id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
16755
[ "Also", ",", "an", "induction", "specific", "DNA", "binding", "protein", "was", "purified", "from", "HeLa", "cells", "that", "interacted", "with", "the", "(", "AAGTGA", ")", "4", "tetrahexamer", "sequence", "and", "the", "PRDI", "domain", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0 ]
8573
[ "This", "phenomenon", "has", "been", "termed", "``", "A/R", "tolerance.", "''" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
559
[ "Electrophoretic", "mobility", "shift", "assays", "using", "protein", "extracts", "from", "EBV-B", "cells", "and", "the", "IL-2", "NF-chi", "B", "probe", "revealed", "the", "constitutive", "generation", "of", "chi", "B", "complexes", "in", "IL-2-secreting", "cells", "consisting", "mainly", "of", "heterodimeric", "p50/p65", "complexes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 5, 6, 0, 0, 0, 9, 10, 10, 0 ]
5766
[ "We", "provide", "evidence", "that", "Zta", "up-regulation", "of", "p53", "leads", "to", "p53", "-mediated", "interference", "with", "JAK", "/STAT", "activation", "of", "Qp", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 0, 9, 9, 0, 0, 1, 0 ]
17913
[ "A", "PEBP2", "alpha/AML-1-related", "factor", "increases", "osteocalcin", "promoter", "activity", "through", "its", "binding", "to", "an", "osteoblast-specific", "cis-acting", "element", "." ]
[ 0, 9, 10, 10, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
13835
[ "Stimulation", "of", "activated", "LN", "cells", "with", "D5", "tumor", "cells", "induced", "the", "nuclear", "translocation", "of", "NF-kappaB", "." ]
[ 0, 0, 7, 8, 8, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 0 ]
15729
[ "Cellular", "immune", "and", "cytokine", "pathways", "resulting", "in", "tissue", "factor", "expression", "and", "relevance", "to", "septic", "shock", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
3740
[ "In", "21", "of", "27", "informative", "female", "patients", "the", "majority", "of", "the", "granulocytes", "were", "clonally", "derived", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
1355
[ "Findings", "from", "this", "analysis", "prompted", "sequencing", "of", "the", "gamma", "c", "gene", "in", "this", "pedigree", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0 ]
939
[ "Cells", "originating", "from", "cases", "of", "Burkitt", "'s", "lymphoma", "were", "negative", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3968
[ "The", "BCL6", "gene", "encodes", "a", "95-kDa", "protein", "containing", "six", "C-terminal", "zinc-finger", "motifs", "and", "an", "N-terminal", "POZ", "domain", ",", "suggesting", "that", "it", "may", "function", "as", "a", "transcription", "factor", "." ]
[ 0, 1, 2, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
3788
[ "Vaccination", "with", "synthetic", "peptides", "representing", "cytotoxic", "T", "lymphocyte", "(", "CTL", ")", "epitopes", "can", "lead", "to", "a", "protective", "CTL-mediated", "immunity", "against", "tumors", "or", "viruses", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1053
[ "E2F", "binding", "was", "not", "observed", "in", "both", "granulocytes", "and", "monocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0 ]
18318
[ "Tyrosine", "phosphorylation", "of", "Jak1", ",", "Jak2", ",", "and", "Stat1", "increased", "markedly", ",", "in", "a", "dose-dependent", "manner", ",", "in", "U-937", "cells", "incubated", "with", "gamma", "interferon", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 9, 10, 0 ]
11845
[ "The", "in", "vitro", "transendothelial", "migration", "of", "circulating", "filarial", "antigen-specific", "T-cells", "was", "examined", "in", "Wuchereria", "banerofti", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
16157
[ "Finally", ",", "RNA", "from", "activated", "lymphocytes", "was", "amplified", "by", "polymerase", "chain", "reaction", "using", "oligonucleotide", "primers", "flanking", "the", "196", "base", "pair", "long", "region", "encoding", "the", "DNA-binding", "domain", "of", "the", "human", "intestinal", "receptor", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0 ]
2401
[ "Arrested", "development", ":", "understanding", "v-abl", "." ]
[ 0, 0, 0, 0, 1, 0 ]
1927
