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both animals disposed of free or food-derived amino acids more rapidly than could be accounted for by catabolism alone , but the transient increases in turtle plasma concentrations consisted mostly of essential amino acids , whereas the alligator plasma showed little increase in essential amino acids and considerable rises in four nonessential amino acids , glutamine , glutamic acid , glycine and alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
46,
57
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
400,
407
]
} |
both animals disposed of free or food-derived amino acids more rapidly than could be accounted for by catabolism alone , but the transient increases in turtle plasma concentrations consisted mostly of essential amino acids , whereas the alligator plasma showed little increase in essential amino acids and considerable rises in four nonessential amino acids , glutamine , glutamic acid , glycine and alanine . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
360,
369
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
372,
385
]
} |
safflower oil , a highly unsaturated fat , added to a diet with cholesterol resulted in at least as high an incidence of cholesterol gallstones as butter added to the same diet . | NA | {
"id": "C0036048",
"name": "safflower oil",
"pos": [
0,
13
]
} | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
25,
40
]
} |
gallbladder biles from monkeys fed semipurified diets with cholesterol had a significantly higher lithogenic index than the comparable groups without cholesterol . | NA | {
"id": "C0008395",
"name": "diets",
"pos": [
48,
53
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
150,
161
]
} |
when dietary lysine was increased , plasma concentrations of essential amino acids except methionine and lysine , half cystine and tyrosine tended to decrease . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
61,
82
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
90,
100
]
} |
[ freeze-drying of hemoglobin solutions : a research of compounds preventing the oxidation to ferrihemoglobin ( author 's transl ) ] . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
19,
29
]
} | {
"id": "C0025635",
"name": "ferrihemoglobin",
"pos": [
94,
109
]
} |
the rabbit stomach serosal strip , was found to contract to adrenaline and noradrenaline but not to isoprenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
60,
70
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
the responses to adrenaline and noradrenaline were markedly potentiated in the presence of monoamine oxidase inhibitors , guanethidine or reserpine , indicating the presence of mao activity in the tissue and possible catecholamine stores . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
17,
27
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
32,
45
]
} |
k+ was released by the slice system after addition of norepinephrine , epinephrine or phenylephrine , but not after addition of isoproterenol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
54,
68
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
71,
82
]
} |
some related drugs-oxyphenbutazone , d-naproxen , l-naproxen , ibuprofen , phenylbutazone and pirprofen-were also found to be effective inhibitors of 3h accumulation ( i50 for anterior uvea , 6-28 mum ) whereas aspirin , dexamethasone phosphate and penicillin had an inhibitory effect only at much higher concentrations ( i50 0.1-2.0 mm ) . | NA | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
19,
34
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
75,
89
]
} |
the related alkaline earth metals , barium , strontium , and magnesium , resembled calcium in inhibiting the response to sodium lack . | NA | {
"id": "C0025555",
"name": "alkaline earth metals",
"pos": [
12,
33
]
} | {
"id": "C0004749",
"name": "barium",
"pos": [
36,
42
]
} |
the related alkaline earth metals , barium , strontium , and magnesium , resembled calcium in inhibiting the response to sodium lack . | NA | {
"id": "C0025555",
"name": "alkaline earth metals",
"pos": [
12,
33
]
} | {
"id": "C0038467",
"name": "strontium",
"pos": [
45,
54
]
} |
the related alkaline earth metals , barium , strontium , and magnesium , resembled calcium in inhibiting the response to sodium lack . | NA | {
"id": "C0025555",
"name": "alkaline earth metals",
"pos": [
12,
33
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
61,
70
]
} |
the net effluxes of cl produced by noradrenaline ( 1-6 x 10 ( -5 ) m ) , isoprenaline ( 8 x 10 ( -7 ) m ) and adrenaline ( 6 and 15 x 10 ( -6 ) m ) were of similar magnitude for each catecholamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
35,
48
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
110,
120
]
} |
the net effluxes of cl produced by noradrenaline ( 1-6 x 10 ( -5 ) m ) , isoprenaline ( 8 x 10 ( -7 ) m ) and adrenaline ( 6 and 15 x 10 ( -6 ) m ) were of similar magnitude for each catecholamine . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
