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stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
in intact mice , ht gnrh content increased twofold during aging while gnrh receptor sites in pt remained unchanged . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "ht",
"pos": [
17,
19
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
70,
74
]
} |
ovx resulted in a significant decrease in both ht gnrh content and pt receptor sites and no age difference was observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "ht",
"pos": [
47,
49
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
50,
54
]
} |
after e2 therapy for 7 days , ht gnrh content and pt gnrh receptor sites returned to normal levels in all age groups . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "ht",
"pos": [
30,
32
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
53,
57
]
} |
our results demonstrate an age related dichotomy in the pt production of fsh : lh unrelated to changes in either ht gnrh content or its pt receptor sites , thus suggesting cellular defects in post-receptor binding events within the pituitary . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "ht",
"pos": [
113,
115
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
116,
120
]
} |
the hormonal induction of thyroid peroxidase ( tpo ) mrna is studied in the functional rat thyroid cell line frtl-5 and compared to the induction of thyroglobulin ( tg ) mrna and i- uptake . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
26,
33
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
149,
162
]
} |
thus , when another differentiated rat thyroid cell line , the pc cells , are transformed by human c-myc ( pc myc ) , tpo and tg mrnas are both present at normal levels , while i- uptake is slightly decreased ; | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
39,
46
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
126,
128
]
} |
these data suggest that the hypothalamic control of gonadotropic function is operating by day 19 of fetal life and that a negative feedback of testosterone on lh and probably gnrh release is also operating in rat fetuses on days 19 and 21 of gestation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
175,
179
]
} |
these results suggest that the inhibitory effects of exogenous glucocorticoids on testosterone secretion could be mediated in both fetuses and newborns at least partially through suppression of the hypothalamic and pituitary secretion of gnrh and lh , respectively , and provide insight how stress or hormone imbalance may affect the development of this neuroendocrine system . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
198,
210
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
238,
242
]
} |
a norepinephrine-dependent mechanism in the preoptic/anterior hypothalamic area but not in the mediobasal hypothalamus is involved in the regulation of the gonadotropin-releasing hormone pulse generator in ovariectomized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
106,
118
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
156,
186
]
} |
the changes in thermoregulatory effectors produced by an injection of polyriboinosinic acid : polyribocytidylic acid ( poly i : c ) or interferon were assessed and compared in control rats , in rats with hypothalamic somatostatin ( ss ) receptor blockade and in rats with hypothalamic ss depletion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
204,
216
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
285,
287
]
} |
a t lymphocyte expresses on its surface one of two types of antigen receptor , t-cell receptor alpha beta or t-cell receptor gamma delta , encoded by a pair of somatically rearranged alpha and beta or gamma and delta genes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocyte",
"pos": [
2,
14
]
} | {
"id": "C0085247",
"name": "t-cell receptor alpha beta",
"pos": [
79,
105
]
} |
a t lymphocyte expresses on its surface one of two types of antigen receptor , t-cell receptor alpha beta or t-cell receptor gamma delta , encoded by a pair of somatically rearranged alpha and beta or gamma and delta genes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocyte",
"pos": [
2,
14
]
} | {
"id": "C0085246",
"name": "t-cell receptor gamma delta",
"pos": [
109,
136
]
} |
in 8-week-old obese rats , a decrease of gh pituitary content and an increase of hypothalamic somatostatin ( srif ) concentration were observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
81,
93
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
109,
113
]
} |
mediobasal hypothalami of 18-month-old male rats were perifused in vitro either in the presence or in the absence of a gnrh agonistic analogue ( buserelin : [ d-ser ( tbu ) 6 , des-gly10 ] gnrh ethylamide ) and stimulated with 5-min pulses of k+ ( for a total of six pulses ) in order to test their ability to release gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
11,
22