[ "Gel-shift", "analysis", "in", "HUVECs", "demonstrated", "that", "PDTC", "prevented", "NF-kappa", "B", "mobilization", "by", "TNF", ",", "suggesting", "that", "only", "VCAM-1", "induction", "was", "controlled", "by", "NF-kappa", "B", "." ]
[ 0, 0, 0, 5, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]
8432
[ "The", "immunoglobulin", "heavy", "chain", "(", "IgH", ")", "class", "switch", "recombination", "of", "B", "lymphocytes", "preferentially", "targets", "unrearranged", "IgH", "genes", "that", "have", "already", "been", "rendered", "transcriptionally", "active", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
854
[ "LMP-1", "induces", "the", "expression", "of", "bcl2", ",", "an", "oncogene", "which", "protects", "cells", "from", "apoptosis", ",", "as", "well", "as", "of", "genes", "encoding", "other", "proteins", "involved", "in", "cell", "regulation", "and", "growth", "control", "." ]
[ 9, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11665
[ "No", "degradation", "of", "p105", "and", "p100", "inhibitors", "was", "observed", "under", "these", "conditions", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0 ]
6826
[ "Altered", "memory", "T", "cell", "differentiation", "in", "patients", "with", "early", "rheumatoid", "arthritis", "." ]
[ 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
16744
[ "Such", "segments", "accord", "well", "with", "empirically", "known", "T-cell", "determinants", "and", "our", "algorithm", "produces", "a", "lower", "number", "of", "false", "positive", "predictions", "than", "the", "principle", "based", "on", "discrete", "Fourier", "transformations", "previously", "described", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17302
[ "Stimulation", "of", "the", "human", "immunodeficiency", "virus", "type", "2", "(", "HIV-2", ")", "gene", "expression", "by", "the", "cytomegalovirus", "and", "HIV-2", "transactivator", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
10241
[ "These", "markers", "will", "be", "useful", "to", "study", "the", "role", "of", "genetic", "variation", "in", "these", "genes", "in", "the", "pathogenesis", "of", "type", "2", "diabetes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14338
[ "To", "dissect", "the", "molecular", "basis", "for", "the", "unusually", "persistent", "transcription", "of", "the", "IL-2R", "alpha", "gene", ",", "we", "analyzed", "nuclear", "NF-kappa", "B", "binding", "to", "a", "radiolabeled", "IL-2R", "alpha", "kappa", "B-specific", "oligonucleotide", "probe", "during", "the", "time", "course", "of", "CD2", "+", "CD28", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
1726
[ "We", "also", "examined", "tow", "of", "the", "XISTE-", "ring", "chromosomes", "to", "determine", "whether", "genes", "that", "are", "normally", "silent", "on", "an", "inactive", "X", "are", "expressed", "from", "these", "chromosomes", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0 ]
2938
[ "To", "examine", "the", "behavior", "of", "Bcl-2", "in", "normal", "cells", ",", "T", "cell", "blasts", "were", "transiently", "transfected", "with", "Bcl-2", "and", "related", "gene", "products", "to", "determine", "the", "effect", "on", "apoptotic", "signaling", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 7, 8, 0, 7, 8, 8, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
10718
[ "Our", "investigation", "of", "the", "human", "TCR", "beta", "gene", "uncovers", "a", "surprisingly", "complex", "and", "tissue-specific", "structure", "at", "the", "TCR", "Vbeta", "8.1", "promoter", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
817
[ "We", "thus", "conclude", "that", "PHA", "-induced", "proliferation", "of", "PBMCs", "derived", "from", "patients", "with", "breast", "cancer", "depends", "upon", "the", "tumour", "load", "and", "is", "a", "good", "clinical", "predictor", "for", "the", "further", "course", "of", "the", "disease", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10883
[ "One", "possibility", "toward", "this", "goal", "is", "to", "try", "to", "dissociate", "two", "main", "activities", "of", "glucocorticoids", ",", "i.e.", "transactivation", "and", "transrepression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1120
