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stringlengths 57
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dict |
|---|---|---|---|
previous studies indicated that when the mitochondrial translocator protein is in the c-state ( i.e. , when its binding site faces the cytosol side ) the protein binds primarily the ligand carboxyatractylate ( cat ) , and when the translocator protein is in the m-state ( i.e. , when its binding site faces the mitochondrial matrix ) the translocator protein binds primarily bongkrekate . | NA | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
41,
54
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
351,
358
]
} |
the rate of r-loop formation is maximal at the temperature at which half of the duplex dna is irreversibly converted to single-stranded dna ( the strand separation temperature of tss ) of the duplex dna and falls precipitously a few degrees above or below that temperature . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
120,
139
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
199,
202
]
} |
a protein fraction from the cellular slime mold dictyostelium discoideum confers ca2+-sensitivity on the activation of purified myosin adenosinetriphosphatase ( atp phosphohydrolase , ec 3.6.1.3 ) from dictyostelium by purified dictyostelium actin . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
81,
84
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
161,
181
]
} |
comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
75,
86
]
} | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
106,
124
]
} |
since it is rather well established that 8-substituted purine nucleosides are predominantly in the syn conformation in aqueous solution , it follows that the 3-deazapurine nucleosides , whether substituted at position 8 or not , also favor the syn conformation . | NA | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
55,
73
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
172,
183
]
} |
certain purine-nucleoside-utilizing enzymes fail to interact effectively with either the unsubstituted 3-deaza analogs or the 8-substituted derivatives of adenosine and guanosine . | NA | {
"id": "C0034136",
"name": "purine-nucleoside",
"pos": [
8,
25
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
155,
164
]
} |
certain purine-nucleoside-utilizing enzymes fail to interact effectively with either the unsubstituted 3-deaza analogs or the 8-substituted derivatives of adenosine and guanosine . | NA | {
"id": "C0034136",
"name": "purine-nucleoside",
"pos": [
8,
25
]
} | {
"id": "C0018330",
"name": "guanosine",
"pos": [
169,
178
]
} |
the excision capacity of whole-cell homogenates of fibroblasts from two of four patients with fanconi 's anemia was substantially below normal . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} |
although fibroblasts from a patient with the homozygous form of familial hypercholesterolemia contained the same number of indented , coated membrane regions per millimeter of cell surface as did normal cells , no ldl-ferritin was observed to bind to the cell membrane in these mutant cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
9,
20
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
196,
208
]
} |
sindbis virus obtained after passage on human fibroblasts from patients with i-cell disease ( mucolipidosis ii ) and called i-cell virus differed from sindbis virus obtained from chick fibroblasts or from normal human fibroblasts in two ways : ( 1 ) the i-cell virus was extremely unstable to freezing and thawing , ( 2 ) the i-cell virus showed greatly exaggerated sensitivity to inactivation by triton x-100 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
328,
332
]
} |
when freeze-sensitive i-cell virus was passaged once in mouse l-cells or normal human fibroblasts , the virus was no longer abnormal . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
24,
28
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} |
a radioactive probe of complementary dna ( cdna ) was prepared by transcription of purified k-chain mrna from mouse myeloma mopc-41 with reverse transcriptase ( rna-dependent-dna nucleotidyltransferase ) from avian myeloblastosis virus . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
175,
178
]
} |
however , some elements of the copulatory act appear to be modified by noradrenaline and/or adrenaline as well . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
71,
84
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
92,
102
]
} |
investigation of the role of noradrenaline ( na ) and dopamine ( da ) in self-stimulation showed that d-amphetamine ( which releases more da than does l-amphetamine , but not more na ) was much more effective than l-amphetamine in enhancing self-stimulation of na sites in the locus coeruleus and near-lateral hypothalamus . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
102,
115
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
216,
227
]
} |
substitution of calorigenic effects of noradrenaline and adrenaline and differences in their inhibition by propranolol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} |
the adrenaline dose-response curve showed a shift to the right , towards higher infusion doses , compared with the noradrenaline curve . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
4,
14
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
115,
128
]
} |
in interaction with noradrenaline , propranolol caused a parallel shift of the dose-response curve to the right , whereas in interaction with adrenaline it depressed the maximum . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
