text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
two other minor pathways of ds metabolism , that is , loss to the fetus and excretion as unaltered ds into urine , accounted for less than 1 per cent of total metabolism in each instance . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
76,
85
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
159,
169
]
} |
the final pathway of ds metabolism was excretion as neutral steroids such as urinary 17-ketosteroids and other undefined losses . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
24,
34
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
39,
48
]
} |
significant increases in certain factors of the blood coagulation and fibrinolysin systems ( factors i , ii , vii , viii , ix , and x and plasminogen ) were observed in the treated groups . | NA | {
"id": "C0005789",
"name": "factors",
"pos": [
33,
40
]
} | {
"id": "C0033706",
"name": "factors",
"pos": [
93,
100
]
} |
significant increases in certain factors of the blood coagulation and fibrinolysin systems ( factors i , ii , vii , viii , ix , and x and plasminogen ) were observed in the treated groups . | NA | {
"id": "C0005789",
"name": "factors",
"pos": [
33,
40
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
123,
125
]
} |
thus , capillary hemangioma of the retina is a more correct histopathologic designation for the von hippel angioma than terms such as hemangioblastoma or hemangioendothelioma . | NA | {
"id": "C0018916",
"name": "angioma",
"pos": [
20,
27
]
} | {
"id": "C0018915",
"name": "hemangioendothelioma",
"pos": [
154,
174
]
} |
the specificity of each antiserum was verified by immunodiffusion , immunoelectrophoresis , and blocking experiments utilizing unlabeled antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
24,
33
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
137,
145
]
} |
intravenous sincalide circumvents the problem of unpredictability of response of the gallbladder to a fatty meal and variability in the rate of release of endogenous cholecystokinin . | NA | {
"id": "C0037167",
"name": "sincalide",
"pos": [
12,
21
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
166,
181
]
} |
[ comparative elevation of blood lactic acid levels in the conscious rabbit during perfusion with adrenaline and noradrenaline ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
98,
108
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
113,
126
]
} |
the effects of the analgesics sulfentanil ( r 30730 ) and fentanyl , on autonimic stability , cardiovascular stability , respiratory depression and post-operative behaviour were compared in a standardised anaesthetic technique . | NA | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
30,
41
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
58,
66
]
} |
the analgesic potency of sulfentanil proved to be 12 times that of fentanyl while ( in contrast to fentanyl ) , the duration of the respiratory depression after sulfentanil did not differ significantly from the duration of optimal analgesia . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
67,
75
]
} | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
161,
172
]
} |
a new method for the evaluation of reaction kinetics of immobilized enzymes investigated in single enzyme -- sepharose beads by microfluorometry . | NA | {
"id": "C0014444",
"name": "immobilized enzymes",
"pos": [
56,
75
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
99,
105
]
} |
abdominal distension , hepatomegaly , splenomegaly , cutaneous manifestations and purpura were the most frequent clinical findings in our patients . | NA | {
"id": "C0037285",
"name": "cutaneous manifestations",
"pos": [
53,
77
]
} | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
113,
130
]
} |
statistically significant ( p less than 0.005 ) increases in total length of hospitalization , length of hospitalization before infection , presence and duration of indwelling foley catheterization , prior exposure to antibiotics , and the prevalence of paraplegia were present in p. rettgeri urinary tract infections as compared with a control group . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
128,
137
]
} | {
"id": "C0042029",
"name": "urinary tract",
"pos": [
293,
306
]
} |
a new nucleotidyltransferase has been obtained from clinical isolates of kanamycin , amikacin , tobramycin , neomycin and lividomycin resistant strains of staphylococcus aureus . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
73,
82
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
85,
93
]
} |
the remaining 34 cases constitute a miscellaneous group which includes foreign bodies , bilateral neck dissection , infection , congenital lesions , trauma , and idiopathic paralyses . | NA | {
"id": "C0016542",
"name": "foreign bodies",
"pos": [
71,
85
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
149,
155
]
} |