73,
85
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
183,
196
]
} |
it is concluded that the presynaptic actions of pentobarbitone and phenobarbitone contribute significantly to barbiturate-induced changes in synaptic efficacy at low levels of transmitter release in the frog neuromuscular junction . | NA | {
"id": "C0030883",
"name": "pentobarbitone",
"pos": [
48,
62
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
110,
121
]
} |
it is concluded that the presynaptic actions of pentobarbitone and phenobarbitone contribute significantly to barbiturate-induced changes in synaptic efficacy at low levels of transmitter release in the frog neuromuscular junction . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
67,
81
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
110,
121
]
} |
in fasting anaesthetized cats in which the pylorus and common bile duct were occluded , acid secretion in response to caerulein , desulphated caerulein , histamine and n methyl histamine given singly and combined with boots secretin 4 c.h.r . u./kg hr has been studied . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
154,
163
]
} | {
"id": "C0025779",
"name": "methyl histamine",
"pos": [
170,
186
]
} |
outputs of acid in response to the smallest doses of desulphated caerulein , histamine and n methyl histamine increased significantly when secretin was infused ( p less than 0-05 ) . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
77,
86
]
} | {
"id": "C0025779",
"name": "methyl histamine",
"pos": [
93,
109
]
} |
on a weight basis caerulein was 23 , 474 and 95 times more potent than desulphated caerulein , histamine and n methyl histamine respectively . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
95,
104
]
} | {
"id": "C0025779",
"name": "methyl histamine",
"pos": [
111,
127
]
} |
when secretin was infused simultaneously caerulein was 8 , 171 and 165 times more potent than desulphated caerulein , histamine and n methyl histamine respectively . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
118,
127
]
} | {
"id": "C0025779",
"name": "methyl histamine",
"pos": [
134,
150
]
} |
it is possible that the excessive re-utilization of hypoxanthine and xanthine in this disease prevents the allopurinol-induced inhibition of de novo purine biosynthesis that is seen in normal subjects . | NA | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
107,
118
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
149,
155
]
} |
this removes any water added during heating by condensing steam and also removes steam-volatile off-flavours . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
17,
22
]
} | {
"id": "C0038225",
"name": "steam",
"pos": [
81,
86
]
} |
it has been found that 2 reacts with acetylcholinesterase and butyrylcholinesterase within seconds in h2o at ph7.4 . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
37,
57
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
62,
83
]
} |
in the presence of calf thymus dna , pm2 dna , and the synthetic d ( a-t ) -like copolymers containing 2,6-diaminopurine ( dap ) , poly [ d ( dap-t ) ] , and poly [ d ( dap-a-t ) ] , the rotational strengths of the optically active transitions in the visible region of the actinomycins increased , and the cd spectra in the presence of the various dna duplexes were qualitatively similar . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
31,
34
]
} | {
"id": "C0012925",
"name": "cd",
"pos": [
306,
308
]
} |
the irreversible activation of adenylate-cyclase by 5'guanylylimidodiphosphate , a phosphoramidate analog of 5'gtp , has been examined in toad ( bufus marinus ) plasma membranes using the technique of preincubating the membranes with the nucleotide under various controlled conditions followed by washing and subsequent assay of enzyme activity . | NA | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
54,
78
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
111,
114
]
} |
activation of adenylate cyclase by gpp ( nh ) p , but not gtp , is essentially permanent and persists following extensive washing , prolonged incubation at 30 degrees c in the absence of the nucleotide , and after dissolution of the membranes with lubrol px . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
35,
47
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
58,
61
]
} |
the results of ion replacement studies and of treatment with ouabain or amiloride suggest that the short-circuit current isc is determined solely by the rate of active na transport and that the net movements of cl and hco3 are mediated by a na-independent , electrically-neutral , anion exchange process . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
15,
18
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
281,
286
]
} |
