Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "We", "have", "examined", "the", "effects", "of", "RA", "on", "normal", "hematopoiesis", "by", "using", "early", "hematopoietic", "progenitor", "cells", "(", "HPC", ")", "stringently", "purified", "from", "adult", "peripheral", "blood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Jak", "2", "was", "tyrosine", "phosphorylated", "within", "1", "to", "3", "min", "after", "stimulation", "of", "eosinophils", "with", "IL-5", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0 ]

[ "We", "find", "that", "the", "dissociation", "constant", "of", "rapamycin", "to", "the", "FK506", "binding", "protein", "FKBP", "(", "Kd", "=", "0.2", "nM", ")", "is", "close", "to", "the", "dissociation", "constant", "of", "FK506", "to", "FKBP", "(", "Kd", "=", "0.4", "nM", ")", "and", "to", "their", "effective", "biologic", "inhibitory", "concentrations", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "results", "demonstrate", "that", "physiologic", "concentrations", "of", "all", "three", "of", "these", "agents", "inhibit", "the", "anti-CD3", "mAb", "-induced", "proliferation", "of", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0 ]

[ "Interestingly", ",", "the", "tissue", "pattern", "of", "expression", "of", "the", "NFAT-1", "activity", "resembles", "the", "expression", "pattern", "described", "for", "HIV-LTR/tat", "transgenic", "mice", "(", "Vogel", ",", "J.", ",", "Hinrichs", ",", "S.", "H.", ",", "Reynolds", ",", "R.", "K.", ",", "Luciw", ",", "P.", "A.", ",", "and", "Jay", ",", "G.", "(", "1988", ")", "Nature", "335", ",", "606-611", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "studied", "mutations", "in", "the", "5", "'", "noncoding", "region", "of", "the", "Bcl6", "gene", "in", "different", "subtypes", "of", "lymphomas", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]

[ "Activity", "of", "the", "CBF", "site", "is", "shown", "to", "be", "critically", "dependent", "on", "the", "adjacent", "activator", "site", "Act-1", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "The", "effect", "is", "mediated", "by", "the", "NF-kappa", "B", "transcription", "factor", "which", "is", "potently", "and", "rapidly", "activated", "by", "an", "H2O2", "treatment", "of", "cells", "from", "its", "inactive", "cytoplasmic", "form", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Gel", "retardation", "and", "methylation", "interference", "studies", "revealed", "that", "bacterially", "produced", "AP-2", "bound", "specifically", "and", "with", "high", "affinity", "to", "all", "three", "21", "bp", "repeats", ",", "and", "that", "it", "required", "the", "core", "sequence", "AGGC", "for", "specific", "binding", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "(", "ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")" ]

[ 0, 0, 0, 0, 0, 0, 0 ]

[ "[", "The", "value", "of", "the", "clinical", "test", "of", "glucocorticoid", "receptors", "of", "peripheral", "blood", "leukocytes", "in", "patients", "with", "chronic", "pulmonary", "heart", "disease", "]" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "other", "neuroblastoma", "cell", "lines", ",", "such", "as", "SK-N-Be", "(", "2", ")", ",", "the", "lack", "of", "PMA", "induction", "of", "differentiation", "was", "correlated", "with", "the", "lack", "of", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 5, 6, 6, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "Because", "the", "DSE", "are", "also", "TRE", "sites", ",", "we", "assessed", "the", "effect", "of", "the", "agonist", "combinations", "on", "AP-1", "-dependent", "transcription", "." ]

[ 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "Glucocorticoid", "receptors", "in", "systemic", "lupus", "erythematosus", "." ]

[ 9, 10, 0, 0, 0, 0, 0 ]

