text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
rna synthesized in vitro from dna or chromatin templates by escherichia coli rna polymerase , as well as in vivo mouse liver nuclear rna , were each hybridized to 125i-labeled dna of high , intermediate , or low reiteration frequency . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
125,
136
]
} |
chromatin-primed and nuclear rna saturate a smaller portion of each dna fraction than does dna-primed rna . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
21,
32
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
102,
105
]
} |
however , chromatin-primed rna saturates more high and low reiteration frequency dna than does nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
27,
30
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
95,
106
]
} |
simultaneous hybridization of nuclear-and chromatin-primed rna with 125i-labeled dna indicates that chromatin-primed rna contains all of the sequences present in nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
59,
62
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
162,
173
]
} |
myosin messenger ribonucleoprotein-translational control ribonucleic acid ( mrnp-tcna ) from myosin mrnps found in embryonic chick muscle has been further purified by dowex chromatography and , from a number of controls , it is suggested that this small rna is not an artifact produced through the degradation of rna during its isolation . | NA | {
"id": "C0035696",
"name": "messenger",
"pos": [
7,
16
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
313,
316
]
} |
the extent of hybridization of poly ( a ) -lacking rna with mitochondrial dna was not significantly affected by the presence of excess mitochondrial rrna , cytoplasmic rrna , or a tenfold concentration of poly ( a ) -containing rna isolated from total mitochondrial rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
149,
153
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
266,
269
]
} |
we propose that this intermediate is a weak mn3+ -azide complex in which the metal ion remains out-of-plane toward the imidazole of the proximal histidine , but that the metal lies toward the anion in the `` '' final '' '' complex . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
83,
86
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
192,
197
]
} |
they have similar molecular weights and amino acid compositions , and each has an n-terminal alanine residue . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
40,
50
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
93,
100
]
} |
the organic phosphate bound to these phosphoproteins was shown to be directly responsible for the formation of the apatite phase , since removal of 60 % of the covalently bound phosphate with alkaline phosphatase destroyed the protein 's ability to induce hydroxylapatite formation . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
37,
52
]
} | {
"id": "C0033684",
"name": "protein 's",
"pos": [
227,
237
]
} |
mechanism of hydrolysis by serine proteases : direct determination of the pka 's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
27,
43
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
124,
131
]
} |
crude calf thymus dna-dependent rna polymerase , rna polymerase b ( ribonucleoside triphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) , was incubated with the tritium labeled , potent inhibitor [ 3h ] amanin , in order to form the enzymatically inactive [ 3h ] amanin-polymerase complex ( [ 3h ] a-p complex ) . | NA | {
"id": "C0035681",
"name": "dna-dependent rna polymerase",
"pos": [
18,
46
]
} | {
"id": "C0035673",
"name": "rna nucleotidyltransferase",
"pos": [
98,
124
]
} |
unfixed nucleoproteins may be banded isopycnically in metrizamide ( 2 ( 3-acetamido-5-n-methylacetamido-2,4,6-triiodobenzamido ) -2-deoxy-d-glucose ) according to the protein/nucleic acid ratio . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
8,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
167,
174
]
} |
quantitation of rna and protein in polyribosomal mrnps suggested that each molecule of mrna bound a molecule of each of the two major proteins of 78 000 and 52 000 apparent molecular weights and/or one or more of several minor proteins found in mrnps . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
16,
19
]
} | {
"id": "C0035696",
"name": "mrna",
"pos": [
87,
91
]
} |
the fluorescence probe 1,6-diphenyl-1,3,5-hexatriene was used to study and compare the dynamic properties of the hydrophobic region of vesicular stomatitis virus grown on l-929 cells , plasma membrane of l-929 cells prepared by two different methods , liposomes prepared from virus lipids and plasma membrane lipids , and intact l-929 cells . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
282,
288
]
} | {
"id": "C0025249",
"name": "plasma membrane",
"pos": [
293,
308
]
} |
the data presented here also suggest that labile rna-protein cross-links are present in the uv-irradiated 30s ribosomal subunits , and that neither peptide-bond cleavage nor photoinduced modification of the charged side-chain groups in the ribosomal proteins accompanied the cross-linkage reaction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
53,
60
