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it was shown that the cells bound about the same amount of lectin at 0 and 37 degrees c , but less protein was bound at 25 degrees c .
NA
{ "id": "C0023206", "name": "lectin", "pos": [ 59, 65 ] }
{ "id": "C0033684", "name": "protein", "pos": [ 99, 106 ] }
these same effects of the blocking agents were observed when adrenaline was used instead of na .
NA
{ "id": "C0014563", "name": "adrenaline", "pos": [ 61, 71 ] }
{ "id": "C0028351", "name": "na", "pos": [ 92, 94 ] }
temperature recordings in vivo revealed , in fact , that the tissue was maintained at a temperature close to that of the body core during immersion of the pups in ice-water .
NA
{ "id": "C0020746", "name": "ice", "pos": [ 163, 166 ] }
{ "id": "C0043047", "name": "water", "pos": [ 167, 172 ] }
beta-adrenergic blockade markedly increased the cooling rates at both locations in ice-water , while curarization , accompanied by artificial respiration did not .
NA
{ "id": "C0020746", "name": "ice", "pos": [ 83, 86 ] }
{ "id": "C0043047", "name": "water", "pos": [ 87, 92 ] }
the results of bone scanning with the newer technetium-99m complexes were correlated with clinical , laboratory , and radiographic findings in 26 patients with malignant lymphoma ( 10 with hodgkin 's disease and 16 with non-hodgkin 's lymphomas ) .
NA
{ "id": "C0024299", "name": "malignant lymphoma", "pos": [ 160, 178 ] }
{ "id": "C0019829", "name": "hodgkin 's disease", "pos": [ 189, 207 ] }
the results of bone scanning with the newer technetium-99m complexes were correlated with clinical , laboratory , and radiographic findings in 26 patients with malignant lymphoma ( 10 with hodgkin 's disease and 16 with non-hodgkin 's lymphomas ) .
NA
{ "id": "C0024299", "name": "malignant lymphoma", "pos": [ 160, 178 ] }
{ "id": "C0024305", "name": "non-hodgkin 's", "pos": [ 220, 234 ] }
the literature is reviewed regarding the incidence of prominent lymphadenopathy and chromosome abnormalities in agnogenic myeloid metaplasia and other myeloproliferative disorders .
NA
{ "id": "C0001815", "name": "agnogenic myeloid metaplasia", "pos": [ 112, 140 ] }
{ "id": "C0027022", "name": "myeloproliferative disorders", "pos": [ 151, 179 ] }
this is not due to detectable alterations in the ability of the glucocorticoid receptor to bind the steroid hormone , or of the hormone-receptor complex to undergo activation , or of the activated steroid-receptor complex to bind to nuclei derived from the hepatoma or normal liver .
NA
{ "id": "C0034809", "name": "glucocorticoid receptor", "pos": [ 64, 87 ] }
{ "id": "C0034840", "name": "steroid-receptor", "pos": [ 197, 213 ] }
this biphasic effect , which was less prominent in human fibroblasts , may reflect a selective sensitivity either of part of the cell population or of part of the dna within individual cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 57, 68 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 185, 190 ] }
the production and repair of dna single-strand breaks after bleomycin treatment were the same in normal human and xeroderma pigmentosum fibroblasts , indicating that these events do not require the excision endonuclease that appears to be defective in these ultraviolet light-sensitive xeroderma cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 136, 147 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 296, 301 ] }
studies of ischaemic myocardium following occlusion of coronary arterial branches revealed a substantial decline in creatine phosphate , adenosine triphosphate , and total adenine nucleotide contents over 40 min .
NA
{ "id": "C0001480", "name": "adenosine", "pos": [ 137, 146 ] }
{ "id": "C0001413", "name": "adenine nucleotide", "pos": [ 172, 190 ] }
for the nuclear rnas , melting curve , density , and size determinations on the hybrids confirmed the presence of an rna species indistinguishable by cdna hybridization from reticulocyte globin mrna .
