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stringlengths 57
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stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
during diving there are dramatic increases in both epinephrine and norepinephrine concentrations , which returned to control values by 30 min of the postdiving recovery period . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
67,
81
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
187,
194
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
206,
213
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
253,
273
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
253,
273
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
304,
311
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
253,
273
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
301,
311
]
} |
comparison of amino acid release , normalized for phenylalanine concentration , suggested the following alterations in amino acid metabolism by the wounded tissue : depressed threonine , glycine serine and alanine release , and increased release of the branched chain amino acids ( bcaa ) , leucine , isoleucine , and valine . | NA | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
253,
273
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
318,
324
]
} |
the diagnosis of lymphoma was based on the identification of monomorphous foci of atypical lymphoid cells except in the cases of hodgkin 's disease . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
17,
25
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
129,
147
]
} |
with antibody 18 and other monoclonal antibodies of known specificity , da2 and genox 3.53 , we showed that a remarkably high proportion of human pulmonary macrophages express hla-dr framework and dc1 polymorphic determinants in culture . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
27,
48
]
} |
more radical procedures than wide local excision are not justified for cystosarcoma phylloides which behaves more like a soft tissue sarcoma than a breast gland tumor . | NA | {
"id": "C0010701",
"name": "cystosarcoma phylloides",
"pos": [
71,
94
]
} | {
"id": "C1261473",
"name": "soft tissue sarcoma",
"pos": [
121,
140
]
} |
early jaundice group bilirubinemia was x = 7.4 ( sd +/- 1.59 mg./dl . at 14 ( +/- 6.6 ) hours of age , and physiologic jaundice group bilirubinemia was x = 9.8 ( sd +/- 2.25 ) mg./dl . at 53 ( +/- 21.3 ) hours at age . | NA | {
"id": "C0022346",
"name": "jaundice",
"pos": [
6,
14
]
} | {
"id": "C0020433",
"name": "bilirubinemia",
"pos": [
134,
147
]
} |
on the other hand , some parameters deserve to be searched : family antecedents ( greater than 60 p. 100 ) , obesity ( approximately 20 p. 100 ) , ocular repercussion ( approximately 15 p. 100 ) , perturbation of lipidemia , above all hypertriglyceridemia , hyperuricemia and urinary sediment abnomalies . | NA | {
"id": "C0020473",
"name": "lipidemia",
"pos": [
213,
222
]
} | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
235,
255
]
} |
using agarose isoelectric focusing , the isoenzyme patterns of 7 different enzymes were compared in 52 naegleria strains . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
41,
50
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
75,
82
]
} |
relaxin-induced elevations of cathepsin b and dipeptidyl peptidase i in the mouse pubic symphysis , with localization by fluorescence enzyme histochemistry . | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
30,
39
]
} | {
"id": "C0058361",
"name": "dipeptidyl peptidase i",
"pos": [
46,
68
]
} |
full-thickness chest wall defects after ablative surgery for metastatic cancer , trauma , infection , or irradiation injury have posed major and often impossible dilemmas for reconstruction . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
81,
87
]
} | {
"id": "C0034530",
"name": "irradiation injury",
"pos": [
105,
123
]
} |
these findings can be explained either by the presence of two alleles at a different sord locus determining the enzyme in seminal plasma or by the formation of secondary isozymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
112,
118
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
170,
178
]
} |
parents ' body-build and number of siblings were more strongly related to our measures of obesity in the older age groups and in girls , whereas child 's birth-weight was more associated with weight for height and triceps skinfold in the younger age groups . | NA | {
"id": "C0005612",
"name": "birth-weight",
"pos": [
154,
166
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
192,
198
]
} |
however , the increase in the association between our measures of obesity in parents and older children provides a possible tool for the early detection of children who may become obese . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
89,
103
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
156,
164
]
} |
continued effort in investigating the chemically induced peripheral neuropathy is essential not only to define the precise molecular mechanism , but to advance our basic understanding of other polyneuropathies as well . | NA | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
57,
78
]
} | {
"id": "C0152025",
"name": "polyneuropathies",
"pos": [
193,
209
]
} |