[ "The", "molecule", "bound", "CD40", "with", "a", "high", "affinity", "(", "2.2", "nM", ")", "and", "was", "a", "monomer", "in", "solution", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Neutral", "SMase", "activity", "was", "assessed", "in", "membranes", "from", "Jurkat", ",", "a", "human", "T-cell", "line", ",", "and", "EL4", ",", "a", "murine", "T-cell", "line", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 5, 0, 0, 5, 6, 6, 0, 0, 5, 0, 0, 5, 6, 6, 0 ]

[ "A", "human", "homologue", "of", "the", "Drosophila", "Toll", "protein", "signals", "activation", "of", "adaptive", "immunity", "[", "see", "comments", "]" ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]

[ 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "shortened", "life", "span", "of", "EKLF-/-", "adult", "erythrocytes", ",", "due", "to", "a", "deficiency", "of", "beta-globin", "chains", ",", "is", "ameliorated", "by", "human", "gamma-globin", "chains", "." ]

[ 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Our", "findings", "show", "that", "suppression", "of", "NF-kappa", "B", "activity", "with", "cell-permeable", "SN50", "peptide", ",", "which", "masks", "the", "nuclear", "localization", "sequence", "of", "NF-kappa", "B1", "dimers", "and", "prevents", "their", "nuclear", "localization", ",", "induces", "apoptosis", "in", "resting", "normal", "human", "PBL", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "C/EBP", "beta", "regulation", "of", "the", "tumor", "necrosis", "factor", "alpha", "gene", "." ]

[ 9, 10, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "The", "differentiation", "of", "myeloid", "precursors", "into", "mature", "myelomonocytic", "cells", "is", "characterized", "by", "the", "induction", "of", "the", "gene", "encoding", "the", "beta2", "integrin", "CD11b", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0 ]

[ "We", "demonstrated", ",", "by", "applying", "the", "electrophoretic", "mobility", "shift", "assay", ",", "slightly", "impaired", "AP-1", "DNA", "binding", "activity", "in", "NCL", "lymphocytes", "and", "strong", "in", "DS", "ones", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 7, 8, 0 ]

[ "MZF-1", "transcriptional", "regulation", "of", "this", "physiologically", "relevant", "promoter", "was", "assessed", "in", "both", "hematopoietic", "and", "nonhematopoietic", "cell", "lines", "." ]

[ 1, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 5, 0, 5, 6, 6, 0 ]

[ "A", "point", "mutation", "of", "a", "potential", "phosphatidylinositol", "3-kinase", "(", "PI3-K", ")", "binding", "site", "(", "Y731EAM", "to", "Y731EAC", ")", "in", "70Z/3", "disrupted", "the", "association", "of", "PI3-K", "with", "70Z/3", ",", "but", "did", "not", "reduce", "the", "induction", "of", "NFAT", "activity", ",", "suggesting", "that", "the", "interaction", "between", "Cbl", "and", "PI3-K", "is", "not", "required", "in", "the", "70Z/3", "-mediated", "induction", "of", "NFAT", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 1, 0, 1, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0 ]

[ "Interferon", "gamma", "induces", "class", "II", "expression", "in", "this", "glioblastoma", "cell", "line", "and", ",", "in", "parallel", ",", "up-regulates", "X1", "and", "X2", "box", "protein-DNA", "interactions", ",", "while", "all", "other", "interactions", "remain", "unchanged", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "Syk", "-mediated", "T", "cell", "antigen", "receptor", "-induced", "MAPK", "activation", "was", "detectable", "within", "1", "min", "of", "receptor", "stimulation", "and", "peaked", "at", "3-5", "min", "." ]

[ 0, 9, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "most", "cell", "lines", ",", "proteins", "of", "molecular", "weight", "49", "and", "44", "kDa", "were", "found", ",", "however", "two", "myeloid", "cell", "lines", "expressed", "only", "lower", "molecular", "weight", "species", "of", "24", "and", "22", "kDa", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0 ]

[ "To", "characterize", "the", "human", "elk-1", "promoter", ",", "we", "mapped", "the", "transcriptional", "start", "site", "and", "isolated", "elk-1-specific", "genomic", "phage", "clones", "that", "contained", "extensive", "upstream", "and", "downstream", "sequences", "." ]