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
240,
258
]
} |
we now report evidence showing that after incubation of intact nil , bhk , and 3t3 fibroblasts with cmp-sialic acid , at least 78 % of the sialic acid incorporated by these cells is the result of free sialic acid uptake . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
when cells growing in a monolayer were incubated with a mixture of cmp- [ 14c ] sialic acid and [ 3h ] cmp-sialic acid with a ratio of 3h/14c=0.60 , this ratio was found to be markedly increased in whole cells . | NA | {
"id": "C0010729",
"name": "cmp",
"pos": [
67,
70
]
} | {
"id": "C0010731",
"name": "cmp-sialic acid",
"pos": [
103,
118
]
} |
the 7s nerve growth factor protein ( 7s ngf ) is a multisubunit zinc metalloprotein containing a masked trypsin-like esteropeptidase activity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
27,
34
]
} | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
69,
83
]
} |
the theory for this procedure is applied to thermal denaturation data , obtained at the ph of optimum stability , for the serine proteases , thermomycolase and subtilisin types carlsberg and bpn ' , and for the zinc metalloendopeptidases , thermolysin and neutral protease a . | NA | {
"id": "C1442934",
"name": "metalloendopeptidases",
"pos": [
216,
237
]
} | {
"id": "C0039815",
"name": "thermolysin",
"pos": [
240,
251
]
} |
for the metalloendopeptidases the total kinetic thermal stability is largest for thermolysin , the difference between thermolysin and neutral protease a being dominated by bound calcium ion contributions . | NA | {
"id": "C1442934",
"name": "metalloendopeptidases",
"pos": [
8,
29
]
} | {
"id": "C0039815",
"name": "thermolysin",
"pos": [
118,
129
]
} |
this supports the conclusion that these factors are initiation factors for protein synthesis and not ribosomal structural proteins . | NA | {
"id": "C0030943",
"name": "initiation factors",
"pos": [
52,
70
]
} | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
101,
110
]
} |
a model is proposed in which divalent cations are transported by at least two mechanisms : ( 1 ) a passive uniport and ( 2 ) and active pump , cation antiport or anion symport . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
29,
45
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
143,
149
]
} |
however , in the presence of 0.1 % sodium dodecyl sulfate , subtilisin-treated e3 shows a 20-30-fold augmentation in in vitro activity which is again associated with the smaller fragment extracted from the sodium dodecyl sulfate gel . | NA | {
"id": "C0058632",
"name": "dodecyl sulfate",
"pos": [
42,
57
]
} | {
"id": "C0037506",
"name": "sodium dodecyl sulfate",
"pos": [
206,
228
]
} |
spectrophotometric and fluorimetric techniques were employed to charcterize the environment of the heme chromophore of rabbit hemopexin and to monitor changes in the environment of aromatic amino acid residues induced by the interaction of hemopexin with porphyrins and metalloporphyrins . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
99,
103
]
} | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
270,
287
]
} |
spectrophotometric and fluorimetric techniques were employed to charcterize the environment of the heme chromophore of rabbit hemopexin and to monitor changes in the environment of aromatic amino acid residues induced by the interaction of hemopexin with porphyrins and metalloporphyrins . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
255,
265
]
} | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
270,
287
]
} |
each glycoprotein had a unique amino acid composition , but in general low levels of tyrosine , tryptophan , and basic amino acids were found along with relatively high contents of serine , threonine , glutamic acid , and proline . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
31,
41
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
113,
130
]
} |
carbohydrate analysis revealed little difference in the monosaccharide compositions of types i and iv glycoproteins , except that only the type i contained sialic acid . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
0,
12
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
56,
70
]
} |
the kinetics of the hydrogen-deuterium exchange reaction in a subtilisin inhibitor from streptomyces albogriseolus has been examined by infrared absorption measurement in aqueous solutions at various ph values and temperatures . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
20,
28
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
29,
38
]
} |
the conformations of the sugar rings of the neutral forms of araa and adenosine in aqueous medium differ appreciably , whereas in the solid state they are very similar . | NA | {
"id": "C0042646",
"name": "araa",
"pos": [
61,
65
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
70,
79
]
} |
the lipid-alamethecin and lipid-valinomycin interactions produced a decrease in the lipid raman intensity ratio i1064/i1089 again indicating an increase in the gauche hydrocarbon chain character of dicyristoyl phosphatidylcholine while producing no change in this ratio for dipalmitoyl phosphatidylcholine . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
210,
229