it was found that , in general , where two or more separate gene loci are concerned in determining sets of isozymes with the same or very similar enzyme characteristics , there is a close correlation in subunit size and in most , though not all , cases the subunit numbers are the same . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
107,
115
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
146,
152
]
} |
spontaneous conversion of precursor cells into cells producing antibodies against sheep erythrocytes in cultures of mouse peritoneal cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
26,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
in order to determine whether the anaphylactic reaction produced by one class of antibody is modified by the simultaneous presence of the other class of antibody , sites were prepared in normal rats with ige antibody and 24 hours later igga antibody was injected into the same sites . | NA | {
"id": "C0021017",
"name": "class",
"pos": [
72,
77
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
241,
249
]
} |
penetration of chlolincocin and lincomycin from the lungs into the blood was better in healthy animals . | NA | {
"id": "C0008947",
"name": "chlolincocin",
"pos": [
15,
27
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
32,
42
]
} |
when chlolincocin and lincomycin were administered intravenously , their concentrations in the lung tissue were lower and detected for a shorter period of time than after the inhalation administration . | NA | {
"id": "C0008947",
"name": "chlolincocin",
"pos": [
5,
17
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
22,
32
]
} |
inhalation administration of chlolincocin aerosol is supposed to be expedient for the treatment of inflammatory diseases of the respiratory organs caused by lincomycin sensitive flora . | NA | {
"id": "C0008947",
"name": "chlolincocin",
"pos": [
29,
41
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
157,
167
]
} |
maximum potentiation of mics was observed when smx and tmp were combined in ratios close to those of the ratios of their mics , that is , smx/tmp 20:1 for large inocula and the reverse for small inocula for determinations on dst and usually 20:1 for all inoculum sizes on mh . | NA | {
"id": "C0038689",
"name": "smx",
"pos": [
47,
50
]
} | {
"id": "C0041044",
"name": "smx/tmp",
"pos": [
138,
145
]
} |
insoluble derivatives of neomycin , polymyxin b , streptomycin , ampicillin , penicillin g , and chloramphenicol were prepared by chelation with zirconium hydroxide , and these derivatives similarly reflected the antibacterial activities of the parent compounds . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
65,
75
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
78,
90
]
} |
the in vitro antibacterial activity of four beta-lactam antibiotics ( cefatrizine [ bl-s640 ] , cefamandole , cefoxitin , and carbenicillin ) and three aminoglycosides ( amikacin , gentamicin , and tobramycin ) was determined against 197 strains of cephalothin-resistant enterobacteriaceae . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
152,
167
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
181,
191
]
} |
to study the possibility that cephalosporins augment the nephrotoxicity of gentamicin , groups of rats were given four hourly subcutaneous doses of : gentamicin ( 5 mg/kg ) , gentamicin plus cephalothin ( 100 mg/kg ) , gentamicin plus cefazolin ( 20 mg/kg ) , gentamicin plus cefazolin ( 50 mg/kg ) , gentamicin plus cephaloridine ( 50 mg/kg ) , or saline diluent for 15 days . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
30,
44
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
317,
330
]
} |
bovine factor xa and bovine trypsin : a comparison with respect to inhibition by some amidines and guanidines . | NA | {
"id": "C0002483",
"name": "amidines",
"pos": [
86,
94
]
} | {
"id": "C0018320",
"name": "guanidines",
"pos": [
99,
109
]
} |
guinea pigs were sensitized to neomycin ( a , b , or c ) , paromomycin , gentamicin , kanamycin , streptomycin , and dihydrostreptomycin via intradermal or foot-pad injection with an adjuvant containing killed mycobacterium butyricum or m tuberculosis h37ra ( ra ) . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
31,
39
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
59,
70
]
} |
after repeated intradermal injections ( adjuvant ra ) of neomycin , guinea pigs showed cross-sensitization to paromomycin , kanamycin , and streptomycin . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
57,
65
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
110,
121
]
} |
eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride ( nitrogen mustard ) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization . | NA | {
"id": "C0600266",
"name": "mechlorethamine hydrochloride",
"pos": [
67,
96
]
} | {
"id": "C0025033",
"name": "nitrogen mustard",
"pos": [