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
318,
322
]
} |
cd4+ lymphocytes from patients with acute severe asthma showed significant increases in the expression of three surface proteins associated with lymphocyte activation ( interleukin-2 receptor [ il-2r ] , class ii histocompatibility antigen [ hla-dr ] , and `` '' very late activation '' '' antigen [ vla-1 ] ) as compared with those from normal control subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
0,
3
]
} | {
"id": "C0019630",
"name": "class ii histocompatibility antigen",
"pos": [
204,
239
]
} |
cd4+ lymphocytes from patients with acute severe asthma showed significant increases in the expression of three surface proteins associated with lymphocyte activation ( interleukin-2 receptor [ il-2r ] , class ii histocompatibility antigen [ hla-dr ] , and `` '' very late activation '' '' antigen [ vla-1 ] ) as compared with those from normal control subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
0,
3
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
242,
248
]
} |
the incubation of erythrocyte suspensions or isolated membranes containing a residual amount of hemoglobin ( 0.04 % of original cellular hemoglobin ) with tert-butyl hydroperoxide ( tbhp , 0.5 mm ) caused significant inhibition of basal and calmodulin-stimulated ca2+ + mg2 ( + ) -atpase activities and the formation of thiobarbituric acid reactive products measured as malondialdehyde . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
18,
29
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
137,
147
]
} |
both concentrations of endothelin-1 led to a significant increase ( p less than 0.01 ) in the release of substance p from the hypothalamus and pituitary , but not of vasoactive intestinal peptide , 7b2 , or somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
126,
138
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
207,
219
]
} |
we conclude that npy has a physiologically significant inhibitory action within the hypothalamus to suppress gh release in ovariectomized female and intact male rats by stimulation of srif release by alpha 1 and beta-adrenergic receptor-mediated mechanisms . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
84,
96
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
184,
188
]
} |
increasing amounts of lymphocyte lysate displaced [ 125-i ] lhrh from lhrh antibody in a manner parallel to that produced by synthetic hypothalamic lhrh , suggesting immunologic similarity between lymphocyte and hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
135,
147
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
225,
229
]
} |
furthermore , when lymphocyte lysate and identically treated synthetic lhrh were hplc fractionated , there was coelution of lysate and hypothalamic lhrh bioactivity . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
135,
147
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
148,
152
]
} |
the first aim was to determine whether the hypothalamic gnrh secretory system is capable of normal function . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
43,
55
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
56,
60
]
} |
the initial approach was to compare hypothalamic gnrh content between lambs on a restricted diet with low lh pulse frequency ( less than 1 pulse/4 h ; n = 5 ) and lambs on an ad libitum diet with high lh pulse frequency ( 4.5 +/- 0.4 pulses/4 h ; n = 5 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
36,
48
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
49,
53
]
} |
we attempted to examine the immunopathological change of the pancreatic islets of newly diagnosed type 1 ( insulin-dependent ) diabetic patients and thereby to obtain useful information for the therapy of the patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
61,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
107,
114
]
} |
previous studies have suggested that hla dq molecules control low responsiveness through activating cd4 t cells which generate cd8 positive t cells , whereas hla -dr molecules control high responsiveness through activating cd4 helper t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4 t cells",
"pos": [
100,
111
]
} | {
"id": "C0019764",
"name": "hla",
"pos": [
158,
161
]
} |
plasma levels of hemopexin and of c3 decreased to 75 % and 30 % of normal , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
0,
6
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
17,
26
]
} |
double-negative ( cd4-/cd8- ) t cells expressing the alpha/beta transgenic tcr from the 2c cell line ( anti-h-2ld ) were examined in the periphery of animals whose mhc type produces positive , negative , or no selection for differentiation of the tcr on single positive ( cd8+ ) cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
30,
37
]
} | {
"id": "C0085247",
"name": "alpha/beta",
"pos": [
53,
63
]
} |