20,
33
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
142,
152
]
} |
we describe three patients with fibrous dysplasia of bone in whom there was evidence of hypophosphataemic osteomalacia or rickets . | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
106,
118
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
122,
129
]
} |
in all cases the manifestations of osteomalacia or rickets were controlled with large doses of vitamin d . | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
35,
47
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
51,
58
]
} |
this paper describes five patients , including four siblings in one family , who have diabetes insipidus , diabetes mellitus , optic atrophy and deafness ( the didmoad syndrome ) . | NA | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
86,
104
]
} | {
"id": "C0043207",
"name": "didmoad syndrome",
"pos": [
160,
176
]
} |
in case of diffuse liver disease the accuracy of both methods is about the same except for fatty liver which is poorly diagnosed by scintigraphy . | NA | {
"id": "C0023895",
"name": "liver",
"pos": [
19,
24
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
91,
102
]
} |
a discussion of the principal causes of oesophageal dysmotility is followed by a detailed account of two manifestations of dysmotility : diffuse oesophageal spasm and diffuse oesophageal hypertrophy . | NA | {
"id": "C0014858",
"name": "oesophageal dysmotility",
"pos": [
40,
63
]
} | {
"id": "C0014863",
"name": "diffuse oesophageal spasm",
"pos": [
137,
162
]
} |
a series of 11-deoxy prostaglandin derivatives and some naturally occurring prostaglandins have been investigated in the anaesthetized artificially respired guinea-pig for their effect on blood pressure , bronchial resistance ( overflow pressure at constant volume ) , tracheal segment pressure , and on intestinal and uterine smooth muscle . | NA | {
"id": "C0033555",
"name": "a series",
"pos": [
0,
8
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
76,
90
]
} |
the authors discuss , in connection with a penetrating wound of the right ventricle induced with a knife , associated to hemoperitoneum ( 1 400 ml ) following transfixiant hepatic wound on the importance of a complete diagnosis in complex trauma . | NA | {
"id": "C0043254",
"name": "penetrating wound",
"pos": [
43,
60
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
239,
245
]
} |
cultured fibroblasts from patients with partial or complete deficiencies of enzymes involved in purine metabolism provide a model for investigating the biosynthesis , interconversion , and excretion of purine metabolites at the cellular level . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
9,
20
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
228,
236
]
} |
elution of igm , igg , iga and albumin was monitored by examination of fractions in agar gel diffusion against antisera specific to these proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
31,
38
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
138,
146
]
} |
after taking 0.5 mg f in the form of naf tablets a group of children without previous f supply attained within 1 d a 24-h urinary f concentration which was about the same as that in children who had been taking caries-preventive tablet doses for years . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
37,
40
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
242,
243
]
} |
the alpha chain of this protein appears to have more glutamic acid or glutamine , or both , and less isoleucine residues than other human alpha chains . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
53,
66
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
70,
79
]
} |
the findings are compatible with the poor allergenic and antigenic properties attributed to these two species in comparison with a. fumigatus . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
42,
52
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
57,
66
]
} |
the c-reactive protein ( crp ) , an acute phase reactant which binds selectively to t ( thymus-derived ) lymphocytes , was found to bind to lymphoblasts formed upon stimulation with antigens but not with mitogens . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
4,
22
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
36,
56
]
} |
idiopathic stone disease is characterized by recurrent formation of calcium oxalate , calcium phosphate , and hydroxyapatite stones without an apparent underlying cause . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
68,
75
]
} | {
"id": "C0006711",
"name": "calcium phosphate",
"pos": [
86,
103
]
} |
the hepatorenal syndrome is defined as the spontaneous onset of progressive renal failure in patients with far advanced hepatic disease , usually on the basis of cirrhosis . | NA | {
"id": "C0023895",
"name": "hepatic disease",
"pos": [
120,
135
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
162,
171
]
} |
if ischemia then is repeated , the additional insult results in increasing edema and possible infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
3,
11
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
94,
104
]
} |
exercise-induced asthma ( eia ) was provoked by standardized treadmill running for 6 minutes in 15 asthmatic children . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
0,
23
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
99,
108
]
} |
the anatomical distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract , and the relative proportions of the immunoglobulin classes have been estimated on necropsy tissues from nine adult human subjects without respiratory disease , five non-smokers and four smokers , none of whom had cough or sputum . | NA | {