NA
{ "id": "C0035700", "name": "nuclear rnas", "pos": [ 8, 20 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 195, 198 ] }
the proportion of the globin rna sequences in the nuclear rna that are found associated with poly ( a ) sequences does not vary markedly from one tissue or cell line to another .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 29, 32 ] }
{ "id": "C0035700", "name": "nuclear rna", "pos": [ 50, 61 ] }
both the kinetics of entry of labeled 75s rna into the cytoplasm-that is , a constant rate of increase after a brief lag-and chase data are incompatible with a precursor-product relationship between the great majority of nuclear 75s rna and cytoplasmic 75s rna with messenger characteristics .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 42, 45 ] }
{ "id": "C0035700", "name": "nuclear", "pos": [ 221, 228 ] }
one antiserum contained antibodies that reacted with these dna-binding proteins , while the second antiserum did not contain detectable levels of antibody .
NA
{ "id": "C0003241", "name": "antibodies", "pos": [ 24, 34 ] }
{ "id": "C0020960", "name": "antiserum", "pos": [ 99, 108 ] }
the dimer linkage dissociates at temperature estimated to be 87 degrees c in aqueous 0.1m na+ for rd-114 and baboon viral rnas , but at the lower temperature of 66 degrees c for woolly monkey rna .
NA
{ "id": "C0035736", "name": "viral rnas", "pos": [ 116, 126 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 192, 195 ] }
from an examination of the kinetics of digestion of h3/h4 reconstitutes , we conclude that although the other histones have a role in dna organization within the nucleosome , the arginine-rich histone pair , h3/h4 , can organize dna segments the length of the nucleosome core in the absence of all other histones .
NA
{ "id": "C0000702", "name": "a", "pos": [ 5, 6 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 229, 232 ] }
one of the membrane proteins iodinated has been shown to be myosin as follows : it has the same electrophoretic mobility ( molecular weight 200,000 daltons ) as myosin heavy chain on sodium dodecylsulfate polyacrylamide gels and the labeled myosin is specifically precipitated by fibroblast myosin antiserum from a preparation of purified plasma membrane that have been solubilized by treatment with 1 % triton x-100 .
NA
{ "id": "C0027100", "name": "myosin", "pos": [ 60, 66 ] }
{ "id": "C0027096", "name": "myosin", "pos": [ 291, 297 ] }
in the normal fibroblasts , the binding of insulin was low in growing cells and increased 2-9 fold in confluent stationary cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 14, 25 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 123, 128 ] }
since the location of the ecori sites in rdna is known , and the specificity of the two exonucleases for 5 ' and 3 ' ends of dna strands has been established , the hybridization of the different partially digested rdna fragments with either 18s or 28s rrna could be interpreted in terms of polarity of the coding strand of rdna , and consequently of the rna ( see models in figure 1 ) .
NA
{ "id": "C0012933", "name": "rdna", "pos": [ 41, 45 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 324, 327 ] }
since the location of the ecori sites in rdna is known , and the specificity of the two exonucleases for 5 ' and 3 ' ends of dna strands has been established , the hybridization of the different partially digested rdna fragments with either 18s or 28s rrna could be interpreted in terms of polarity of the coding strand of rdna , and consequently of the rna ( see models in figure 1 ) .
NA
{ "id": "C0035701", "name": "rrna", "pos": [ 252, 256 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 354, 357 ] }
comparison of the microsome catalysed hydrocarbon-deoxyribonucleoside products with those obtained by reaction with dna of 7meba-5,6-oxide suggested that this k-region epoxide made a significant contribution to the liver microsome-induced dna binding .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 116, 119 ] }
{ "id": "C0000702", "name": "a", "pos": [ 241, 242 ] }
as the oxidized bis ( gs ) -dmap was bound to hemoglobin more slowly and to a lesser extent , it produced more ferrihemoglobin than dmap .
NA
{ "id": "C0019046", "name": "hemoglobin", "pos": [ 46, 56 ] }
{ "id": "C0025635", "name": "ferrihemoglobin", "pos": [ 111, 126 ] }
in contrast to the reactions of dmap with hemoglobin , hydrogen peroxide and superoxide radicals are involved in the ferrihemoglobin formation by bis ( gs ) -dmap .