double-negative ( cd4-/cd8- ) t cells expressing the alpha/beta transgenic tcr from the 2c cell line ( anti-h-2ld ) were examined in the periphery of animals whose mhc type produces positive , negative , or no selection for differentiation of the tcr on single positive ( cd8+ ) cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
30,
37
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
247,
250
]
} |
diminished expression of i-a membrane glycoproteins on spleen lymphocytes was noted , however , perhaps reflecting reduced availability of i-a-inducing lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
62,
73
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
152,
163
]
} |
at least two membrane receptors have been defined through which human t lymphocytes can be induced to proliferate and differentiate , namely the cd3-ti antigen receptor complex and the cd2 molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
1,
2
]
} | {
"id": "C0108773",
"name": "cd2 molecule",
"pos": [
185,
197
]
} |
observation of rats given oral administration of 59fe-labeled cationic cacodylate ferric ( 59fe-cac ) colloid , anionic citrate ferric ( 59fe-cit ) colloid , cationic 59fe-cac complex and anionic 59fe-cit complex revealed that iron absorption was more efficient in the 59fe-cac colloid , moderate in the 59fe-cac complex , low in the 59fe-cit colloid , and lowest in the 59fe- cases given 59fe-cac colloid and 59fe-cac complex , a very high ratio activity was found in the liver and in the erythrocyte or hemoglobin in circulating blood , while the blood plasma , bone marrow , and spleen were low in activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
490,
501
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
505,
515
]
} |
studies using isolated pancreatic islets indicated that islet sensitivity to glucose was increased by either endotoxin or il-1 to a similar extent , but there was no effect of endotoxin or il-1 on the maximal insulin secretory response of islets to glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
23,
40
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
209,
216
]
} |
precise sonographic measurements did not prove a correlation between the volume of the thyroid gland and basic laboratory parameters ( plasma thyroxine , triiodothyronine , thyroglobulin level , level of free fractions of thyroxine and triiodothyronine , globulin binding thyroxine and adenopituitary thyrotropic hormone ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
87,
100
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
173,
186
]
} |
conversely , during exposure to hypertonic media , net glutamine release from the liver increased due to inhibition of glutaminase flux and slight stimulation of flux through glutamine synthetase . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
82,
87
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
119,
130
]
} |
the three phase partitioning method of protein fractionation was successfully applied to human erythrocyte hemolysates for the removal of hemoglobin and the concentration of soluble enzymes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
95,
106
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
138,
148
]
} |
a second experiment was done to verify the activity of the rbc systems responsible for maintaining the hemoglobin molecule in the reduced state . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
59,
62
]
} | {
"id": "C0057437",
"name": "state",
"pos": [
138,
143
]
} |
this study was designed to evaluate profiles of serum concentrations of lh , pituitary content of lh and gnrh receptors , and hypothalamic content of gnrh in undernourished , ovariectomized ewes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
126,
138
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
150,
154
]
} |
individuals with sarcoidosis were evaluated for preferential usage of t cells with the gamma delta-positive ( + ) type of t cell antigen receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
70,
77
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
122,
145
]
} |
to determine the origin of these expanded populations of lpr and gld t cells , we examined the expression of cd2 molecules and mrna transcripts in association with other cell surface phenotypes of these cells and correlated them with subpopulations of dn t cells in the thymus and peripheral lymphoid tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
69,
76
]
} | {
"id": "C0108773",
"name": "cd2 molecules",
"pos": [
109,
122
]
} |
both lpr and gld dn t cells were cd2- , cd3+ , cd4- , cd8- , cd25- , cd45r+ , tcr alpha/beta+ , tcr gamma/delta- , hsa ( j11d ) -/+ , thy-1+/- , and lp-1-/+ . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
20,
27
]
} | {
"id": "C0085247",
"name": "tcr",
"pos": [
96,
99
]
} |
both lpr and gld dn t cells were cd2- , cd3+ , cd4- , cd8- , cd25- , cd45r+ , tcr alpha/beta+ , tcr gamma/delta- , hsa ( j11d ) -/+ , thy-1+/- , and lp-1-/+ . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
20,
27
]
} | {
"id": "C0085246",
"name": "tcr gamma/delta",
