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stringlengths 57
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stringclasses 125
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dict |
|---|---|---|---|
besides these three disaccharides , heparitin sulfate b yields , by the action of heparitinase i , an oligosaccharide ( with an average molecular weight of 6000 ) which is completely degraded by the heparitinase ii yielding a disaccharide composed of glucosamine 2,6-disulfate and unsaturated uronic acid . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
102,
117
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
226,
238
]
} |
we evaluated brown and white adipose tissues for the presence of creatine , phosphocreatine and creatine phosphokinase activity . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
65,
73
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
76,
91
]
} |
the specific activities of free creatine and phosphocreatine of brown adipose tissue differed strikingly as long as 24 h after radioactive creatine was injected ; | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
45,
60
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
139,
147
]
} |
bis ( n-maleimidomethyl ) ether-hemoglobin ( hbbme ) is a well known derivative of hemoglobin obtained by reaction with bis ( n-maleimidomethyl ) ether , which forms an intra-chain bond in each of the beta subunit of the protein . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
32,
42
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
204,
205
]
} |
this fact admits the possibility of ion pair formation between fixed sites and mobile cations . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
36,
39
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
86,
93
]
} |
thus , it is assumed that mobile cations and ion pairs are potential determining species at the surface . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
33,
40
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
45,
48
]
} |
in examining the content of free ammonia , glutamine and some free amino acid s in the brain tissue of mice under normal conditions , in hypoxia and under the effect of succinic acidsemialdehyde , in hypoxia there was revealed a marked increase in comparison with the normal conditions ) of the content of free ammonia , and alpha-alanine , a reduction of glutamine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
67,
77
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
331,
338
]
} |
phenomenon of the cytopathogenic action of uropathogenic e. coli strains , containing heterogenous antigens , type o ( h ) and b , on the human cell strains possessing corresponding isoantigens was revealed on the 6th hour of the interaction . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
99,
107
]
} | {
"id": "C0022145",
"name": "isoantigens",
"pos": [
182,
193
]
} |
evidence was obtained that the antibodies elaborated to the cr determinant of polysaccharide a and of the tissue epithelium should be classed as autoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
31,
41
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
145,
159
]
} |
fibroblast colonies ( clones ) are formed in monolayer cultures of the bone marrow , spleen and thymus cells from adult mice , the colony-forming efficiency ( per 105 cells ) was 2.2 , 0.2 and 0.16 , respectively . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
0,
10
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
twenty-two of the 50 cases were diagnosed as acute myelocytic leukemia ( aml ) , 24 as acute myelomonocytic leukemia ( ammol ) , 2 as acute promyelocytic leukemia ( apl ) , and 2 as erythroleukemia . | NA | {
"id": "C0023467",
"name": "acute myelocytic leukemia",
"pos": [
45,
70
]
} | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
134,
162
]
} |
uptake and incorporation of endogenous plasma lysolecithin by platelets and , possibly , direct exchanged of platelet lecithin may be important mechanisms in the modification by plasma lipids of platelet membrane phospholipid fatty acid composition and platelet function . | NA | {
"id": "C0025249",
"name": "plasma",
"pos": [
39,
45
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
213,
225
]
} |
thrombins prepared from plasmas deficient in various clotting factors are capable of inducing vasodilator response to the hindlimb of the dog and this response proved to be similar to that produced by thrombins prepared from normal plasmas . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
53,
69
]
} | {
"id": "C0040018",
"name": "thrombins",
"pos": [
201,
210
]
} |
thus the vascular effect of thrombin is not mediated by any other clotting factor which might be present in small amounts in the thrombin preparations . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
