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the authors studied comparatively the properties of two angiotensin ii analogues , a new compound ( 1-hydantoin acid , 5-valine , 8-alanine ) -angiotensin ii ( compound iii ) and ( 1-asparagine , 5-valine , 8-alanine ) -angiotensin ii ( compound ii ) , as of the myotropic action of angiotensinamide ( these experiments were conducted on the rat isolated ascending colon ) ; | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
56,
70
]
} | {
"id": "C0003001",
"name": "angiotensinamide",
"pos": [
283,
299
]
} |
four microgrammes of 1-alpha-hydroxycholecalciferol ( 1-alpha-oh d3 ) or 200 mug of 25-hydroxycholecalciferol ( 25-oh d3 ) were given orally every other day respectively to 10 uraemic patients ( 8 on chronic haemodialysis ) for 1-12 weeks and to 3 patients on chronic haemodialysis for 4-8 weeks . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
84,
109
]
} | {
"id": "C2713074",
"name": "25-oh d3",
"pos": [
112,
120
]
} |
plasma concentrations of noradrenaline ( na ) , adrenaline ( a ) and renin ( r ) were measured in 29 regular haemodialysis patients ( rhp ) [ 13 normotensive , 10 hypertensive , 6 binephrectomised ] and in 15 healthy control subjects ( c ) under various physiological conditions : supine-standing-walking . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
48,
58
]
} |
here we show that several ribosomal proteins alone stimulate the synthesis of ( p ) ppgpp in the presence of stringent factor ( protein system ) . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
26,
44
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
128,
135
]
} |
measurements of cytidine 2'-phosphate binding during refolding , after stopped-flow dilution of guanidine hydrochloride ( gdn.hcl ) or urea , show that functional bovine pancreatic ribonuclease a ( rnase a ; | NA | {
"id": "C0035541",
"name": "pancreatic ribonuclease",
"pos": [
170,
193
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
198,
203
]
} |
a mutant j protein , with a defective interaction site but intact histidine-binding site , can function in histidine transport if an appropriate compensating mutation is introduced in the p protein . | NA | {
"id": "C1564139",
"name": "mutant",
"pos": [
2,
8
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
190,
197
]
} |
we conclude that in semliki-forest-virus-infected cells two polyproteins are synthesized , one for the structural ( 130,000 daltons ) , the other for the nonstructural proteins ( close to 300,000 daltons ) . | NA | {
"id": "C0032583",
"name": "polyproteins",
"pos": [
60,
72
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
168,
176
]
} |
the inhibitor has no effect on bovine carboxypeptidases a or b but exhibits homology with a carboxypeptidase inhibitor that is also present in potato tubers . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
38,
55
]
} | {
"id": "C0054755",
"name": "a carboxypeptidase",
"pos": [
90,
108
]
} |
a portion of the nicked circular dna isolated from purified simian virus 40 contains a protein-dna complex in which protein ( s ) is covalently attached to the end of a dna single strand . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
24,
36
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
169,
172
]
} |
these data suggest that 6-aminonicotinamide and dibutyryl camp induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
162,
174
]
} |
untransformed cells ( mouse 3t3 and chick fibroblasts ) , cells transformed by simian virus 40 ( sv 3t3 ) , and chick fibroblasts infected with schmidt-ruppin strain of rous sarcoma virus ( sr-rsv-a-infected cells ) were first compared for differences in microfilament and microtubule patterns after treatment with fluorescein-labeled antibodies to actin and tubulin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
42,
53
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
208,
213
]
} |
this morphine-like compound has biological activity as it inhibits the electrically induced contractions both of the guinea pig ileum and mouse vas deferens but the inhibition is not reversed by naloxone or naltrexone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
195,
203
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
207,
217
]
} |
a simple and rapid fractionation procedure of the three transcobalamins , tci , tcii , and tcii , of human serum was achieved by filtration through a stack of charged cellulose filters composed of one cellulose-nitrate and three deae-cellulose ( de-81 ) disks . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
167,
176
]
} | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
229,
243
]
} |
insulin biosynthesis by beta cell adenomata was demonstrated by in vitro incorporation of [ 14c ] leucine into proinsulin and insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