99,
115
]
} |
the absence of bilirubinaemia and jaundice in a high proportion of the patients was attributed to the ability of the liver to conjugate large amounts of bilirubin . | NA | {
"id": "C0020433",
"name": "bilirubinaemia",
"pos": [
15,
29
]
} | {
"id": "C0022346",
"name": "jaundice",
"pos": [
34,
42
]
} |
the extreme bilirubinaemia and jaundice observed in a minority of cases was attributed to the existence of an additional hereditary factor affecting the liver . | NA | {
"id": "C0020433",
"name": "bilirubinaemia",
"pos": [
12,
26
]
} | {
"id": "C0022346",
"name": "jaundice",
"pos": [
31,
39
]
} |
hydrocortisone and hydrocortisone acetate exerted a significant inhibitory action only in the case of g-6-pdh-activity. -- on pure g-6-pdh from yeast , the inhibition exerted by hydrocortisone butyrate was significantly stronger than the inhibition exerted by the two other steroids . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
0,
14
]
} | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
19,
41
]
} |
hydrocortisone and hydrocortisone acetate exerted a significant inhibitory action only in the case of g-6-pdh-activity. -- on pure g-6-pdh from yeast , the inhibition exerted by hydrocortisone butyrate was significantly stronger than the inhibition exerted by the two other steroids . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
0,
14
]
} | {
"id": "C0352536",
"name": "hydrocortisone butyrate",
"pos": [
178,
201
]
} |
the responses of rabbit aortic strips superfused with noradrenaline , adrenaline and 5-ht were studied alone and in combination with ketamine ( 50 mug/ml ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
54,
67
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
ketamine caused a slight depression of the isolated aorta but potentiated responses to adrenaline but not to noradrenaline or 5-hydroxytryptamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
87,
97
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
109,
122
]
} |
results obtained with aortas contracted by adrenaline and noradrenaline with ketamine present , followed by oil immersion , showed that ketamine prolonged greatly the relaxation induced by adrenaline and to a lesser extent the relaxation induced by noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
249,
262
]
} |
the association of aortic incompetence and ventricualr septal defect is rare , but justifies the regular supervision of all patients with vsd . | NA | {
"id": "C0018816",
"name": "septal defect",
"pos": [
55,
68
]
} | {
"id": "C0018818",
"name": "vsd",
"pos": [
138,
141
]
} |
during mak-chromatography the high-molecular-weight fractions were eluted together with the nucleic acids ( trna and dna ) while most of the low-molecular-weight fractions left the column immediately on elution . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
92,
105
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
117,
120
]
} |
incorporation of u-14c-proteinhydrolyzate into membrane proteins showed that proteins are mainly formed which are specific for photosynthetic membranes . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
47,
64
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
77,
85
]
} |
[ on the essential oil of green algae . ii . the oils of the genera ankistrodesmus and scendesmus ] . | NA | {
"id": "C0028910",
"name": "essential oil",
"pos": [
9,
22
]
} | {
"id": "C0028908",
"name": "oils",
"pos": [
49,
53
]
} |
immune complexes of this antigen and its antibody have been implicated in the pathogenesis of the renal disease . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
41,
49
]
} |
the study demonstrates that the nephritis was mediated by immune complexes of hbsag and its antibody , and the presence of immunoglobulin on the kidney did not represent trapping from the circulation . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
58,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} |
headache pain decreased with training ( within the boundaries of a placebo effect ) , and there was no difference in headache decrease between feedback and pseudofeedback patients . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
0,
8
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
9,
13
]
} |
penetrating abdominal stab wounds and gunshot wounds must be considered separately , and mandatory routine abdominal exploration for all penetrating gunshot wounds is advised . | NA | {
"id": "C0043252",
"name": "gunshot wounds",
"pos": [
38,
52
]
} | {
"id": "C0043254",
"name": "penetrating",
"pos": [
137,
148
]
} |
colitis has been reported after parenteral administration of penicillin , ampicillin , streptomycin , tetracycline , and , most recently , lincomycin and its analogue , clindamycin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
139,
149
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
169,
180
]
} |
