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we recommend that ( i ) immuno-cytochemical stains for prostatic specific antigen are applied to all lung , pleural and mediastinal biopsy specimens showing adenocarcinoma in male patients , and ( ii ) all males with intrathoracic adenocarcinoma have prostatic aspiration cytology performed if the prostatic specific antigen stain is positive . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
55,
64
]
} | {
"id": "C0138741",
"name": "prostatic specific antigen",
"pos": [
298,
324
]
} |
this report summarizes the clinical and laboratory findings from a group of our patients and literature reviews from several families who have a genetic deficiency in three related leukocyte membrane surface antigens known as cr3 , lfa-1 , and p150,95 . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
181,
190
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
226,
229
]
} |
although tcr alpha/beta+ iel dominated both in controls and coeliac disease , t cells expressing the tcr gamma/delta were preferentially located within the epithelium rather than in the lamina propria . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
78,
85
]
} | {
"id": "C0085246",
"name": "tcr gamma/delta",
"pos": [
101,
116
]
} |
a retrospective study of basement membrane ( bm ) components ( laminin and type iv collagen ) in urothelial tissues was performed by applying an immunoperoxidase method to 64 formalin-fixed specimens . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
25,
42
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
75,
82
]
} |
when this dose of clenbuterol was injected twice daily , the changes in muscle metabolite concentrations which followed its acute administration persisted until day 7 of treatment , and were accompanied by increases in muscle mass , body weight and muscle protein synthesis rate ( ks ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
72,
78
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
249,
263
]
} |
[ cloning and sequence analysis of cdna of common precursors of three hypothalamic neuropeptides immunologically related to human somatocrinin 1-37 , alpha melanotropin and salmon melanin-concentrating hormone ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
70,
82
]
} | {
"id": "C0037668",
"name": "somatocrinin",
"pos": [
130,
142
]
} |
the results may explain why red cells containing gels occlude the microcirculation and/or undergo hemolysis in patients with sickle-cell anemia , why patients with hb s-hpfh are mildly affected with red-cell sickling , and why individuals with hb as have no clinical manifestations of the hb abnormality . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red-cell",
"pos": [
199,
207
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
289,
291
]
} |
phenotypic and functional characterization of human t lymphocytes expressing a gamma/delta t cell antigen receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
52,
65
]
} | {
"id": "C0085246",
"name": "gamma/delta t cell",
"pos": [
79,
97
]
} |
( b ) the proportion of t cells in the periphery which use tcr gamma/delta is greater than in thymus ; | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
24,
31
]
} | {
"id": "C0085246",
"name": "tcr gamma/delta",
"pos": [
59,
74
]
} |
it is thus likely that 33c4 is a unique molecule involved in b cell aggregation and is clearly distinct from other cell adhesion molecules such as lfa-1 , icam-1 , and lfa-3 . | tissue_is_expression_site_of_gene_product | {
"id": "C0004561",
"name": "b cell",
"pos": [
61,
67
]
} | {
"id": "C0063695",
"name": "icam-1",
"pos": [
155,
161
]
} |
since the influence of sex steroids on hypothalamic gnrh mrna levels remains to be elucidated , quantitative in situ hybridization was used to study the effect of sex steroids on cellular levels of pro-gnrh mrna in adult rats of both sexes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
202,
206
]
} |
t cells recognize peptides in association with self-mhc structures on antigen-presenting cells and become activated upon ligand binding to the t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "t cell",
"pos": [
143,
149
]
} |
of particular interest is the finding that the two triazolobenzodiazepines exert effects on crf concentrations in the locus coeruleus and hypothalamus that are opposite to crf changes seen after stress . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
138,
150
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
172,
175
]
} |
the cellular reactivity varies according to the degree of muscular differentiation that can be defined either by studying the type of intermediate filaments present or the expression of specific muscle contractile proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscular",
"pos": [
58,
66
]
} | {
"id": "C0026832",
"name": "muscle",
"pos": [
195,
201
]
} |
the seemingly direct activation of t cells by other t cells is rather surprising in view of the known apc dependence of antigen , lectin and anti-tcr mediated t cell activation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
35,
42
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
146,
149
]
} |
for instance , it is possible that apc independent activation of t cells by lectins and anti-tcr antibodies would require high concentrations of activators to overide their dependence on apc . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
65,
72
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
93,
96
]
} |