111,
121
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
126,
133
]
} |
the effect of oral administration of d-amphetamine ( 5 mg/kg ) , ethanol ( 2.5 g/kg ) , genever ( equivalent to 2.5 g/kg ethanol ) and the combinations d-amphetamine-ethanol and d-amphetamine-genever was studied on learning in the rat , using a shuttle-box in 4 sessions at 24 hr intervals . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
39,
50
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
178,
191
]
} |
acquisition was significantly favored by all treatments , being more constant in the 4 sessions when combinations d-amphetamine-ethanol and d-amphetamine-genever were administered . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
116,
127
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
140,
153
]
} |
injection of morphine sulfate ( 4 mg/kg ) 144 hr after implantation increased both the core temperature and the time taken to escape from heat suggesting that the effect of morphine in the dependent rat is to produce an upward setting of the thermostats . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
13,
29
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
173,
181
]
} |
systemic administration of 5-hydroxytryptophan or monoamine oxidase inhibition plus tryptophan administration abolishes the abnormal grooming behavior in each group of cats , and microinjections of 5-hydroxytryptophan or serotonin into the superior colliculi has the same effect , indicating that the change in a serotonergic system is a critical aspect of the abnormal behavior in cats with lesions and that a serotonergic system may also be involved in the genesis of the abnormal grooming behavior in thyroidectomized cats . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
36,
46
]
} | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
200,
217
]
} |
the data indicated , overall , that the dipsogenic effect of supraphysiological cerebral blood concentrations of angiotensin ii is biased to water drinking when the choice is between water and 900 mm nacl and kcl solutions . | NA | {
"id": "C0599638",
"name": "water drinking",
"pos": [
141,
155
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
183,
188
]
} |
thc caused an inhibition of the incorporation of 5-3h-uridine into ribosomal rna ( 17s and 25s rna ) and ribosomal precursor rna ( 35s rna ) of synchronized cells . | NA | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
67,
76
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
135,
138
]
} |
although both cl-dma and acryl-dma are inhibitors of chac , only cl-dma appears to have sufficient specificity for use as a possible chac inhibitor in vivo . | NA | {
"id": "C0008407",
"name": "chac",
"pos": [
53,
57
]
} | {
"id": "C0001068",
"name": "chac",
"pos": [
133,
137
]
} |
the inhibitory actions of polyphloretin phosphate ( ppp ) and related compounds , di-4-phloretin phosphate ( dpp ) , phloretin and trihydroxy propiophenone ( thpp ) on the contractile responses to prostaglandin ( pg ) and acetylcholine ( ach ) in longitudinal smooth muscle of guinea-pig stomach were studied . | NA | {
"id": "C0032574",
"name": "polyphloretin phosphate",
"pos": [
26,
49
]
} | {
"id": "C0031560",
"name": "phloretin",
"pos": [
117,
126
]
} |
[ physiology and physiopathology of ketone bodies , synthesis , utilization , psychological significance , metabolic control , hormonal factors and main ketone status ] . | NA | {
"id": "C0022631",
"name": "ketone bodies",
"pos": [
36,
49
]
} | {
"id": "C0022634",
"name": "ketone",
"pos": [
153,
159
]
} |
physiological measurements showed that imipramine pretreatment 2 hr prior to pentobarbital ( 70 mg/kg , ip ) enhanced barbiturate depression in mean blood pressure , oxygen consumption and respiration rate , but not in heart rate or back skin temperature . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
77,
90
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
118,
129
]
} |
blockade of selective neurotoxic induced depletions of biogenic amines is a useful in vivo technique for determining the effects of drugs on the amine uptake systems . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
55,
70
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
145,
150
]
} |
the toxic effects of these tryptamines are discussed with regard to the phenomena of specific neurodegeneration induced by 5,6- and 5,7-dihydroxytryptamines . | NA | {
"id": "C0041248",
"name": "tryptamines",
"pos": [
27,
38
]
} | {
"id": "C0012338",
"name": "dihydroxytryptamines",
"pos": [
136,
156
]
} |
no effect of hydroxycobalamin ( hco ) and cyanocobalamin ( cnco ) was observed on isolated cytochrome c oxidase . | NA | {
"id": "C0020316",
"name": "hydroxycobalamin",
"pos": [
13,
29
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
42,
56