this compound at 10 ( -5 ) molar concentration in the medium of human cell cultures appeared to inhibit dna , rna , and protein synthesis by 50 , 40 , and 30 % respectively , as measured by incorporation of radioactive precursors into acid-insoluble cell fractions in human diploid fibroblasts , human neuroblastoma cells , and mouse neuroblastoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
282,
293
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
348,
353
]
} |
the effect of a standardised exercise procedure on plasma growth hormone ( hgh ) and prolactin has been assessed in 10 normal human subjects . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
58,
72
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
75,
78
]
} |
the only significant glycosidase contaminant after affinity chromatography on the mannosylamine ligand was alpha-l-fucosidase , which was selectively removed by affinity chromatography on the corresponding fucosylamine ligand . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
21,
32
]
} | {
"id": "C0016787",
"name": "alpha-l-fucosidase",
"pos": [
107,
125
]
} |
they are also further evidence that mannosidosis is a lysosomal storage disease resulting from a deficiency of acidic alpha-mannosidase . | NA | {
"id": "C1257960",
"name": "mannosidosis",
"pos": [
36,
48
]
} | {
"id": "C0024748",
"name": "deficiency of",
"pos": [
97,
110
]
} |
this procedure was applied to myelin basic protein , a variety of protamines , histone iv , silk fibroin , rat skin collagen alpha1 chain and a sheep keratin . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
92,
96
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
97,
104
]
} |
maximum inhibition of phenylalanine hydroxylase activity in the liver ( 85 % ) and in the kidney ( 50 % ) of suckling rats required the administration of over 9 mumol of p-chlorophenylalanine/10g body weight . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
22,
35
]
} | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
170,
191
]
} |
in rats injected with p-chlorophenylalanine every 48h and with phenylalanine every 24h from 3 to 18 days of age , the hepatic and renal phenylalanine hydroxylase remained inhibited , whereas the activities of three other hepatic enzymes were unchanged . | NA | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
22,
43
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
136,
149
]
} |
injections of phenylalanine increased a 2.5-fold in 9 h the hepatic phenylalanine hydroxylase activity of 6-day-old or adult rats that had been pretreated ( 24h earlier ) with p-chlorophenylalanine ; | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
14,
27
]
} | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
176,
197
]
} |
the bulk of the mg2+-dependent adenosine triphosphatase ( mg-atpase ) was coincident with the main peak of phospholipid and sterol , at median density 1.10 , which was also rich in smooth-membrane vesicles . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
16,
19
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
61,
67
]
} |
from studies of ( a ) the yield of reactions ( 1 ) and ( 2 ) at variable [ haemoglobin ] and rates of production of o2- , ( b ) their suppression by superoxide dismutase , and ( c ) equilibria observed with mixtures of oxyhaemoglobin and methaemoglobin , it is shown that k1/k2=0.7 +/- 0.2 and k1 = ( 4 +/- 1 ) x 10 ( 3 ) m-1-s-1 at ph7 , and k1 and k2 decrease with increasing ph . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
75,
86
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
238,
252
]
} |
this preparation appears to be free of lipoproteins as determined by immunoelectrophoresis against anti-human serum and is minimally contaminated with albumin ( less than 30 mug/mg of enzyme protein ) as determined by immunodiffusion . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
151,
158
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
191,
198
]
} |
phosphodiesterase ii from extracts of intestinal mucosa of rat and guinea pig was purified by chromatography on deae-cellulose , cm-cellulose and agarose . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
112,
126
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
132,
141
]
} |
the enzyme gave the expected stoicheiometry with p-dimethylaminomethylbenzylamine as substrate ( keq . 2700 ) and also oxidized [ 8-arginine ] vasopressin , [ 8-lysine ] vasopressin , collagen and tropocollagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
184,
192
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
197,
210
]
} |
although the total free amino acid pool size increases by 45 % during incubation , owing to protein breakdown , the tissue concentrations of aspartate , glutamate , glutamine and alanine do not increase . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
24,
34
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