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
274,
285
]
} |
x-ray photoelectron spectroscopy was used to determine the oxidation states of osmium compounds present in erythrocyte ghost preparations and related systems treated with osmium tetroxide . | NA | {
"id": "C0206372",
"name": "osmium compounds",
"pos": [
79,
95
]
} | {
"id": "C0029385",
"name": "osmium tetroxide",
"pos": [
171,
187
]
} |
the secretion of each divalent cation is the sum of two components : an extracellular flux and a flux of protein-associated cations , the so-called secretory flux . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
22,
37
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
124,
131
]
} |
the concentration dependences of response of frog tongue to d-fructose , d-glucose , and sucrose were almost the same , d-galactose , however , elicited a much larger response in comparison with the other sugars in the whole range of concentrations examined . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
89,
96
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
205,
211
]
} |
several commercially available samples of galactose oxidase ( d-galactose : oxygen 6-oxidoreductase , ec 1.1.3.9 ) were found to contain high proteolytic activity on proteins such as fibrinogen , transferrin , albumin and casein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
166,
174
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
210,
217
]
} |
the effect of the addition of several phospholipids ( lysophosphatidylcholine , alpha-lecithin , phosphatidylserine , phosphatidylethanolamine , lysophosphatidyl-ethanolamine , sphingomyelin , and disphosphatidylglycerol and phosphatidic acid ) and related compounds ( glycerophosphocholine , alpha- and beta-glycerophosphate , choline , serine , glycerol , dipalmitoylglycerol , and stearic acid ) on the ability of purified ( from beef pancreas ) and microsomal ( rat liver ) glutathione-insulin transhydrogenase ( glutathione : protein-disulphide oxidoreductase , ec 1.8.4.2 ) to degrade insulin has been examined . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
86,
94
]
} | {
"id": "C0017889",
"name": "glycerophosphocholine",
"pos": [
269,
290
]
} |
the reoxidation of reduced rhus vernicifera laccase ( monophenol , dihydroxyphenylalanine : oxygen oxidoreductase , ec 1.14.18.1 ) by molecular oxygen has been studied by optical absorption and epr methods . | NA | {
"id": "C0064566",
"name": "laccase",
"pos": [
44,
51
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
116,
120
]
} |
the tyrosine-sensitive allosteric first enzyme of the aromatic amino acid biosynthetic pathway , 3-deoxy-d-arabinoheptulosonate 7-phosphate synthetase ( 7-phospho-2-keto-3-deoxy-d-arabino-heptonate d-erythrose 4-phosphate-lyase ( pyruvate phosphorylating ) , ec 4.1.2.15 ) has been purified from a mutant strain of escherichia coli . | NA | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
4,
12
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
54,
73
]
} |
evidence is presented that the enzymes catalyzing the three reactions involved in urea cleavage in candida utilis , biotin carboxylation , urea carboxylation , and allophanate hydrolysis occur as a complex of enzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
31,
38
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
198,
205
]
} |
and dns-ser 221 -- subtilisin carlsberg ( dns-subtilisin ( i ) ) are in the range of 89.5-92.5 on the `` '' z '' '' scale . | NA | {
"id": "C0038597",
"name": "subtilisin",
"pos": [
19,
29
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
46,
56
]
} |
some of the shifts observed with the deuterated heme c are larger than the corresponding shifts in meso-deuterated metalloporphyrins suggesting mixing of peripheral substituent vibrations with the skeletal modes of the porphyrin macrocycle . | NA | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
115,
132
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
219,
228
]
} |
the algal cytochrome exhibits resonance raman spectra roughly similar to those of horse heart cytochrome c , consistent with its optical absorption spectra which is typical of c type cytochromes , although a detailed comparison reveals note-worthy differences between the spectra of the two proteins ; | NA | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
10,
20
]
} | {
"id": "C1256752",
"name": "c type cytochromes",
"pos": [
176,
194
]
} |
the algal cytochrome exhibits resonance raman spectra roughly similar to those of horse heart cytochrome c , consistent with its optical absorption spectra which is typical of c type cytochromes , although a detailed comparison reveals note-worthy differences between the spectra of the two proteins ; | NA | {
"id": "C0010749",
"name": "cytochrome c",
"pos": [
94,
106
]
} | {
"id": "C1256752",
"name": "c type cytochromes",
"pos": [
176,
194
]
} |
from the observations of the release of monosaccharides and analogy with standard features determined by other investigators on soluble aortic glycoproteins , a prediction has been made as to the general features of the carbohydrate moiety of the glycoprotein . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
40,
55
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