]
} |
the drinking response produced by direct injection of angiotensin i and ii into the brain of the rat , was studied , using the angiotensin blocking agents sq-20,881 ( sq ) and p-113 ( saralasin ) . | NA | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
54,
67
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
127,
138
]
} |
these data indicate that conversion of angiotensin i to angiotensin ii is important in angiotensin-induced drinking , although an independent action of angiotensin i on drinking can not be ruled out at this time . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
56,
70
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
152,
163
]
} |
these data indicate that conversion of angiotensin i to angiotensin ii is important in angiotensin-induced drinking , although an independent action of angiotensin i on drinking can not be ruled out at this time . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
39,
50
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
152,
165
]
} |
the butyrophenone tranquilliser , azaperone , was administered intramuscularly to ponies in five series of experiments , using a dose level of 0-4 mg/kg once and 0-8 mg/kg four times . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
4,
17
]
} | {
"id": "C0004477",
"name": "azaperone",
"pos": [
34,
43
]
} |
this ratio was found to be normal in the right lung and tendentially high ( though not to a statistically significant degree ) in the left lung , this being probably due to the presence of an enlarged heart ( 13 patients showed evidence of right ventricle hypertrophy and/or overload ) . | NA | {
"id": "C0018800",
"name": "enlarged heart",
"pos": [
192,
206
]
} | {
"id": "C0162770",
"name": "right ventricle hypertrophy",
"pos": [
240,
267
]
} |
therefore , the relationship between plasma and csf hco3 changes was studied during 4 hours of respiratory alkalosis ( paco2=20 mm hg ) in anesthetized dogs when plasma hco3 : ( 1 ) fell normally , ( 2 ) kept 'normal ' by nahco3 infusion , ( 3 ) increased by infusing more nahco3 , and ( 4 ) reduced by infusing hcl . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
52,
56
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
273,
279
]
} |
four principal components to their arthritis emerged , namely : spondylitis , sacroiliitis , peripheral polyarthritis , oligoarthritis ( involvement of one or two large joints ) . | NA | {
"id": "C0003864",
"name": "arthritis",
"pos": [
35,
44
]
} | {
"id": "C0574960",
"name": "sacroiliitis",
"pos": [
78,
90
]
} |
antrum-bulb resection significantly reduced basal acid secretion and maximal acid responses to the humoral stimuli ( about 45 % reduction ) but did not significantly change the loss of gastric contents to the intestine or the sensitivity to the humoral stimuli ( median ed50 of pentagastrin increased from 5.2 to 6.7 mug/h in 14 patients , and median ed50 of histalog increased from 16.0 to 20.8 mg/h in 12 patients ) , suggesting that the intact antrum-bulb region of the ulcer patient is controlling the capacity to secrete acid , and indicating that antrum-bulb gastrin is an important trophic factor for the parietal cells in man . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
278,
290
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
565,
572
]
} |
the effect of long-term oral trypsin inhibitor administration on blood glucose , plasma insulin , liver , and muscle glycogen and glucose utilization in vitro by peripheral tissues in normal and diabetic rats was studied . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
65,
78
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
130,
137
]
} |
the absorption of iron from three different iron tablets - rapidly-disintegrating ferrous sulphate and ferrous carbonate tablets and slow-release ferrous sulphate tablets - was studied in healthy subjects with a serum iron technique and by whole-body counter measurements . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
18,
22
]
} | {
"id": "C0060282",
"name": "ferrous sulphate",
"pos": [
146,
162
]
} |
the effect of salicylates on erythrocyte 2,3-diphosphoglycerate ( 2,3-dpg ) and adenosine triphosphate ( atp ) was studied in vivo in 3 groups of healthy subjects receiving acetylsalicyclic acid ( 18 persons ) , sodium salicylate ( 5 persons ) and salicylamide ( 7 persons ) in therapeutic dosage . | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
14,
25
]
} | {
"id": "C0004057",
"name": "acetylsalicyclic acid",
"pos": [
173,
194
]
} |
at the same time it was demonstrated that the combination of trimethoprim and sulphamethoxazole ( co-trimoxazole ) has no effect on genital mycoplasma species . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
78,
95
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
98,
112
]
} |