179,
186
]
} |
an injection of unpurified leucocytice endogenous mediator into rats results in an increased incorporation of [ 6 ( -14 ) c ] orotate into hepatic rna , an increase in the concentration of rna associated with the bound ribosomal fraction of liver , and increases in the concentrations in serum of acute-phase proteins such as alpha2-macrofoetoprotein and haptoglobin . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
297,
317
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
355,
366
]
} |
the ferrochelatase in these two bands had different ph optima , but appeared very similar in their porphyrin specificity and their inhibition by metalloporphyrins . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
99,
108
]
} | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
145,
162
]
} |
these effects resemble the effects of alkylguanidines on mitochondria and are discussed in relation to the effects of alkylguanidines and other lipophilic cations such as ethidium and dibenzyldimethylammonium ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
155,
162
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
209,
213
]
} |
the chemical syntheses of the 3-sulphates of 16 alpha-acetoxy- , 16 alpha-hydroxy- and 16 beta-hydroxy-dehydroepiandrosterone as their triethylammonium salts are described preparatory to studies of the metabolism of [ 7 alpha-3 h ] dehydroepiandrosterone sulphate by homogenates of human foetal liver . | NA | {
"id": "C0011185",
"name": "salts",
"pos": [
152,
157
]
} | {
"id": "C0057277",
"name": "dehydroepiandrosterone sulphate",
"pos": [
232,
263
]
} |
removal of ubiquinone by acetone treatment decreases the ability of mitochondrial preparations to generate o2- and h2o2 , whereas supplementation of the depleted membranes with ubiquinone enhances the peroxide-generating activity in the reconstituted membranes . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
115,
119
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
201,
209
]
} |
parallel measurements of h2o2 production , succinate dehydrogenase and succinate-cytochrome c reductase activities show that peroxide generation by ubiquinone-supplemented membranes is a monotonous function of the reducible ubiquinone content , whereas the other two measured activities reach saturation at relatively low concentrations of reducible quinone . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
25,
29
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
125,
133
]
} |
alkaline treatment of submitochondrial particles causes a significant decrease in succinate dehydrogenase activity and succinate-dependent h2o2 production , which contrasts with the increase of peroxide production by the same particles with nadh as electron donor . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
139,
143
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
194,
202
]
} |
the method measures the change in 2-3h content of protein with time by racemization of the protein hydrolysate with acetic anhydride . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
50,
57
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
91,
110
]
} |
antibodies of polyriboadenylic acid ( poly ra ) are demonstrated by filter radioimmunoassay in 75 % of patients with systemic lupus erythematosus ( sle ) , in 54 % of patients with discoid lupus erythematosus , and in only 0-7 % of normal controls and patients with rheumatoid arthritis or sjogren 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
266,
286
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
290,
309
]
} |
it was found in 67 % of patients with seropositive ra and in 62 % of patients with sjogren 's syndrome associated with ra . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
83,
102
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
119,
121
]
} |
but its frequency was lower in many other connective tissue diseases , including seronegative ra and sjogren 's syndrome without associated ra . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
101,
120
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
140,
142
]
} |
the occurrence and severity of pneumoconiosis were studied in 100 coal miners with rheumatoid arthritis ( ra ) and compared to findings in a geographically relevant survey of coal workers ' pneumoconiosis . | NA | {
"id": "C0032273",
"name": "pneumoconiosis",
"pos": [
31,
45
]
} | {
"id": "C0003165",
"name": "coal workers",
"pos": [
175,
187
]
} |
these changes in electrolyte transport are caused by an inhibition of na+-entry by triamterene as suggested by measurements of ion permeability of the cell membrane . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
17,
28
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
127,
130
]
} |