pnmt inhibitors currently represent the only means of modifying epinephrine neurons pharmacologically without also altering norepinephrine or dopamine neurons in brain . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
64,
75
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
124,
138
]
} |
most morganella , proteus rettgeri , proteus vulgaris , and proteus inconstans were inhibited at concentrations below 1 mg/liter , similar to the concentrations for moxalactam , ceftizoxime , and cefotaxime . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
178,
189
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
196,
206
]
} |
ceftazidime was not hydrolyzed by staphylococcal beta-lactamase or plasmid beta-lactamase of the tem-1 , tem-2 , shv-1 , oxa-1 , pse-1 , pse-2 types or by inducible beta-lactamases of the cephalosporinase type . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
165,
180
]
} | {
"id": "C0728805",
"name": "cephalosporinase",
"pos": [
188,
204
]
} |
all strains carried genetic markers for high-level resistance to streptomycin , kanamycin , neomycin , lividomycin a , and ribostamycin , as well as resistance to macrolides and related drugs , tetracycline , and chloramphenicol . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
92,
100
]
} | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
123,
135
]
} |
the in vitro activity of n-formimidoyl thienamycin was determined against 800 gram-positive and gram-negative aerobic and anaerobic bacteria and compared with the activity of cefoxitin , cefazolin , cefamandole , cefotaxime , moxalactam , ampicillin , cefoperazone , and gentamicin . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
199,
210
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
252,
264
]
} |
the in vitro susceptibility of eight strains of varicella-zoster virus ( vzv ) to e-5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) was examined in human embryonic fibroblasts by the following techniques : inhibition of focus formation by either cell-free vzv ( 4-day assay ) or cell-associated vzv ( 2-day assay ) , inhibition of viral antigen formation ( 2-day assay ) , and inhibition of viral cytopathogenicity ( 15-day assay ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
277,
281
]
} |
effect of clindamycin , erythromycin , lincomycin , and tetracycline on growth and extracellular lipase production by propionibacteria in vitro . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
10,
21
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
39,
49
]
} |
two propionibacteria identified as propionibacterium acnes and propionibacterium granulosum were grown anaerobically in the presence of growth subinhibitory concentrations ( 0.25 and 0.5 minimal inhibitory concentrations ) of clindamycin , erythromycin , lincomycin , and tetracycline . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
226,
237
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
255,
265
]
} |
the results showed that lincomycin and clindamycin could inhibit the production of the enzyme by both strains with little effect on their growth rates . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
24,
34
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
39,
50
]
} |
the uptake , distribution , and anabolism of the nucleoside analog 9- ( 2-hydroxyethoxymethyl ) guanine ( acyclovir ) were compared in herpes simplex virus-infected and uninfected mice . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
96,
103
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
106,
115
]
} |
they inhibited not only penicillinase-type beta-lactamases but also cephalosporinase-type beta-lactamases , which were insensitive to clavulanic acid . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
24,
37
]
} | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
90,
105
]
} |
they inhibited not only penicillinase-type beta-lactamases but also cephalosporinase-type beta-lactamases , which were insensitive to clavulanic acid . | NA | {
"id": "C0728805",
"name": "cephalosporinase",
"pos": [
68,
84
]
} | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
90,
105
]
} |
in combination with beta-lactam antibiotics such as ampicillin , carbenicillin , and cefazolin , carpetimycins a and b showed synergistic activities against beta-lactam-resistant bacteria . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
20,
43
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
157,
168
]
} |
it appears , therefore that in the three organisms , the carbon atoms of the beta-lactam ring of the monobactam are derived directly from serine without the loss of the c-3 hydrogen atoms , probably by an sn2 ring closure mechanism . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
77,
88
]
} | {
"id": "C0026458",
"name": "monobactam",
"pos": [
101,
111
]
} |
with [ methyl-14c ] methionine , most of the radioactivity in the monobactam from acetobacter sp . was in the methyl moiety of the beta-lactam ring methoxyl group . | NA | {
"id": "C0026458",
"name": "monobactam",
"pos": [
66,
76
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
131,
142
]
} |
cephalosporins possessing a 1 , 3-dithiolane , 1 , 3-dithiane , or 1 , 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii , proteus rettgeri , and proteus inconstans , which were not inhibited by clavulanic acid , a well-known beta-lactamase inhibitor . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
0,