220,
232
]
} |
the primary structure of pig heart myoglobin has been established by study of the tryptic peptides of whole globin and by analysis of the fragments obtained by cnbr cleavage . | NA | {
"id": "C0027078",
"name": "myoglobin",
"pos": [
35,
44
]
} | {
"id": "C0017645",
"name": "globin",
"pos": [
108,
114
]
} |
automatic edman degradation of whole globin and of the m fragment completed the sequence of pig myoglobin . | NA | {
"id": "C0017645",
"name": "globin",
"pos": [
37,
43
]
} | {
"id": "C0027078",
"name": "myoglobin",
"pos": [
96,
105
]
} |
the protein was found to occur in normal plasma and urine as free monomers and dimers and as complexes with iga and albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
116,
123
]
} |
this nonidentity was also supported by a comparison between the apoproteins of purified serum lipoproteins and platelet proteins released after solubilization with sodium dodecyl sulfate . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
64,
75
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
120,
128
]
} |
amino acid analysis showed a preponderance of aspartic and glutamic acids and relatively large amounts of glycine , proline , alanine , valine and cysteine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
106,
113
]
} |
amino acid analysis showed a preponderance of aspartic and glutamic acids and relatively large amounts of glycine , proline , alanine , valine and cysteine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
126,
133
]
} |
the amino acid analysis indicated that the inhibitor is rich in half-cystine , glycine and aspartic acid , and contains no tryptophan , histidine , methionine or valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
79,
86
]
} |
to test the relative significance of the possible mechanisms regulating covalent interconversions of pyruvate dehydrogenase , the following parameters were measured in response to the potassium-induced cardiac arrest : concentrations of pyruvate , acetyl-coa , coa-sh , citrate , alpha-oxoglutarate , atp , adp , amp , creatine , creatine phosphate and inorganic phosphate and the mitochondrial nadh/nad+ ratio . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
319,
327
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
330,
348
]
} |
the acidic glycosphingolipids in rat sublingual and submaxillary glands were composed of monohexose sulfatide , dihexose sulfatide and monosialo-and disialogangliosides of hematoside series . | NA | {
"id": "C0600571",
"name": "acidic glycosphingolipids",
"pos": [
4,
29
]
} | {
"id": "C0038727",
"name": "sulfatide",
"pos": [
121,
130
]
} |
under these conditions , for which preferential hydration of the sedimenting species is not involved , it was found that the more highly complexed strand has sustained a 24 % increase in mass and a 28 % decrease in frictional coefficient relative to uncomplexed dna , while the strand binding the lesser amount of rna has increased in mass by 11 % and changed in frictional coefficient by an insignificant amount relative to the uncomplexed species from that of the uncomplexed dna do not contribute significantly to the differences in s 25 , w between the complexed complementary strands . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
45,
46
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
478,
481
]
} |
comparison of the proteins from neurospora crassa mitochondrial ribosomes with ribosomal proteins from neurospora cytoplasm , from rat liver mitochondria and from bacteria . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
18,
26
]
} | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
50,
63
]
} |
neurospora cytoplasmic ribosomes contain 31 proteins in the large , and 21 proteins in the small subunit . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C0599220",
"name": "proteins",
"pos": [
75,
83
]
} |
paramagnetic quenching of erythrocyte membrane protein fluorescence by nitroxide-labelled lipid analogues has been studied as a function of temperature and quencher concentration , as well as after cross-linking of membrane proteins by glutaraldehyde . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
47,
54
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
215,
232
]
} |
the ca2+-stimulated atpase from membranes prepared without ca2+ showed reduced maximum activity , but dialyzed , membrane-free hemolysates , whether prepared with ca2+ present or not , recovered the activity when the hemolysate was present during the atpase assay . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
4,
7
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
251,
257
]
} |
binding studies on sonicated membranes provide evidence for a specific binding site or protein for d-glucose at the plasma membrane by isolating tris-soluble membrane proteins which reveal a higher binding capacity than the unsonicated membrane . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
87,
94
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
158,
175
]
} |
the interaction of components of the prothrombinase complex , i.e . bovine factor x or factor xa , bovine factor v or factor va , phospholipid , and ca2+ , in various combinations was studied primarily by a gel filtration technique . | NA | {