[ "Flow", "cytometric", "analysis", "also", "showed", "that", "at", "72", "h", "of", "virus", "exposure", "fewer", "T", "cells", "from", "the", "elderly", "produced", "interferon-gamma", "(", "IFN-gamma", ")", ",", "suggesting", "a", "link", "between", "the", "magnitude", "of", "the", "Fos", "and", "Jun", "and", "IFN-gamma", "responses", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0 ]
11140
[ "The", "effect", "of", "GH", "appears", "to", "occur", "in", "an", "autocrine", "fashion", ",", "since", "the", "inhibitory", "effect", "on", "TNF-alpha", "secretion", "by", "constitutive", "GH", "production", "could", "be", "abolished", "in", "the", "presence", "of", "anti-hGH", "mAb", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
13963
[ "We", "also", "observed", "hematopoiesis", "outside", "of", "the", "bone", "marrow", "in", "the", "affected", "mutant", "mice", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16651
[ "The", "putative", "intracellular", "receptors", "for", "FK506", "and", "cyclosporin", "are", "cis-trans", "prolyl", "isomerases", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7179
[ "A20", "can", "be", "regulated", "by", "the", "NF-kappaB", "transcription", "factor", ",", "which", "is", "known", "to", "be", "activated", "by", "the", "EBV", "LMP-1", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
17518
[ "The", "expression", "of", "c-fos", ",", "c-jun", ",", "and", "c-myc", "genes", "is", "regulated", "by", "heat", "shock", "in", "human", "lymphoid", "cells", "." ]
[ 0, 0, 0, 1, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
2447
[ "In", "mice", "exposed", "to", "hypoxia", "(", "PO2", "approximately", "30-40", "Torr", ")", ",", "there", "was", "increased", "pulmonary", "leukostasis", ",", "as", "evidenced", "by", "increased", "myeloperoxidase", "activity", "in", "tissue", "homogenates", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
10466
[ "A", "dysfunction", "in", "the", "regulation", "of", "the", "hypothalamic-pituitary-adrenal", "(", "HPA", ")", "axis", ",", "possibly", "attributed", "to", "a", "change", "in", "glucocorticoid", "receptor", "(", "GR", ")", "functionality", ",", "has", "been", "implicated", "in", "depression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5074
[ "IFNalpha-stimulated", "tyrosine", "phosphorylation", "of", "Jak1", "and", "the", "alpha", "subunit", "of", "the", "IFN-alpha", "receptor", "were", "unaffected", "by", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16123
[ "However", ",", "two", "potent", "immunosuppressive", "agents", ",", "glucocorticoids", "and", "cyclosporin", "A", ",", "also", "inhibited", "the", "80-kDa", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
7342
[ "Interestingly", ",", "an", "enhanced", "frequency", "of", "CD16", "and", "CD68", "(", "+", ")", "cells", "among", "the", "CD14", "(", "+", ")", "cells", "was", "observed", "in", "the", "presence", "of", "IL-10", ",", "independently", "of", "the", "pre-culture", "conditions", "of", "the", "PBMC", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
12247
[ "BACKGROUND", ":", "Inhibition", "of", "complement", "in", "small", "animal", "models", "of", "xenotransplantation", "has", "demonstrated", "graft", "infiltration", "with", "natural", "killer", "(", "NK", ")", "cells", "and", "monocytes", "associated", "with", "endothelial", "cell", "(", "EC", ")", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 0 ]
8689
[ "Here", "we", "describe", "an", "alternative", "approach", ",", "based", "on", "in", "vitro", "stimulation", "with", "epitope", "peptide-loaded", "dendritic", "cells", "(", "DCs", ")", ",", "which", "allows", "one", "to", "probe", "the", "CTL", "repertoire", "for", "any", "individual", "reactivity", "of", "choice", ";", "this", "method", "proved", "significantly", "more", "efficient", "than", "stimulation", "with", "peptide", "alone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2782
[ "This", "dispersed", "localization", "of", "a", "group", "of", "functionally", "related", "gene", "provides", "insights", "into", "the", "molecular", "mechanism", "of", "human", "genome", "evolution", "and", "their", "possible", "involvement", "in", "human", "diseases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2808