"pos": [
96,
111
]
} |
immunoreactive somatostatin levels in hypothalamus were unaffected by diabetes , as was the incorporation of [ 35s ] cysteine into hypothalamic somatostatin-14 and somatostatin-28 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
131,
143
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
144,
159
]
} |
the results obtained show that the aromatic polyamidine tapp-br does not affect attachment , but inhibits the `` '' in vitro '' '' invasiveness of tumor cells cultured on a reconstituted basement membrane composed by laminin , type iv collagen , entactin , heparan sulphate proteoglycans . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "d basement membra",
"pos": [
185,
202
]
} | {
"id": "C0009333",
"name": ", type iv collag",
"pos": [
225,
241
]
} |
the role of insulin in modulating phosphoinositide breakdown and accumulation of inositol phosphates was investigated in isolated rat pancreatic islets by using gpais ( guinea-pig anti-insulin antiserum ) that neutralizes effects of insulin in the medium . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
134,
151
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
233,
240
]
} |
the identification of cd2-negative t cells opens a new approach for studying the interrelationship between cd3-tcr and cd2 t-cell activation pathways . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
35,
42
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
111,
114
]
} |
exposure of neonatal rat islets of langerhans for 20 h to sera from diabetic bb rats and rabbit complement resulted in a decrease in insulin content and in insulin release upon glucose stimulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
9,
11
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
156,
163
]
} |
thus , stz is able to induce a specific immune response against islet cells with a progressive damage of malignant insulin producing cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
64,
75
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
115,
122
]
} |
two different methods were used to selectively eliminate t cells expressing a certain t-cell receptor ( tcr ) v beta chain in mouse strains susceptible to cia . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
57,
64
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
86,
101
]
} |
it therefore seems that the requirements for activation of suppression by cd4+ dy+ t-cell clones in this in vitro model bear many similarities to those for cd4+ helper t cells , namely , mediation by mhc class ii with cd4 involvement , dependency on lfa-1-influenced cell interactions , and reliance on clonal expansion caused by il-2 and possibly amplified by il-1 and/or il-6 . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
74,
77
]
} | {
"id": "C0019630",
"name": "mhc class ii",
"pos": [
200,
212
]
} |
transfer of fluorescent fatty acids from liver and heart fatty acid-binding proteins to model membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
41,
46
]
} | {
"id": "C1312696",
"name": "heart fatty acid-binding",
"pos": [
51,
75
]
} |
ffa transfer rates from both liver and heart fabp are independent of acceptor concentration and composition , suggesting that , at least in the case of model membrane acceptor vesicles , the mechanism of transfer is via aqueous diffusion rather than via collision of fabp with membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
29,
34
]
} | {
"id": "C1312696",
"name": "heart fabp",
"pos": [
39,
49
]
} |
glucose uptake changes were closely proportionate to changes in glucose transporter content of plasma membranes as assessed by an antiserum to the c-terminal peptide of the erythrocyte/hepg2/brain-type glucose transporter . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
173,
184
]
} | {
"id": "C1504631",
"name": "hepg2",
"pos": [
185,
190
]
} |
in conclusion , insulin plays a long term regulatory role on cultured adipocyte glucose transporter content through a selective effect on the erythrocyte/hepg2/brain-type glucose transporter . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
142,
153
]
} | {
"id": "C1504631",
"name": "hepg2",
"pos": [
154,
159
]
} |
osmotic shock-induced hemolysis of red cells for the fresh and preserved blood was examined in order to determine the red cell sensitivity to hemolysis in relation to hemoglobin status . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
35,
44
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
167,
177
]
} |
the obtained hemolysis curves suggest that hemolysis depends on the red cell hemoglobin status : a more oxidized hemoglobin is associated with an earlier onset of hemolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
68,
76
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
113,
123
]
} |
basing on these data , the authors conclude that red cell sensitivity to hemolysis depends on the degree of hemoglobin oxidation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