"id": "C0015518",
"name": "factor",
"pos": [
75,
81
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
87,
96
]
} |
the interaction of components of the prothrombinase complex , i.e . bovine factor x or factor xa , bovine factor v or factor va , phospholipid , and ca2+ , in various combinations was studied primarily by a gel filtration technique . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
106,
114
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
118,
127
]
} |
however , the interaction of factor x or factor xa with phospholipids with a negative charge required ca2+ . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
29,
37
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
41,
50
]
} |
it was shown that factor x could bind to the same type of lipid of lipid surface as that noted for factor xa . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
18,
26
]
} | {
"id": "C0015520",
"name": "factor",
"pos": [
99,
105
]
} |
this evidence for a genetic basis of lectin multiple forms in wheat indicates the advisability of using genetically identified plant varieties in lectin research . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
37,
43
]
} | {
"id": "C0304052",
"name": "plant",
"pos": [
127,
132
]
} |
transplantable mouse melanomas possess a melanotropin-sensitive adenylate cyclase system which is responsive to alpha-melanotropin , beta-melanotropin , adrenocorticotropin ( acth ) and prostaglandin e1 . | NA | {
"id": "C0026667",
"name": "melanotropin",
"pos": [
41,
53
]
} | {
"id": "C0002302",
"name": "alpha-melanotropin",
"pos": [
112,
130
]
} |
transplantable mouse melanomas possess a melanotropin-sensitive adenylate cyclase system which is responsive to alpha-melanotropin , beta-melanotropin , adrenocorticotropin ( acth ) and prostaglandin e1 . | NA | {
"id": "C0026667",
"name": "melanotropin",
"pos": [
41,
53
]
} | {
"id": "C0005261",
"name": "beta-melanotropin",
"pos": [
133,
150
]
} |
approximately 70 % of fucose-labeled glycopeptides from the cell surface and cellular material of rat fibroblasts ( 3y1b cells ) were hydrolyzed by endo-beta-n-acetylglucosaminidase d in the presence of neuraminidase , beta-galactosidase and beta-n-acetylglucosaminidase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} |
as reported earlier , under ordinary assay conditions ( 1.0 mm atp , 5 mm mg2+ , 30 degrees c , 10 min incubation ) the enzyme was activated 6-fold by epinephrine in the presence of the gtp analog , 5'-guanylyl-imidodiphosphate [ gmp-p ( nh ) p ] ( cooper , b. et al . ( 1975 ) j. clin . invest . 56 , 1350-1353 ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
186,
189
]
} | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
202,
227
]
} |
in addition , we demonstrated the dissociation of enzyme protein in the presence of 1.0 - 10 ( -2 ) m dithiothreitol , the formation of multiple precipitin bands by aged enzyme , and the identity of the different isoelectric fractions of each of the isozymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
50,
56
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
250,
258
]
} |
both mn2+ and co2+ can replace mg2+ as the required divalent cation for all activities of the enzyme complex between anthranilate synthase ( chorismate pyruvate-lyase ( amino-accepting ) , ec 4.1.3.27 ) and anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase ( n ( 5'-phosphoribosyl ) -anthranilate : pyrophosphate phosphoribosytransferase , ec 2.4.2.18 ) from salmonella typhimurium . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
94,
108
]
} | {
"id": "C0003169",
"name": "anthranilate synthase",
"pos": [
117,
138
]
} |
both mn2+ and co2+ can replace mg2+ as the required divalent cation for all activities of the enzyme complex between anthranilate synthase ( chorismate pyruvate-lyase ( amino-accepting ) , ec 4.1.3.27 ) and anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase ( n ( 5'-phosphoribosyl ) -anthranilate : pyrophosphate phosphoribosytransferase , ec 2.4.2.18 ) from salmonella typhimurium . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
94,
108
]
} | {
"id": "C0003168",
"name": "anthranilate",
"pos": [
303,
315
]
} |
an enzyme complex has been isolated from a mutant strain of s. typhimurium ( so-515 ) that has a variation in the anthranilate synthase subunit which is thought to be a single amino acid substitution . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
3,
17
]
} | {
"id": "C0003169",
"name": "anthranilate synthase",
"pos": [
114,
135
]
} |
these results suggest that the variant enzyme complex has altered tertiary and quaternary structures and that regulation of both activities is effected by tryptophan binding to only anthranilate synthase . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
39,
53
]
} | {
"id": "C0003169",
"name": "anthranilate synthase",
"pos": [
182,
203
]
} |
three branched peptides , namely pentapeptide a and the two decapeptides b and c corresponding respectively to the monomer and the two dimer peptide fragments of the m. lysodeikticus cell wall peptidoglycan , were synthetized by adequate methods of peptide synthesis in homogeneous phase . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
15,