[ "These", "findings", "have", "important", "implications", "in", "regulation", "of", "germline", "transcription", "as", "well", "as", "concomitant", "activation", "of", "the", "V-J", "recombination", "of", "the", "kappa", "light", "chain", "locus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
4558
[ "In", "addition", ",", "the", "results", "of", "competition", "experiments", "analyzing", "the", "normal", "components", "of", "NF-AT", "showed", "that", "the", "age-related", "reductions", "in", "stimulus-dependent", "NF-AT", "complexes", "corresponded", "to", "the", "slow", "migrating", "complexes", "that", "were", "composed", "of", "c-Fos/c-Jun", "AP-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 0 ]
9589
[ "Thus", ",", "we", "conclude", "that", "the", "XP-B", "and", "XP-D", "lymphoblastoid", "cells", "do", "not", "have", "impaired", "RNA", "transcription", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
1661
[ "68", "%", "of", "the", "contractions", "were", "also", "one", "or", "two", "repeats", "but", "six", "(", "16", "%", ")", "were", "very", "large", "(", "12-25", "repeats", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4809
[ "Most", "studies", "on", "the", "expression", "of", "these", "proteins", "in", "relation", "to", "the", "cell", "cycle", "have", "been", "performed", "at", "the", "mRNA", "level", ",", "and", "therefore", "do", "not", "give", "direct", "information", "about", "the", "presence", "of", "the", "proteins", "during", "the", "cell", "cycle", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17845
[ "DCs", "express", "high", "levels", "of", "all", "known", "NF-kappa", "B", "and", "Rel", "proteins", ",", "with", "activity", "residing", "primarily", "within", "RelB", ",", "p50", ",", "and", "p65", "." ]
[ 7, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0 ]
10537
[ "This", "suggests", "that", "higher", "intracellular", "levels", "of", "STAT1", ",", "STAT2", ",", "and", "p48", "protein", "may", "result", "in", "enhanced", "signal", "transduction", "for", "cytokines", "utilizing", "these", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0 ]
15260
[ "T", "cell-specific", "negative", "regulation", "of", "transcription", "of", "the", "human", "cytokine", "IL-4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
3458
[ "This", "RT-PCR", "assay", "can", "detect", "one", "leukemic", "cell", "in", "10", "(", "2", ")", "normal", "cells", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0 ]
17944
[ "The", "lack", "of", "Jak3", "expression", "correlated", "with", "impaired", "B", "cell", "signaling", ",", "as", "demonstrated", "by", "the", "inability", "of", "IL-4", "to", "activate", "Stat6", "in", "the", "EBV-transformed", "cell", "line", "from", "the", "patient.", "These", "observations", "indicate", "that", "the", "functions", "of", "gamma", "c", "are", "dependent", "on", "Jak3", "and", "that", "Jak3", "is", "essential", "for", "lymphoid", "development", "and", "signaling", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
15749
[ "A", "similar", "result", "was", "obtained", "with", "the", "mature", "monocytic", "leukemia", "cell", "line", "THP-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 5, 0 ]
12049
[ "Adaptor", "function", "for", "the", "Syk", "kinases-interacting", "protein", "3BP2", "in", "IL-2", "gene", "activation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0 ]
12775
[ "We", "propose", "that", "the", "inducible", "transcription", "factor", "binding", "sites", "in", "the", "5'-UTR", "comprise", "a", "downstream", "enhancer", "domain", "that", "can", "function", "independent", "of", ",", "or", "in", "concert", "with", ",", "the", "LTR", "promoter", "to", "rapidly", "increase", "latent", "proviral", "transcription", "in", "response", "to", "cell", "activation", "signals", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11014
[ "Dose-response", "experiments", "suggested", "that", "steroid", "doses", "currently", "used", "in", "clinical", "medicine", "are", "suboptimal", "in", "repressing", "NFkappaB", "-mediated", "cytokine", "production", "in", "the", "inflammatory", "lesions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0 ]
9264
[ "Macrophage-differentiation", "of", "NB4", "reduced", "levels", "of", "C/EBP", "epsilon", "mRNA", "." ]
[ 0, 0, 5, 0, 0, 0, 3, 4, 4, 0 ]
16394