in this report we test two hypotheses : ( 1 ) the triggering of resting t cells leading to autocrine cell proliferation depends entirely on cross-linking tcr molecules , and ( 2 ) the presence of activated t cells facilitates tcr mediated activation of resting t cells without the participation of conventional apc . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
72,
79
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
226,
229
]
} |
we have shown in the companion paper that somatotrophs dispersed from streptozotocin diabetic rats exhibit altered sensitivity to the natural hypothalamic controlling hormones , growth hormone releasing factor and somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
142,
154
]
} | {
"id": "C0037668",
"name": "growth hormone releasing factor",
"pos": [
178,
209
]
} |
we have shown in the companion paper that somatotrophs dispersed from streptozotocin diabetic rats exhibit altered sensitivity to the natural hypothalamic controlling hormones , growth hormone releasing factor and somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
142,
154
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
214,
226
]
} |
this study shows that the fisher rat thyroidal cell line ( frtl-5 ) can iodinate newly synthesized thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
37,
46
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
99,
112
]
} |
hypothalamic dopamine ( da ) , acting at da d2-receptors ( d2-r ) on pituitary target cells , mediates peptide release and biosynthesis of rat pituitary anterior lobe ( al ) prolactin , and neurointermediate lobe ( nil ) pro-opiomelanocortin ( pomc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "of",
"pos": [
136,
138
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
174,
183
]
} |
the actual interest of immunoscintigraphy for the detection of alphafetoprotein-producing liver tumors was investigated by both visual examination and quantitative analysis in 61 patients with either hepatocellular carcinoma ( 39 patients , group i ) , secondary liver cancer ( 11 patients , group ii ) , or non tumoral liver ( 9 cirrhosis , 2 healthy liver , group iii ) : all patients received injections of 123i-anti-alphafoetoprotein monoclonal antibodies and planar scans were performed after 28 hours . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
90,
95
]
} | {
"id": "C0002210",
"name": "alphafoetoprotein",
"pos": [
420,
437
]
} |
both human globin genes are expressed at high levels in adult red cells to give human hemoglobin hba in amounts equal to or greater than endogenous mouse hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
62,
71
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
154,
164
]
} |
in periodic light , neonatal androgenization did not change the serum concentration or pituitary contents of gonadotropins , or the hypothalamic content of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
132,
144
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
156,
160
]
} |
they suggest that the hypothalamus is the only source of srif implicated in this effect . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
22,
34
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
57,
61
]
} |
surprisingly , high frequencies of il2-secreting cd4+ t cells were noted in certain hla-dr-identical responder-stimulator combinations . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
49,
52
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
84,
90
]
} |
together these data demonstrate that : 1 ) cd4+ and cd8+ cells are stimulated to il2 production by hla class ii and class i antigens , respectively ; | tissue_is_expression_site_of_gene_product | {
"id": "C0242629",
"name": "cd8",
"pos": [
52,
55
]
} | {
"id": "C0019629",
"name": "class i antigens",
"pos": [
116,
132
]
} |
and 3 ) significant numbers of cd4+ il2-producing t cells can be activated by selected hla-dr-identical , dp-different stimulator cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
31,
34
]
} | {
"id": "C0019759",
"name": "hla",
"pos": [
87,
90
]
} |
simultaneous immunocytochemical localization of either dbh- or th-ir fibers and corticotropin releasing hormone-synthesizing neurons in the hypothalami from brainstem-lesioned , colchicine treated animals revealed that the distribution of catecholaminergic fibers and crh neurons is homologous within the pvn of the intact side . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
140,
151
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
268,
271
]
} |
by converting soluble fibrinogen into insoluble fibrin , the erythrocyte packing could either be inhibited or stopped , and this process could be monitored by assessing the change in the rate of signal increase for haemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
61,
72
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
215,
226
]
} |
in muscle dystrophies as in other muscle-wasting diseases and states , a progressive loss of muscle protein occurs , probably as a result of an imbalance between muscle protein synthesis and degradation . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
3,
9
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
162,
176
]
} |
the enzyme degrades both soluble and basement membrane type iv collagen , but does not specifically degrade types i or v collagen or casein . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
37,
54
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
55,
71
]
} |
in order to investigate the mechanism underlying ovarian steroid action on gene expression of hypothalamic luteinizing hormone releasing hormone ( lhrh ) , changes in lhrh mrna level were determined by rna-blot hybridization assay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
