.05 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "poa-mbh",
"pos": [
0,
7
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
75,
80
]
} |
there were no differences in the mean total number of hypothalamic lhrh cell bodies identified in the three treatment groups . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
54,
66
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
67,
71
]
} |
the gels were digested with collagenase , and total lymphocyte populations and motile subpopulations were collected and compared with respect to their lymphokine-activated killer activity ( measured as 4-h cytotoxicity against the natural killer-resistant mammary adenocarcinoma line 410.4 ) , their natural killer activity ( measured as 4-h cytotoxicity versus lymphoma yac-1 ) , and their subset distribution ( defined by immunofluorescence ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
52,
62
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
151,
161
]
} |
in the vascular bed , endothelial cells provide a nonthrombogenic lining layer and release small amounts of tissue plasminogen activator into the circulation , maintaining patency of the vascular bed , whereas the alveolar epithelial surface is replete with active enzymes of the extrinsic pathway of coagulation as well as urokinase . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
22,
39
]
} | {
"id": "C0042071",
"name": "urokinase",
"pos": [
324,
333
]
} |
freezing has been shown to damage pancreatic islets and to disrupt their insulin release , probably because of intracellular ice formation . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
34,
51
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
73,
80
]
} |
in chicken and rat pituitary cell bioassays and in rat receptor binding studies , the mammalian form of gnrh in hplc fractions of the sheep and human hypothalamus displayed activity appropriate for this immunoreactive peak being mammalian gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
150,
162
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
239,
243
]
} |
at 10 , 30 , 60 , and 120 minutes after the onset of stress , their fetuses were dissected out , and the contents of hypothalamic and pituitary immunoreactive beta-endorphin ( ir-beta-ep ) and hypothalamic immunoreactive growth hormone-releasing factor ( ir-grf ) were determined by specific radioimmunoassays . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
117,
129
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
221,
252
]
} |
tyrosine supplementation tended to attenuate stress-induced changes in hypothalamic and pituitary ir-beta-ep , but the response of hypothalamic ir-grf was less modified by tyrosine . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
71,
83
]
} | {
"id": "C0037668",
"name": "ir-grf",
"pos": [
144,
150
]
} |
hypothalamus-hypophysis and testicular gnrh control of gonadal activity in the frog , rana esculenta : seasonal gnrh profiles and annual variations of in vitro androgen output by pituitary-stimulated testes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
112,
116
]
} |
the gene coding for human thrombomodulin , a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein c zymogen , was isolated from a human genomic library by employing human thrombomodulin cdna as a probe . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial",
"pos": [
66,
77
]
} | {
"id": "C2744539",
"name": "human thrombomodulin",
"pos": [
210,
230
]
} |
a severalfold stimulation of 32pi uptake was observed after exposure of the membranes to an erythrocyte lysate or to hemoglobin in the presence of mg2+ . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
92,
103
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
117,
127
]
} |
when unilateral lesions included the rostral part of the hypothalamus , crf-like immunoreactive ( crfi ) ipsilateral fibers in the ls decreased in number . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
57,
69
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
98,
101
]
} |
tcr had modulated from t cells in spleen and lymph node early after treatment , and tcr expression remained subnormal for at least 51 days posttreatment . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
23,
30
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
84,
87
]
} |
we show that , even in t cells with this mhc restriction degeneracy , the tcr expressed in the two strains are different . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
23,
30
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
74,
77
]
} |
characterization of a monoclonal antibody to guinea pig t cells that inhibits rosette formation of the cells with rabbit erythrocytes : similarity of the antigen to e-receptor on human t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
56,
63
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
167,
175
]
} |
we examined this hypothesis using an organ culture system that measures the ability of single rat hypothalami to secrete immunoreactive crh ( ir-rcrh ) in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
98,
109
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
146,
149
]
} |
release of hypothalamic neuropeptide y and effects of exogenous npy on the release of hypothalamic gnrh and pituitary gonadotropins in intact and ovariectomized does in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
11,
23
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
99,
103
]
} |
the effect of npy on the hypothalamic release of gnrh and pituitary release of gonadotropins was examined in intact and ovariectomized ( ovex ) rabbits in a superfusion system . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
25,
37
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
49,
53
]
} |
exposure of mediobasal hypothalami ( mbh ) from intact rabbits to npy ( 8 x 10 ( -8 ) m ) resulted in a sustained stimulation of gnrh secretion into the medium . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