66,
81
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
129,
137
]
} |
since the vasodilating effect of thrombin is not mediated by ( i ) a nervous mechanism , ( ii ) any known vasodilating substance or ( iii ) any other clotting factor , it is concluded that the thrombin moiety possesses vasodilating properties . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
150,
165
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
193,
201
]
} |
identification of separate receptors for adenosine and adenosine 5'-triphosphate in causing relaxations of the isolated taenia of the guinea-pig caecum . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
41,
50
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
55,
66
]
} |
1 the mechanisms by which adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine relax the taenia caecum preparation of the guineapig have been studied . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
26,
37
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
97,
108
]
} |
1 the mechanisms by which adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine relax the taenia caecum preparation of the guineapig have been studied . | NA | {
"id": "C0001459",
"name": "adenosine",
"pos": [
26,
35
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
97,
108
]
} |
atp and adp produced similar effects which were qualitatively different from those of amp and adenosine . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
0,
3
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
86,
89
]
} |
atp and adp produced similar effects which were qualitatively different from those of amp and adenosine . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
8,
11
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
86,
89
]
} |
2 2-2'pyridylisatogen tosylate ( pit : 50 mum for 30 min ) blocked the effects of atp and adp , but exhibited weak activity against amp and failed to antagonize the effects of adenosine . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
82,
85
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
132,
135
]
} |
2 2-2'pyridylisatogen tosylate ( pit : 50 mum for 30 min ) blocked the effects of atp and adp , but exhibited weak activity against amp and failed to antagonize the effects of adenosine . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
90,
93
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
132,
135
]
} |
the experiment showed that the pressor response to intraventricular angiotensin ii is due to both sympathetic and pituitary hormonal components and both are dependent on sites sensitive to angiotensin in the anterior third ventricule . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
68,
82
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
189,
200
]
} |
these data are consistent with a role for the dipeptide carnosine in olfactory neural transmission . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
46,
55
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
56,
65
]
} |
disaccharides possessing 1 leads to 3 , 1 leads to 4 , or 1 leads to 6 linkages were poor stimuli compared to sucrose which has a 1 leads to 2 linkage . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
0,
13
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
110,
117
]
} |
responses to mixtures of d-sorbitol and sucrose suggest that these sugars compete for a common receptor site . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
40,
47
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
67,
73
]
} |
nausea often accompanies pain in the early postoperative period and can be relieved concomitant with the pain by the intravenous use of opiates in adequate doses in a high proportion of cases . | NA | {
"id": "C0030201",
"name": "pain",
"pos": [
25,
29
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
105,
109
]
} |
amylose and amylopectin from two starch sources were partially degraded by alpha-amylase immobilized on a phenol-formaldehyde resin . | NA | {
"id": "C0002732",
"name": "amylose",
"pos": [
0,
7
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
33,
39
]
} |
amylose and amylopectin from two starch sources were partially degraded by alpha-amylase immobilized on a phenol-formaldehyde resin . | NA | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
12,
23
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
33,
39
]
} |
there was little inhibition of the reaction by a series of monosaccharides , except for 2-amino-2-deoxy-d-glucose , d-mannitol , and 3-deoxy-d-ribo-hexose . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
59,
74
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
148,
154
]
} |
there was little inhibition of the reaction by a series of monosaccharides , except for 2-amino-2-deoxy-d-glucose , d-mannitol , and 3-deoxy-d-ribo-hexose . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