NA
{ "id": "C0019046", "name": "hemoglobin", "pos": [ 42, 52 ] }
{ "id": "C0025635", "name": "ferrihemoglobin", "pos": [ 117, 132 ] }
a significant weight increase of the glands is observed while norepinephrine and epinephrine content is depleted after dichlorvos intoxication .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 62, 76 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 81, 92 ] }
v.s.v . induced polycaryocytes in rat embryonic fibroblasts , transformed by the prague strain of sarcoma rous ( xc cells ) .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 48, 59 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 116, 121 ] }
the transcapillary escape rate of albumin ( teralb ) , i.e. , the fraction of intravascular mass of albumin that passes to the extravascular space per unit of time , was determined from the disappearance of intravenously injected 125i-labeled human serum albumin during the first 60 minutes after injection in 10 subjects with chronic right heart failure .
NA
{ "id": "C0001924", "name": "albumin", "pos": [ 34, 41 ] }
{ "id": "C0304925", "name": "human serum albumin", "pos": [ 243, 262 ] }
consistent with reported observations that ouabain-binding , metabolism , and excretion do not change with age , we found no significant differences in the transfer coefficients in a linear two-compartment open model for ouabain pharmacokinetics following a bolus of 0.05 mg/kg .
NA
{ "id": "C0025519", "name": "metabolism", "pos": [ 61, 71 ] }
{ "id": "C0221102", "name": "excretion", "pos": [ 78, 87 ] }
at least 15 dipeptides were identified in the urine , most of which contained proline or hydroxyproline in the carboxy terminal position .
NA
{ "id": "C0033382", "name": "proline", "pos": [ 78, 85 ] }
{ "id": "C0020388", "name": "hydroxyproline", "pos": [ 89, 103 ] }
hyperuricaemia and hyperlipidaemia ( elevated fasting plasma cholesterol or triglycerides ) were frequently found in 219 males and 63 females with peripheral vascular disease ( pvd ) .
NA
{ "id": "C0020473", "name": "hyperlipidaemia", "pos": [ 19, 34 ] }
{ "id": "C0020443", "name": "elevated", "pos": [ 37, 45 ] }
response of plasma testosterone , urinary 17-oxosteroids , oestrogens , and androsterone plus aetiocholanolone to human chorionic gonadotrophin in dexamethasone-suppressed men .
NA
{ "id": "C0000167", "name": "17-oxosteroids", "pos": [ 42, 56 ] }
{ "id": "C0002865", "name": "androsterone", "pos": [ 76, 88 ] }
response of plasma testosterone , urinary 17-oxosteroids , oestrogens , and androsterone plus aetiocholanolone to human chorionic gonadotrophin in dexamethasone-suppressed men .
NA
{ "id": "C0000167", "name": "17-oxosteroids", "pos": [ 42, 56 ] }
{ "id": "C0015124", "name": "aetiocholanolone", "pos": [ 94, 110 ] }
the administration of human chorionic gonadotrophin ( hcg ) to dexamethasone-suppressed men caused parallel changes in the concentration of plasma testosterone and in the urinary output of androsterone+aetiocholanolone , total 17-oxosteroids and oestrogens .
NA
{ "id": "C0002865", "name": "androsterone", "pos": [ 189, 201 ] }
{ "id": "C0000167", "name": "17-oxosteroids", "pos": [ 227, 241 ] }
the administration of human chorionic gonadotrophin ( hcg ) to dexamethasone-suppressed men caused parallel changes in the concentration of plasma testosterone and in the urinary output of androsterone+aetiocholanolone , total 17-oxosteroids and oestrogens .
NA
{ "id": "C0015124", "name": "aetiocholanolone", "pos": [ 202, 218 ] }
{ "id": "C0000167", "name": "17-oxosteroids", "pos": [ 227, 241 ] }
with these exceptions , the response to hcg could by followed as well by measuring androsterone+aetiocholanolone , 17-oxosteroid or oestrogen excretion rates as by following plasma testosterone levels .
NA
{ "id": "C0002865", "name": "androsterone", "pos": [ 83, 95 ] }
{ "id": "C0000167", "name": "17-oxosteroid", "pos": [ 115, 128 ] }
with these exceptions , the response to hcg could by followed as well by measuring androsterone+aetiocholanolone , 17-oxosteroid or oestrogen excretion rates as by following plasma testosterone levels .
NA
{ "id": "C0015124", "name": "aetiocholanolone", "pos": [ 96, 112 ] }
{ "id": "C0000167", "name": "17-oxosteroid", "pos": [ 115, 128 ] }
fibroblast cultures differed from the lymphocytes : in the former the majority of the cells lacked the abnormal y-chromosome , their karyotype being 45 , x0 .