167,
171
]
} |
poly ( a ) rna fractions from hypothalami ( 40-50/group ) were isolated , blotted onto nitrocellulose paper and hybridized with 32p-end-labeled lhrh oligonucleotides ( 29 mer ) which are complementary to rat lhrh mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
30,
41
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
208,
212
]
} |
[ enzymatic activity in the organism in experimental crush syndrome of the limbs . iii . arginase in kidney and liver , glutaminase in kidney ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
112,
117
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
120,
131
]
} |
( 51cr ) sodium chromate incorporation ito the soluble protein fractin of the human erythrocyte : binding not associated with the hemoglobin monomeric subunit . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
84,
95
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
130,
140
]
} |
adenyl cyclase activity of rat pancreatic islet membrane was increased by secretin , pancreozymin , and isoproterenol , while acth , glucagon , growth hormone , and insulin had no effect . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
31,
47
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
165,
172
]
} |
although the suppression of lh and fsh response during oestrogen treatment may point to a direct inhibitory effect of oestrogen on pituitary gonadotrophin release , an indirect hypothalamic pathway , through suppression of endogenous lhrh , can not be ruled out . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
177,
189
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
234,
238
]
} |
while radiation caused profound inhibition of prostatic dna synthesis , only modest effects on nuclear uptake of dihydrotestosterone and on prostatic 5alpha-reductase were observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
46,
55
]
} | {
"id": "C0039602",
"name": "5alpha-reductase",
"pos": [
150,
166
]
} |
the effect of incubating the hypothalamus of adult male rats with various neurotransmitters upon the release of corticotrophin-releasing hormone ( crh ) was studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
29,
41
]
} | {
"id": "C0010132",
"name": "corticotrophin-releasing hormone",
"pos": [
112,
144
]
} |
hypoxic acclimation is , howeveer , accompanied by a strong decrease in red cell nucleoside triphosphates , particularly guanosine triphospphate ( gtp ) , which depresses oxygen affinity of the composite and component haemoglobins more strongly than does the concurring atp . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
72,
80
]
} | {
"id": "C0019046",
"name": "haemoglobins",
"pos": [
218,
230
]
} |
binding to intact red cells and to purified hemoglobin are nonsaturated processes approximately equal in magnitude , which strongly suggests that most of the red cell binding may be ascribed to hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
18,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
194,
204
]
} |
in this review of the role of the hypothalamus as a regulator of reproductive function we have presented a short history of the important anatomical and physiological findings , the structure and properties of gonadotrophin releasing hormone and its function and mode of action in the reproductive process . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "gonadotrophin releasing",
"pos": [
210,
233
]
} |
thus , the known difference in 2 , 3-dpg binding to fetal or adult deoxyhemoglobin does not measurably influence the erythrocyte 2 , 3-dpg concentration , indicating that in vivo the 2 , 3-dpg synthesis in hypoxia is virtually regulated by the erythrocyte ph , which in turn is determined by plasma ph and the oxygenation state of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
117,
128
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
331,
341
]
} |
in double plabelled studies ki decreased [ 3h ] leucine incorporation into thyroid soluble proteins and into immunoprecipitable thyroglobulin ( t4 ) while it did not modify that of [ 14c ] galactosamine . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
75,
82
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
128,
141
]
} |
within a few hours after acute blood loss there was a respiratory alkalosis with an increase in blood ph , a decrease in pco2 and an increase in the red cell affinity of hb for oxygen in vivo that was temporally related to an increase in ep production . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
149,
157
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
170,
172
]
} |
the primitive or embryonic red cells of early development are replaced by the definitive red cells which contain fetal or adult haemoglobin ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
27,
30
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
128,
139
]
} |
early lesions , i.e. , hyperplastic foci and areas , did not accumulate iron in siderotic livers , had persistent glycogen stores , were not more agglutinable by concanavalin a , and were associated with alpha-fetoprotein secretion , but were not independent secretors of high amounts . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "livers",
"pos": [
90,
96
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
204,
221
]
} |
the distribution of radioactivity in the rat hypothalamus after intraventricular injection of tritiated luteinizing hormone-releasing hormone ( lh-rh ) was studied by autoradiography and compared with that expected from fick 's second law which defines the character of ordinary diffusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