[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 5, 6, 6, 6, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "In", "infected", "monocytes", ",", "which", "die", "by", "apoptosis", ",", "the", "expression", "of", "CREB", ",", "CTF", ",", "and", "OTF-2", "was", "rather", "suppressed", "8", "hours", "after", "infection", "." ]

[ 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Instead", ",", "regulation", "of", "activation", "involved", "a", "region", "of", "the", "cytoplasmic", "domain", "common", "to", "both", "the", "lymphocyte", "and", "macrophage", "receptor", "isoforms", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]

[ "We", "have", "also", "investigated", "A-myb", "expression", "in", "49", "fresh", "cases", "of", "B", "leukemias", "." ]

[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "region", "which", "induced", "these", "inductions", "was", "identified", "as", "being", "confined", "to", "40", "nucleotides", "5", "'", "to", "the", "major", "transcriptional", "initiation", "site", "by", "testing", "a", "series", "of", "clones", "with", "truncated", "promoter", "of", "IRF-2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0 ]

[ "Major", "recent", "developments", ",", "including", "the", "identification", "of", "novel", "families", "of", "transcription", "factors", "that", "regulate", "multiple", "T-cell", "genes", "during", "thymocyte", "ontogeny", "and", "T-cell", "activation", ",", "are", "described", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]

[ "This", "reduction", "was", "accompanied", "by", "rapid", "changes", "in", "the", "cellular", "adhesion", "of", "dimethyl", "sulfoxide-differentiated", "HL-60", "leukemia", "cells", "stimulated", "by", "12-O-tetradecanoylphorbol", "13-acetate", "(", "TPA", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "TCL1", "protein", "expression", "is", "restricted", "to", "tumor", "cells", "in", "AIDS", "IBLP", "tissue", "samples", "analyzed", "with", "immunohistochemical", "staining", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Unexpectedly", ",", "none", "of", "them", "reported", "a", "family", "history", "for", "breast/ovarian", "cancer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Since", "these", "findings", "supported", "the", "involvement", "of", "serine/threonine", "protein", "phosphorylation", "in", "the", "regulation", "of", "EGR-1", "expression", ",", "we", "studied", "activation", "of", "the", "40S", "ribosomal", "protein", "S6", "serine/threonine", "kinases", ",", "pp70S6K", "and", "pp90rsk", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 9, 0 ]

[ "To", "help", "elucidate", "further", "the", "mechanism", "by", "which", "ZAP-70", "regulates", "these", "initial", "events", ",", "we", "used", "a", "dominant-negative", "mutant", "approach", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "An", "increased", "rate", "of", "lysosomal", "degradation", "is", "one", "of", "the", "mechanisms", "responsible", "for", "the", "loss", "of", "zeta-chain", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "In", "contrast", ",", "the", "Rap1", "protein", "was", "differentially", "phosphorylated", "when", "using", "15", "micrograms/ml", "of", "the", "C.", "Sub", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10 ]

[ "Expression", "of", "wild-type", "SHP1", "had", "a", "very", "small", "effect", "on", "the", "TCR-induced", "tyrosine", "phosphorylation", "of", "ZAP-70", "and", "Syk", ",", "even", "when", "SHP1", "was", "overexpressed", "20", "-", "100-fold", "over", "endogenous", "SHP1", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Identification", "of", "essential", "GATA", "and", "Ets", "binding", "motifs", "within", "the", "promoter", "of", "the", "platelet", "glycoprotein", "Ib", "alpha", "gene", "." ]

[ 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Because", "the", "binding", "site", "showed", "some", "sequence", "similarity", "with", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "binding", "site", ",", "we", "compared", "the", "kinetics", "of", "induction", "of", "the", "two", "binding", "complexes", "and", "the", "molecular", "masses", "of", "the", "two", "proteins", "." ]