106,
113
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
148,
154
]
} |
the blocked and methylated 5 ' terminal sequence of a specific cellular messenger : the mrna for silk fibroin of bombyx mori . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
97,
101
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
102,
109
]
} |
two relatively abundant rna molecules , sedimenting at 16s and at 19s , transcribed from the l strand of the viral dna , as well as a minor 20s species transcribed from the e strand of the dna , were detected . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
109,
118
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
189,
192
]
} |
the progeny mulv from such a mixed infection are sensitive to fv-1 restriction in both n- and b-type cells , but are still highly infectious for mouse cells which do not exhibit fv-1 restriction . | NA | {
"id": "C0275524",
"name": "mixed",
"pos": [
29,
34
]
} | {
"id": "C0009450",
"name": "infectious",
"pos": [
130,
140
]
} |
although the larger protein is removed by some but not all of the proteases examined , every protease tested removed the smaller cell surface proteins ; | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
66,
75
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
93,
101
]
} |
saturation-hybridization of in vitro labeled ad 12 dna ( 2-4 x 10 ( 8 ) cpm/mug ) with he c19 dna showed that 93-100 % of viral dna sequences are present in the transformed cell . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
51,
54
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
122,
131
]
} |
studies on the molecular mechanism of this amino acid-mediated control of rrna synthesis indicate that this effect is not caused by different growth rates of the rna chains , but rather by an altered initiation frequency of the rna polymerase in vivo . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
74,
78
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
228,
231
]
} |
after a fuel spillage , a coastal zone was polluted and wild mussels were contaminated by paraffinic and naphtenic hydrocarbons and 3,4-benzopyrene . | NA | {
"id": "C0030415",
"name": "paraffinic",
"pos": [
90,
100
]
} | {
"id": "C0020242",
"name": "hydrocarbons",
"pos": [
115,
127
]
} |
following the who tri-axial classification of mental disorders , which set out possibilities for differential classification and diagnosis among the syndromes , the present article suggests complementary axes upon which educational therapy can be based in the psychoses of autism and allied disorders . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
149,
158
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
291,
300
]
} |
significant ( p less than 0.05 ) inhibition of renin release was induced by l-epinephrine or l-norepinephrine ( 10 ( -5 ) m ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} | {
"id": "C0028351",
"name": "l-norepinephrine",
"pos": [
93,
109
]
} |
in the presence of an alpha-receptor blocking drug , phenoxybenzamine ( 10 ( -5 ) m ) , inhibition no longer occurred with epinephrine and stimulation was observed with l-norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
171,
185
]
} |
in the quadriplegics the average resting blood pressure was 107/59 ( mean , 75 ) mmhg , heart rate was 65 beats/min , and plasma norepinephrine ( ne ) and epinephrine ( e ) levels were 0.05 and 0.005 ng/ml , respectively . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
129,
143
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
155,
166
]
} |
another group of patients with different arrhythmias ( recurrent paroxysmal atrial tachycardia , sustained ectopic atrial tachycardia , or sinus rhythm with premature atrial beats which precipitated runs of atrial fibrillation ) was treated with continuous rapid atrial pacing to produce 2:1 a-v block . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
41,
52
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
207,
226
]
} |
with age there was little change in alpha-lipoprotein levels , a significant increase in pre-beta-lipoprotein levels and a slight but significant decrease between 11 and 14 years in beta-lipoprotein levels . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
42,
53
]
} | {
"id": "C0023825",
"name": "pre-beta-lipoprotein",
"pos": [
89,
109
]
} |
lipoprotein values from a total community study are now available for comparison with the currently recommended upper normal limits for lipoproteins . | NA | {
"id": "C0065058",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
136,
148
]
} |
in order to compare the venodilation effect of morphine in normal individuals ( 22 ) with that in patients ( 13 ) with heart failure morphine sulfate ( 0.1 mg/kg ) was administered to 13 patients with mild pulmonary edema . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