14
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
160,
173
]
} |
a combination of a dithiolane cephalosporin and cephaloridine synergistically inhibited in vitro growth of strains of p. morganii , p. rettgeri , p. inconstans , enterobacter aerogenes , enterobacter cloacae , and serratia marcescens . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
30,
43
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
48,
61
]
} |
with a greater dosage ( 3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg ) , the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml . | NA | {
"id": "C0110038",
"name": "clavulanate",
"pos": [
34,
45
]
} | {
"id": "C0055860",
"name": "clavulanic acid",
"pos": [
147,
162
]
} |
the activities of n-formimidoyl thienamycin and azlocillin were compared with those of tobramycin , gentamicin , amikacin , and ticarcillin against 175 pseudomonas aeruginosa isolates , including 24 strains with known mechanisms of resistance to aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
100,
110
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
246,
261
]
} |
the main amino acids of the toxin were glutamic acid , asparatic acid , alanine , glycine , arginine , and leucine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
9,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
72,
79
]
} |
the main amino acids of the toxin were glutamic acid , asparatic acid , alanine , glycine , arginine , and leucine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
9,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
82,
89
]
} |
a total of 75 compounds , including antioxidants , preservatives , gallic acid and p-hydroxybenzoic acid esters , hydroquinones , hydroxyquinolines , phenol derivatives , and related compounds , were screened for their antibotulinal activity in prereduced thiotone-yeast extract-glucose broth . | NA | {
"id": "C0020307",
"name": "hydroquinones",
"pos": [
114,
127
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
150,
156
]
} |
the development of three different autoimmune disorders in this patient may be related to the presence of hla-b8 and hla-dw3 , the prevalence of which is known to be increased in celiac disease and keratoconjunctivitis sicca and that of hla-b8 in autoimmune thrombocytopenic purpura . | NA | {
"id": "C0004364",
"name": "autoimmune",
"pos": [
35,
45
]
} | {
"id": "C0398650",
"name": "autoimmune thrombocytopenic",
"pos": [
247,
274
]
} |
[ examinations by psychological tests in basic stages and pure residual syndromes of schizophrenic diseases ( author 's transl ) ] . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
72,
81
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
99,
107
]
} |
reversible postpsychotic asthenic basic stages could not be significantly differentiated in psychological tests from pure residual syndromes which were comparable with regard to sex and age at the onset of the disease and -- in the pure residues group of 1980 -- with regard to age and school success . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
131,
140
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
210,
217
]
} |
male wistar rats were fed a fluoride deficient diet ( less than 0.5 parts/10 ( 6 ) f ) , and either distilled water or fluoridated water ( 1.0 parts/10 ( 6 ) ) . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
100,
115
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
131,
136
]
} |
for the purpose of improving the repeated attacks of vertigo , isosorbide as an oral hyperosmotic diuretic was first administered orally to 21 patients with meniere 's disease from november 1979 to january 1981 for reducing the endolymphatic hydrops that can be presumed to be of pathogenetic importance . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
157,
175
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
228,
249
]
} |
no correlation existed between aortic dilatation and severity of disease estimated by acute phase proteins -- caerulo plasmin , alpha 1-antitrypsin , alpha 1 acid glycoprotein , ferritin and c reactive protein . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
86,
106
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
128,
147
]
} |
no correlation existed between aortic dilatation and severity of disease estimated by acute phase proteins -- caerulo plasmin , alpha 1-antitrypsin , alpha 1 acid glycoprotein , ferritin and c reactive protein . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
86,
106
]
} | {
"id": "C0029297",
"name": "alpha 1 acid glycoprotein",
"pos": [
150,
175
]
} |
no correlation existed between aortic dilatation and severity of disease estimated by acute phase proteins -- caerulo plasmin , alpha 1-antitrypsin , alpha 1 acid glycoprotein , ferritin and c reactive protein . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
86,
106
]
} | {
"id": "C0006560",
"name": "c reactive protein",
"pos": [
191,
209
]
} |
also the combination of ipratropium bromide and terbutaline aerosols was compared with both ipratropium and terbutaline alone in short-term and long-term studies . | NA | {
"id": "C0700580",
"name": "ipratropium bromide",
"pos": [
24,
43
]
} | {
"id": "C0027235",
"name": "ipratropium",
"pos": [
92,
103
]
} |
the assimilatory nitrite reductase ( ferredoxin : nitrite oxidoreductase , ec 1.7.7.1 ) from barley ( hordeum vulgare l. ) leaves has been purified over 1500-fold with a recovery of 30 % and a specific activity of 84 mumol of nitrite reduced/min per mg of protein . | NA | {