the clinical efficacies of co-trimoxazole and nitrofurantoin were compared in patients with urinary-tract infections associated with significant bacteriuria with coliform bacteria tested and found to be sensitive to both drugs . | NA | {
"id": "C0042029",
"name": "urinary-tract infections",
"pos": [
92,
116
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
145,
156
]
} |
of 27 patients treated with co-trimoxazole , 23 were cured after 10 days ' treatment with 320 mg trimethoprim and 1600 mg sulphamethoxazole daily ( 85 % ) . | NA | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
28,
42
]
} | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
122,
139
]
} |
such varying prevalences of anf with disease types might indicate that jra is a syndrome rather than a disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
80,
88
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
103,
110
]
} |
a large number of families have now been described in whom affected individuals have within their plasmas an abnormal species of fibrinogen ( factor i ) . | NA | {
"id": "C0016013",
"name": "abnormal",
"pos": [
109,
117
]
} | {
"id": "C0016006",
"name": "factor i",
"pos": [
142,
150
]
} |
in contrast , the lesions in the sturge-weber syndrome showed a diffuse angiomatosis involving more than one-half of the choroid , as well as the episcleral and intrascleral perilimbal plexuses . | NA | {
"id": "C0038505",
"name": "sturge-weber syndrome",
"pos": [
33,
54
]
} | {
"id": "C0002992",
"name": "diffuse angiomatosis",
"pos": [
64,
84
]
} |
the prevalence of hepatitis-b antigen ( hb s ag ) and its antibody ( anti-hbs ) among 49 london hemophiliacs was compared with that among women attending an antenatal clinic and healthy blood donors from london and from two parts of the tropics ( mauritius and zambia ) . | NA | {
"id": "C0019165",
"name": "hepatitis-b antigen",
"pos": [
18,
37
]
} | {
"id": "C0019168",
"name": "hb s ag",
"pos": [
40,
47
]
} |
their antisera were active in antibody-induced cell-mediated cytotoxicity ( aicc ) and inhibited the mixed lymphocyte culture ( mlc ) , but were negative in complement-dependent cytoxicity ( cdc ) . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
6,
14
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
30,
38
]
} |
murine lymphoma cells were lysed by using either an allogeneic or a xenogeneic ( rat ) antiserum and antibody-dependent effectors from mice and rats . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
87,
96
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
101,
109
]
} |
the fact that the repopulating cells are not all donor type suggests that there are at least two classes of precursor cells that populate the immune system of w-anemic mice , and that not all classes are derived from the grafted cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
31,
36
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
108,
123
]
} |
previous experiments in this laboratory demonstrated a progressive decrease in cell-mediated cytotoxicity ( cmc ) against allogeneic tumor cells by immune spleen cells from mice repeatedly immunized with those tumor cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
122,
132
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
[ catheterization of the vena cava and determination of plasma noradrenaline and plasma adrenaline in the localization of pheochromocytoma ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
63,
76
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} |
streptomycin concentrations were determined in various calf tissues after i. m. administration of streptomycin sulphate preparation of rumanian provenience in the dose of l g pro toto using the biological diffusion method according to gartside ( 1960 ) . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
0,
12
]
} | {
"id": "C0038426",
"name": "streptomycin sulphate",
"pos": [
98,
119
]
} |
with increasing doses of paracetamol , urinary excretion of the glucuronide and sulphate conjugates reached a plateau , whereas the output of cysteine and mercapturic acid conjugates increased markedly . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
142,
150
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
155,
171
]
} |
checkerboard titrations revealed that the platelet reactivity of immune complexes formed was maintained in a range of up to 625-fold alterations of the antibody : antigen ratio . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
65,
81
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
152,
160
]
} |
if the frg took part in the game , ventricular extrasystoles were two times , auricular extrasystoles were four times more frequent than during games between foreign countries . | NA | {
"id": "C0151636",
"name": "ventricular extrasystoles",
"pos": [
35,
60
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