"id": "C0035204",
"name": "respiratory disease",
"pos": [
251,
270
]
} | {
"id": "C0010200",
"name": "cough",
"pos": [
326,
331
]
} |
in vitro activities of penicillin , ampicillin , dihydrostreptomycin , nafcillin , cloxacillin and commercially available combinations of these antibiotics against a variety of gram-positive mastitis-causing micro-organisms were examined . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
23,
33
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
71,
80
]
} |
as a rule , penicillin proved to be more active against penicillin-sensitive strains of micro-organisms than ampicillin and nafcillin and far more so than cloxacillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
12,
22
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
124,
133
]
} |
against strains which were less sensitive to penicillin , there was not much difference in activity between penicillin , ampicillin , nafcillin and cloxacillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
45,
55
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
134,
143
]
} |
the activity of the combination of penicillin , dihydrostreptomycin and nafcillin against most micro-organisms was mainly due to the penicillin in the combination . | NA | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
72,
81
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
133,
143
]
} |
ep 1 produced highly organized blood islands containing developing erythrocyte cells , organized endothelium , fibroblasts , thrombocytes and occasional granulocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
79,
84
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} |
on the understanding that the primary tumor disease had been cured , we can look at the recurrences as at second tumor disease . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
38,
43
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
106,
118
]
} |
a series of 7alpha- and 7beta- alkyl derivatives of steroidal 4-en- and 5-en-3-ones were prepared by 1,6-conjugate addition of organocopper reagents to various steroidal 4,6-dien-3-ones of the androstane , estrane and gonane series . | NA | {
"id": "C0038317",
"name": "steroidal",
"pos": [
52,
61
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
193,
203
]
} |
a series of 7alpha- and 7beta- alkyl derivatives of steroidal 4-en- and 5-en-3-ones were prepared by 1,6-conjugate addition of organocopper reagents to various steroidal 4,6-dien-3-ones of the androstane , estrane and gonane series . | NA | {
"id": "C0038317",
"name": "steroidal",
"pos": [
52,
61
]
} | {
"id": "C0014924",
"name": "estrane",
"pos": [
206,
213
]
} |
the antiserum against 16alpha-oh-dhea and its sulfate ( 16alpha-oh-dhea-3-sulfate ) was produced in rabbits immunized with 16alpha-oh-dhea-3-succinate-bovine serum albumin . | NA | {
"id": "C0057277",
"name": "dhea",
"pos": [
33,
37
]
} | {
"id": "C0011185",
"name": "succinate",
"pos": [
141,
150
]
} |
as a first step in the study of the possible relationship between the t/t and h-2 complexes , the h-2 antigenic composition of the strains carrying factors t12 , tw32 , tw2 , tw8 , t1 , t0 , t6 , tw1 , tw71 , tw73 , tw12 , tw5 , tw75 , and t38 was studied by using a battery of antisera containing antibodies against inbred-derived h-2 antigens . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
278,
286
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
298,
308
]
} |
antigenic activity was detected by the capacity of serum fractions to neutralize reactivity of antibody in hepatoma immune serum for cell surface expressed antigen on viable hepatoma cells as assessed by using the indirect membrane immunofluorescence test . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
95,
103
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
116,
128
]
} |
the most important finding was that cells from mismatched unrelated fetal donors ( using a cell dose per kilogram body weight comparable to the number of fetal liver and thymus cells which would be obtainable from one human fetus at 14 weeks of embryonation ) promoted higher long-term survival rates than did bone marrow transplants from matched unrelated donors . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
19,
26
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
119,
125
]
} |
the reaction of x-chromatin of interphase nuclei was expressed in the increase of the percentage of cells with x-chromatin . beta-merceptoethanol removed a condensing effect induced by spermine on the diffused chromatin of interphase cultured fibroblasts . beta-mercaptoethanol caused a differential staining of metaphase chromosome when added to the cultured cells 0.5 hours prior to fixation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
100,
105
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
243,
254
]
} |
it was shown that the attachment of prelabeled homo- and heterologous cells introduced into epithelial sheets were very low as compared with the free substratum and dense cultures of fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
183,
194
]
} |
the uv irradiation of different wave-lengths ( 254 , 325 and 365 nm , resp . ) irrespective of the degree of absorption by nucleic acids , causes changes in chromatin condensation , thus suggesting the labilization of dna -- protein bounds . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
123,
136
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
218,
221
]
} |