NA
{ "id": "C0016030", "name": "fibroblast", "pos": [ 0, 10 ] }
{ "id": "C0007634", "name": "the", "pos": [ 127, 130 ] }
immunoglobulins and transient paraproteins in sera of patients with the wiskott-aldrich syndrome : a follow-up study .
NA
{ "id": "C0021027", "name": "immunoglobulins", "pos": [ 0, 15 ] }
{ "id": "C0030490", "name": "paraproteins", "pos": [ 30, 42 ] }
immunoglobulin levels of individual classes and igg subclasses and the occurrence of homogeneous immunoglobulins -- paraproteins -- were studied longitudinally in the sera of three patients with the wiskott-aldrich syndrome ;
NA
{ "id": "C0021027", "name": "immunoglobulins", "pos": [ 97, 112 ] }
{ "id": "C0030490", "name": "paraproteins", "pos": [ 116, 128 ] }
an antigen sharing immunological determinants with doc-extractable tissue antigens was released into circulation before and during proteinuria .
NA
{ "id": "C0003320", "name": "antigen", "pos": [ 3, 10 ] }
{ "id": "C0003316", "name": "determinants", "pos": [ 33, 45 ] }
during intravenous infusion with neutral sodium phosphate , the urine ph changed little but the rate of excretion of titratable acid increased in direct proportion to that of urinary phosphate in both groups of patients .
NA
{ "id": "C0074757", "name": "sodium phosphate", "pos": [ 41, 57 ] }
{ "id": "C0031603", "name": "phosphate", "pos": [ 183, 192 ] }
although intrapartum and postpartum pelvic infections consitute the majority such serious infections in pregnancy , attention has also been called to several less frequent but potentially lethal nonpelvic infections .
NA
{ "id": "C0034041", "name": "postpartum", "pos": [ 25, 35 ] }
{ "id": "C0032965", "name": "infections", "pos": [ 205, 215 ] }
the percentages of patients with normal vitamin a absorption were 85 with vitamin a alcohol in oil-water emulsion , 61 with vitamin a alcohol dissolved in oil , 64 with vitamin a palmitate in oil-water emulsion , and 19 with vitamin a palmitate in oil .
NA
{ "id": "C0042839", "name": "vitamin a", "pos": [ 40, 49 ] }
{ "id": "C0073115", "name": "vitamin a palmitate", "pos": [ 225, 244 ] }
angiotensin in acid-ethanol extracts of kidney were adsorbed on to a cation-exchange resin , eluted and further purified with an immobilized angiotensin ii antiserum , before radioimmunoassay .
NA
{ "id": "C0003018", "name": "angiotensin", "pos": [ 0, 11 ] }
{ "id": "C0003009", "name": "angiotensin ii", "pos": [ 141, 155 ] }
a comparison between the release of fluoride from sodium fluoride lozenges and bone meal tablets .
NA
{ "id": "C0016327", "name": "fluoride", "pos": [ 36, 44 ] }
{ "id": "C0037508", "name": "sodium fluoride", "pos": [ 50, 65 ] }
the release of fluoride from a fluoride-containing bone meal tablet and a chewable sodium fluoride lozenge to 0.5 m perchloric acid , deionized water , and saliva was compared .
NA
{ "id": "C0016327", "name": "fluoride", "pos": [ 15, 23 ] }
{ "id": "C0037508", "name": "sodium fluoride", "pos": [ 83, 98 ] }
the release from the sodium fluoride lozenge ( 0.25 mg f ) was essentially complete in water and saliva as well as in acid .
NA
{ "id": "C0037508", "name": "sodium fluoride", "pos": [ 21, 36 ] }
{ "id": "C0016327", "name": "f", "pos": [ 55, 56 ] }
following sucking and chewing on a sodium fluoride lozenge , the mean salivary fluoride concentration increased from 0.04 to 36 parts/10 ( 6 ) 5 min after intake .
NA
{ "id": "C0037508", "name": "sodium fluoride", "pos": [ 35, 50 ] }
{ "id": "C0016327", "name": "fluoride", "pos": [ 79, 87 ] }
arylesterases from various mammalian sera in relation to cholinesterases , carboxylesterases and their activity towards some pesticides .