104,
141
]
} |
hypothalamic lhrh remained low throughout this period , with the exception of a transient rise around day 36 ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
13,
17
]
} |
the coefficient of correlation between body weight and erythrocyte ( r = 0.70015 ) , leucocytes ( r = 0.95861 ) , haemoglobin ( r = 0.96615 ) and heart weight ( 0.97577 ) indicate high degree of correlation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
55,
66
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
114,
125
]
} |
dry weight and noncirculating red cells ( measured by subtracting 51cr-labeled red cell mass from total red cell mass as measured by hemoglobin extraction ) also increased within 3 days after operation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
30,
39
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
133,
143
]
} |
an in vitro system for perifusion of rat pancreatic islets has been utilized to define the effects of epinephrine on acetylcholine-induced insulin release over varying concentrations of the two agents . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
41,
58
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
139,
146
]
} |
intravenous treatment with als for 3 consecutive days caused extensive depletion of the paracortical areas of peripheral lymph nodes whereas treatment with normal serum and anti-lymphokine serum caused no such depletion . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "als",
"pos": [
27,
30
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
178,
188
]
} |
in the cases which the number of langerhans ' islets was large , more favorable insulin secretory function was observed in the remaining pancreas . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
30,
32
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
80,
87
]
} |
twenty-three colonic adenocarcinomas were studied by immunofluorescence with antisera against components of the basement membrane ( type iv collagen , laminin , and heparan sulfate-rich proteoglycan ) as well as antisera against antigens of the connective tissue ( type iii collagen , fibronectin , and hyaluronectin ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
112,
129
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
132,
148
]
} |
the ability of rbc to change their shape or the static deformability is determined by the excess surface regarding to the enclosed volume , by the rheological properties of the hemoglobin content and by the membrane extension and bending moduli . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
15,
18
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
177,
187
]
} |
the direct anti-prostatic activity is the result of the following mechanism : inhibition of serum testosterone uptake into the prostate , inhibition of testosterone-5 alpha-reductase activity and inhibition of 5 alpha-dht . receptor complex formation . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate",
"pos": [
127,
135
]
} | {
"id": "C0039602",
"name": "testosterone-5 alpha-reductase",
"pos": [
152,
182
]
} |
upon stimulation with con a , lymphokine activities in the culture supernatant reached an optimum or plateau after 24 h lymphocytes continued with lymphokine release , when they were restimulated for further 24 h. in fresh medium and mitogen . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
120,
131
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
147,
157
]
} |
the reduction of creatine content in prednisolone treated muscle which are tenotomised is due to perhaps the catabolic effect of glucocorticoid analogue on muscle protein together with inactivity of the muscle . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
58,
64
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
156,
170
]
} |
reduction of protein intake , particularly to 4 % dietary level , caused significant reduction in body weight gain , relative liver weight , hepatic microsomal cytochrome p-450 , liver total protein , and serum albumin concentration as well as elevation of hepatic glucose-6-phosphatase activity , relative heart weight , and serum globulin concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
126,
131
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
332,
340
]
} |
to obtain information about normal values to fep , expressed as microgram/100 ml red cells ( fep % r.c . ) and fep/hb ratio , the group of students with adequate intake of energy and proteins who had normal values for hb and hto . was selected . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
81,
90
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
218,
220
]
} |
phenotypic and functional characteristics of peripheral blood lymphocytes ( pbl ) from 133 patients ( 87 female ; 46 male ) with documented primary or recurrent genital hsv-2 infection were determined by serologic testing and cmi [ lymphocyte blastogenesis and lymphokine ( lf ) ] evaluation . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
62,
72
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
261,
271
]
} |
the use of t-cell clones and hybridomas to analyze t-cell receptors and/or factors is well under way , and will continue to be an area of intense investigation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
11,
17
]
} | {
"id": "C0034790",
"name": "t-cell receptors",
"pos": [
51,
67
]
} |
results of the present experiment indicate that the hypothalamus and anterior pituitary of long-term anestrous sows are capable of responding to endocrine stimuli ( i.e . estradiol and gnrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