88,
101
]
} |
for comparison the serum immunoglobulin levels of iga , igg and igm were determined in 11 corpses of adults directly after death and again 1 or 2 days later . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
90,
97
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
123,
128
]
} |
by following feeding animals in the field and by analysis of their faeces we found that besides fruits they eat special leaves which afford steroidal sapogenins . | NA | {
"id": "C0038317",
"name": "steroidal",
"pos": [
140,
149
]
} | {
"id": "C0036188",
"name": "sapogenins",
"pos": [
150,
160
]
} |
further experiments using immunoprecipitation demonstrated two common antigenic components , a and c , and a partially common antigenic factor bb ( fig . 4 ) , and was the basis for a classification by three groups . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
70,
79
]
} | {
"id": "C0003316",
"name": "antigenic factor",
"pos": [
126,
142
]
} |
with frequent use of aminoglycoside antimicrobials and beta-lactam antibiotics in hospitals in the last few years , the number of bacterial strains resistant to these chemotherapeutics increased . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
21,
35
]
} | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
36,
50
]
} |
lately , strains of e. coli , klebsiella , enterobacter , serratia , proteus and pseudomonas resistant to many antimicrobials ( ampicillin , carbenicillin , cephalothin , chloramphenicol , gentamycin , tobramycin , sisomycin , neomycin , paromomycin , kanamycin , streptomycin , spectinomycin , tetracycline , sulphonamides ) were isolated from patients of the university hospital in zuerich . | NA | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
189,
199
]
} | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
215,
224
]
} |
lately , strains of e. coli , klebsiella , enterobacter , serratia , proteus and pseudomonas resistant to many antimicrobials ( ampicillin , carbenicillin , cephalothin , chloramphenicol , gentamycin , tobramycin , sisomycin , neomycin , paromomycin , kanamycin , streptomycin , spectinomycin , tetracycline , sulphonamides ) were isolated from patients of the university hospital in zuerich . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
227,
235
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
238,
249
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
173,
188
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
228,
238
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
173,
188
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
266,
278
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
173,
188
]
} | {
"id": "C0001268",
"name": "spectinomycin",
"pos": [
281,
294
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
173,
188
]
} | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
309,
323
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
203,
211
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
214,
225
]
} |
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described . | NA | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
228,
238
]
} | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
241,
250
]
} |
analysis of this inactivation with the radioactive methods of davies and his colleagues revealed that the kanamycins , neomycins , paromomycin and gentamycin a were phosphorylated . | NA | {
"id": "C0027603",
"name": "neomycins",
"pos": [
119,
128
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
131,
142
]
} |
for the elimination of o antibodies , this antiserum should be absorbed with a strain fim- of the same o group . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
25,
35
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
43,
52
]
} |
in order to study the correlations between the metabolism of biogenic monoamines and the type of development ) of schizophrenia , the morning urine excretion of 30 patients ( 15 with continuous progressive schizophrenia and 15 with shift-like forms of development ) was examined . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
47,
57
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
148,
157
]
} |
the author studied the percentage of distribution of data , dophamine , noradrenaline and adrenaline and the correlation between these ingredients in the catecholamine system , as well as the distribution of tryptophane . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
90,
100
]
} |
the inhibitory effects of antibiotic such as chloramphenicol and thiamphenicol are discussed from the point of possible complications for cardiac metabolism . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
45,
60
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
65,
78
]
} |
