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stringlengths 57
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dict |
|---|---|---|---|
initiation of the condition by the thyroid antigen , thyroglobulin ( tg ) , requires t cells from susceptible mice ( 2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
35,
42
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
53,
66
]
} |
the concentrations of glipizide that were effective in inhibiting [ 3h ] leucine incorporation into iri were smaller than those required to inhibit the phosphodiesterase activity in isolated islets of 3-day-old rat pancreas . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "",
"pos": [
0,
0
]
} | {
"id": "C0021641",
"name": "iri",
"pos": [
100,
103
]
} |
rapid diagnosis of iron deficiency by measurement of free erythrocyte porphyrins and hemoglobin : the fep/hemoglobin ratio . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "fep",
"pos": [
102,
105
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} |
the fep/hemoglobin ratio is normal in thalassemia trait and renal anemia but it may be elevated in sickle-cell anemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "fep",
"pos": [
4,
7
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
8,
18
]
} |
measurement of fep and hemoglobin on filter paper provides a useful diagnostic tool for the diagnosis of iron deficiency , of anemia , and ( in populations at risk ) of leas intoxication . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "fep",
"pos": [
15,
18
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
23,
33
]
} |
when absolute vco ( mumol/d ) was compared to the daily turnover of circulating red cell haemoglobin haem ( vhaem-c ) , the vco/vhaem-c quotient was 2.1 +/- 0.9 in group a and 1.2 +/- 0.3 in group b . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
80,
88
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
89,
100
]
} |
the abnormal hb constituted 48 % of the total erythrocyte hb of the propositus and her father . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
46,
57
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
58,
60
]
} |
homogenate preparations of pancreatic islets have been found to degrade insulin by cleavage of the interchain disulfide bonds , followed by proteolysis of the resulting a and b chains . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
27,
44
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
72,
79
]
} |
although the exact mechanism by which the thymus exerts its influence on host resistance is not clearly defined , present evidence supports the concept that the thymic hormone , thymosin , may be an important addition in treatment of cancer patients by increasing cell-mediated immunity . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
42,
48
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
178,
186
]
} |
effect of luteinizing hormone releasing hormone ( lhrh ) and an lhrh antagonist of hypothalamic and plasma lhrh of hypophysectomized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
107,
111
]
} |
on the basis of these observations , it seems reasonable to conclude that the narcotics inhibit the secretion of lh , by an action either in the hypothalamus ( e.g. , suppression of lh-releasing hormone ) or directly in the pituitary gland , which leads to a reduction in serum testosterone levels and a subsequent reduction in the wet-tissue weight and secretory activity of the secondary sex organs . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
145,
157
]
} | {
"id": "C0023610",
"name": "lh-releasing hormone",
"pos": [
182,
202
]
} |
more than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone ( lhrh ) and follicle stimulating hormone-releasing hormone ( fshrh ) activities in search for lhrh and fshrh which differ from the decapeptide ( pyro ) glu-his-trp-ser-try-gly-leu-arg-pro-gly-nh2 ( i ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
189,
193
]
} |
it was concluded that the stress-induced decrease of gh secretion in rats is at least partly due to an increased release of hypothalamic somatostatin and/or immunologically related gh release-inhibiting hormone ( s ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
124,
136
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
137,
149
]
} |
recognition of tertiary hypogonadism ( primary , pure , hypothalamic gonadotropin-releasing hormone deficiency ) is of practical importance in selecting those patients who can benefit from long standing lh-rh therapy . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
56,
68
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
203,
208
]
} |
when pancreatic islets were incubated in a fixed volume of stationary buffer containing unlabeled glucose ( 1.0 mg or 3.0 mg/ml ) and glucose-u-14c ( 1.0 muc/ml ) , the amount of insulin secreted and the 14co2 produced by each islet decreased progressively as the number of islets in the sample increased . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
5,
22
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
179,
186
]
} |
when phosphate and tyroxine ( activators of brain glutaminase ) are used in small amounts , a potentiation of their stimulatory effect is observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0006104",
"name": "brain",
"pos": [
44,
49
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
50,
61
]
} |