the thin layers of cellulose jit or ecteolo-cellulose with the solvent 0.01-n hc1 and cellulose jit with the solvent ethyl acetate -- acetic acid-water ( 5:1.5:1.5 ) may be used , respectively , for determining the content of the reactions final products , when measuring the enzymic activities of dopa-decarboxylase and 5-oxytryptophan-decarboxylase . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
19,
28
]
} | {
"id": "C0059756",
"name": "cellulose",
"pos": [
86,
95
]
} |
iodinated protein with electrophoretic behavior consistent with fibrinogen and albumin was always found after plasma exposure , but proteins of apparent mw 7-10,000 ; | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
79,
86
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
132,
140
]
} |
hyperlipidemia in these patients was characterized by both hypercholesterolemia and hypertriglyceridemia and on lipoprotein electrophoresis was demonstrated to be a mixture of types iia , iib and iv hyperlipoproteinemia . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
0,
14
]
} | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
59,
79
]
} |
hyperlipidemia in these patients was characterized by both hypercholesterolemia and hypertriglyceridemia and on lipoprotein electrophoresis was demonstrated to be a mixture of types iia , iib and iv hyperlipoproteinemia . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
0,
14
]
} | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
84,
104
]
} |
hyperlipidemia in these patients was characterized by both hypercholesterolemia and hypertriglyceridemia and on lipoprotein electrophoresis was demonstrated to be a mixture of types iia , iib and iv hyperlipoproteinemia . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
0,
14
]
} | {
"id": "C0020476",
"name": "hyperlipoproteinemia",
"pos": [
199,
219
]
} |
conceivably , cells other than fibroblasts ( i.e. , multipotential cells ) would show the same response to these pressure and flow conditions . | NA | {
"id": "C0016030",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} |
when absorption has been carried out with heterologous antigens a specific protein fraction for asts and cyst fluid is established in the zone of the betaglobulins , which is lacking in the other antigens studied . | NA | {
"id": "C0003333",
"name": "heterologous antigens",
"pos": [
42,
63
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
196,
204
]
} |
[ dynamics of spinal cord motor neuron excitability in epileptic patients following surgical elimination of seizures ] . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
55,
64
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
108,
116
]
} |
the effect of d-penicillamine on experimental allergic arthritis in rabbits ( 16 with arthritis and 15 controls ) was investigated . | NA | {
"id": "C0993582",
"name": "experimental",
"pos": [
33,
45
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
86,
95
]
} |
the results suggest that d-penicillamine affects fast proliferating cells , to which the precursors of immunologically active cells in the synovial membrane also belong . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
68,
73
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
89,
99
]
} |
three types of fibroblasts could be found constituting the great majority of cells in dupuytren 's disease : 1 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
55,
58
]
} |
the enzymes of carbohydrates metabolism ( hyaluronidase , beta-glycosidase and beta-galactosidase ) from the sclera , cornea and ciliary body were examined . | NA | {
"id": "C0020197",
"name": "hyaluronidase",
"pos": [
42,
55
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
63,
74
]
} |
results of epidemiological and statistical analysis of the indices of dysentery morbidity and bacteriological examination of drinking water pointed to the significant role of the water factor in the spread of dysentery on the river vessels . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
125,
139
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
179,
184
]
} |
in immunization of rabbits with a purified enterotoxin preparation an antiserum with the prevalence of antibodies to enterotoxin , type b , was obtained . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
70,
79
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
103,
113
]
} |
cholerogen-toxoid served as a complex vaccine preparation composed of the main pathogenicity factors of cholera vibrio -- cholerogen ( toxoid ) , endotoxin and a number of exoenzymes . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
38,
45
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
135,
141
]
} |
[ fab immunoglobulin fragments . i. the comparative characteristics of the serological and virus-neutralizing properties of a gamma globulin against tick-borne encephalitis and of the fab fragments isolated from it ] . | NA | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
6,
20
]
} | {
"id": "C0017007",
"name": "gamma globulin",
"pos": [
126,
140
]
} |
horse immunoglobulins against the autumno-summer tick-borne encephalitis virus could be disintegrated with the aid of papaine to monovalent fab-fragments which ( according to the complement fixation reaction , the test of suppression of the complement fixation , and the hait ) retained the serological activity whose level was compared with that of the serological activity of gamma-globulin . | NA | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
6,
21
]
} | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
378,
392
]
} |
an examination of 75 patients with the syndrome of pterygopalatine ganglian established that in out-patient practice such disorders are frequently incorrectly diagnosed . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