"id": "C0068815",
"name": "assimilatory nitrite reductase",
"pos": [
4,
34
]
} | {
"id": "C0028135",
"name": "nitrite oxidoreductase",
"pos": [
50,
72
]
} |
glutamic acid , glutamine , and other 15 studied amino acids , added separately at a concentration of 10 or 20 mm to the growing culture , have no effect on the activity of the enzyme . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
0,
13
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
16,
25
]
} |
the chromatophores of rhodospirillum rubrum were found to synthesize in the light not only atp and pyrophosphate but also high molecular weight polyphosphates . | NA | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
99,
112
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
144,
158
]
} |
the development of a new form of cancer chemotherapy by selectively harnessing and stimulating the lipotropic response of the host to a tumour is discussed in terms of the administration of fatty acids which possess specific properties while as the same time raising plasma nefa concentrations and maintaining them at an elevated level . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
190,
195
]
} | {
"id": "C0015688",
"name": "nefa",
"pos": [
274,
278
]
} |
comparison with related myeloproliferative disorders shows that myelofibrosis occurs somewhat less frequently than chronic granulocytic leukaemia and considerably less so than polycythaemia vera . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
24,
52
]
} | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
64,
77
]
} |
the procedure involves partial digestion of the covalently closed circular plasmid dna with an appropriate restriction endonuclease under conditions which allow accumulation of unit-length linear dna molecules , a controlled digestion of the exposed 5 ' ends with the lambda 5'-exonuclease , and in vivo recircularization of the resulting linear dna in a bacterial host cell . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
66,
74
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
346,
349
]
} |
treatment was accompanied by a marked reduction in the proglucagon-like component and the appearance of pancreatic glucagon ( molecular weight of 3500 daltons ) as the major post-therapy fraction . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
55,
66
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
115,
123
]
} |
in addition , the effect of different equimolar concentrations of acetone , acetic acid , ethanol , and sodium acetate was compared at two glucose levels . | NA | {
"id": "C0000983",
"name": "acetic acid",
"pos": [
76,
87
]
} | {
"id": "C0142785",
"name": "sodium acetate",
"pos": [
104,
118
]
} |
restriction enzyme analysis and nucleic acid hybridisation show that there is a repeated sequence in human male dna which is not present in human female dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
19,
20
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
153,
156
]
} |
adrenaline ( 1 or 10 mg/kg ) given as a s.c. depot in oil produced a significant increase of serum ck , as well as noradrenaline ( 0.1 , 1 , or 10 mg/kg ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
115,
128
]
} |
approximately 60 % of associated 4s rna is successively released during treatment of viral rna with increasing formamide concentration , concomitantly with the transition of 60s rna aggregate through 50 -- 55s rna intermediate into the final 30 -- 40s rna subunits . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
85,
94
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
252,
255
]
} |
the lipid fractions free fatty acids , triglycerides , cholesterol , cholesterol esters and phospholipids of rat kidney cortex , outer and inner medulla were analyzed by thin-layer chromatography . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
55,
66
]
} | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
69,
80
]
} |
the author concluded that these extravasation of contrast media not only demonstrated the bleeding artery but also indicated the process of the hematoma formation in each case . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
90,
98
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
144,
152
]
} |
pituitary cyclic amp levels were increased 10 min after the intraveneous injection of 2 mg dibutyryl cyclic amp ( db-cyclic amp ) or 25 mg aminophylline . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
91,
111
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
117,
127
]
} |
inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan : blockade by inhibiting serotonin synthesis with ro-4-4602 . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
42,
52
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
57,
76
]
} |
dose-response relationships between systemically administered l-tryptophan or l-5-hydroxytryptophan and raphe unit activity in the rat . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
64,
74
]
} | {
"id": "C0000578",
"name": "l-5-hydroxytryptophan",
"pos": [
78,
99
]
} |
our two epileptic patients showing marked purkinje cell loss before cerebellar stimualtaion appeared to have better seizure control during stimulation than the patient who had only mild reduction in purkinje cell density . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