NA
{ "id": "C0008429", "name": "cholinesterases", "pos": [ 57, 72 ] }
{ "id": "C0007067", "name": "carboxylesterases", "pos": [ 75, 92 ] }
the findings are discussed in relation to recent studies of continuous recognition memory after head injury and hypotheses concerning neurological dysfunction in head injury .
NA
{ "id": "C0018674", "name": "head injury", "pos": [ 96, 107 ] }
{ "id": "C0751792", "name": "neurological", "pos": [ 134, 146 ] }
sisomicin and gentamicin were tested in vitro against 222 clinical isolates of pathogenic bacteria using the ics agar dilution procedure .
NA
{ "id": "C0037209", "name": "sisomicin", "pos": [ 0, 9 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 14, 24 ] }
ampicillin ( semicillin ) and amoxycillin ( amoxil ) have a strong leptospirocidal effect in vitro and also in vivo .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 0, 10 ] }
{ "id": "C0002645", "name": "amoxycillin", "pos": [ 30, 41 ] }
the patients generally received per os 3 g ampicillin ( semicillin ) or 2 g amoxycillin ( amoxil ) per day over a period of 6 days .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 43, 53 ] }
{ "id": "C0002645", "name": "amoxil", "pos": [ 90, 96 ] }
in the groups treated with ampicillin and amoxycillin the average durations of fever during the treatment were 1.6 and 1.2 days , respectively .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 27, 37 ] }
{ "id": "C0002645", "name": "amoxycillin", "pos": [ 42, 53 ] }
in the first group ( ampicillin ) a 'second wave of fever ' occurred in one case ( 5 % ) and in the second group ( amoxycillin ) , in 0 % ( as compared to 22 % after treatment with benzylpenicillin ) .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 21, 31 ] }
{ "id": "C0002645", "name": "amoxycillin", "pos": [ 115, 126 ] }
in the first group ( ampicillin ) a 'second wave of fever ' occurred in one case ( 5 % ) and in the second group ( amoxycillin ) , in 0 % ( as compared to 22 % after treatment with benzylpenicillin ) .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 21, 31 ] }
{ "id": "C0030827", "name": "benzylpenicillin", "pos": [ 181, 197 ] }
on the basis of our experiences , ampicillin and amoxycillin are strongly recommended for the treatment of human leptospira infections .
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 34, 44 ] }
{ "id": "C0002645", "name": "amoxycillin", "pos": [ 49, 60 ] }
a characteristic pattern of dna digestion products is obtained , containing approximately integral multiples of a basic 140 base pair dna segment that resembles very closely the pattern in g2 phase nuclei of physarum and of calf lymphocyte nuclei .
NA
{ "id": "C0000702", "name": "a", "pos": [ 0, 1 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 134, 137 ] }
rna was extracted from isolated salivary glands , enriched for messenger rna by poly u sepharose chromatography , and labelled with 125iodine .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 0, 3 ] }
{ "id": "C0035696", "name": "messenger rna", "pos": [ 63, 76 ] }
in situ hybridization showed that , apart from rrna , balbiani ring 1 and 2 transcripts are the major hybridizing rna species present in this enriched preparation .
NA
{ "id": "C0035701", "name": "rrna", "pos": [ 47, 51 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 114, 117 ] }
saturation hybridization levels of rrna and balbiani ring ( br1 plus br2 ) rna with polytene dna from salivary glands were determined and compared with the saturation levels measured for dna from adult flies and larvae .
NA
{ "id": "C0035701", "name": "rrna", "pos": [ 35, 39 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 75, 78 ] }
the results suggest that monitering urinary dopamine and 3-methoxytyramine excretion in tourette 's disease may predict the clinical response to pharmacotherapy , and that a dopaminergic mechanism may be associated with this type of motor hyperkinesia .
NA
{ "id": "C0013030", "name": "dopamine", "pos": [ 44, 52 ] }
{ "id": "C0282151", "name": "dopaminergic", "pos": [ 174, 186 ] }
[ effect of different volume rates of artificial blood circulation on hemodynamics in animals resuscitated after death from asphyxiation ] .