[ 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "location", "of", "Sp140", "in", "the", "NB", ",", "and", "expression", "of", "this", "gene", "in", "cells", "involved", "in", "host", "defense", ",", "suggest", "that", "Sp140", "may", "be", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "now", "demonstrate", "that", "a", "forced", "exogenous", "expression", "of", "the", "four", "different", "isoforms", "of", "WT1", "in", "K562", "does", "not", "affect", "the", "differentiation", "response", ",", "as", "judged", "by", "accumulation", "of", "hemoglobin", "in", "response", "to", "hemin", "or", "the", "expression", "of", "megakaryocytic", "cell", "surface", "markers", "in", "response", "to", "12-O-tetradecanoylphorbol-13-acetate", "(", "TPA", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "the", "major", "problem", "still", "remains", "the", "high", "incidence", "of", "leukemic", "relapse", "following", "autologous", "PBSCT", ",", "which", "may", "be", "caused", "by", "the", "reinfusion", "of", "PBSC", "contaminated", "by", "leukemic", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0 ]

[ "The", "binding", "of", "the", "most", "prominent", "factor", ",", "named", "TCF-1", "(", "T", "cell", "factor", "1", ")", ",", "is", "correlated", "with", "the", "proto-enhancer", "activity", "of", "TCEd", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "corroborate", "previous", "findings", "that", "the", "presence", "of", "ER", "variants", "is", "not", "a", "characteristic", "of", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "examined", "25", "(", "OH", ")", "D3", "transport", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "order", "to", "understand", "the", "role", "of", "NF-kappaB", "in", "EBV", "transformation", "we", "have", "established", "stably", "transfected", "IkappaBalpha", "into", "lymphoblastoid", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]

[ "The", "precise", "molecular", "abnormalities", "that", "cause", "primary", "cortisol", "resistance", "have", "not", "been", "completely", "described", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cross-linking", "CD40", "on", "B", "cells", "rapidly", "activates", "nuclear", "factor-kappa", "B", "." ]

[ 0, 9, 0, 7, 8, 0, 0, 9, 10, 10, 0 ]

[ "The", "crux", "of", "transcriptional", "activation", "is", "how", "the", "locus", "control", "region", "communicates", "with", "the", "gene-proximal", "regulatory", "elements", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 2, 2, 0 ]

[ "These", "results", "may", "also", "relate", "to", "recent", "data", "implicating", "GATA-1", "function", "in", "apoptosis", "and", "cell", "cycle", "progression" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "Indeed", ",", "when", "Tax", "is", "coexpressed", "with", "the", "E2F-1", "transcription", "factor", "in", "CEM", "T-cells", ",", "which", "lack", "expression", "of", "p16", "(", "INK4A", ")", ",", "it", "strongly", "potentiates", "the", "E2F", "-dependent", "activation", "of", "a", "reporter", "construct", "driven", "by", "a", "promoter", "containing", "E2F", "binding", "sites", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 9, 10, 0, 5, 6, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "The", "gene", "encoding", "the", "105-kDa", "protein", "(", "p105", ")", "precursor", "of", "the", "p50", "subunit", "of", "transcription", "factor", "NF-kappa", "B", "also", "encodes", "a", "p70", "I", "kappa", "B", "protein", ",", "I", "kappa", "B", "gamma", ",", "which", "is", "identical", "to", "the", "C-terminal", "607", "amino", "acids", "of", "p105", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0 ]

[ "Human", "T-cell", "leukemia", "virus", "type", "I", "(", "HTLV-I", ")", "is", "the", "etiologic", "agent", "of", "the", "adult", "T-cell", "leukemia", ",", "an", "aggressive", "and", "often", "fatal", "malignancy", "of", "activated", "human", "CD4", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "A", "procedure", "suitable", "for", "cloning", "labile", "mRNAs", "that", "contain", "AU", "motifs", "is", "presented", "(", "AU-DD", ")", "." ]