acute exposure of cell homogenates to 100 mm ethanol inhibited mg2+ atpase and ( na+ + k+ ) atpase of astroblasts but not that of neublastoma cells . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
63,
66
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
92,
98
]
} |
early antigen , viral capsid antigen , and virions were produced in raji cells superinfected with ebv . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
6,
13
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
16,
21
]
} |
virions produced by the raji cells contained a 55s dna but failed to induce early antigen , viral capsid antigen , and viral dna synthesis after a second superinfection of raji cells . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
82,
89
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
119,
124
]
} |
this allowed viral proteins to be synthesized in increased amounts relative to host proteins after removal of ch and pulse-labeling with ( 35s ) methionine . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
13,
27
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
84,
92
]
} |
excision of viral dna from host cell dna after induction of simian virus 40-transformed hamster cells . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
12,
21
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} |
a portion of the simian virus-40 dna , which is integrated into the host cell genome in uninduced cells , was recovered in a pool of relatively low-molecular-weight dna early after induction treatment in the absence of dna replication . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
219,
222
]
} |
among the dna-negative mutants , h2ts206 synthesized the smallest amount of viral dna at the nonpermissive temperature ( 39.5 c ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
10,
13
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
76,
85
]
} |
presently , this technique may be useful in directing the evaluation of a renal mass to either arteriography , if a tumor is suspected , or needle aspiration and renal cystogram , if a cyst is suspected . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
116,
121
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
185,
189
]
} |
after repeated blood-pressure measurement , however , there were only 9 % with sustained hypertension , while 11 % had labile hypertension . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
89,
101
]
} | {
"id": "C0262534",
"name": "labile hypertension",
"pos": [
119,
138
]
} |
eighty-two percent who initially were unaware of hypertension had labile hypertension after repeated blood-pressure measurement , and 18 % were unaware of having , sustained hypertension . | NA | {
"id": "C0262534",
"name": "labile hypertension",
"pos": [
66,
85
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
174,
186
]
} |
labile hypertension was most prevalent in white men , and sustained hypertension was more prevalent in blacks than in whites . | NA | {
"id": "C0262534",
"name": "labile hypertension",
"pos": [
0,
19
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
68,
80
]
} |
labile hypertension represents a large segment ( 52 % ) of the population initially identified as having hypertension in a home blood-pressure survey . | NA | {
"id": "C0262534",
"name": "labile hypertension",
"pos": [
0,
19
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
105,
117
]
} |
twelve patients with severe renal failure and intercurrent urinary tract infections were treated with either ampicillin trihydrate , 500 mg four times a day , or trimethoprim-sulfamethoxazole , two tablets ( 80 mg trimethoprim , 400 mg sulfamethoxazole ) twice a day . | NA | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
162,
191
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
236,
252
]
} |
the results of quantitative microanalysis , borohydride reduction , the morgan-elson reaction and enzymic hydrolysis with betagalactosidase using isolated oligosaccharides obtained by partial acid hydrolysis indicated that the o-specific side chain of the polysaccharide has a pentassaccharide unit which is beta-d-gal- ( 1 leads to 3 ) -d-galnac- ( 1 leads to 3 ) -d-galnac-fuc with a d-glucose residue bound at some undetermined point on this structure . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
155,
171
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
256,
270
]
} |
examinations of cross reactivity between tumor antigens revealed that such reactivity exists between cancer antigens and antigens originating in hydatidiform moles and that there is also a very strong cross reactivity between allogeneic cancer antigens regardless of differences in the organs of origin . | NA | {
"id": "C0003335",
"name": "tumor antigens",
"pos": [
41,
55
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
244,
252
]
} |
no obvious changes on both activities were obtained in cyclic gmp and dibutyryl cyclic gmp . | NA | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
55,
65
]
} | {
"id": "C0012055",
"name": "dibutyryl cyclic gmp",