47,
55
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
133,
149
]
} |
the v-a ap is established as an essential link of the tachycardia circuit , as evidenced by : 1 ) retrograde atrial activation of the left atrium ( la ) 60 msec or more before the low and high right atrium during reciprocating tachycardia and during v-a conduction ; | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
54,
65
]
} | {
"id": "C0242514",
"name": "reciprocating tachycardia",
"pos": [
213,
238
]
} |
there was close agreement of end-diastolic , end-systolic , and stroke volumes as determined by the angiographic and epicardial marker methods for premature atrial contraction beats and post premature contraction beats , and in studies performed during rest and exercise . | NA | {
"id": "C0033036",
"name": "premature atrial contraction",
"pos": [
147,
175
]
} | {
"id": "C0340464",
"name": "premature",
"pos": [
191,
200
]
} |
thus t-lymphocyte sensitization to a. fumigatus as demonstrated by these in vitro methods , although present in occasional patients , was not clearly related to any one particular clinical syndrome in this small group of patients with aspergillus related pulmonary disease . | NA | {
"id": "C0004037",
"name": "fumigatus",
"pos": [
38,
47
]
} | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
235,
246
]
} |
as long as the antibody is in slight excess or near equivalency , the antigen/antibody complex remains insoluble . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
15,
23
]
} | {
"id": "C0003313",
"name": "antigen/antibody complex",
"pos": [
70,
94
]
} |
it was shown that the free erythrocyte porphyrins are mixture of protoporphyrin 9 , the main component , and minor proportions of coproporphyrin , uroporphyrin iii and phyriaporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
39,
49
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
65,
79
]
} |
it was shown that the free erythrocyte porphyrins are mixture of protoporphyrin 9 , the main component , and minor proportions of coproporphyrin , uroporphyrin iii and phyriaporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
39,
49
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
130,
144
]
} |
the most variable amino acids are alanine , valine , metionine , isoleucine , leucine , tyrosine , phenylalanine , lysine and histidine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
18,
23
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
105,
112
]
} |
the elevated binding of dit to bovine serum is essentially due to albumin whose affinity constant for dit is 16-times higher than that of human serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
66,
73
]
} | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
138,
157
]
} |
the method is useful for differentiation of organ-specific proteins from serum proteins , for identification of identical and not-identical antibodies in antisera and for checking protein products and antisera for their purity . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
140,
150
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
201,
209
]
} |
the pterins are then converted to their corresponding trimethylsilyl derivatives and the base peaks of biopterin ( m/e 409 ) , neopterin ( m/e 409 ) and 6,7-dimethylpterin ( m/e 320 ) are determined . | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
103,
112
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
127,
136
]
} |
by means of this method , the urinary excretion of biopterin and neopterin from 9 healthy subjects has been determined . | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
51,
60
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
65,
74
]
} |
a specific and quantitative immunological method for determination of human erythrocyte carbonic anhydrase ( hca ) isoenzyme b has been used to determine the contents of enzyme in the erythrocytes from healthy persons and from subjects with different types of anemia . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
115,
124
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
170,
176
]
} |
the red cell gsh levels were low during the crisis , together with the levels of gssg : nadph reductase , gsh : h2o2 peroxidase , aspartate aminotransferase and alanine aminotransferase . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
81,
85
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
106,
109
]
} |
the concentration of urinary oxalic acid is calculated by using the difference between two determinations of calcium : first , the excess of calcium in the supernatant after precipitation as calcium oxalate at ph 5 , and second , the total calcium determined at ph less than 1 ( endogenous and added ) . | NA | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