8,
17
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
116,
123
]
} |
the meaning of the change of systemic pain is discussed , with special reference to the possible correlation with the hypothesis of a central origin of pain in essential headaches . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
38,
42
]
} | {
"id": "C0018681",
"name": "headaches",
"pos": [
170,
179
]
} |
[ the action of reserpine on the concentration of 5-hydroxytryptamine , epinephrine and norepinephrine in the venous blood of migraine patients ] . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} |
an approach to dietary management of lactose intolerance is given and use of a carbohydrate-free formula in secondary monosaccharide intolerance is described . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
79,
91
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
118,
132
]
} |
experience with a cryoprobe for the surgical removal of encapsulated and circumscribed tumors , cysts , and neoplasms in the posterior orbit indicates that the instrument is a useful and efficient adjunct to the surgical management of orbital tumors . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
87,
93
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
96,
101
]
} |
[ use of corticosteroid hormones and enzyme preparations in local treatment of injuries of the musculo-skeletal apparatus in sportsmen ] . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
9,
23
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
24,
32
]
} |
the qualitative content of ingested fats has , too , a great influence : lipids containing short and medium-chain fatty acids , essential fatty acids and oleic acid stimulate calcium absorption . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
36,
40
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
73,
79
]
} |
in adult pathology , lipidic deficiency of steatorrhea is partially responsible for calcium and vitamin d malabsorption . | NA | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
43,
54
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
106,
119
]
} |
repeated daily administration of an oral dose of 1000 mg of alpha-methyl-dopa ( methyl dopa ) to conscious dogs produced a conditioned adaptive hypertensive systolic and diastolic arterial pressure response along with the direct hypotensive pharmacological effect . | NA | {
"id": "C0025741",
"name": "alpha-methyl-dopa",
"pos": [
60,
77
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
87,
91
]
} |
the specific radioactivity expressed per mg of protein was similar for both schilder and control fibroblasts . tafter labeling the pre-existing cellular cholesterol pool , the rate of loss of label was followed up for a 6-day period . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
97,
108
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
144,
152
]
} |
intestinal absorption of proline , hydroxyproline , and glycine was interpreted by investigation of a type i hyperprolinemia patient and six control subjects . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
25,
32
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
35,
49
]
} |
when proline ( pro ) , hydroxyproline ( oh-pro ) , and glycine ( gly ) were infused together , an increase in proline concentration did not alter aminoacid uptake in the control subjects ; | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
23,
37
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
110,
117
]
} |
when hydroxyproline was infused with an increased concentration of proline in the hyperprolinemic patient , hydroxyproline uptake first increased ( 9.8 -- 14.3 mum/min/20 cm ) then decreased to its basal value , whereas , in the control subjects , uptake increased without decreasing subsequently . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
12,
19
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
108,
122
]
} |
human chorionic gonadotropin ( hcg ) concentrations were determined in paired maternal and cord sera using an essay specific for the beta subunit of hcg . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
31,
34
]
} | {
"id": "C0106132",
"name": "beta subunit",
"pos": [
133,
145
]
} |
mean cord hcg concentrations of male ( 0.09 +/- 0.02 iu/ml ) and female ( 0.09 +/- 0.04 iu/ml ) infants were not different as determined by the beta hcg assay . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
10,
13
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
144,
152
]
} |
an ultrastructural study of chick embryo fibroblasts infected with herpesvirus of turkeys ( hvt ) revealed that infection produced degenerative effects in the cells ranging from alteration of cellular structures to complete lysis of the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
237,
242
]
} |
previous studies ( parizek et al. , 1969 ) have shown significant interactions between selenium and certain heavy metals , particularly mercury and cadmium . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
108,
120
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
136,
143
]
} |
previous studies ( parizek et al. , 1969 ) have shown significant interactions between selenium and certain heavy metals , particularly mercury and cadmium . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
108,
120