NA
{ "id": "C0011065", "name": "death", "pos": [ 113, 118 ] }
{ "id": "C0004044", "name": "asphyxiation", "pos": [ 124, 136 ] }
fecal excretion was the major route of tracer elimination in the rat ( 70 % ) and dog ( 80 % ) , whereas the monkey , baboon , and man excreted the majority of the dose via the urine ( 40-80 % ) .
NA
{ "id": "C1373190", "name": "fecal", "pos": [ 0, 5 ] }
{ "id": "C1373186", "name": "route of", "pos": [ 30, 38 ] }
in a comparison of the antibacterial in-vitro activity of sisomicin , gentamicin , and tobramycine , sisomicin showed a higher activity against e. coli , indole-positive proteus spp . and organisms of the klebsiella-enterobacter-serratia group , whereas tobramycine was superior against pseudomonas spp .
NA
{ "id": "C0017436", "name": "gentamicin", "pos": [ 70, 80 ] }
{ "id": "C0037209", "name": "sisomicin", "pos": [ 101, 110 ] }
however , the differences in activity between sisomicin and gentamicin were only within one step of dilution which is hardly sufficient to guarantee a basic superiority of one or the other preparation for clinical purposes .
NA
{ "id": "C0037209", "name": "sisomicin", "pos": [ 46, 55 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 60, 70 ] }
with corresponding serum levels , almost identical elimination half-lives of 109 and 111 minutes , and recovery values of 84 and 88.4 % , respectively , there were no significant differences in the pharmacokinetics of sisomicin and gentamicin .
NA
{ "id": "C0037209", "name": "sisomicin", "pos": [ 218, 227 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 232, 242 ] }
thus in the antibacterial treatment of gentamicin-sensitive gram-negative organisms sisomicin presents an equally good alternative .
NA
{ "id": "C0017436", "name": "gentamicin", "pos": [ 39, 49 ] }
{ "id": "C0037209", "name": "sisomicin", "pos": [ 84, 93 ] }
with organisms only moderately sensitive or resistant to gentamicin , sisomicin , tobramycine and amikacin should be additionally tested .
NA
{ "id": "C0017436", "name": "gentamicin", "pos": [ 57, 67 ] }
{ "id": "C0037209", "name": "sisomicin", "pos": [ 70, 79 ] }
the effect of beta-sitosterol on the lipid and lipoprotein level was evaluated in a randomised double-blind cross-over trial in 24 patients with primary familial type ii hyperlipoproteinaemia over a period of 16 weeks .
NA
{ "id": "C0023779", "name": "lipid", "pos": [ 37, 42 ] }
{ "id": "C0023820", "name": "lipoprotein", "pos": [ 175, 186 ] }
a cure was achieved after long-term administration of penicillin g in high doses , at first combined with ampicillin .
NA
{ "id": "C0030827", "name": "penicillin g", "pos": [ 54, 66 ] }
{ "id": "C0002680", "name": "ampicillin", "pos": [ 106, 116 ] }
when individual hcg subunits were treated with the same reagent , the number of tyrosyls acetylated in each subunit again increased with increasing amounts of reagent , up to three in the alpha subunit and two in the beta subunit in the absence of urea .
NA
{ "id": "C0018062", "name": "hcg", "pos": [ 16, 19 ] }
{ "id": "C0017963", "name": "alpha subunit", "pos": [ 188, 201 ] }
injection of frogs with beta-adrenergic catecholamines produced a selective desensitization ( loss of responsiveness ) of the erythrocyte membrane adenylate cylase to subsequent stimulation in vitro by isoproterenol .
NA
{ "id": "C0007412", "name": "catecholamines", "pos": [ 40, 54 ] }
{ "id": "C0022245", "name": "isoproterenol", "pos": [ 202, 215 ] }
effects of excess iodide and other anions on thyroid hormone secretion in normal or hypophysectomized rats treated with graded doses of thyroid hormone .
NA
{ "id": "C0021966", "name": "iodide", "pos": [ 18, 24 ] }
{ "id": "C0003075", "name": "anions", "pos": [ 35, 41 ] }
the stimulatory action on thyroid hormone secretion was specific for iodide and was not shared by other anions .