[ "Synergism", "between", "two", "distinct", "elements", "of", "the", "HTLV-I", "enhancer", "during", "activation", "by", "the", "trans-activator", "of", "HTLV-I", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 0, 0 ]
17156
[ "Results", "in", "all", "cell", "lines", "indicated", "that", "mutations", "of", "the", "SP1", ",", "TATA", "and", "the", "TAR", "loop", "and", "stem", "secondary", "structure", "resulted", "in", "marked", "decreases", "in", "gene", "expression", "while", "mutations", "of", "the", "enhancer", "motif", "or", "TAR", "primary", "sequence", "resulted", "in", "only", "slight", "decreases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0 ]
378
[ "We", "further", "show", "that", "this", "G", "+", "C-rich", "region", "is", "required", "for", "the", "activation", "of", "alpha-globin", "gene", "expression", "during", "erythroid", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]
4624
[ "Both", "cytokines", "activated", "factors", "that", "bound", "to", "the", "sis-inducible", "element", "and", "included", "STAT1", "and", "STAT3", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 9, 0, 9, 0 ]
3088
[ "To", "examine", "the", "mechanisms", "by", "which", "salicylates", "affect", "cytokine", "gene", "transcription", ",", "the", "amount", "of", "active", "and", "inactive", "NF-kappa", "B", "and", "NF-kappa", "B", "mRNA", ",", "in", "Porphyromonas", "gingivalis", "lipopolysaccharide-stimulated", "human", "monocytic", "cells", "was", "assessed", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 3, 4, 4, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0 ]
15314
[ "This", "HIV-mediated", "mechanism", "results", "in", "a", "self-perpetuating", "loop", "of", "NF-kappa", "B", "production", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
16282
[ "A", "murine", "monoclonal", "antibody", "raised", "to", "an", "unidentified", "estrogen", "receptor-related", "29-kDa", "protein", "selectively", "recognized", "these", "proteins", "as", "well", "as", "a", "more", "basic", ",", "unphosphorylated", "27-kDa", "protein", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
13700
[ "In", "6", "of", "14", "patients", ",", "T", "lymphocytes", "displayed", "an", "impaired", "ability", "to", "translocate", "NFeB", "p65", "(", "Rel-A", ")", "following", "activation", "by", "anti-CD3", "and", "IL-2", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
9695
[ "The", "breakpoints", "of", "most", "transcript", "deletions", "coincide", "with", "genuine", "or", "cryptic", "splice", "site", "sequences", ",", "suggesting", "that", "they", "result", "from", "alternative", "or", "aberrant", "splicing", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14180
[ "Overexpression", "of", "cJun", "or", "JunD", ",", "but", "not", "JunB", ",", "also", "eliminates", "the", "requirement", "for", "PMA", ",", "indicating", "that", "many", "but", "not", "all", "Jun-", "and", "Fos-related", "proteins", "functionally", "activate", "NF-AT", "-dependent", "transcription", "in", "the", "presence", "of", "the", "cytoplasmic", "component", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17612
[ "The", "human", "protein", "recognized", "by", "the", "EC1", "antibody", "is", "a", "56-kDa", "protein", "(", "p56", ")", "of", "moderate", "abundance", "located", "predominantly", "in", "the", "cytoplasm", "by", "indirect", "immunofluorescence", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4999
[ "Finally", ",", "we", "have", "studied", "the", "progression", "of", "one", "case", "of", "CLL", "into", "Richter", "'s", "syndrome", "and", "have", "found", "that", "the", "Richter", "'s", "cells", "expressed", "about", "25-fold", "less", "A-myb", "RNA", "than", "the", "CLL", "cells", "from", "the", "same", "patient.", "The", "pattern", "of", "c-myb", "and", "B-myb", "was", "clearly", "distinct", "from", "that", "of", "A-myb", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 3, 4, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0 ]
17381
[ "The", "authors", "conclude", "that", "the", "microscopic", "examination", "is", "the", "only", "useful", "tool", "for", "assessing", "the", "risk", "of", "local", "failure", ",", "which", "is", "quite", "low", "for", "the", "majority", "of", "patients", "treated", "with", "breast", "conservation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3436