the data obtained indicate that in brain glutamic acid in the presence of phosphate+thyroxine can not be considered as an inhibitor of glutaminase and that the important factor here is not so much the absolute levels of the activators as their favorable combinations . | tissue_is_expression_site_of_gene_product | {
"id": "C0006104",
"name": "brain",
"pos": [
35,
40
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
135,
146
]
} |
the role of red cell 2,3-diphosphoglycerate ( 2,3-dpg ) in increasing the availability of haemoglobin oxygen in neonatal jaundice and hereditary haemolytic anaemias was investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
12,
20
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
90,
101
]
} |
the distribution of basement membrane glycoproteins , fibronectin , laminin , and type iv collagen was studied in experimentally induced skin blisters in which the epidermis is separated from the dermis through the lamina lucida part of basal lamina . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
20,
37
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
82,
98
]
} |
this study was designed to compare the effectiveness of laboratory tests for iron deficiency ( mean corpuscular volume , erythrocyte protoporphyrin , transferrin saturation , and serum ferritin ) in predicting hemoglobin response to iron therapy in infants found to have low hgb concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
121,
132
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
210,
220
]
} |
c ) high nk cell activity was codominantly inherited and high serum nab levels were recessive , which argues against the theory that the nk cell receptor is a passively acquired nab . | tissue_is_expression_site_of_gene_product | {
"id": "C0022688",
"name": "nk cell",
"pos": [
9,
16
]
} | {
"id": "C0382839",
"name": "nk cell receptor",
"pos": [
137,
153
]
} |
basement membrane collagens type iv and v as well as the cysteine-rich collagenous components `` '' 7 s collagen '' '' and `` '' short chain collagen '' '' have been shown to occur in extracts prepared after limited pepsin digestion . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
0,
17
]
} | {
"id": "C0009333",
"name": "collagens type iv",
"pos": [
18,
35
]
} |
further , it has been shown that incubation in 3h-leucine of anterior pituitary glands from these tumor-bearing rats demonstrates a marked inhibition of 3h-prolactin synthesis and release . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary glands",
"pos": [
61,
86
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
156,
165
]
} |
fixed , washed platelets ( fwp ) are usually stable to aggregation with von willebrand factor ( vwf ) from human and certain animal plasmas over several months of storage . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
15,
24
]
} | {
"id": "C0795677",
"name": "von",
"pos": [
72,
75
]
} |
in brain and liver , the 4-methylumbelliferyl beta-galactosidase with acidic ph optimum and lactosylceramidase ii were deficient while other hydrolases were present in normal amounts , including sialidase determined with n-acetylneuramin-lactose and fetuin as substrates . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
13,
18
]
} | {
"id": "C0002210",
"name": "fetuin",
"pos": [
250,
256
]
} |
a conclusion is drawn that in native erythrocyte pb2+ may exert a pro-oxidant effect , possibly by interacting with hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
37,
48
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
116,
126
]
} |
effect of 20 alpha-dihydroprogesterone , progesterone , and their 5 alpha-reduced metabolites on serum gonadotropin levels and hypothalamic lhrh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
127,
139
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
140,
144
]
} |
enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene : the fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
25,
36
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
177,
187
]
} |
high gradient magnetic separation ( hgms ) is a rapid and straightforward technique that has previously been proven effective in extracting erythrocytes from a flowing cell suspension if the red cell hemoglobin is in a paramagnetic state . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
191,
199
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
200,
210
]
} |
influence of neonatal ovariectomy on the developmental patterns of serum gonadotropins , hypothalamic lh-rh concentration and organ weights in female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
89,
101
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
102,
107
]
} |
moreover , trh immunological and biological activities have been demonstrated in the pancreatic islets , but experiments with isolated rat pancreas have failed to show any direct stimulatory effect of trh on glucagon and insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
85,
95
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
221,
228
]
} |
in both lizard species four cell types were observed in the endocrine pancreas , namely insulin ( b ) , glucagon ( a ) , somatostatin ( d ) and pancreatic polypeptide ( pp ) cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine pancreas",
"pos": [
60,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
88,
95
]
} |
after the administration of estradiol ( e2 ) on diestrus i , hypothalamic lh-rh content increased gradually and reached the peak about one day later . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
61,
73
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
74,
79
]
} |