23
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
141,
158
]
} |
the synthetized peptides showed the same electrophoretic and chromatographic behavior as the natural peptide fragments . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
16,
24
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
101,
118
]
} |
the half-life of the unstable rna as well as of the messenger rna of the beta-galactosidase is increased to a considerable degree . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035696",
"name": "messenger",
"pos": [
52,
61
]
} |
adaptation of yeast torulopsis candida to d-arabinose , d-lyxose and l-oxylose is shown to be due to the appearance of a new enzyme which catalyzes the reduction of these pentoses to d-arabitol and xylitol , respectively . | NA | {
"id": "C0003682",
"name": "arabinose",
"pos": [
44,
53
]
} | {
"id": "C0030894",
"name": "pentoses",
"pos": [
171,
179
]
} |
the two pathways for de novo lecithin ( phosphatidylcholine ) biosynthesis , choline incorporation ( 1 ) and phosphatidylethanolamine methylation ( ii ) , were examined simultaneously in lung and other tissues of rhesus monkey fetuses . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
29,
37
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
40,
59
]
} |
in this paper , we discuss the case of hemoglobin m boston characterizing this abnormal hemoglobin as valency hybrid by spectral studies and utilising this mutant as a marker , in isoelectricfocusing , we bring the arguments that the two intermediary bands of oxidation correspond to alpha2+beta2+2 and alpha2+2beta2+3 we also indicate that the abnormal spectrum of hb m interferes with the estimation of methemoglobin , giving erroneous values . | NA | {
"id": "C0019047",
"name": "abnormal hemoglobin",
"pos": [
79,
98
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
366,
368
]
} |
in this paper , we discuss the case of hemoglobin m boston characterizing this abnormal hemoglobin as valency hybrid by spectral studies and utilising this mutant as a marker , in isoelectricfocusing , we bring the arguments that the two intermediary bands of oxidation correspond to alpha2+beta2+2 and alpha2+2beta2+3 we also indicate that the abnormal spectrum of hb m interferes with the estimation of methemoglobin , giving erroneous values . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
366,
368
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
405,
418
]
} |
however , in media where the only hexose was galactose there was almost no growth of homozygous mutant cells or of maternal heterozygous cells and slight growth of paternal heterozygous cells . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
34,
40
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
45,
54
]
} |
in all cell lines there was a direct relation between the degree of enhancement of galactokinase activity and the ability of cells to adapt to growth in media where the only hexose was galactose . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
174,
180
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
185,
194
]
} |
the heterozygous state may be expressed phenotypically in the patient by the appearance of cataracts and in cultured cells by their defective growth in media where galactose is the only hexose . | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
164,
173
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
186,
192
]
} |
the preparation arrested the auricular arrhythmias caused by electric stimulation of the auricles or by aconitine application , eliminated the auricular arrhythmias resulting from occlusion of a branch of the coronary artery or oubaine intoxication , prevented lethal auricular fibrillation in rats after the calcium chloride intoxication . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
39,
50
]
} | {
"id": "C0004238",
"name": "auricular fibrillation",
"pos": [
268,
290
]
} |
at the peak of the primary immune response to sheep erythrocytes there appeared in the spleen of mice rosette-forming cells ( rfc ) effectively inactivated with antibodies against aggregated mouse immunoglobulins and with the complex of polyadenylic-polyuridylic acids ( poly-a , poly-u , respectively ) . | NA | {
"id": "C0032402",
"name": "polyadenylic-polyuridylic acids",
"pos": [
237,
268
]
} | {
"id": "C0032400",
"name": "poly-a",
"pos": [
271,
277
]
} |
norepinephrine , epinephrine and serotonin levels were studied in male rabbit hypothalamus and midbrain under the influence of different factors potentiating the hypophysial adrenocorticotropic function . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} |
intensification of this adrenohypophysial function was accompanied by a certain decrease in the hypothalamic and midbrain norepinephrine level and by the appearance of epinephrine normally absent here . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
122,
136
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
168,
179
]
} |
the mesentery and the cheek pouch homogenates , albumin proteins , histamine and some amino acids were capable of activating the salivary kallikreins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
48,
55
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
56,
64
]
} |