23,
34
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
129,
133
]
} |
the hypothalamic distribution of immunopositive lgnrh neurons is similar to that observed for those containing the mammalian gonadotropin-releasing hormone ( mgnrh ) , indicating a possible role for this newly identified peptide in the regulation of pituitary function . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
125,
155
]
} |
in addition to the histology of epithelial and stromal elements of prostates from intact dogs ( group 0 ) and castrated dogs ( group i ) , the latter of which were treated with androstenedione ( group ii ) , androstenedione plus the aromatase inhibitor 1-methyl-1,4-androstadiene-3,17-dione ( group iii ) , or androstenedione plus aromatase inhibitor and cyproterone acetate ( group iv ) ( habenicht and el etreby : the prostate 11:133-143 , 1987 ) it was of interest to study the influence of such in vivo treatment on the prostatic 5 alpha-reductase , which is responsible for the cellular conversion of testosterone to 5 alpha-dihydrotestosterone . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
524,
533
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
534,
551
]
} |
3 ) in prostates of intact dogs and dogs of group ii the proportion of epithelial 5 alpha-reductase exceeded distinctly that of stromal 5 alpha-reductase . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostates",
"pos": [
7,
16
]
} | {
"id": "C0039602",
"name": "5",
"pos": [
136,
137
]
} |
nitrogen retention , hormone concentrations , and weight gain were measured in five bull calves ( 90 kg body wt ) administered 0 or 0.067 microgram nle rat hypothalamic grf ( 1,29 ) nh2/kg body wt every 4 hr for 10 days . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
156,
168
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
169,
172
]
} |
our previous data indicated that changes in pancreatic islet hormones are not normally critical but decrements in insulin , increments in glucagon , or both become critical when catecholamine actions are blocked pharmacologically . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
44,
60
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
114,
121
]
} |
and ( b ) when a metastatic signet-ring-cell carcinoma with negative intracytoplasmic mucin is identified , a prostatic origin should be considered , and prostatic-specific antigen and prostatic acid phosphatase immunostaining should be performed . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
110,
119
]
} | {
"id": "C0138741",
"name": "prostatic-specific antigen",
"pos": [
154,
180
]
} |
immunohistochemical staining was used to demonstrate basement membrane ( bm ) laminin and type iv collagen in eight cases of kaposi 's sarcoma ( ks ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
53,
70
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
90,
106
]
} |
since our recent studies implicated arachidonic acid and other polyunsaturated fatty acids in ca2+ mobilization and insulin release from pancreatic islets , we have now examined the effect of dantrolene on fatty acid-induced 45ca2+ efflux and insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
137,
154
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
243,
250
]
} |
fetal haemoglobin ( alpha 2 gamma 2 ) is predominant in red cells of the fetus and newborn baby , and is largely replaced after birth by adult haemoglobin ( alpha 2 beta 2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
56,
65
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
143,
154
]
} |
discrimination between growth hormone ( gh ) deficiency of hypothalamic or pituitary origin : an aid in selecting patients for gh-releasing hormone ( rh ) prolonged therapy . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
59,
71
]
} | {
"id": "C0037668",
"name": "gh-releasing hormone",
"pos": [
127,
147
]
} |
it is suggested that patients with a partial ghd due to a hypothalamic lesion might benefit from long-term therapy with gh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
58,
70
]
} | {
"id": "C0037668",
"name": "gh-rh",
"pos": [
120,
125
]
} |
the 3 antisera were similar to each other in their reactivity with thyroid tg samples from 25 patients with various thyroid disorders and from 10 normal subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
67,
74
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
75,
77
]
} |
this conclusion is important to an understanding of tg structure in thyroid disease and to the use of thyroid tg for preparation of antisera and standards for measuring serum tg concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
68,
75
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
175,
177
]
} |
it is concluded that , in the rat hypothalamus , the locations of neurons containing hypophysiotrophic srif are confined within the rostral periventricular region and the parvicellular paraventricular nucleus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
34,
46
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
103,
107
]
} |
at 72 h , distribution of 75se in erythrocyte was 35 to 40 % in glutathione peroxidase , 50 % in hemoglobin , and 5 % in a selenite plus selenopolypeptide fraction . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
34,
45
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
secretion of gh occurs in episodic bursts under the dual control of two hypothalamic peptides , gh-releasing factor ( grf ) and gh-inhibiting factor ( somatostatin , srif ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
166,
170
]
} |
to test the possibility that grf discharge is functionally coupled with the withdrawal of srif , we investigated whether acute withdrawal of srif can induce grf release by the rat hypothalamus using highly specific antisera against srif and rat grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