effects of oestradiol , hypothalamic extracts and luteinizing hormone releasing hormone on rat anterior pituitary gland gonadotrophin release in vitro before and after the preovulatory luteinizing hormone surge at pro-oestrus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing",
"pos": [
50,
79
]
} |
studies of cell-mediated immunity , comprising delayed hypersensitivity skin testing with four antigens , pha and antigen-induced lymphocyte transformation and detection of the lymphokine , monocyte chemotactic factor , were undertaken in 14 women during pregnancy and in the post-natal period . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
130,
140
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
177,
187
]
} |
phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin , haptoglobin , and g6pd phenotypes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
44,
52
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
75,
86
]
} |
the phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin , haptoglobin , and g6pd phenotypes was investigated in three populations in the sudan and one population in nilgiris , india . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
48,
56
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
79,
90
]
} |
the number of t cells ( t cell rosettes , tcr ) in the peripheral blood was the same as controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
14,
20
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
42,
45
]
} |
just as the prolytic loss of k occurs without the loss of any hb , so in concentrations of lysin sufficient to produce hemolysis the loss of k , expressed as a percentage of the total red cell k , increases much more rapidly with lysin concentration than does the loss of hb expressed as a percentage of the total hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
184,
192
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
314,
316
]
} |
the suggested explanation for this phenomenon is a porphyrin-binding plasma factor , hemopexin , which is a natural beta-glycoprotein believed to be responsible for the transport of circulating porphyrins to the liver for their elimination . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
69,
75
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
85,
94
]
} |
to determine whether the pituitary-gonadal deficiency in heroin addicts is related to heroin 's effect on the hypothalamus , the authors administered gonadotropin hormone-releasing hormone ( gnrh ) to 10 male heroin addicts and 5 controls and measured follicle-stimulating hormone ( fsh ) and luteinizing hormone ( lh ) response . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
110,
122
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
191,
195
]
} |
the muscle content of ntau-methylhistidine was at least 40 % higher than the only other reported value and therefore the method of calculating muscle protein breakdown based on ntau-methylhistidine excretion requires revision . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
4,
10
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
143,
157
]
} |
degradation of [ 125i ] -lh-rh by peptidases of hypothalamus , liver and heart of the rat and the effects of lh-rh , lh-rh antagonist d-phe2-phe3-d-phe6-lh-rh , lh-rh5-10 , oxytocin , bradikinin , thyrotrophin-releasing hormone , melanocyte-inhibiting factor , luteinizing , follicle-stimulating , lactogenic and growth hormones were studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
48,
60
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
161,
166
]
} |
high correlations were found between hb and pcv in the various age groups studied , while lower correlations were found between erythrocyte counts on one hand and hb or pcv on the other . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
128,
139
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
163,
165
]
} |
an investigation of defects of the haemostatic mechanism in 41 children with cyanotic congenital heart disease concluded that such abnormalities were common and normally involved factors synthesised in the liver , that is the vitamin k dependent factors ( rothrombin , factors vii and ix ) and factor v . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
206,
211
]
} | {
"id": "C0015502",
"name": "factors vii",
"pos": [
269,
280
]
} |
addition of non-saturating amounts of 2,3-dpg ( 2,3-diphosphoglycerate ) within the red cell ( 2,3-dpg/haemoglobin less than 1 ) initially reduces hill 's parameter , n . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
84,
92
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
103,
114
]
} |
[ hypothalamic somatostatin levels in the rat : with special references to development , nycthemeral cycle , sex difference and food restriction ( author 's transl ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
2,
14
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
15,
27
]
} |
these data suggest that gnrh is distributed throughout regions of the human brain outside the hypothalamus and suggest new , non-endocrine functions for gnrh in the human cns , analogous the those reported recently for gnrh in experimental animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
219,
223
]
} |
five different types were obtained , including two new molecular species , one characteristic of basement membranes , or type iv collagen , and the other the recently described `` '' a-b '' '' collagen derived from fetal membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