29,
40
]
} | {
"id": "C0006706",
"name": "calcium oxalate",
"pos": [
191,
206
]
} |
analytical parameters ( ph of precipitation , temperature , calcium and oxalate added , precipitation time , interfering substances ) were studied with the aid of [ 14c ] oxalic acid . | NA | {
"id": "C0029988",
"name": "oxalate",
"pos": [
72,
79
]
} | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
171,
182
]
} |
from the clinical and genetic data available at the present time , is seems that the muscular dystrophy in the k. kindred is one of the varieties ( namely , a descending type with a `` '' jump '' '' ) of the facio-scapulo-limb ( or facioscapulohumeral ) muscular dystrophy . | NA | {
"id": "C0026850",
"name": "muscular dystrophy",
"pos": [
85,
103
]
} | {
"id": "C0238288",
"name": "facioscapulohumer",
"pos": [
232,
249
]
} |
this indicates the presence of a cross-reactivity between antigens in these bacteria , different from the o antigen , and antigens in thyroid epithelial cells . | NA | {
"id": "C0003321",
"name": "antigens",
"pos": [
58,
66
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
122,
130
]
} |
a soluble hapten ( dinitrobenzene sulphonic acid ( dnbso3 ) ) and particulate antigens consisting of dncb , dnfb or dnbso3 complexed with erythrocytes , all induce a specific blastogenic response and lymphokine production in leucocyte cultures from human subjects topically sensitized to dinitrochlorobenzene ( dncb ) . | NA | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
19,
33
]
} | {
"id": "C0012463",
"name": "dnfb",
"pos": [
108,
112
]
} |
there was no statistically significant correlation between the reactivity to lsp stimulation and the presence or absence of hepatitis-associated antigen ( hbag ) in serum , or with the biochemical liver parameters . | NA | {
"id": "C0019168",
"name": "hepatitis-associated antigen",
"pos": [
124,
152
]
} | {
"id": "C0019165",
"name": "hbag",
"pos": [
155,
159
]
} |
pretreatment of guinea-pigs with cyclophosphamide ( cy ) ( 300 mg/kg ) 3 days before cutaneous infection with leishmania enriettii caused an increased intensity of the lesion at the site of infection and an increase in the incidence of widespread metastases . | NA | {
"id": "C0037278",
"name": "cutaneous infection",
"pos": [
85,
104
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
190,
199
]
} |
it was found that cyclic amp , dibutyryl cyclic amp , theophyline , and prostaglandins e1 and e2 inhibited the production of leucocyte inhibiting factor by ha pulsed lymphocytes inhibition only occured when the drugs were present during or after the pha pulse . | NA | {
"id": "C0001455",
"name": "cyclic",
"pos": [
18,
24
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
31,
51
]
} |
these findings indicate that the lowering effect of cpib on non-esterified fatty acid concentrations derives principally from decreased mobilization rather than from increased tissue uptake of the fatty acids , and that this reflects both inhibited lipolysis and enhanced re-esterification of the fatty acids in adipose tissue . | NA | {
"id": "C0015688",
"name": "non-esterified fatty acid",
"pos": [
60,
85
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
297,
308
]
} |
a clinical evaluation was carried out in 19 patients with lichen ruber planus to assess the effectiveness of 0.05 % betamethasone-17,21-dipropionate ointment in the treatment of patients whose lesions had developed resistance to prolonged treatment with 0.1 % betamethasone-17-valerate ointment . | NA | {
"id": "C0005308",
"name": "betamethasone",
"pos": [
116,
129
]
} | {
"id": "C0750848",
"name": "betamethasone-17-valerate",
"pos": [
260,
285
]
} |
the in vitro and in vivo activity of the 5 injectable cephalosporins , cefazolin , cephaloridine , cephalothin , cephapirin , cephacetrile , and ampicillin was compared . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
54,
68
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
83,
96
]
} |
the in vitro and in vivo activity of the 5 injectable cephalosporins , cefazolin , cephaloridine , cephalothin , cephapirin , cephacetrile , and ampicillin was compared . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
54,
68
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
126,
138
]
} |
the in vitro and in vivo activity of the 5 injectable cephalosporins , cefazolin , cephaloridine , cephalothin , cephapirin , cephacetrile , and ampicillin was compared . | NA | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
99,
110
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
126,
138
]
} |
the in vitro and in vivo activity of the 5 injectable cephalosporins , cefazolin , cephaloridine , cephalothin , cephapirin , cephacetrile , and ampicillin was compared . | NA | {
"id": "C0007737",
"name": "cephapirin",
"pos": [