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
148,
155
]
} |
electrophoretic gels of serum from birds fed lead containing diets showed increased protein bands in the transferrin and globulin regions regardless of the presence of 1 p.p.m . selenium . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
121,
129
]
} |
l-aspartic acid , l-alanine and the mixture of dispensable amino acids devoid of l-glutamic acid were found not as effective as l-glutamic acid . | NA | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
18,
27
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
59,
70
]
} |
in the first study , 15 % protein diets were formulated using either whole egg protein , soybean meal , safflower meal or casein , or the latter 3 proteins supplemented with their most limiting amino acid ( methionine , lysine and arginine , respectively ) . | NA | {
"id": "C0013700",
"name": "egg protein",
"pos": [
75,
86
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
147,
155
]
} |
fractionation studies showed that a protective factor in linseed meal was extracted by methanol and ethanol and was not destroyed by autoclaving . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
87,
95
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
100,
107
]
} |
it is suggested that a portion of the arginine in rapeseed meal may be required for metabolic processes involved in tannic acid excretion . | NA | {
"id": "C0025519",
"name": "metabolic processes",
"pos": [
84,
103
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
128,
137
]
} |
infections of coccidia and low levels of methionine , which in themselves did not produce any significant change in weight gain , did give a significant weight depression in combination . | NA | {
"id": "C0005911",
"name": "change in weight",
"pos": [
106,
122
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
153,
159
]
} |
rate of egg production , average egg weight , feed consumption , and body weight change during the experiment were not significantly affected by and dietary treatments . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
37,
43
]
} | {
"id": "C0005911",
"name": "body weight change",
"pos": [
69,
87
]
} |
quail drenched with plain water or tylosine had less ( p less than .01 ) mortality than those given tylosin in the drinking water or the untreated control birds . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
26,
31
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
115,
129
]
} |
significant differences between an iron source with known low availability ( ferric oxide ) and a highly available iron source ( ferrous sulfate ) were not detected with the degerminated corn-fish meal-isolated soy or the degerminated corn-fish meal-dehulled soy diets . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
35,
39
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
129,
144
]
} |
the enzymatic activity of tissues of insulomas and also the proinsulin and insulin content in them was studied . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
60,
70
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
75,
82
]
} |
proinsulin content in the tumours of the islar tissue depended on the presence in them of an enzyme catalyzing the splitting of the substrate at ph 6.8 -- 7.2 , this pointing to its participation in the conversion of proinsulin into insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
233,
240
]
} |
proceeding from the evidence on the role played by calcium and cyclic 3 ' -- 5'-adenosinmonophosphate in the regulation of the external pancreatic secretion the effect of calcium gluconate and euphylline was tested ; | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
51,
58
]
} | {
"id": "C0006699",
"name": "calcium gluconate",
"pos": [
171,
188
]
} |
the paper discusses of the results of treatment with preparations of phenylethylbiguanide ( dibotin , meltrol , dipar , dibophen-retard ) , of butylbiguanide ( silubin-retard , buforming-retard ) and of dimethyl-biguanide ( glucophage-retard ) . | NA | {
"id": "C0031404",
"name": "phenylethylbiguanide",
"pos": [
69,
89
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
212,
221
]
} |
the paper discusses of the results of treatment with preparations of phenylethylbiguanide ( dibotin , meltrol , dipar , dibophen-retard ) , of butylbiguanide ( silubin-retard , buforming-retard ) and of dimethyl-biguanide ( glucophage-retard ) . | NA | {
"id": "C0006359",
"name": "butylbiguanide",
"pos": [
143,
157
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
212,
221
]
} |
prolonged administration to male sexually-mature rats weighing 180-200 g of hydrocortisone , protamine-zinc-insulin enhanced considerably the synthesis of dna-like rna , precursor of ribosomal rna in the nuclei and ribosomal rna in the cytoplasm of the liver ; | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
164,
167
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
215,
228
]
} |
the data obtained were in favour of the participation of dna-like rna , precursor of ribosomal rna of the nuclei and ribosomal rna of the cytoplasm of the liver of male sexually-mature rats in the synthesis of transaminases of their liver . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
66,
69
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
117,
130
]
} |
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