52,
64
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
185,
189
]
} |
the authors suggest that the sexual maturation of girls is initiated by the enhanced hypothalamic activity , reflected in higher concentrations of immunoreactive lh-rh in peripheral serum . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
85,
97
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
162,
167
]
} |
isoelectric focusing ( ief ) of human erythrocyte hemolystaes on polyacrylamide slab gels over a ph gradient of 6 to 8 provides sufficient resolution of hemoglobin aic ( hbaic ) from other hemoglobin components ( aia , aib , aii , s , and f ) to allow quantification by high-resolution microdensitometry . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
38,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
189,
199
]
} |
human lymphocytes pulsed with phytothaemagglutinin ( pha ) release mitogenic factors and other lymphokines upon subsequent incubation in fresh medium . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
6,
17
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
95,
106
]
} |
these results are compared with reported values for the 3-mehis content of mixed proteins in muscle of various species , and with published estimates , computed by other techniques , of the rate of muscle protein breakdown in human subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
93,
99
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
198,
212
]
} |
the antagonistic activity of bromperidol on da receptors regulating the hypothalamic lh-rh release was compared in vitro to that of haloperidol . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
85,
90
]
} |
thus , i.v . infusion of low doses of da in oep animals or by pulse injection in both ovx and oep rats can elevate plasma lh by activating the release of lh-rh from the hypothalamus , while large doses of da in ovx animals may suppress the release of lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
169,
181
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
251,
256
]
} |
in order to assess how the number of cell divisions influences the red blood cell ( rbc ) content of proteins other than hemoglobin , we measured the activity of two age-independent glycolytic enzymes in macrocytic , normal , and microcytic rbcs . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood",
"pos": [
67,
76
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
121,
131
]
} |
separation of thyroidal iodoproteins and purification of thyroglobulin by gel filtration and density gradient centrifugation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
14,
23
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
57,
70
]
} |
when stimulated in vitro , lymphocytes from cyclosporine-treated patients display an impaired ability to produce the critical lymphokine interleukin-2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
27,
38
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
126,
136
]
} |
these differential lhrh release responses reflected the differences in the mbh-poa lhrh concentrations that normally occur between intact and castrated rats and also estimated at the end of the perifusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh-poa",
"pos": [
75,
82
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
83,
87
]
} |
involvement of hypothalamic growth hormone ( gh ) -releasing factor in gh secretion induced by intracerebroventricular injection of somatostatin in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0037668",
"name": "growth hormone",
"pos": [
28,
42
]
} |
involvement of hypothalamic growth hormone ( gh ) -releasing factor in gh secretion induced by intracerebroventricular injection of somatostatin in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
132,
144
]
} |
these results suggest that the central stimulating effect of srif-14 on rat gh secretion is mediated , at least in part , by hypothalamic grf and not due to a direct action on the pituitary . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
125,
137
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
138,
141
]
} |
the present experiments tested the ability of the hypothalamus of old male rats to release lhrh in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
50,
62
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
91,
95
]
} |
these data suggest that the alterations of the function of the hypothalamic-pituitary-gonadal complex observed in aged male rats are not due to an intrinsic age-related defect of lhrh-synthesizing neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
63,
75
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
179,
183
]
} |
these findings suggest that cc increases the frequency of hypothalamic gnrh secretory episodes , perhaps by an action involving a decrease in endogenous opioid peptide activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
58,
70
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
71,
75
]
} |
these data are consistent with a two-receptor model for the platelet-surface expression of the endogenous tsp pool . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
60,
68
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
106,
109
]
} |
the alveolar epithelial lining and the basement membranes were disrupted in all patients , as evidenced by ultrastructural observations and by immunofluorescent studies showing gaps in the distribution of type 4 collagen and laminin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