113,
123
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
126,
138
]
} |
pivmecillinam ( fl 1039 ) is the pivaloyloxymethyl ester of mecillinam ( fl 1060 ) which has considerable in vitro activity against enterobacteriaceae . | NA | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
0,
13
]
} | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
60,
70
]
} |
three enzymes are involved in the ionic pumps : carbonate dehydratase ( ec 4.2.1.1 ; carbonic anhydrase ) , sodium/potassium-stimulated adenosine-triphosphatase ( ec 3.6.1.3 , atpase ) and anion-stimulated atpase . | NA | {
"id": "C0001479",
"name": "sodium/potassium",
"pos": [
108,
124
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
206,
212
]
} |
trypsin-like and carboxypeptidase b-like proteinases are believed to play important roles in the conversion of proinsulin into insulin as well as in the intracellular processing of a variety of other precursor forms . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
111,
121
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
127,
134
]
} |
no protein co-migrating with proinsulin or insulin was detected in either the ascites or wheat-germ cell-free systems . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
29,
39
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
43,
50
]
} |
avidin mrna was separated from the bulk of the total messenger rna activity of the oviduct and from all ribosomal rnas to produce greater than a 1000-fold enrichment of avidin mrna activity compared with total cellular rna . | NA | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
104,
118
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
219,
222
]
} |
avidin mrna was separated from the bulk of the total messenger rna activity of the oviduct and from all ribosomal rnas to produce greater than a 1000-fold enrichment of avidin mrna activity compared with total cellular rna . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
7,
11
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
219,
222
]
} |
the following gradation of posttraumatic epilepsy is predicted for the 1,900,000 with the greater implication of brain damage : 1,340,000 will never have a seizure ; | NA | {
"id": "C0014557",
"name": "posttraumatic epilepsy",
"pos": [
27,
49
]
} | {
"id": "C0270611",
"name": "brain damage",
"pos": [
113,
125
]
} |
the effects of varying concentrations of the organophosphorus inhibitor e600 ( diethyl-p-nitrophenyl phosphate ) have been studied on the hydrolysis of a homologous series of n-alkyl aliphatic esters of alpha-naphthol by carboxylesterases of whole rat serum and by an esterase isozyme purified from the latter . | NA | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
221,
238
]
} | {
"id": "C0014894",
"name": "esterase",
"pos": [
268,
276
]
} |
chromatin solubility as a function of ionic strength shows a relaxation at salt concentrations higher than in the case of calf thymus nucleoprotein . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
0,
9
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
134,
147
]
} |
in aminoacyl-trna binding to ribosomes , there is only a limited turnover of the enzyme , but the protein acts catalytically in amino acid polymerization . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
3,
17
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
128,
138
]
} |
a requirement for divalent cation is best satisfied by mg2+ or ca2+ and the requirement for dna best by the single-stranded , circular dna of phages phix174 ( km 62 nm nucleotide ) and fd indicating that the enzyme recognizes internal dna regions . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
108,
123
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
235,
238
]
} |
the nuclear proteins are phosphorylated at decreasing rates in the order : labile-bound non-histone proteins greater than firmly bound non-histone proteins greater than 'free ' nuclear sap proteins = proteins of ribonucleoprotein particles greater than histones . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
4,
20
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
200,
208
]
} |
the nuclear proteins are phosphorylated at decreasing rates in the order : labile-bound non-histone proteins greater than firmly bound non-histone proteins greater than 'free ' nuclear sap proteins = proteins of ribonucleoprotein particles greater than histones . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
4,
20
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
253,
261
]
} |
the complex produced by the antibiotic and the fraction-3 enzyme is about ten times more stable and is formed about ten times more slowly than the complex with fraction-4 enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
58,
64
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
147,
154
]