[ 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Gel-shift", "analysis", "reveals", "the", "constitutive", "presence", "of", "nuclear", "factors", "in", "resting", "PBL", "that", "bind", "to", "the", "proximal", "AP-1", "site", "of", "the", "IL-2", "promoter", "and", "that", "contain", "immunoreactive", "c-Jun", "but", "not", "c-Fos", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0 ]

[ "The", "authors", "revealed", "alterations", "in", "the", "functional", "activity", "of", "the", "indicated", "endocrine", "glands", "depending", "on", "the", "intensity", "of", "bronchial", "patency", "disorders", "and", "the", "nature", "of", "the", "therapeutic", "measures", "carried", "out", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "is", "concluded", "that", "(", "i", ")", "patients", "with", "CLL", "rarely", "express", "ER", "and", "(", "ii", ")", "immunocytochemical", "staining", "of", "cytospin", "preparations", "is", "a", "valid", "technique", "for", "the", "measurement", "of", "ER", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Supershift", "analysis", "revealed", "these", "proteins", "to", "be", "Egr-1", "and", "Egr-2", "(", "Krox-20", ")", ";", "Egr-3", "was", "not", "detected", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Human", "monocyte", "binding", "to", "fibronectin", "enhances", "IFN-gamma", "-induced", "early", "signaling", "events", "." ]

[ 7, 8, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0 ]

[ "Mononuclear", "phagocytes", "are", "exposed", "to", "fibrinous", "provisional", "matrix", "throughout", "migration", "into", "inflammatory", "foci", ",", "so", "this", "study", "was", "undertaken", "to", "determine", "whether", "fibrinogen", "triggers", "activation", "of", "NF-kappa", "B", "transcription", "factors", "." ]

[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "effect", "of", "CD70", "transfectants", "was", "dose", "dependent", "and", "was", "completely", "blocked", "by", "anti-CD70", "mAb", "." ]

[ 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10 ]

[ "Nuclear", "levels", "of", "NF-kappaB", "correlate", "with", "syncytium-forming", "capacity", "of", "8e51", "cells", ",", "expressing", "a", "defective", "HIV", "virus", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "peripheral", "blood", "monocytes", "responded", "to", "stimulation", "of", "platelet-activating", "factor", "(", "PAF", ")", "with", "up-regulation", "of", "the", "transcript", "for", "heparin-binding", "epidermal", "growth", "factor-like", "growth", "factor", "(", "HB-EGF", ")", ",", "a", "potent", "mitogen", "for", "vascular", "smooth", "muscle", "cells", "." ]

[ 0, 0, 0, 7, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0 ]

[ "We", "examined", "signaling", "molecules", "of", "peripheral", "blood", "T", "lymphocytes", "obtained", "from", "women", "with", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "biologic", "functions", "are", "modulated", ",", "in", "that", "the", "hormone", "inhibits", "proliferation", "in", "a", "subset", "of", "the", "activated", "B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "The", "altered", "kappa", "B-binding", "activity", "in", "T", "cells", "from", "RCC", "patients", "may", "impair", "their", "capacity", "to", "respond", "normally", "to", "various", "stimuli", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "indicate", "that", "ATRA", "as", "well", "as", "VD", "efficiently", "increases", "the", "nuclear", "abundance", "of", "VD", "receptor", "(", "VDR", ")", "and", "promotes", "monocytic", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Using", "UT-7/GMT", "cells", ",", "we", "examined", "how", "TPO", "promotes", "hemoglobinization", "." ]

[ 0, 5, 6, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "CONCLUSIONS", ":", "Human", "NK", "cell", "membrane-bound", "LT", "signals", "across", "species", "via", "TNFRI", ",", "leading", "to", "NF-kappaB", "nuclear", "translocation", "and", "transcription", "of", "E-selectin", "and", "IL-8", ",", "which", "results", "in", "EC", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 7, 0, 0 ]