39,
57
]
} | {
"id": "C0009333",
"name": "type 4 collagen",
"pos": [
205,
220
]
} |
human platelet thrombospondin adsorbed on plastic promotes attachment and spreading of human g361 melanoma cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
6,
14
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
15,
29
]
} |
we conclude that the hypercortisolism of anorexia nervosa reflects a defect at or above the hypothalamus which results in the hypersecretion of endogenous crh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
92,
104
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
155,
158
]
} |
in placenta , there was abundant expression of the cg beta gene , but no expression of the lh beta gene , consistent with the acquisition of tissue-specific regulatory sequences in the recently evolved upstream promoter recognition site of the cg beta gene . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
3,
11
]
} | {
"id": "C0106132",
"name": "cg beta",
"pos": [
244,
251
]
} |
first-trimester placentas demonstrated plentiful syncytiotrophoblast cytoplasmic granules , some undergoing exocytosis , when stained using specific beta-hcg antiserum in the abc and protein a-gold methods . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placentas",
"pos": [
16,
25
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
149,
157
]
} |
these results indicate that iat epitopes originally defined as unique i region-controlled determinants selectively expressed on t cells are not encoded by the i region genes but are associated with the t cell receptor that sees the self ia . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
128,
135
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
202,
217
]
} |
characteristic differences were found in the alteration modes of hepatic lactate level , muscle adenine nucleotide concentrations , and muscle protein content between these shock models . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
89,
95
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
136,
150
]
} |
the epithelial origin of these cells was confirmed by positive immunoperoxidase staining for carcinoembryonic antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial",
"pos": [
4,
14
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
93,
117
]
} |
endogenous opioid peptides tonically inhibit lh by acting on hypothalamic mechanisms which regulate lhrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
61,
73
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
100,
104
]
} |
we conclude that progesterone slows the frequency of lh pulsatility by increasing endogenous opioid activity in the hypothalamus which may in turn inhibit the firing rate of the gnrh neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
116,
128
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
178,
182
]
} |
per cells synthesized collagen types i , iii , iv and v , laminin and fibronectin , and organized a pericellular matrix made up of only basement membrane components ( type iv collagen and laminin ) and fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
136,
153
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
167,
183
]
} |
in the dorsal region of the neural tube , from which nccs originate , the basement membrane was depleted or absent , and with the immunofluorescence technique it was shown that this pattern was reflected in a deficit of type-iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
74,
91
]
} | {
"id": "C0009333",
"name": "type-iv collagen",
"pos": [
220,
236
]
} |
lymphocytes are activated to produce lymphokines which may enhance macrophage phagocytosis and intracellular killing of ingested cryptococci . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
0,
11
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
37,
48
]
} |
the luteinising hormone releasing hormone ( lhrh ) release from hypothalamic slices superfused in vitro with crf ( 10 ( -12 ) m - 10 ( -8 ) m ) was markedly reduced . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
109,
112
]
} |
in addition , several blood samples ( n = 35 ) from 14 of these wolves ( 6 pups and 8 adults ) were evaluated simultaneously for erythrocyte and leukocyte counts , and for hemoglobin and blood urea nitrogen concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
129,
140
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
172,
182
]
} |
thus , we would propose that l3t4 initiates t cell : ia-bearing cell interactions and , a finite time later , signals the t cell to discontinue the interaction unless a stimulating level of the antigen : ia complexes for which the t cell 's receptor is specific is present . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
44,
50
]
} | {
"id": "C0034790",
"name": "t cell 's",
"pos": [
231,
240
]
} |
in the germinal centers of extra-nodal tissues , including the thyroid tissues accompanying the lymph follicles , rheumatoid arthritis synovial tissues as well as warthin 's tumors , thyroglobulin , rheumatoid factor and salivary amylase were detected as specific antigens , occurring in lace-like patterns . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
63,
70
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
183,
196
]
} |
low normal peroxidase activity was demonstrated in fresh thyroid tissue but gel electrophoresis demonstrated an absence of normal thyroglobulin from extracts of the goitrous thyroid . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
57,
64
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
130,
143
]
} |
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