49,
57
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
108,
118
]
} |
in the hypothalamus there are significant positive correlations between the neuropeptides galanin and corticotropin-releasing factor on the one hand , and age over 60 on the other . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing factor",
"pos": [
102,
132
]
} |
the distribution of these components ( pg-m and pna binding material ) overlaps , but differs from that of type i collagen and fibronectin and basement membrane components , such as laminin , basement membrane heparan sulfate proteoglycan , and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
143,
160
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
245,
261
]
} |
the genes coding for the two polypeptide chains , alpha 1 ( iv ) and alpha 2 ( iv ) , which form together the molecule of the basement membrane type iv collagen , were found to have a special and unusual genomic arrangement . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
126,
143
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
144,
160
]
} |
we and others have previously reported the existence of hypothalamic and anterior pituitary ( ap ) enzymes that degrade luteinizing hormone ( lh ) -releasing hormone ( lhrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
56,
68
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
168,
172
]
} |
these t cells have been isolated and characterized as cd3+ , cd4+ cells expressing the alpha/beta t cell receptor ( tcr ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
6,
13
]
} | {
"id": "C0085247",
"name": "alpha/beta t cell receptor",
"pos": [
87,
113
]
} |
means and standard deviations of selenium parameters were : plasma selenium 106.4 +/- 23.7 micrograms/l , erythrocyte selenium 0.59 +/- 0.19 microgram/g hb , toenail selenium 0.78 +/- 0.17 ppm , and erythrocyte glutathione peroxidase activity 28.0 +/- 8.1 u/g hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
106,
117
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
260,
262
]
} |
stz-induced changes in copulatory behavior were associated with changes in hypothalamic lhrh levels and catecholamine turnover . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
88,
92
]
} |
we have investigated the effects of sulfated chitin derivatives and heparin on the invasion of b16-bl6 melanoma cells through reconstituted basement membrane matrigel which contains laminin , type iv collagen , heparin sulfate proteoglycan , and entactin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
140,
157
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
192,
208
]
} |
stratification of the red cell pool is the reason why there is a smaller clinical difference between glycosylated protein and haemoglobin than corresponds to their half-times . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
22,
30
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
126,
137
]
} |
at diagnosis 33 of the 39 patients ( 85 % ) were positive for thyroid microsomal antibodies , 13 ( 33 % ) were positive for thyroglobulin antibodies , and 4 ( 10 % ) were positive for iaa . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
62,
69
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
124,
137
]
} |
pancreatic islets isolated from adult wistar male rats were incubated with these agents and insulin release in the media was measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
0,
17
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
92,
99
]
} |
this is caused by a drop in the mchc and erythrocyte 2,3-bpg concentration that give rise to a decrease in the 2,3-bpg/hb ratio . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
41,
52
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
119,
121
]
} |
our data show that , despite the increase in 2,3-dpg and the decrease in average erythrocyte age , the in vivo hemoglobin-o2 affinity remains unchanged . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
81,
92
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
111,
121
]
} |
in fact , when 6- ( n-propyl ) -2-thiouracil ( ptu ) -treated , iodine-deficient animals were injected with 125i and killed shortly after , we isolated from thyroid glands poorly iodinated thyroglobulin ( about 1 iodine atom/thyroglobulin molecule ) , nearly 90 % of the radioactivity of which was found as monoiodotyrosine . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
157,
171
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
225,
238
]
} |
the monoclonal antibody b6 , obtained after immunization of balb/c mice with human fibroblast ifn-beta , was capable of binding and neutralizing both ifn-alpha 2 and natural ifn-beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
83,
93
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
174,
182
]
} |
prostate cancer detection in a clinical urological practice by ultrasonography , digital rectal examination and prostate specific antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate",