in vivo treatment of rabbits with the chloramphenicol analogue thiamphenicol causes a strong fall in the cytochrome aa3 content of the hearts . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
38,
53
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
63,
76
]
} |
ascites fluid in liver cirrhosis and heart failure , representing a true transudate , had a comparatively low protein content while the ascites fluid in inflammatory bowel diseases including crohn 's disease had high protein content . | NA | {
"id": "C0021390",
"name": "inflammatory bowel diseases",
"pos": [
153,
180
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
191,
207
]
} |
dextran 40 did not influence the formation of pulmonary metastases after intravenous tumour cell injection in untraumatized dextran non-sensitive wistar rats . | NA | {
"id": "C0011793",
"name": "dextran 40",
"pos": [
0,
10
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
124,
131
]
} |
the effects of cyclic amp and its analogue , dibutyryl cyclic amp ( dbcamp ) on the pigmentary system were studied by using human epidermal melanocytes in culture . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
15,
25
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
45,
65
]
} |
a 17-hydroxyprogesterone value of 1.0 ng/ml , or more , was seen for the first time in the cycle on the day of the lh peak in 13 cycles and a progesterone + 17-hydroxyprogesterone level of at least 1.8 ng/ml in 14 of the 15 cycles studies . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
12,
24
]
} | {
"id": "C0020387",
"name": "hydroxyprogesterone",
"pos": [
160,
179
]
} |
these data seem to warrant a study of the predictive value of progesterone and 17-hydroxyprogesterone assays in a much larger population . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
62,
74
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
79,
101
]
} |
in an attempt to find suitable animal models to aid in the study of the reproductive processes of the human male , plasma levels of unconjugated pregnenolone , 17-hydroxypregnenolone , dehydroepiandrosterone , 20alpha-dihydroprogesterone , 17-hydroxyprogesterone , androstenedione , testosterone , dihydrotestosterone , oestrone and oestradiol were measured in 18 male baboons and 10 male rhesus monkeys and the steroid levels were compared with those previously established in normospermic , middle-aged men . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
145,
157
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
160,
182
]
} |
whereas the approximate relationship of pregnenolone to 17-hydroxypregnenolone and dehydroepiandrosterone was 1:2:4 in men , the corresponding relationship was 1:5:30 in rhesus monkeys and 1:10:10 in baboons . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
40,
52
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
56,
78
]
} |
antibodies of various immunoglobulin classes against e. coli o antigens were determined with the enzyme-linked immunosorbent assay ( elisa ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
22,
44
]
} |
thus in early childhood , it may be difficult to differentiate between a normal child , a child with pseudohypoparathyroidism and a child with pseudo-pseudohypoparathyroidism unless the renal parathyroid hormone responsiveness is studied . | NA | {
"id": "C0033806",
"name": "pseudohypoparathyroidism",
"pos": [
101,
125
]
} | {
"id": "C0033835",
"name": "pseudo-pseudohypoparathyroidism",
"pos": [
143,
174
]
} |
the increased urinary protein excretion was dominated by albumin and the low molecular weight proteins retinol-binding protein ( rbp ) and beta2-microglobulin , indicating the presence of proximal tubular dysfunction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
57,
64
]
} |
of the sugars used for the production of citric acid , sucrose in an unautoclaved medium was found to be the best carbon source . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
7,
13
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
55,
62
]
} |
two protein peaks were obtained from each layer ( rs-ml-1 and rs-ml-2 from medium , and rs-hl-1 and rs-hl-2 from the heavy layer ) , corresponding to rs virus proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0042736",
"name": "virus",
"pos": [
153,
158
]
} |
no 16 or 23 ribosomal rna was found in the profiles of de novo synthesized rna in minicells . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
12,
25
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
75,
78
]
} |
plasma prekallikrein ( kallikreinogen ) and kallikrein inhibitor , assayed with the kaolin activable esterase method , have been evaluated in 20 patients with hepatic cirrhosis , in 12 cases with jaundice from acute viral hepatitis , and in 9 normal . | NA | {
"id": "C0033024",
"name": "kallikreinogen",
"pos": [
23,
37
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
44,
54