180,
192
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
232,
236
]
} |
pretreatment with cysteamine ( 300 mg/kg , s.c. ) , a known depletor of hypothalamic srif , or with anti-srif serum ( 0.5 ml/rat ) completely counteracted the lessening of the gh response to ghrh induced by 2.0 micrograms gh injected i.c.v . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
105,
109
]
} |
the present data substantiate that high mr forms , slightly heavier than authentic pituitary lh ( mr 23,000 daltons ) and therefore not identical to the hypothalamic decapeptide lh-rh , represent ovine pineal factors which can increase the concentration of lh in the medium of cultured anterior pituitaries , but does not influence the secretion of prolactin in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
153,
165
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
178,
183
]
} |
t-cell activation and induction of interleukin-2 ( il-2 ) expression in human t lymphocytes require both interaction of foreign antigen with the t-cell antigen receptor and protein kinase c ( pkc ) stimulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
0,
1
]
} | {
"id": "C0034790",
"name": "t-cell antigen",
"pos": [
145,
159
]
} |
xylazine-treated camels had significantly lower values for rbc , hemoglobin , and packed cell volume , and significantly higher blood glucose concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
59,
62
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
65,
75
]
} |
peaks in plasma levels of lh were especially conspicuous and from the changes in frequency and amplitude of these peaks it was possible to predict the way in which photoperiod influenced gonadotrophin secretion by its effect on hypothalamic lh-rh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
228,
240
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
241,
246
]
} |
finally , we have made an effort to formulate some of the mechanisms whereby individual red cells may come to contain varying proportions of specific hemoglobins . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
88,
97
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
150,
161
]
} |
no increase in red-cell turnover was detected by indirect measurement ( hemoglobin , reticulocyte count , plasma hemoglobin , serum haptoglobin ) or by turnover of 51cr-labeled erythrocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red-cell",
"pos": [
15,
23
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
113,
123
]
} |
the data obtained permitted to suppose that feed-back of the hypothalamus with the epiphysis could be realized with the aid of lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
61,
73
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
127,
132
]
} |
to remove the non-alpha ( 2u ) -globulin sequences , this cdna preparation is hybridized to an rna concentration x incubation time ( r ( 0 ) t ) of 1000 mol of ribonucleotide per liter x sec with female rat liver mrna , which , though it shares the vast majority of mrna sequences with male liver , contains no alpha ( 2u ) -globulin mrna sequences . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
207,
212
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
325,
333
]
} |
there were no significant changes in the haematological parameters studied ( blood erythrocytes , leucocytes , haemoglobin , haematocrit , and the volume , amount of haemoglobin , and haemoglobin concentration of the red cells ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "blood",
"pos": [
77,
82
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
184,
195
]
} |
changes of outflux extractability and enzyme activity of proteins during the thermal alteration of muscle are considered with regard to data about the complexing of muscle proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
99,
105
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
165,
180
]
} |
erythrocyte lysate and preparations of haemoglobin derived from the lysate increase the number and size of the colonies growing in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
39,
50
]
} |
hypoglycemia induced by insulin and arginine infusion failed to increase gh levels , and the administration of the hypothalamic lh-fsh releasing hormone ( lh-rh ) did not elicit any response in the secretion of gonadotropins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
115,
127
]
} | {
"id": "C0023610",
"name": "lh-fsh releasing hormone",
"pos": [
128,
152
]
} |
the oxygen capacity of eryhem as per 1 g of hb constituted 72 % only of the oxygen capacity of erythrocyte hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
95,
106
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
107,
109
]
} |
islets of langerhans were stablished in the spaces between 9 synthetic hollowfibers in a `` '' bio-artificial insulin distributor '' '' which was implanted in the carotid artery of totally pancreatectomized dogs . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
0,
20
]
} | {
"id": "C0021641",
"name": "insuli",
"pos": [
110,
116
]
} |
treatment with rat thyroid extract during the course of irradiation and before the onset of thyroiditis prevented the expected development of thyroid lesions and autoantibodies to thyroglobulin in these animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
19,
26
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
180,
193
]
} |
the sensitized effect of prestimulation with 16.7 mm glucose on insulin release with a slow-rise glucose stimulation from the perifused rat islets of langerhans was studied , together with the kinetic analysis of insulin release , and the interrelationship between the prestimulation time and the maximal rate of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
140,
160
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
313,
320
]
} |