NA
{ "id": "C0021966", "name": "iodide", "pos": [ 69, 75 ] }
{ "id": "C0003075", "name": "anions", "pos": [ 104, 110 ] }
abp activity was also increased by intratesticular injection of an analog of cyclic amp , 8-bromo camp .
NA
{ "id": "C0001455", "name": "cyclic amp", "pos": [ 77, 87 ] }
{ "id": "C0000661", "name": "8-bromo camp", "pos": [ 90, 102 ] }
glu and gln were predominant amino acids in the caput , and their amounts occupied more than half of the total ninhydrin reactive compounds .
NA
{ "id": "C0061472", "name": "glu", "pos": [ 0, 3 ] }
{ "id": "C0017797", "name": "gln", "pos": [ 8, 11 ] }
such a high concentration of glu and gln was not observed either in the cauda or in the testis .
NA
{ "id": "C0061472", "name": "glu", "pos": [ 29, 32 ] }
{ "id": "C0017797", "name": "gln", "pos": [ 37, 40 ] }
testosterone treatment to castrated animals did not restore glu and gln contents in the pressed fluid from the caput epididymis to the level observed in intact rats completely .
NA
{ "id": "C0061472", "name": "glu", "pos": [ 60, 63 ] }
{ "id": "C0017797", "name": "gln", "pos": [ 68, 71 ] }
fluctuations of ovarian biosynthetic activity and effects of exogenous lh and fsh on it during the estrous cycle were investigated by measuring in vitro transfer rates of 14c from 14c-1-acetate into progesterone ( p ) , 20 alpha-hydroxy-pregn-4-en-3-one ( 20 alpha-oh-p ) and estrogen ( estradiol and estrone , e ) in the ovarian homogenates from rats autopsied at 2 hour intervals .
NA
{ "id": "C0033308", "name": "progesterone", "pos": [ 199, 211 ] }
{ "id": "C0012311", "name": "20", "pos": [ 256, 258 ] }
the time course of the release of labelled dna into the fraction of dna soluble in 0.14 m nac1 indicates that a fraction of labelled dna was rapidly removed from the spleen after injection of cortisol .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 43, 46 ] }
{ "id": "C0000702", "name": "a", "pos": [ 173, 174 ] }
the similarity to the kidney enzyme was confirmed by the use of polymerization in phosphate borate of the isozyme from a mammary carcinoma to effect its purification .
NA
{ "id": "C0014442", "name": "enzyme", "pos": [ 29, 35 ] }
{ "id": "C0022173", "name": "isozyme", "pos": [ 106, 113 ] }
the pheromones usually depend on the sexual hormones ( pheromones of sexual attraction which promote or inhibit aggression , etc . )
NA
{ "id": "C0031516", "name": "pheromones", "pos": [ 4, 14 ] }
{ "id": "C0036863", "name": "pheromones", "pos": [ 55, 65 ] }
in the past widespread use was made of cheap synthetic estrogens such as diethylstilbestrol and hexestrol .
NA
{ "id": "C0012203", "name": "diethylstilbestrol", "pos": [ 73, 91 ] }
{ "id": "C0019467", "name": "hexestrol", "pos": [ 96, 105 ] }
chromatographic behaviour of various metal cations in fused salts on gamma-alumina and synthetic inorganic ion exhange materials .
NA
{ "id": "C0007447", "name": "cations", "pos": [ 43, 50 ] }
{ "id": "C0022023", "name": "ion", "pos": [ 107, 110 ] }
[ comparative studies on the histotopochemical properties of tetrazolium salts mmt , nitro-bt and tnbt in enzyme histochemistry ] .
NA
{ "id": "C0039704", "name": "tetrazolium salts", "pos": [ 61, 78 ] }
{ "id": "C0028147", "name": "nitro-bt", "pos": [ 85, 93 ] }
separation of lipids from whole leaves and from their chlorophyll lipoprotein of sapium sebiferum roxb .
NA
{ "id": "C0023779", "name": "lipids", "pos": [ 14, 20 ] }
{ "id": "C0023820", "name": "lipoprotein", "pos": [ 66, 77 ] }
it is devoid of lipid and separate from the streptolysin o inhibitory lipoprotein that is also induced by administration of the streptococcal toxin .