"pos": [
0,
8
]
} | {
"id": "C0138741",
"name": "prostate specific antigen",
"pos": [
112,
137
]
} |
among 1,807 men a detection rate of 14.6 % was achieved in a clinical urological practice by physician-conducted prostate ultrasonography , digital rectal examination and determination of serum prostate specific antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate",
"pos": [
113,
121
]
} | {
"id": "C0138741",
"name": "prostate specific antigen",
"pos": [
194,
219
]
} |
previously , kidneys from three-week-old cpk/cpk c57/b16 mice were found to contain elevated mrna levels for the basement membrane components collagen iv and laminin [ 1 ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
113,
130
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
142,
153
]
} |
the b-lymphocyte-specific activity of the immunoglobulin mu heavy-chain gene enhancer has been attributed to the octamer motif ( atttgcat ) present within the enhancer that binds a b-cell-specific factor designated nf-a2/otf-2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0004561",
"name": "b-cell",
"pos": [
181,
187
]
} | {
"id": "C1442823",
"name": "otf-2",
"pos": [
221,
226
]
} |
the human hypothalamic gnrh cdnas isolated thus far have all contained a short 5 ' untranslated region which would correspond to this start site . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
23,
27
]
} |
the first intron is removed from the hypothalamic , but retained in the placental , gnrh mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
37,
49
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
84,
88
]
} |
the creation and analysis of t cells bearing aberrant tcrs has led to a number of important conclusions and provided a framework for some educated speculation about t-cell biology . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
29,
36
]
} | {
"id": "C0034790",
"name": "tcrs",
"pos": [
54,
58
]
} |
finally , the identification of t-cell superantigens and their ability to stimulate t cells on the basis of tcr v beta expression alone has defined a new and distinct type of tcr/ligand interaction . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
32,
38
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
175,
178
]
} |
although these two keratins are coexpressed in the suprabasal layers of the epidermis , it was found that while k1 mrna was detectable as soon as day 10 , k10 mrna was not detectable before day 12 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014520",
"name": "epidermis",
"pos": [
76,
85
]
} | {
"id": "C1721009",
"name": "k1",
"pos": [
155,
157
]
} |
the hskt-c cells are small , roundish or spindle-like in shape and form monolayer sheets of epithelial pavement cells and produce carcinoembryonic proteins such as carbohydrate antigen 19-9 ( ca 19-9 ) , carcinoembryonic antigen ( cea ) , tissue polypeptide antigen ( tpa ) , etc . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial",
"pos": [
92,
102
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
204,
228
]
} |
t cell recognition of foreign antigens is a result of a ternary complex between t cell receptor , nominal peptide and major histocompatibility complex molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
0,
6
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
80,
95
]
} |
thyroid hormonogenesis in thyroglobulin results in the conversion of an `` '' acceptor '' '' iodotyrosine to a hormone residue and a `` '' donor '' '' iodotyrosine to a dehydroalanine residue . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
26,
39
]
} |
the purpose of these studies was to evaluate the effect of age-related differences in growth rate on the hypothalamic content of growth hormone-releasing factor ( ghrh ) and somatostatin ( ss ) and on the short loop feedback regulation of ghrh and ss . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
105,
117
]
} | {
"id": "C0037668",
"name": "growth",
"pos": [
129,
135
]
} |
the purpose of these studies was to evaluate the effect of age-related differences in growth rate on the hypothalamic content of growth hormone-releasing factor ( ghrh ) and somatostatin ( ss ) and on the short loop feedback regulation of ghrh and ss . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
105,
117
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
248,
250
]
} |
effects of inhibition of norepinephrine synthesis on spontaneous and growth hormone-releasing hormone-induced gh secretion in cynomolgus macaques : evidence for increased hypothalamic somatostatin tone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
171,
183
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
184,
196
]
} |
invasion and development of p. falciparum in iron deficient red cells ( mean values for mean cell volume [ mcv ] 66 fl , mean cell haemoglobin [ mch ] 19 pg ) and in the red cells of two gene deletion forms of alpha-thalassaemia ( mean mcv 71 fl , mch 22 pg ) were normal , assessed both morphologically , and by 3h-hypoxanthine incorporation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