"pos": [
70,
90
]
} |
the activation of adenylate cyclase by naf was dependent on the previous incubation time and the concentration of f- . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
39,
42
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
114,
115
]
} |
the state of the kinin system of blood was studied in terms of its content of kininogen , prekallikrein , kallikrein inhibitor and the spontaneous esterase activity . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
90,
103
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
106,
116
]
} |
during treatment with indomethacin in a patient with bartter 's syndrome , hypokalemia , high plasma renin concentration , hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected . | NA | {
"id": "C0004775",
"name": "bartter 's syndrome",
"pos": [
53,
72
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
123,
141
]
} |
to study bicarbonate 's effect onplasma potassium , blood bicarbonate in normal , hypokalemic or hyperkalemic rats was either maintained constant , lowered by hydrochloric acid or raised by sodium bicarbonate administraion . | NA | {
"id": "C0005367",
"name": "bicarbonate 's",
"pos": [
9,
23
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
190,
208
]
} |
in 7 out-patients with addison 's disease , plasma renin activity ( pra ) , plasma concentrations of angiotensin ii ( at ii ) , renin substrate ( prs ) , potassium , sodium and total protein , hematocrit , blood pressure , heart rate and body weight were studied after 2 weeks each on 2 mg of dexamethasone , 25 mg hydrocortisone ( hc ) , 25 mg hc + 0.05 mg 9-alpha-fluorohydrocortisone ( fc ) , 25 mg hc + 0.1 mg fc and 25 mg hc + 0.2 mg fc . | NA | {
"id": "C0016280",
"name": "9-alpha-fluorohydrocortisone",
"pos": [
358,
386
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
427,
429
]
} |
further analysis of the endogenous products by sucrose gradient sedimentation suggested the presence of high molecular weight rna : dna hybrids generally felt to be indicative of a faithful copy of a lengthy stretch of viral specific rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
126,
129
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
219,
224
]
} |
the patients were divided into three clinical groups -- those with systemic vasculitis without respiratory tract involvement , those with systemic vasculitis with respiratory tract involvement ( particularly churg-strauss vasculitis and wegener 's granulomatosis ) , and those with limited vasculitis without visceral involvement . | NA | {
"id": "C0264939",
"name": "systemic vasculitis",
"pos": [
67,
86
]
} | {
"id": "C0042384",
"name": "vasculitis",
"pos": [
290,
300
]
} |
the main steps in collagen biosynthesis are transcription and translation , hydroxylations of prolyl and lysyl residues , glycosylations of hydroxylysyl residues , chain association and disulphide bonding , triple helix formation , secretion of procollagen into the extracellular matrix , conversion of procollagen into collagen , specific aggregation of collagen molecules and crosslink formation . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
245,
256
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
355,
363
]
} |
recent studies have revealed that the membrane proteins are diverse and suggest that protein dysfunction may also account for clinical disease . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
38,
55
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
85,
92
]
} |
a major problem that needs to be resolved is to find the operating mechanism by which malignant cells interact with their constantly proliferating fibroblastic stroma . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
53,
56
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
147,
159
]
} |
following injection with triton wr-1339 , the concentration of vldl lipids was higher in female rats ( triacylglycerol ) or similar ( phospholipid , cholesterol , and cholesteryl esters ) in both sexes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
149,
160
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
167,
185
]
} |
the systematic use of excretion urography , nephrotomography , ultrasonography , renal scanning , renal arteriography and cyst puncture then may allow the accuracy of radiologic diagnosis of this tumor to approach 100 % . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
122,
126
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
196,
201
]
} |
the bacterium utilizes thiosulphate yielding sulphates and assimilates molecular hydrogen in the darkness under aerobic conditions . | NA | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
23,
35
]
} | {
"id": "C0038720",
"name": "sulphates",
"pos": [
45,
54
]
} |
some patients follow a pathway characterized by confusion , hallucinations , mumbling delirium , myoclonic jerks , and seizures . | NA | {
"id": "C0009676",
"name": "confusion",