NA
{ "id": "C0023779", "name": "lipid", "pos": [ 16, 21 ] }
{ "id": "C0023820", "name": "lipoprotein", "pos": [ 70, 81 ] }
the factor , moreover , appears clearly distinct from haptoglobin or c-reactive protein and seems to be a unique type of acute phase protein .
NA
{ "id": "C0018595", "name": "haptoglobin", "pos": [ 54, 65 ] }
{ "id": "C0001347", "name": "acute phase protein", "pos": [ 121, 140 ] }
the factor , moreover , appears clearly distinct from haptoglobin or c-reactive protein and seems to be a unique type of acute phase protein .
NA
{ "id": "C0006560", "name": "c-reactive protein", "pos": [ 69, 87 ] }
{ "id": "C0001347", "name": "acute phase protein", "pos": [ 121, 140 ] }
[ biosynthesis in vitro of vitamin b12 and other cobalamins by bacterial strains isolated from the digestive tract of the rat ] .
NA
{ "id": "C0042845", "name": "vitamin b12", "pos": [ 27, 38 ] }
{ "id": "C0086024", "name": "cobalamins", "pos": [ 49, 59 ] }
effects of added electrolytes on the aggregation rates of latex particles in aqueous ionic surfactant solutions .
NA
{ "id": "C0013832", "name": "electrolytes", "pos": [ 17, 29 ] }
{ "id": "C0022023", "name": "ionic", "pos": [ 85, 90 ] }
[ sensitivity of 207 staphylococcus aureus strains to penicillin g , penicillin v , methicillin , cloxacillin and oxacillin ] .
NA
{ "id": "C0009077", "name": "cloxacillin", "pos": [ 98, 109 ] }
{ "id": "C0029983", "name": "oxacillin", "pos": [ 114, 123 ] }
[ glycoproteins and mucoproteins in bone marrow blood and peripheral venous blood in diverse disease conditions ] .
NA
{ "id": "C0017968", "name": "glycoproteins", "pos": [ 2, 15 ] }
{ "id": "C0026714", "name": "mucoproteins", "pos": [ 20, 32 ] }
[ determination by thin layer chromatography of some phospho-organic insecticides : parathion , methylparathion , diazinon , malation , gusation , metasystoks and dipterex ] .
NA
{ "id": "C0030514", "name": "parathion", "pos": [ 84, 93 ] }
{ "id": "C0025709", "name": "methylparathion", "pos": [ 96, 111 ] }
[ study of displacement reactions between polyribonucleotides by use of ethidium hydrobromate ( etb ) . demonstration of displacement of the poly ( a-2 i ) by poly u ] .
NA
{ "id": "C0032590", "name": "polyribonucleotides", "pos": [ 42, 61 ] }
{ "id": "C0032413", "name": "poly", "pos": [ 159, 163 ] }
[ study of displacement reactions between polyribonucleotides by use of ethidium hydrobromate ( etb ) . demonstration of displacement of the poly ( a-2 i ) by poly u ] .
NA
{ "id": "C0032590", "name": "polyribonucleotides", "pos": [ 42, 61 ] }
{ "id": "C0032417", "name": "poly", "pos": [ 159, 163 ] }
interrelation between human chorionic gonadotrophin inhibitory activity in plasma and urine and the rate of urinary gonadotrophin excretion .
NA
{ "id": "C0018062", "name": "human chorionic gonadotrophin", "pos": [ 22, 51 ] }
{ "id": "C0018061", "name": "gonadotrophin", "pos": [ 116, 129 ] }
the radioactive material in urine after parenteral radioactive hydroxocobalamin is composed of radioactive cyanocobalamin , radioactive hydroxocobalamin , and a radioactive anionic complex .
NA
{ "id": "C0042845", "name": "cyanocobalamin", "pos": [ 107, 121 ] }
{ "id": "C0020316", "name": "hydroxocobalamin", "pos": [ 136, 152 ] }
comparison of the amounts of radioactive and microbiologically active material in urine after parenteral radioactive hydroxocobalamin show a significant correlation both in the first and second 24 hours after injection showing that the amount of radioactivity is an acceptable measure of the loss of cobalamin in urine .
NA
{ "id": "C0020316", "name": "hydroxocobalamin", "pos": [ 117, 133 ] }
{ "id": "C0042845", "name": "cobalamin", "pos": [ 300, 309 ] }