]
} |
these data confirm the implication of the prekallikrein-kallikrein system in severe liver diseases , and indirectly points out the role of the liver in maintaining the physiological balance of the kallikrein system . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
42,
55
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
197,
207
]
} |
in order to reveal the possible physiological role of the kallikrein during the stress of birth , the prekallikrein and kallikrein inhibitor were evaluated in 15 pregnant women and in 15 newborns from terminated pregnancies . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
102,
115
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
120,
130
]
} |
thus , the ideal goal can be achieved by immediate biological cure of hyperpituitarism with preservation of other pituitary functions , resulting in normal physiological eupituitarism . | NA | {
"id": "C0020506",
"name": "hyperpituitarism",
"pos": [
70,
86
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
114,
123
]
} |
histamine is generally considered as the principal chemical mediator in experimental allergy of type i and anaphylaxis . | NA | {
"id": "C0020523",
"name": "allergy",
"pos": [
85,
92
]
} | {
"id": "C0002792",
"name": "anaphylaxis",
"pos": [
107,
118
]
} |
the principal gases evolved during pouring and shakeout of castings include hydrogen , carbon monoxide , carbon dioxide , methane and other low molecular weight hydrocarbons with smaller amounts of ammonia , hydrogen cyanide , and sulfur dioxide . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
14,
19
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
198,
205
]
} |
the principal gases evolved during pouring and shakeout of castings include hydrogen , carbon monoxide , carbon dioxide , methane and other low molecular weight hydrocarbons with smaller amounts of ammonia , hydrogen cyanide , and sulfur dioxide . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
14,
19
]
} | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
231,
245
]
} |
the second stage is the major mitotic stage although the cells now resemble chondrocytes and cartilage matrix production evidently continues . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
57,
62
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
76,
88
]
} |
in the first part of this study , the effect of four isocaloric mixed breakfast meals on the blood glucose and urinary glucose losses was tested in nine adult diabetics and in three healthy subjects , ages 60 to 75 . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
93,
106
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
119,
126
]
} |
the serum levels of vitamin c in the deficient animals indicated a progressive state of ascorbic acid deficiency with time and this correlated well with clinical signs and symptoms of scurvy . | NA | {
"id": "C0003969",
"name": "of",
"pos": [
17,
19
]
} | {
"id": "C0036474",
"name": "scurvy",
"pos": [
184,
190
]
} |
type of standardization , i.e. , commercial serum , bovine serum albumin , human serum albumin , or pooled serum , did not appear to be a factor in the estimation of albumin in the normal serum submitted for analysis . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
75,
94
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
166,
173
]
} |
adults had higher local reaction rates than children and some vaccines containing larger amounts of viral antigen induced significantly higher rates of reactivity than did vaccines containing smaller amounts of antigen . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
100,
113
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
211,
218
]
} |
these arrhythmias include cardiac arrest due to ventricular fibrillation , recurrent ventricular tachycardia causing syncope or sustained ventricular tachycardia requiring electroversion . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
6,
17
]
} | {
"id": "C0042510",
"name": "cardiac arrest",
"pos": [
26,
40
]
} |
although the incidence of fatal arrhythmias in the mitral prolapse syndrome is probably small , we suggest that such arrhythmias may not be extremely rare , particularly among those patients who have repolarization abnormalities in the resting electrocardiogram and frequent premature beats . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
32,
43
]
} | {
"id": "C0340464",
"name": "premature beats",
"pos": [
275,
290
]
} |
the results indicate that the renal synthesis of prostaglandins is increased in bartter 's syndrome and that prostaglandins mediate the hyperreninemia and hyperaldosteronism which characterize the disorder . | NA | {
"id": "C0004775",
"name": "bartter 's",
"pos": [
80,
90
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
155,
173
]
} |
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