60,
69
]
} | {
"id": "C0019046",
"name": "mch",
"pos": [
248,
251
]
} |
study objective : to examine the potential diagnostic value of the cardiac myofibrillar protein troponin-i as a target for radiolabelled antibodies in detecting heart damage , the uptake of 131i labelled polyclonal cardiac troponin-i fab was investigated in necrotic myocardial cells in canine myocardial infarction . | tissue_is_expression_site_of_gene_product | {
"id": "C0018787",
"name": "heart",
"pos": [
161,
166
]
} | {
"id": "C1305957",
"name": "cardiac",
"pos": [
215,
222
]
} |
when dt4 was added ( patient 1 , 3 mg daily ; patients 2 and 3 , 2 mg daily ) to the same dose of atd , plasma tsh and tg levels fell but were still over the upper limit of normal and thyrotoxicosis persisted as illustrated by a recurrence of atrial fibrillation in one patient . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "atd",
"pos": [
98,
101
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
119,
121
]
} |
stimulation of t cells via the cd3/tcr complex is associated with the reduced expression of accessory molecules , a phenomenon called modulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
15,
22
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
35,
38
]
} |
since it has been shown that t cells whose cd3/tcr is modulated are hyporesponsive to various mitogenic signals , our observation seems to represent another aspect of the mechanism whereby the local pulmonary milieu maintains the autoregulation of immune response . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
29,
36
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
47,
50
]
} |
the data demonstrate that mechanical stress of red cells due to the activation of large muscle masses led to increased intravascular haemolysis , accompanied by a slightly elevated erythropoiesis , which had no detectable influence on hb-o2 affinity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
47,
56
]
} | {
"id": "C0030069",
"name": "hb-o2",
"pos": [
235,
240
]
} |
we investigated whether hypothalamic prostaglandin e2 ( pge2 ) and corticotropin releasing factor ( crf ) are responsible for the development of the adrenocorticotropic hormone ( acth ) response induced by interleukin-1 alpha ( il-1 alpha ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0010132",
"name": "corticotropin",
"pos": [
67,
80
]
} |
the factors controlling the expression of the hypothalamic neuropeptide , corticotropin releasing hormone ( crh ) , are poorly understood . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
46,
58
]
} | {
"id": "C0010132",
"name": "corticotropin releasing hormone",
"pos": [
74,
105
]
} |
increased immunohistochemical staining for the basement membrane components type iv collagen and laminin was also found in a similar distribution . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
47,
64
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
76,
92
]
} |
in contrast , after chronic iron treatment , no variations were found in the steady-state level of mrnas transcribed from liver-specific and preferentially expressed genes ( albumin , alpha-fetoprotein , apolipoprotein a-1 ) , growth-related genes ( c-myc , c-ha-ras and c-fos ) and stress-induced genes ( heat shock protein 70 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
122,
127
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
184,
201
]
} |
we also propose that stress-induced crh release will not be similarly quenched by the crh-bp in the hypothalamic portal system , as the concentration of crh released will be high , and the exposure time before reaching pituitary corticotropes will be low . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
100,
112
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
153,
156
]
} |
both groups of patients had normal number of total cd3+ t-cells , cd4+ helper t-cells , cd8+ suppressor t-cells , hla-dr+ cells and il-2r+ cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
66,
69
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
114,
120
]
} |
cell lines were chosen that in vitro do ( wish , kb ) or do not ( 5583-e ; ht-29 ) produce bm components , more specifically , type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
91,
93
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
127,
143
]
} |
basement membrane deposition was studied by immunohistochemistry , using species cross-reactive polyclonal anti-human type iv collagen antiserum , mouse- and rat-specific polyclonal anti-mouse type iv collagen antiserum , human-specific monoclonal anti-type-iv collagen antibody , and by in situ hybridization , using a 32s-labeled species cross-reactive cdna probe , specific for type iv collagen mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
0,
17
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
381,
397
]
} |
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