chronic oral treatment of male diabetic chinese hamsters with 100 mg/kg/day 5-methoxyindole-2-carboxylic acid ( mica ) causes a depression of blood glucose in fasted animals and an improvement in the glucose profile in fed animals . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
142,
155
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
200,
207
]
} |
the sum of specifically measured metabolites ( oxyphenbutazone , gamma-hydroxyphenylbutazone , p , gamma-dihydroxyphenylbutazone ) and phenylbutazone in urine did not cover more than about 10 % . | NA | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
47,
62
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
135,
149
]
} |
lipoprotein density classes were characterized by analytical ultracentrifugation , agarose electrophoresis , immunodiffusion and immunoelectrophoresis , and by quantitative determination of protein , lipids and individual phosphatides . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
200,
206
]
} |
( 5 ) immunological and electrophoretic studies showed that all three major density classes consisted of two lipoprotein families designated , in analogy to the human serum lipoprotein system [ 1 ] , as lp-a and lp-b . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
109,
120
]
} | {
"id": "C0065058",
"name": "lp-a",
"pos": [
203,
207
]
} |
isolation and characterization of lipoprotein a and lipoprotein b , two major lipoprotein families of the male turkey serum lipoprotein system . | NA | {
"id": "C0065058",
"name": "lipoprotein a",
"pos": [
34,
47
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
124,
135
]
} |
( 1 ) male turkey serum contains two major lipoprotein families designated as lp-a and lp-b in its lipoprotein density classes . | NA | {
"id": "C0065058",
"name": "lp-a",
"pos": [
78,
82
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
99,
110
]
} |
( 4 ) isolation of lp-a and lp-b from the major lipoprotein density classes provided further experimental evidence to confirm the existence of chemically distinct lipoprotein families as the fundamental physical-chemical entities of the serum lipoprotein system . | NA | {
"id": "C0065058",
"name": "lp-a",
"pos": [
19,
23
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
243,
254
]
} |
the lipid compositions of cultured rabbit aortic smooth muscle cells , adventitial fibroblasts and skin fibroblasts were determined for cells grown in media containing either normolipemic or hyperlipemic serum . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
136,
141
]
} |
the content of dermatan sulphate , chondroitin-4 , 6-sulphate and hydroxyproline was lowest during sheeding and highest outside the sheeding period . | NA | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
15,
32
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
35,
46
]
} |
the decrease in the concentration of hyaluronic acid simultaneously with an increase in the aortic content of collagen as well as of chondroitin-4 , 6-sulphate and dermatan sulphate may imply a greater stiffness of the aorta resulting in a higher susceptibility to injury . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
133,
144
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
164,
172
]
} |
oral administration of the benzodiazepines ( diazepam , lorazepam , chlordiazepoxide , bipotassium chlorazepate ) in triton wr-1339-induced ( 200 mg/kg , blood collection 18 h later ) hyperlipidaemia in rats elicited marked decrease of serum total lipids , total cholesterol and triglyceride levels , and alterations in free fatty acid and free glycerol content . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
27,
42
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
68,
84
]
} |
other benzodiazepines , namely oxazepam , medazepam and nitrazepam , elicited only minor changes in serum lipids levels , while with grandaxin no change was observed . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
6,
21
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
42,
51
]
} |
we obtained highly significant stimulation with ppd , tryptophane peptide of myelin , and tumour basic protein using mantoux + cancer patients , but found no response to other basic proteins . | NA | {
"id": "C0027642",
"name": "tumour",
"pos": [
90,
96
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
182,
190
]
} |
those patients with the combination of calcinosis , raynaud 's phenomenon , sclerodactyly and telangiectasia have the same degree of systemic involvement and the same prognosis as other patients with systemic sclerosis , and the term 'crst syndrome ' should be abandoned . | NA | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
39,
49
]
} | {
"id": "C0206138",
"name": "crst",
"pos": [
235,
239
]
} |
insignificant variation was noted in the mean levels of the complement components ciq , c4 , c2 , c3 , c5 and c3pa between various groups of sera from patients with urticaria , angio-oedema , dermatitis herpetiformis , alopecia areata , or hay fever . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