97,
115
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
121,
137
]
} |
the incubation of lh-rh with tissue extracts showed that extracts of the hypothalamus and anterior pituitary gland degraded lh-rh to a similar extent . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
124,
129
]
} |
both the hypothalamic and anterior pituitary gland extracts degraded more lh-rh than did lung extract , which in turn destroyed more lh-rh than did extracts of kidney or liver tissue . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
9,
21
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
133,
138
]
} |
although lh-rh was rapidly destroyed by hypothalamic extract in vitro , of the analogues , only des gly-nh2 ( 10 ) lh-rh ethylamide was degraded . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
40,
52
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
115,
120
]
} |
the effects of ether and pentobarbital anesthesia on hypothalamic and cerebrospinal fluid ( csf ) lh-rh content were studied in male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
98,
103
]
} |
red cells and hemoglobin recovery begins only 3 days after acute bleeding , when albumin concentration rises by 90 % of the normal level . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
14,
24
]
} |
among the pool of those newly iodinated thyroid proteins , 27-s molecules were reabsorbed faster than 19-s molecules and iodine-rich thyroglobulin molecules were reabsorbed faster than the iodine-poor ones . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
40,
47
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
133,
146
]
} |
in ketoacidotic diabetics , it required at least a month for high hb ai levels ( 16.9 +/- 2.6 per cent ) to stabilize at nonacidotic levels ( 12.8 +/- 0.3 per cent ) , suggesting that decreases occur only as new red cells form under conditions less favorable to hb ai synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
212,
221
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
262,
264
]
} |
the relationship between morphological changes in the liver during azo dye hepatocarcinogenesis in rats and cell proteins , especially alpha1-fetoprotein and alpha1-acid glycoprotein , was investigated by the immunofluorescence method . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
54,
59
]
} | {
"id": "C0002210",
"name": "alpha1-fetoprotein",
"pos": [
135,
153
]
} |
obviously , the analysis of dynamic changes in the hypothalamic activity of corticotropin-releasing factor ( crf ) is essential for understanding of the central regulatory mechanism of acth secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
109,
112
]
} |
of the six adult red cell hemoglobins , hemoglobin 5 is synthesized most actively in the earliest erythroid cell whereas hemoglobin 4 ( the major hemoglobin of the red cell ) is synthesized most actively in the latest erythroid cells , e.g . the reticulocyte . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
17,
20
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
146,
156
]
} |
it was demonstrated that beta-cells are more accessible to glucose than alpha-cells , that glucose entry into islet cells is not significantly modified by insulin and that glucose had no effect on atp , lactate and cyclic 3':5'-amp levels of islet tissue under any of the conditions investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
110,
121
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
155,
162
]
} |
there were slight differences in red cell parameters ( rbc , hb , pcv , mcv , mch , & mchc ) between cuis and guinea-pigs . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
55,
58
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
61,
63
]
} |
plasma and hypothalamic lhrh was measured by specific radioimmuno-assay in intact and ovariectomized rats , and the values were correlated with peripheral plasma ( pp ) fsh and lh titers . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
11,
23
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
24,
28
]
} |
in intact rats , hypothalamic lhrh content was slightly lower at 10.00 h on diestrus day 1 than at other sample times . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
17,
29
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
30,
34
]
} |
thus , the synthesis of beta interferon in poly ( ri ) .poly- ( rc ) -induced human fibroblasts is controlled both by activation of transcription of the beta-interferon gene and by alteration of the beta-interferon mrna stability . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
84,
95
]
} | {
"id": "C0015980",
"name": "beta-interferon",
"pos": [
199,
214
]
} |
comparison of t3-associated 49- and 43-kilodalton cell surface molecules on individual human t-cell clones : evidence for peptide variability in t-cell receptor structures . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "cell",
"pos": [
50,
54
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
145,
151
]
} |
the anomeric specificity of hexose metabolism in pancreatic islets supports the fuel hypothesis for insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
49,
66
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
100,
107
]
} |
the depression of the t4 cells by ifn was accompanied by a decrease in the number of activated t cells expressing ia antigens . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "t4 cells",
"pos": [
22,
30
]
} | {
"id": "C0019630",
"name": "ia antigens",
"pos": [
114,
125
]
} |