"pos": [
48,
57
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
86,
94
]
} |
acne vulgaris should be regarded as a cosmetically unacceptable biological variation in most cases , a syndrome rather than a disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
103,
111
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
126,
133
]
} |
in a wild type strain , the rate of stable rna ( srna : essentially ribosomal rna ) synthesis increased 2.3 fold shortly after the shift-up to the rate characteristic of the post-shift steady state growth . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
43,
46
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
68,
81
]
} |
paraneoplastic hypercorticism appears either as a fullfledged cushing 's syndrome with adiposity of the trunk , moon face and striae or as a biochemical form with hypokalemic alkalosis , adynamia and muscular atrophy . | NA | {
"id": "C0001622",
"name": "hypercorticism",
"pos": [
15,
29
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
62,
81
]
} |
a form of the disease with the biochemical type in bronichial carcinoma is reported , which emphasizes also the significance of paraneoplastic syndromes for the early diagnosis of neoplasia . | NA | {
"id": "C0030472",
"name": "paraneoplastic syndromes",
"pos": [
128,
152
]
} | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
180,
189
]
} |
hemoperfusion with activated charcoal is indicated in intoxications and in hepatic comma because the charcoal absorbs toxic substances . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
19,
37
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
101,
109
]
} |
normal fibroblasts , lesch-nyhan fibroblasts , xeroderma pigmentosum fibroblasts , hela cells , wild type mouse cells , and adenine phosphoribosyl-transferase-deficient mouse cells all seem to metabolize caffeine similarly . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
175,
180
]
} |
we studied the effects of cigarette smoking , sham smoking and smoking during adrenergic blockade in 10 subjects to determine whether smoking released the sympathetic neurotransmitter norepinephrine , as well as the adrenomedullary hormone epinephrine , and whether smoking-associated hemodynamic and metabolic changes were mediated through adrenergic mechanisms . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
184,
198
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
240,
251
]
} |
smoking-associated increments in mean ( +/- s.e.m . ) plasma norepinephrine ( 227 +/- 23 to 324 +/- 39 pg per milliliter , p less than 0.01 ) and epinephrine ( 44 +/- to 113 +/- 27 pg per milliliter , p less than 0.05 ) were demonstrated . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
146,
157
]
} |
amiloride inhibited in a similar fashion the na+-k+-atpase , the mg2+-atpase and the hco-/3-atpase , but did not influence active hco-/3 secretion . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
45,
47
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
92,
98
]
} |
amiloride inhibited in a similar fashion the na+-k+-atpase , the mg2+-atpase and the hco-/3-atpase , but did not influence active hco-/3 secretion . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
65,
68
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
92,
98
]
} |
digoxigenin-bis-digiitoxoside ( with two sugar residues ) digoxigenin-monodigitoxoside ( with one sugar residue ) and digoxigenin ( with no sugar ) were compared with the parent compound , digoxin . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
0,
11
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
189,
196
]
} |
all the compounds produced postive inotropic responses , the mondigitoxoside producing the greatest effect , digoxigenin next in order of inotropic response magnitude , the bis-digitoxoside produced the least effect , and digoxin was intermediate between the genin and bis-digitoxoside . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
109,
120
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
222,
229
]
} |
patients with chronic renal failure who were on maintenance haemodialysis , were given monthly 600 mg iron intravenously as iron-dextran complex to a body replacement total of 5-6 g iron . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
102,
106
]
} | {
"id": "C0022092",
"name": "iron-dextran complex",
"pos": [
124,
144
]
} |
the tumor was confirmed as tuberculoma not only by histological findings but also by the vertification of tuberculous bacilli in it . | NA | {
"id": "C0041295",
"name": "tuberculoma",
"pos": [
27,
38
]
} | {
"id": "C0041296",
"name": "tuberculous",
"pos": [
106,
117
]
} |
in two patients with postanoxic action myoclonus , l-tryptophan or a monoamine oxidase inhibitor induced a moderate improvement , but l-5-hydroxytryptophan had greater therapeutic effect . | NA | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
51,
63
]
} | {
"id": "C0000578",
"name": "l-5-hydroxytryptophan",