hypothalamic lhrh , pituitary lh and plasma lh levels were measured in rats of both sexes from day 5-60 after birth . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
13,
17
]
} |
subsequently the content of hypothalamic lhrh increased and showed peak values on day 25 in the female rat and on day 45 in the male rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
41,
45
]
} |
observations on days 17 , 25 and 37 in the female rat and on days 5 , 7 , 10 and 22 in the male rat clearly show an inverse relationship between hypothalamic lhrh and plasma lh and a parallel relationship between pituitary and plasma lh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
145,
157
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
158,
162
]
} |
the pattern of lysosomal enzyme activities in isolated pancreatic islets was studied in 3 different strains of mice , nmri , cba , and c-57 , and related to the in vivo insulin release following injection of the insulin scretagogues glucose and carbachol . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
55,
72
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
212,
219
]
} |
a definite augmentation of the tumor growth , as evidenced by the dissemination of the tumor into the spleen , liver and kidney , was evident in the globulin-treated series . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
111,
116
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
149,
157
]
} |
in the rat hypothalamus , crf activity was most concentrated in the median eminence , but crf was present in the stalk and the posterior pituitary gland in much higher concentrations than in the median eminence in both species . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
11,
23
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
90,
93
]
} |
the ability of the rat hypothalamus to produce corticotrophin releasing hormone ( crh ) in vitro was studied in the presence and absence of neurotransmitter substances , angiotensin and corticosterone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
23,
35
]
} | {
"id": "C0010132",
"name": "corticotrophin releasing",
"pos": [
47,
71
]
} |
changes in blood ( bv ) , red cell ( rcv ) , and plasma ( pv ) volumes were computed from hemoglobin and hematocrit values during submaximal treadmill exercise at 5 work intensities ( 30 , 45 , 60 , 75 , and 90 % vo2 max ) in 5 male subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
26,
34
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
90,
100
]
} |
the pituitary lh response to synthetic lh-rh was the same in ovariectomized rats with or without pituitary grafts , and the decrease in hypothalamic lh-rh after orchidectomy was prevented by pituitary grafts . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
136,
148
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
149,
154
]
} |
administration of the progestins , progesterone and dihydroprogesterone ( dhp ) , and of the hypothalamic decapeptide , lh-rh , 6 hr prior to testing restored receptivity to varying degrees in these e2b + dht treated mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
93,
105
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
120,
125
]
} |
the ( 125 ) i label of ( 125 ) i-labelled liposomes was incorporated into thyroid protein and/or thyroglobulin at a higher rate than was the ( 131 ) i label of either na ( 131 ) i or ( 131 ) i ( 2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
74,
81
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
97,
110
]
} |
a very strong inhibition of iodide ; uptake ' from na ( 131 ) i , caused by thiosulphate , produced only a minor inhibition of the incorporation of ( 125 ) i from ( 125 ) i-labelled liposomes into thyroid protein and/or thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
197,
204
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
220,
233
]
} |
blockade of progesterone-induced increase in hypothalamic luteinizing hormone-releasing hormone levels and serum gonadotropins by intrahypothalamic implantation of 6-hydroxydopamine . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
58,
69
]
} |
the present study was undertaken to identify the hypothalamic locus where norepinephrine ( ne ) nerve terminals communicate with luteinizing hormone-releasing hormone ( lh-rh ) -containing neurons involved in the stimulatory feedback action of gonadal steroids on lh and fsh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
49,
61
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
129,
140
]
} |
hypothalamic srif containing neuronal perikarya are predominantly located in the anterior hypothalamic area ( aha ) , a region implicated in the inhibitory control of gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
13,
17
]
} |
the effect of aha lesions on srif in the me , posterior pituitary , pancreas , stomach , and small intestine was studied in the rat in order to elucidate the source of me and posterior pituitary srif and to determine if depletion of hypothalamic srif affects peripheral organ concentrations of the peptide . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
233,
245
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
246,
250
]
} |
lesioned animals showed a highly significant ( p less than 0.01 ) 83 % and 82 % reduction in me and posterior pituitary srif and to determine if depletion of hypothalamic srif affects peripheral organ concentrations of the peptide . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
158,
170
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
171,
175
]
} |
these data suggest that the hypothalamic srif pathway begins in the aha , from where axons of somatostatinergic neurosecretory neurons project to both me and posterior pituitary . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
41,
45
]
} |
Subsets and Splits
No saved queries yet
Save your SQL queries to embed, download, and access them later. Queries will appear here once saved.