the infected anemic ( ia ) mice had significantly higher reticulocyte counts ( p less than 0.025 ) , spleen ( p less than 0.001 ) and liver ( p less than 0.005 ) weights , and higher parasitemia than did infected nonanemic ( ina ) mice . gamma-globulin concentrations of infected mice were markedly increased , and values for ina mice were 10 % higher than values for ia mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
134,
139
]
} | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
238,
252
]
} |
microcapsules containing insulin crystals or islets of langerhans were made by extruding a mixture of insulin crystals or islets and sodium alginate into a calcium chloride solution , and then coating it with poly-l-lysine . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
45,
65
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
102,
109
]
} |
to further understand the mechanism of action by which ethanol ( etoh ) decreases plasma luteinizing hormone ( lh ) levels , the effects of multiple i.p . injections of eoh ( 1.0 -- 1.5 g/kg ) or saline on hypothalamic luteinizing hormone releasing hormone ( lhrh ) and plasma lh concentrations were evaluated in intact and castrate male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
206,
218
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing",
"pos": [
219,
248
]
} |
in response to castration , both saline and etoh-treated rats showed a decrease in hypothalamic lhrh content with a concomitant increase in plasma lh ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
96,
100
]
} |
thus , these data from both intact and castrate rats provide evidence to support the hypothesis that alcohol-induced decreases in lh levels are due to a diminished release rate of hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
180,
192
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
193,
197
]
} |
it was concluded that although there is a possibility that monocytes are not depleted completely , pma did not seem to require monocytes for b-cell activation , whereas the level of t-cell activation was potentiated by monocyte addition and pma probably activated t cells via receptors that are different from those used by con a and pha or probably activated t cells without hla-dr antigen receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
264,
271
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
360,
367
]
} |
thyroidal iodine , protein and thyroglobulin ( tg ) were investigated in a hibernator , spermophilus richardsoni , sampled in the field and from laboratory-held winter colonies . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
0,
9
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
31,
44
]
} |
involvement of hypothalamic luteinizing hormone-releasing hormone in the regulation of the estrous follicle-stimulating hormone surge in the female golden hamster . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
28,
65
]
} |
hypothalami collected from female hamsters during proestrus and estrus were assessed for lhrh content by bioassay and ria . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
0,
11
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
89,
93
]
} |
the pattern of hypothalamic lhrh accumulation and depletion during proestrus and estrus as well as changes in serum and pituitary fsh concentrations were altered as a result of phenobarbital administration at 1200 h on proestrus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
28,
32
]
} |
the results of the present study suggest that the estrous fsh surge in hamsters is mediated , at least in part , by a concurrent discharge of hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
142,
154
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
155,
159
]
} |
coincubation of hypothalamic extract with the high concentration of somatostatin significantly attenuated the effect of the extract in stimulating gh release from pituitaries of 1-day-old rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
16,
28
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
68,
80
]
} |
the results of this study show that two drugs which block lhrh-mediated gonadotropin release have no effect on the postovulatory secretion of fsh and support the concept that this episode of fsh secretion occurs via a pathway which does not include the hypothalamic secretion of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
253,
265
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
279,
283
]
} |
this study demonstrates immune complexes in thyroid glands of obese strain ( os ) chickens , that consist of thyroglobulin ( tg ) and antibodies to tg . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
44,
58
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
109,
122
]
} |
by all of the methods tested , bullous pemphigoid antigen remained closely associated with the epidermis while laminin , the basement membrane heparan sulfate proteoglycan , and collagen types iv and v remained with the dermal side of the separation . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
125,
142
]
} | {
"id": "C0009333",
"name": "collagen types iv",
"pos": [
178,
195
]
} |
confluent cultures of cloned bovine endothelial cells , which were derived from large vessels , produced and secreted plasminogen activator ( pa ) at constant rates . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
36,
53
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
118,
139
]
} |