39,
47
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
122,
131
]
} |
the substrate specificity of rat skin bana hydrolase resembled that of an amino acid naphthylamidase , naphthylamides of methionine , lysine , arginine , and alanine being hydrolyzed most rapidly . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
74,
84
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
158,
165
]
} |
the present study describes the results of examinations of the noradrenaline and adrenaline concentrations in the human pancreas as well as in a number of other organs . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
63,
76
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
81,
91
]
} |
adrenaline was present in small amounts in the cardiovascular system , the liver and the spleen in comparison with the noradrenaline concentration . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
119,
132
]
} |
adrenaline was present in the pancreas of the rat , dog and rabbit but in small amounts in comparison with the noradrenaline concentration . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
111,
124
]
} |
using the single radial immunodiffusion method , the serum levels of igg , iga , ig m , transferrin , haptoglobin , alpha2-macroglobulin , alpha1-antitrypsin and alpha1-acid glycoprotein were estimated in healthy subjects and patients with liver diseases consisting of chronic active and inactive hepatitis , incipient cirrhosis , cirrhosis and primary liver cancer . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
240,
254
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
297,
306
]
} |
using the single radial immunodiffusion method , the serum levels of igg , iga , ig m , transferrin , haptoglobin , alpha2-macroglobulin , alpha1-antitrypsin and alpha1-acid glycoprotein were estimated in healthy subjects and patients with liver diseases consisting of chronic active and inactive hepatitis , incipient cirrhosis , cirrhosis and primary liver cancer . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
240,
254
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
331,
340
]
} |
ii ) the increased transferrin levels were found in chronic active and inactive hepatitis , and the increased alpha1-antitrypsin levels were observed in chronic inactive hepatitis , in incipient cirrhosis in cirrhosis and in primary liver cancer was higher than those of the other liver diseases . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
80,
89
]
} | {
"id": "C0019189",
"name": "chronic",
"pos": [
153,
160
]
} |
ii ) the increased transferrin levels were found in chronic active and inactive hepatitis , and the increased alpha1-antitrypsin levels were observed in chronic inactive hepatitis , in incipient cirrhosis in cirrhosis and in primary liver cancer was higher than those of the other liver diseases . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
80,
89
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
281,
295
]
} |
ii ) the increased transferrin levels were found in chronic active and inactive hepatitis , and the increased alpha1-antitrypsin levels were observed in chronic inactive hepatitis , in incipient cirrhosis in cirrhosis and in primary liver cancer was higher than those of the other liver diseases . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
195,
204
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
281,
295
]
} |
( 1 ) cholinesterase activity was investigated in some human lymphatic organs ( palatine tonsil , 'normal ' spleen , 'bilharzial ' spleen , thymus , lymph node and appendix ) using gomori 's modification of koelle and friedenwald 's thiocholine iodide method , hydrolyzing acetylthiocholine iodide and butyrylthiocholine iodide . | NA | {
"id": "C0039883",
"name": "thiocholine",
"pos": [
233,
244
]
} | {
"id": "C0006528",
"name": "butyrylthiocholine",
"pos": [
302,
320
]
} |
[ histoautoradiography of the dna in trophoblast giant cells of the mouse placenta . a contribution to the problem of metabolic dna ] . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
30,
33
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
130,
131
]
} |
there are various overlaps between migraine and epilepsy and another is suggested here in patients who develop seizures following surgery for intracranial aneurysm . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
48,
56
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
111,
119
]
} |
baclofen is a gaba-like drug which passes through the blood-brain barrier and which reduces the neuroleptic-induced increase of dopamine turn-over . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
0,
8
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
14,
18
]
} |
in tardive dyskinesia is found dopaminergic hypersensitivity , and baclofen is supposed to exert its action by inhibiting the dopamine activity . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
31,
43
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
126,
134
]
} |
we have proposed that the rapid turnover pool may be the phosphoglycerides that are exchangable with cytosol carrier proteins and that the slow turnover may represent the catabolism of membrane segments including the intrinsic proteins . | NA | {
"id": "C0007292",
"name": "carrier proteins",
"pos": [
109,
125
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
227,
235
]
} |
compared to base-line values , there resulted no significant alteration in urinary excretion of dopa , dopamine , norepinephrine , epinephrine , or vma for either the patient or a group of controls , receiving 1 g/day vitamin c . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