} |
a series of bacterial cell wall glycopeptides of low molecular weight and cell wall nucleotide precursors have been tested for their inhibitory action on the digestion by t4 lysozyme of a radioactively labeled linear uncrosslinked peptidoglycan . | NA | {
"id": "C0017953",
"name": "glycopeptides",
"pos": [
32,
45
]
} | {
"id": "C0030958",
"name": "peptidoglycan",
"pos": [
231,
244
]
} |
the hypothesis has been formulated that when the former process is normal , a defect of fatty acid removal ( a low rate of fatty acid incorporation into glycerides ) may be responsible for an impaired removal of plasma triglyceride-fatty acids . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
153,
163
]
} | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
219,
231
]
} |
whereas at 37 degrees and 55 degrees amp inhibits synergistically with amino acids ( glycine , glutamine , histidine ) , the 75 degrees enzyme is inhibited directly by the products adp , ( which assumes the role of amp ) and glutamine , plus other ligands . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
71,
82
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
85,
92
]
} |
thermolysin and neutral protease a are neutral metalloendopeptidases having similar specificity , molecular weight , metal content , and amino acid composition . | NA | {
"id": "C0039815",
"name": "thermolysin",
"pos": [
0,
11
]
} | {
"id": "C1442934",
"name": "metalloendopeptidases",
"pos": [
47,
68
]
} |
the mammalian major histocompatibility system ( mhs ) includes genes determining the structure of the classical major transplantation antigens ( h-2k and h-2d ) , the i region-associated ( ia ) antigens , and genes determining the structure level or both of the first four components of complement . | NA | {
"id": "C0019628",
"name": "transplantation antigens",
"pos": [
118,
142
]
} | {
"id": "C0019630",
"name": "ia",
"pos": [
189,
191
]
} |
during the treatment cycles , plasma levels of estradiol , progesterone , and 17-hydroxyprogesterone remained within the range observed during the early follicular phase . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
59,
71
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
78,
100
]
} |
g6pd was localized in the cells of cortical stroma and hilus using a histochemical technique for the reduction of the tetrazolium salt , nitro-blue tetrazolium . | NA | {
"id": "C0039704",
"name": "tetrazolium salt",
"pos": [
118,
134
]
} | {
"id": "C0028147",
"name": "nitro-blue tetrazolium",
"pos": [
137,
159
]
} |
injection of ecdysterone into non-blood fed adult female aedes aegypti results in a marked stimulation of aromatic-l-amino-acid decarboxylase ( formerly dopa-decarboxylase ) activity ( schlaeger and fuchs , 1974a ) . | NA | {
"id": "C1412028",
"name": "aromatic-l-amino-acid decarboxylase",
"pos": [
106,
141
]
} | {
"id": "C0003806",
"name": "dopa-decarboxylase",
"pos": [
153,
171
]
} |
keto analogues of five essential amino acids ( valine , leucine , isoleucine , methionine , and phenylalanine ) were given either parenterally or orally in varying proportions to 11 patients with portal-systemic encephalopathy and hyperammonemia . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
23,
44
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
79,
89
]
} |
because aluminum solubility drops as ph is raised , those antacids which neutralize more effectively than aluminum hydroxide gel alone and which contain `` '' nonreactive '' '' aluminum hydroxide result in lower aluminum concentration and do not affect the rate of gastric emptying in animals or in man . | NA | {
"id": "C0002372",
"name": "aluminum hydroxide gel",
"pos": [
106,
128
]
} | {
"id": "C0002371",
"name": "aluminum hydroxi",
"pos": [
106,
122
]
} |
when the results were analyzed separately for extrahepatic ( 29 patients ) or intrahepatic ( 31 patients ) cholestasis , percutaneous cholangiography was successful in 95 % of patients with extrahepatic cholestasis but in only 25 % with intrahepatic cholestasis . | NA | {
"id": "C0008370",
"name": "cholestasis",
"pos": [
107,
118
]
} | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
237,
261
]
} |
[ determination of the total amount of rare earth elements of the yttrium subgroup and thorium in biological material ] . | NA | {
"id": "C0025556",
"name": "rare earth elements",
"pos": [
39,
58
]
} | {
"id": "C0043432",
"name": "yttrium",
"pos": [
66,
73
]
} |
effects on platelet aggregation were examined of acetylsalicylic acid ( asa ) , indomethacin and a number of other agents including dipyridamole , phenylbutazone and sulfinpyrazone under standardized conditions . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
147,
161
]
} | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
166,
180
]
} |
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