165,
174
]
} | {
"id": "C0002994",
"name": "angio-oedema",
"pos": [
177,
189
]
} |
these results suggest that collagen-induced release of platelet constituents is in part due to a direct effect on the platelet , and , in part , to an indirect effect involving coagulation factors and mediated by thrombin . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
177,
196
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
213,
221
]
} |
all the red cells from persons with sickle cell trait and sickle cell anaemia are labelled with the anti-hb s-fitc , while red cells from persons with normal haemoglobin or other mutant haemoglobin genotypes are not . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
36,
53
]
} | {
"id": "C0002895",
"name": "sickle cell anaemia",
"pos": [
58,
77
]
} |
the activities of glucose-6-phosphate dehydrogenase ( d-glucose-6-phosphate : nadp oxidoreductase , g6pd ) , 6 phosphate glucono dehydrogenase ( 6 phospho-d-gluconate : nadp oxidoreductase , 6pgd ) lactate dehydrogenase ( d-lactate : nad oxidoreductase , ldh ) , glutamate oxaloacetate transaminase ( l-aspartate : 2-oxo-glutarate aminotransferase , got ) and hexokinase ( atp : d-hexo-6-phosphotrans-ferase , hx ) were measured over 24 h in isolated lymphocytes of normal subjects and in white cells of patients with chronic lymphatic leukaemia ( cll ) . | NA | {
"id": "C0004002",
"name": "glutamate oxaloacetate transaminase",
"pos": [
263,
298
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
331,
347
]
} |
thiamin and erythrocyte transketolase ( ec 2.2.1.1 ) activity , riboflavin , nicotinic acid , pantothenic acid , total and pyridoxal fraction of vitamin b6 , folate and total vitamin b12 were estimated in the blood and the cerebrospinal fluid ( csf ) of these patients , and also in the blood of sixty-nine control subjects and in the csf of some of them . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
123,
132
]
} | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
145,
155
]
} |
the administration of pyridoxine resulted in a significant increase in the blood levels of riboflavin and the pyridoxal fraction of vitamin b6 . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
110,
119
]
} | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
132,
142
]
} |
with the exceptions of lysine , threonine , cystine and tyrosine , the concentrations of all other essential amino acids were reduced more in liver than in muscle . | NA | {
"id": "C0040005",
"name": "threonine",
"pos": [
32,
41
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
99,
120
]
} |
the site of histidine substitution by the 8alpha-methylene of the flavin moiety was shown by methylation of the imidazole ring with methyl iodide , cleavage of the methylhistidine-flavin bond by acid hydrolysis at 150 degrees c , and identification of the methylhistidine isomer by electrophoresis . | NA | {
"id": "C0019602",
"name": "histidine",
"pos": [
12,
21
]
} | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
256,
271
]
} |
we conclude that the dna binding of the estrogen receptor can not be simply interpreted in terms of electrostatic interactions but requires a particular double-helical structure of dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
21,
24
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
183,
184
]
} |
an additional lipoprotein referred to as ldl-ii appeared to be equivalent to the human lp ( a ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
14,
25
]
} | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
87,
93
]
} |
since ribosomal rna does not turn over in exponentially growing tissue , its rate of synthesis was measured ( 14 mg g-1h-1 ) and compared with the rate of accumulation of rna ( 12 mg g-1h-1 ) . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
6,
19
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
171,
174
]
} |
the similarity between ribosomal rna synthesis and total rna accumulation confirmed the assumption that these methods measured an absolute rate of rna synthesis . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
23,
36
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
147,
150
]
} |
polypeptide segments , composed of alpha helixes with specific surface topography termed amphipathic helixes , have been proposed as the basic lipid-associating domains of apolipoproteins from the plasma lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
143,
148
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
204,
216
]
} |
the acyl group composition of the phospholipids from normal chick embryo fibroblasts and from cells transformed by rous sarcoma virus was determined by gas-liquid chromatography . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
73,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
94,
99
]
} |
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