[ "GrpL", ",", "a", "Grb2", "-related", "adaptor", "protein", ",", "interacts", "with", "SLP-76", "to", "regulate", "nuclear", "factor", "of", "activated", "T", "cell", "activation", "." ]

[ 9, 0, 0, 9, 0, 9, 10, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0 ]

[ "We", "conclude", "that", "the", "transrepressive", "effect", "of", "glucocorticoids", "on", "IL-2", "gene", "transcription", "is", "exclusively", "mediated", "by", "GRalpha", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0 ]

[ "Ectopic", "ALF1", "and", "E2A", "proteins", "required", "intact", "E", "(", "gre", ")", "motifs", "for", "mediating", "transcriptional", "activation", "." ]

[ 0, 9, 0, 9, 10, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0 ]

[ "Using", "the", "[", "3H", "]", "thymidine", "proliferation", "assay", ",", "we", "determined", "reactivity", "to", "purified", "recombinant", "SSB", "(", "rSSB", ")", "in", "20", "patients", "with", "SS", "and", "19", "controls", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "An", "understanding", "of", "these", "molecules", "may", "be", "informative", "about", "negative", "regulatory", "circuits", "that", "can", "potentially", "limit", "blood", "cell", "formation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Despite", "the", "absence", "of", "these", "ER", "peptides", ",", "the", "TAP1-/-", "cells", "were", "able", "to", "efficiently", "cross-prime", "E1A-", "and", "E1B-specific", "CTLs", "following", "immunization", "of", "syngeneic", "mice", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "In", "addition", ",", "electrophoretic", "mobility", "shift", "and", "supershift", "assays", "revealed", "that", "important", "NF-kappaB", "binding", "activity", "composed", "of", "at", "least", "p50", ",", "p65", ",", "and", "c-Rel", "NF-kappaB", "subunits", "was", "present", "in", "nuclei", "of", "CD40-stimulated", "B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "The", "novel", "aldosterone", "membrane", "receptor", "was", "analyzed", "on", "SDS-PAGE", "after", "labeling", "of", "microsomal", "membranes", "from", "human", "mononuclear", "leukocytes", "with", "a", "[", "125I", "]", "-aldosterone-derivative", "by", "use", "of", "BASED", "as", "a", "photoactivatable", "crosslinker", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "4.", "Danazol", "may", "release", "estrogen", "predominance", "via", "the", "reduction", "of", "transcription", "for", "ER", "gene", ",", "which", "leads", "to", "the", "reduction", "of", "ER", "mRNA", "and", "ER", "expressions", "in", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 0, 0, 7, 0 ]

[ "Thus", ",", "Tax1", "was", "suggested", "to", "replace", "growth", "signals", ",", "at", "least", "in", "part", ",", "by", "this", "mechanism", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "fusion", "cDNA", "results", "from", "an", "interstitial", "deletion", "between", "a", "previously", "unknown", "locus", ",", "SIL", "(", "SCL", "interrupting", "locus", ")", ",", "and", "the", "5", "'", "untranslated", "region", "of", "SCL", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 9, 0 ]

[ "The", "results", "obtained", "by", "duplication", "of", "activation", "domains", "or", "their", "mixed", "combination", "suggest", "that", "the", "domains", "are", "functionally", "independent", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Fewer", "apoptotic", "cell", "bodies", "were", "present", "in", "ectopic", "pregnancy", "." ]

[ 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "Comparison", "of", "KG1", "to", "the", "PMA-unresponsive", "subline", "KG1a", "reveals", "differences", "in", "expression", "of", "TNF", "receptors", "1", "and", "2", ";", "PKC", "isoforms", "alpha", ",", "beta", "I", ",", "beta", "II", ",", "and", "mu", ";", "and", "RelB", ",", "suggesting", "that", "these", "components/pathways", "are", "important", "for", "DC", "differentiation", "." ]

[ 0, 0, 5, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]