studies of the influence of contrycal on condition of the enzyme systems of the muscles , liver , kidneys and heart of rats with developing granulation tissue showed contrycal , a protease inhibitor , to have a stimulating effect on the ldh and mdh activity and on their isozyme spectrum . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
58,
64
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
271,
278
]
} |
monkey antisera to amml cells , by direct microcytotoxicity testing , were cytotoxic for cells from all amml patients , as well as for cells of certain patients with myeloid leukemia . | NA | {
"id": "C0023479",
"name": "amml",
"pos": [
19,
23
]
} | {
"id": "C0023470",
"name": "myeloid leukemia",
"pos": [
166,
182
]
} |
( 1 ) the inhibition of spontaneous action potentials in guinea pig cerebellar cortex slices by gaba , glycine , taurine and beta-alanine is maintained when c1- in the superfusion medium is almost completely replaced by no3- or i- ( 'permeant ' anion ) , but the inhibition decreases in magnitude with repeated application of the amino acid . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
103,
110
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
330,
340
]
} |
( 1 ) the inhibition of spontaneous action potentials in guinea pig cerebellar cortex slices by gaba , glycine , taurine and beta-alanine is maintained when c1- in the superfusion medium is almost completely replaced by no3- or i- ( 'permeant ' anion ) , but the inhibition decreases in magnitude with repeated application of the amino acid . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
10,
11
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
245,
250
]
} |
replacement of c1- by sulfate or isethionate ( 'impermeant ' anion ) causes a conversion of inhibition by these amino acids to excitation . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
22,
29
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
61,
66
]
} |
( 5 ) these results are consistent with the hypothesis that the inhibitory amino acids , gaba , glycine , taurine and beta-alanine , cause inhibition via increase of c1- ( and perhaps k+ ) permeability and that glycine , taurine and beta-alanine also interact with strychnine-sensitive receptors mediating ( perhaps indirectly ) increased permeability to na+ and , therefore , excitation in low c1- media . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
75,
80
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
211,
218
]
} |
the concentrations of noradrenaline and lopamine of 92 brain regions have been measured by a radiometric method which enabled discrimination between noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
22,
35
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
167,
177
]
} |
microphthalmic mice of these two stocks and their hybrids were treated as newborn by intraperitoneal injection and at weaning or maturity by intravenous injection of cell suspensions containing hematopoietic stem cells from phenotypically normal mice . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
166,
170
]
} | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
194,
218
]
} |
resolution of much of the osteopetrosis but not the other phenotypic effects occurred within a few months in the majority of cases , provided syngeneic or h-2 compatible allogeneic cells were given : it did not occur spontaneously or on giving h-2 incompatible cells or on giving compatible material by an inappropriate route . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
170,
186
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
261,
266
]
} |
the results accord with hypotheses that ( 1 ) osteoclasis of scaffoldtype woven bone is impaired in mi mi , ( 2 ) that osteoclastic cells are derived through circulating monocytes from hematopoietic stem cells , and ( 3 ) in mi mi this defect can be overcome by a transplant of normal hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
185,
209
]
} |
if osteolysis occurs 21 days after the injection of these markers , under our experimental conditions , any increase in the urinary excretion of 177lu and 237np represents a rise in bone resorption , whereas an increase in sr excretion reflects both and renal tubular events . | NA | {
"id": "C0221204",
"name": "osteolysis",
"pos": [
3,
13
]
} | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
182,
197
]
} |
analysis of the apoproteins of the golgi vldl by polacrylamide gel electrophoresis revealed protein bands with similar mobility to those of serum vldl , except that the former contained virtually no rapidly migrating peptides with the mobility of serum apo-c-ii and apo-c-iii . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
16,
27
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
92,
99
]
} |
in the isolated perfused liver the percentage incorporation of [ 3h ] leucine into the rapidly migrating apoproteins of golgi vldl was considerably less than that found in the corresponding apoproteins of perfusate vldl , where circulating c lipoproteins are virtually absent . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
126,
130
]
} | {
"id": "C0023820",
"name": "circulating",
"pos": [
228,
239
]
} |
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