"pos": [
134,
155
]
} |
the series shows the high frequency in arrhythmic atrial disease of episodes of incipient loss of consciousness or authentic syncopal phenomena . | NA | {
"id": "C0041657",
"name": "of",
"pos": [
65,
67
]
} | {
"id": "C0039070",
"name": "syncopal",
"pos": [
125,
133
]
} |
gilbert 's icterus is a term used to cover certain forms of free bilirubin hyperbilirubinaemia which occur without any clear signs of hyperhaemolysis and are thus based on a fundamental defect in bilirubin liver cell clearance . | NA | {
"id": "C0022346",
"name": "icterus",
"pos": [
11,
18
]
} | {
"id": "C0020433",
"name": "hyperbilirubinaemia",
"pos": [
75,
94
]
} |
on the basis of such data , gilbert 's icteruses have been traditionally subdivided into two types : the first , with slight bilirubinaemia , due to an uptaking defect , the second , with higher bilirubin , due to a reduction in glycuronide conjugation . | NA | {
"id": "C0022346",
"name": "icteruses",
"pos": [
39,
48
]
} | {
"id": "C0020433",
"name": "bilirubinaemia",
"pos": [
125,
139
]
} |
blood sugar , insulin and gh values were examined in two groups of cirrhosis of the liver patients , with and without ascites , after the administration of 100 g glucose per os . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
0,
11
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
162,
169
]
} |
preoperative and postoperative studies including serum estrone , estradiol , prolactin , fsh , and lh , as well as urinary estrogens , 17-ketosteroids , and 17-hydroxysteroids are reported . | NA | {
"id": "C0014942",
"name": "estrone",
"pos": [
55,
62
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
135,
150
]
} |
serum levels of cortisol ( f ) , pregnenolone ( delta5-p ) , 17-hydroxypregnenolone ( 17-delta5-p ) , dehydroepiandrosterone ( dhea ) , dehydroepiandrosterone sulfate ( dhea-s ) , progesterone ( p ) , 17-hydroxyprogesterone ( 17-p ) , androstenedione ( a ) , testosterone ( t ) , dihydrotestosterone ( dht ) , androst-5-ene-3beta , 17beta-diol ( delta5-diol ) , estrone ( e1 ) , and estradiol-17beta ( e2 ) were measured in 10 postmenopausal and 5 premenopausal women before ( control ) and after 7 days of dexamethasone ( post-dex ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
33,
45
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
61,
83
]
} |
serum levels of cortisol ( f ) , pregnenolone ( delta5-p ) , 17-hydroxypregnenolone ( 17-delta5-p ) , dehydroepiandrosterone ( dhea ) , dehydroepiandrosterone sulfate ( dhea-s ) , progesterone ( p ) , 17-hydroxyprogesterone ( 17-p ) , androstenedione ( a ) , testosterone ( t ) , dihydrotestosterone ( dht ) , androst-5-ene-3beta , 17beta-diol ( delta5-diol ) , estrone ( e1 ) , and estradiol-17beta ( e2 ) were measured in 10 postmenopausal and 5 premenopausal women before ( control ) and after 7 days of dexamethasone ( post-dex ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
180,
192
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
201,
223
]
} |
a total of 50.3 per cent of the patients were symptomatic before seeking treatment , the most common finding being intraoral drainage and swelling . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
101,
108
]
} | {
"id": "C0013604",
"name": "swelling",
"pos": [
138,
146
]
} |
experimental infection of males and females of phlebotomus papatasi sc . with leishmania tropica major from man and l. gimnodactyli from agama sanguinolenta was carried out in order to obtain mixed infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
13,
22
]
} | {
"id": "C0275524",
"name": "mixed infection",
"pos": [
192,
207
]
} |
effect of postweanling pyridoxine deficiency on growth and concentration of the coenzyme pyridoxal-5'-phosphate in heart , kidneys , lungs , and adrenals in rats . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
80,
88
]
} | {
"id": "C0034266",
"name": "pyridoxal-5",
"pos": [
89,
100
]
} |
the depletion of the coenzyme pyridoxal-5'-phosphate from these tissues was extensive ( heart 48 % , lungs 85 % , and kidneys and adrenals 88 % . ) | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
21,
29
]
} | {
"id": "C0034266",
"name": "pyridoxal-5",
"pos": [
30,
41
]
} |
no significant differences were found in the rate of growth in crown-rump length , in femoral length , in head circumference , or in rate of gain in weight from time of regaining birthweight to time of discharge at 2,400 gm . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
149,
155
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
179,
190
]
} |
national mortality statistics for hyaline membrane disease ( hmd ) and respiratory distress syndrome ( rds ) were examined in this study for the years 1968 to 1973 . | NA | {
"id": "C0020192",
"name": "hyaline membrane disease",
"pos": [
34,
58
]
} | {
"id": "C0035220",
"name": "respiratory",
"pos": [
71,
82
]
} |