114,
128
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
131,
142
]
} |
the haptoglobin-hemoglobin complex activates the incorporation of 14c-proline into the collagen hydroxyproline of rat or human dermis slices incubated in vitro . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
70,
77
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
96,
110
]
} |
( 3 ) lymph node enlargement with histological features simulating lymphoma or hodgkin 's disease , which occurred in patients receiving phenylbutazone in particular . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
67,
75
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
79,
97
]
} |
these data support the view that under certain conditions , fibroblasts can differentiate into a cell type structurally and functionally similar to smooth muscle and this cell , the 'myofibroblast ' , plays an important role in connective tissue contraction . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
171,
175
]
} |
bacteriolysis by the lytic agents is strongly inhibited by the anionic polyelectrolytes , heparin , chondroitin sulphate , dna , dextran sulphate and other sulphated mucopolysaccharides , by the cationic materials , histone , protamine sulphate , leucocyte cationic proteins and polylysine . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
90,
97
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
166,
185
]
} |
the authors present the results of a systematic study of autoantibody occurrence during d-pen.-treatment of the rheumatoid arthritis ( ra ) : ( 1 ) anti-nuclear antibodies are slightly positive in 34 % of the untreated ra . | NA | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
57,
69
]
} | {
"id": "C0003243",
"name": "anti-nuclear antibodies",
"pos": [
148,
171
]
} |
in a combined clinical trial with gold in patients with rheumatoid arthritis ( ra ) 95 patients were treated with a high initial dosage of 2,500 mg aurothioglucose in 21 weeks . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
148,
163
]
} |
cells participating in an inflammatory response are derived from the bone marrow ( i.e . granulocytes and monocytes ) or lymphoid organes ( i.e . t and b lymphocytes ) , or of mesenchymal origin ( i.e . fibroblast , reticulum cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
203,
213
]
} |
persisting ischemia leads to infarction via a series of events which may include myocardial edema formation , increased beta-sympathetic tone , and others which have been experimentally modified by interventions designed to limit infarct size . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
11,
19
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
230,
237
]
} |
rhabdomyomas derive from cardiac muscle cells and appear to represent hamartomas rather than true tumors . | NA | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
70,
80
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
98,
104
]
} |
cytodifferentiated renal tumors occurring with wilms ' tumors of the opposite kidneys : report of two cases . | NA | {
"id": "C0022665",
"name": "renal tumors",
"pos": [
19,
31
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
47,
52
]
} |
the cases of two patients found to have well-differentiated renal neoplasms after being treated for wilms ' tumor of the opposite kidneys are reported . | NA | {
"id": "C0022665",
"name": "renal neoplasms",
"pos": [
60,
75
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
100,
105
]
} |
a new infant with classical features of holoprosencephaly and multiple extracranial malformations was found to have abnormal karyotype : 47 , xx , + 13 . | NA | {
"id": "C0079541",
"name": "holoprosencephaly",
"pos": [
40,
57
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
62,
70
]
} |
in 16 experiments on 4 healthy subjects , the effect of procedures which alter blood glucose , ie , infusion of 0.2 units/kg body wt/hr insulin and/or 0.66 g/kg body wt/hr glucose , on gastric acid secretion , plasma gastrin , and plasma osmolality was studied , each subject underwent four different experimental procedures , each lasting 4 hr . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
79,
92
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
172,
179
]
} |
the decrease in recipient cases and the increase in contact cases in 1965-1972 compared with the previous 3-year period are explained by the general curtailing of routine vaccination of adults after 1964 , a switch from monovalent oral polio vaccine to topv , improved recognition of contact cases and a shift in emphasis from mass vaccination campaigns and communitywide programs to routine vaccination of infants . | NA | {
"id": "C0032375",
"name": "oral polio vaccine",
"pos": [
231,
249
]
} | {
"id": "C0032374",
"name": "vaccine",
"pos": [
242,
249
]
} |
the allelic frequency of undetected antigens of the hla-a locus was .14-.37 , and that of the hla-b locus , .32-.67 , indicating that there were serological difficulties in typing for japanese antigens using antisera from caucasians . | NA | {
"id": "C0019721",
"name": "antigens",
"pos": [
36,
44
]
} | {
"id": "C0019737",
"name": "hla-b locus",
"pos": [
94,
105
]
} |
sulfasalazine and topical corticosteroids ( i.e. , hydrocortisone , hydrocortisone acetate or methylprednisolone acetate ) are effective in many patients with mild distal ulcerative colitis . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
51,
65
]
} | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
68,
90
]
} |
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