two weeks later , rats were treated for 5 days with estradiol benzoate ( e , 5 micrograms/kg ) , progesterone ( p , 10 mg/kg ) , e + p ( 5 micrograms e + 10 mg/kg ) or corn oil , after which time they were killed for determination of hypothalamic lhrh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
234,
246
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
247,
251
]
} |
the young and old ovx rats had similar levels of lhrh in the medial basal ( mbh ) and anterior ( ah ) hypothalamus , but e treatment was only effective in increasing mbh-lhrh content in the young animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
102,
114
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
170,
174
]
} |
in conclusion , it appears that hypothalamic lhrh content of young and old ovx rats does not differ with age despite a marked attenuation of serum lh levels with age . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
45,
49
]
} |
the hypothalamus from old rats , however , is less responsive to steroid stimulation of lhrh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
88,
92
]
} |
rats were passively immunized with an antiserum against somatostatin and a monoclonal antibody against rat hypothalamic growth hormone-releasing factor ( rgrf-mab ) which does not recognize the biologically active 1-40 amino acid fragment of hpgrf-44 ( hpgrf-40 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
107,
119
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
120,
151
]
} |
these results correlate with earlier physiological data on hypothalamic control of growth hormone secretion and suggest that grf is also involved in interneuronal relationships related or unrelated to neurohumoral control of pituitary secretions . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
59,
71
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
125,
128
]
} |
among the peripheral blood mononuclear cells ( pbmc ) e rosette forming cells ( t-cells ) , surface immunoglobulin bearing cells ( b-cells ) , and t-cells with igg fc receptor ( t gamma ) were determined . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cells",
"pos": [
80,
87
]
} | {
"id": "C0034790",
"name": "t-cells",
"pos": [
147,
154
]
} |
the proportions of total t lymphocytes ( tt ) , t lymphocytes with fc receptors for igm , t suppressor/cytotoxic cells ( leu2a ) , t helper/inducer ( leu3a ) as defined by monoclonal antibodies were within normal range as compared to the normal donors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
25,
38
]
} | {
"id": "C0034790",
"name": "t lymphocytes",
"pos": [
48,
61
]
} |
mean erythrocyte zinc ( 40.8 micrograms/g hb +/- 9.2 ) and copper levels ( 3.56 micrograms/g hb +/- 0.50 ) were very significantly increased ( 30.4 micrograms/g hb +/- 5.2 and 2.73 micrograms/g hb +/- 0.30 respectively , for age-matched controls ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
5,
16
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
194,
196
]
} |
mean plasma and erythrocyte selenium levels ( 63 ng/ml +/- 15 and 329 ng/g hb +/- 86 ) were significantly lower than those in age-matched controls ( 82 ng/ml +/- 13 and 404 ng/g hb +/- 116 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
16,
27
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
178,
180
]
} |
red cells from newborn lambs were separated into different age populations by centrifugation , and cells with fetal hemoglobin ( hb ) were distinguished from those with adult hb by an acid elution technique . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
175,
177
]
} |
in order to elucidate the effect of glucagon antiserum on the endocrine pancreas , the release of somatostatin , glucagon , and insulin from the isolated perfused rat pancreas was studied following the infusion of arginine both with and without pretreatment by glucagon antiserum . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine",
"pos": [
62,
71
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
the morphology of the thyroid lesion and frequent occurrence of circulating thyroglobulin autoantibodies suggested that lymphocytic thyroiditis was immune-mediated in pet dogs . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
22,
29
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
76,
89
]
} |
splenic lymphocytes obtained from mice with delayed hypersensitivity to staphylococci , when stimulated with staphylococcal corpuscular antigen in vitro , released lymphokines into the culture fluid . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
8,
19
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
164,
175
]
} |
in healthy red cells chromium is partially bound to haemoglobin and partially to small molecular weight substances , probably in the trivalent form . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
11,
20
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
52,
63
]
} |
all responders to fluoxymesterone therapy showed a 50 % or more maximum uptake of injected ferrous citrate fe 59 into rbc hemoglobin , whereas no nonresponder met this criterion . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
118,
121
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
122,
132
]
} |
in several strains of human fibroblasts , treatment with human alpha- or beta-interferon ( ifn ) resulted in an induction of 2 ' , 5'-oligoadenylate synthetase but no protein kinase activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
} | {
"id": "C0015980",
"name": "beta-interferon",
"pos": [
73,
88
]
} |
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