during the six-year interval , hmd/rds was determined to be the underlying cause of death in 54,064 infants or 9,010 +/- 560 ( mean +/- sd ) infants per year . | NA | {
"id": "C0020192",
"name": "hmd",
"pos": [
31,
34
]
} | {
"id": "C0035220",
"name": "rds",
"pos": [
35,
38
]
} |
a review of the literature on cholelithiasis and hbss disease presents adequate evidence to cause us to urge investigation of the gallbladder in all patients with hbss disease and abdominal crises , and cholecystectomy as an elective procedure should stones be present . | NA | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
30,
44
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
251,
257
]
} |
sixteen patients with anorexia nervosa and secondary amenorrhoea received clomiphene citrate , eight before any other treatment ( 200 mg of clomiphene citrate per day for four days ) and eight others after partial or total correction of weight loss ( 50 mg of clomiphene citrate per day for five days ) . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
74,
92
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
260,
270
]
} |
in contrast to our findings on polyoma late giant rna , nuclear polyoma rna synthesized in the presence of fdu sedimented in denaturing me2so-chloral hydrate gradients considerably slower ( from 15 to 30s ) in relation to hnrna and ribosomal precursor rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
50,
53
]
} | {
"id": "C0035700",
"name": "nuclear",
"pos": [
56,
63
]
} |
in contrast to our findings on polyoma late giant rna , nuclear polyoma rna synthesized in the presence of fdu sedimented in denaturing me2so-chloral hydrate gradients considerably slower ( from 15 to 30s ) in relation to hnrna and ribosomal precursor rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
50,
53
]
} | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
232,
241
]
} |
in contrast to our findings on polyoma late giant rna , nuclear polyoma rna synthesized in the presence of fdu sedimented in denaturing me2so-chloral hydrate gradients considerably slower ( from 15 to 30s ) in relation to hnrna and ribosomal precursor rna . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
56,
63
]
} | {
"id": "C0035695",
"name": "hnrna",
"pos": [
222,
227
]
} |
pk values of ionisation of cytidine residues , in poly c and poly i. poly c , have been determined by potentiometric titration as a function of either ionic strength ( na+ ) or mg2+ concentration . | NA | {
"id": "C0032408",
"name": "poly c",
"pos": [
50,
56
]
} | {
"id": "C0032414",
"name": "poly i",
"pos": [
61,
67
]
} |
on treatment with acetyl bromide , the nucleoside bond of purine nucleosides is quantitatively cleavaged ( 4 h , 20 degrees c ) with the formation of tri-o-acetyl-d-ribofuranosyl bromide ( x ) . | NA | {
"id": "C0034136",
"name": "nucleoside",
"pos": [
39,
49
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
65,
76
]
} |
thus , s1 nuclease prepared by this procedure is suitable for use in removing single strand regions in dna/dna duplexes and dna/rna hybrids . | NA | {
"id": "C0012935",
"name": "single strand",
"pos": [
78,
91
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
compounds 1 and 2 with h2s and triethylamine give thioamides 3 , which were converted into amides 4 and amidoximes 5 . | NA | {
"id": "C0039875",
"name": "thioamides",
"pos": [
50,
60
]
} | {
"id": "C0002482",
"name": "amides",
"pos": [
91,
97
]
} |
the treatments consisted of adding sodium fluoride to the drinking water at the levels of 100 , 150 , 200 , and 200 p.p.m . of fluoride in the four experiments , respectively . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
35,
50
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
127,
135
]
} |
as dietary protein increased , the increases in body weight from added methionine became smaller , i.e. , 16.9 , 14.4 and 4.8 % in diets containing 24 , 27 , and 30 % protein , respectively . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
3,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
167,
174
]
} |
specific radioactivities of choline , acetylcholine , phosphocholine , lecithin , lysolecithin , and glycerophosphorylcholine have been measured in brain , blood , liver , and muscle after the intravenous injection of three labeled precursors : choline , methyl-labeled methionine , and ethanolamine . | NA | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
54,
68
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
245,
252
]
} |
specific radioactivities of choline , acetylcholine , phosphocholine , lecithin , lysolecithin , and glycerophosphorylcholine have been measured in brain , blood , liver , and muscle after the intravenous injection of three labeled precursors : choline , methyl-labeled methionine , and ethanolamine . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
71,
79
]
} | {
"id": "C0017889",
"name": "glycerophosphorylcholine",
"pos": [
101,
125
]
} |
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