[ "To", "characterize", "these", "regulatory", "elements", "further", ",", "mutations", "in", "these", "regions", "were", "inserted", "into", "both", "the", "5", "'", "and", "3", "'", "HIV", "LTRs", "and", "infectious", "proviral", "constructs", "were", "assembled", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "During", "Epstein-Barr", "virus", "latent", "infection", "of", "B", "lymphocytes", "in", "vitro", ",", "six", "viral", "nuclear", "antigens", "(", "EBNAs", ")", "are", "expressed", "from", "one", "of", "two", "promoters", ",", "Cp", "or", "Wp", ",", "whose", "activities", "are", "mutually", "exclusive", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]

[ "GR", "expression", "levels", "were", "shown", "to", "be", "rate-limiting", "for", "initiating", "the", "apoptotic", "pathway", ",", "and", "a", "positive", "correlation", "between", "steroid", "sensitivity", "and", "GR", "-mediated", "induction", "of", "an", "integrated", "mouse", "mammary", "tumor", "virus", "(", "MMTV", ")", "LTR", "reporter", "gene", "was", "observed", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0 ]

[ "The", "amplified", "product", "showed", "an", "identical", "nucleotide", "sequence", "to", "the", "DNA-binding", "domain", "of", "the", "human", "intestinal", "receptor", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0 ]

[ "These", "results", "indicate", "that", "cepharanthine", "is", "a", "highly", "potent", "inhibitor", "of", "HIV-1", "replication", "in", "a", "chronically", "infected", "monocytic", "cell", "line", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "Since", "human", "T", "cells", "and", "T", "cell", "lines", "do", "not", "metabolize", "arachidonic", "acid", ",", "our", "data", "suggest", "that", "ALD", "can", "protect", "human", "T", "lymphocytes", "against", "a", "metabolite", "of", "benzene", "by", "induction", "of", "QR", "activity", "." ]

[ 0, 7, 8, 8, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Since", "the", "AES", "proteins", "are", "part", "of", "a", "set", "of", "transcriptional", "repressors", "encoded", "by", "the", "Enhancer", "of", "split", "[", "E", "(", "spl", ")", "]", "genes", ",", "and", "since", "these", "repressors", "are", "activated", "to", "suppress", "cell", "differentiation", "in", "response", "to", "Notch", "receptors", "signalling", ",", "the", "AES", "peptides", "may", "represent", "a", "novel", "class", "of", "self-antigens", "that", "deserve", "further", "consideration", "as", "tumor", "Ag", "in", "epithelial", "cancers", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "Cellular", "and", "molecular", "mechanisms", "of", "IL-5", "synthesis", "in", "atopic", "diseases", ":", "a", "study", "with", "allergen-specific", "human", "helper", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "These", "mutations", "were", "introduced", "in", "the", "tax", "gene", "of", "the", "ACH", "functional", "molecular", "clone", "of", "HTLV-1", ",", "and", "virus", "produced", "from", "the", "mutant", "ACH", "clones", "was", "examined", "for", "the", "ability", "to", "replicate", "and", "immortalize", "primary", "human", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "These", "results", "suggest", "that", "activation", "of", "the", "protein", "kinase", "A", "pathway", "inhibits", "NF-kappaB", "transcription", "by", "phosphorylating", "CREB", ",", "which", "competes", "with", "p65", "for", "limiting", "amounts", "of", "CBP", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0 ]

[ "No", "group", "differences", "in", "cortisol", "levels", "were", "observed", ",", "nor", "were", "glucocorticoid", "receptor", "number", "and", "cortisol", "levels", "correlated", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

[ "PRRI", "is", "an", "inducible", "proximal", "enhancer", ",", "located", "between", "nucleotides", "-276", "and", "-244", ",", "which", "contains", "NF-kappaB", "and", "SRE/CArG", "motifs", "." ]

[ 1, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 1, 2, 2, 2, 0 ]