[ "Moreover", ",", "ZK161422", ",", "but", "not", "ZK157202", ",", "showed", "preference", "for", "gene", "activation", "from", "a", "promoter", "carrying", "a", "VD", "response", "element", "with", "a", "palindromic", "arrangement", "of", "two", "hexameric", "receptor", "binding", "sites", "spaced", "by", "9", "nucleotides", "(", "IP9", ")", "rather", "than", "for", "activation", "from", "a", "response", "element", "formed", "by", "a", "direct", "repeat", "spaced", "by", "3", "nucleotides", "(", "DR3", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2165
[ "In", "addition", "to", "PMA", ",", "cells", "of", "the", "THP-1", "myeloid", "leukemia", "cell", "line", "acquire", "macrophage-like", "characteristics", "after", "treatment", "with", "all-trans", "retinoic", "acid", "(", "RA", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6567
[ "Live-attenuated", "human", "immunodeficiency", "viruses", "(", "HIVs", ")", "are", "candidates", "for", "Acquired", "Immunodeficiency", "Syndrome", "(", "AIDS", ")", "vaccine", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17492
[ "Octamer-dependent", "activation", "of", "a", "reporter", "plasmid", "or", "NF-kappa", "B", "-dependent", "activation", "of", "the", "human", "immunodeficiency", "virus", "(", "HIV", ")", "enhancer", "was", "inhibited", "when", "the", "appropriate", "phosphorothioate", "oligonucleotide", "was", "added", "to", "a", "transiently", "transfected", "B", "cell", "line", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 9, 10, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
7873
[ "Here", "we", "report", "that", "in", "T", "cells", ",", "Tcf-1", "also", "becomes", "transcriptionally", "active", "through", "interaction", "with", "beta-catenin", ",", "suggesting", "that", "the", "Wnt", "signal", "transduction", "pathway", "is", "operational", "in", "T", "lymphocytes", "as", "well", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0 ]
17719
[ "However", ",", "supershift", "assays", "using", "the", "available", "mAb", "recognizing", "the", "T", "cell", "NFATc", "revealed", "no", "detectable", "NFATc", "protein", "in", "nuclear", "and", "cytoplasmic", "extracts", "from", "CD16-", "or", "phorbol", "ester-stimulated", "cells", "at", "any", "time", "tested", ",", "up", "to", "4", "h", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2282
[ "Interleukin-4", "(", "IL-4", ")", "is", "an", "immunomodulatory", "cytokine", "secreted", "by", "activated", "T", "lymphocytes", ",", "basophils", ",", "and", "mast", "cells", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 7, 8, 0 ]
10599
[ "Compared", "with", "monocytes", "in", "suspension", "or", "adherent", "on", "plastic", "surfaces", ",", "monocytes", "adherent", "to", "fibronectin", "or", "RGD", "exhibited", "a", "greater", "than", "threefold", "increase", "in", "steady", "state", "levels", "of", "IFN-gamma-induced", "mRNA", "for", "the", "high", "affinity", "Fc", "gammaRI", "receptor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 9, 10, 10, 10, 10, 0 ]
10231
[ "The", "results", "indicated", "that", "the", "apoptosis", "induced", "by", "bufalin", "in", "U937", "cells", "was", "significantly", "inhibited", "by", "overexpression", "of", "the", "Bcl-2", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
14810
[ "In", "human", "monocytes", ",", "the", "inhibitors", "of", "these", "phosphatases", ",", "okadaic", "acid", "and", "calyculin", "A", ",", "were", "found", "to", "increase", "the", "mRNA", "accumulation", "and", "cytokine", "production", "of", "interleukin-1", "beta", "and", "interleukin-1", "alpha", "." ]
[ 0, 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]
6682
[ "We", "have", "investigated", "several", "molecular", "pathways", "that", "are", "known", "to", "be", "activated", "by", "IL-2", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
12523
[ "The", "JAK", "/STAT", "pathway", "is", "one", "of", "the", "signaling", "pathways", "implicated", "in", "mediating", "biological", "responses", "induced", "by", "these", "cytokines", "." ]
[ 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
802
[ "The", "nuclear", "factor", "STAT-1", "(", "p91", ")", "was", "investigated", "by", "immunoprecipitation", "followed", "by", "immunoblotting", "for", "tyrosine", "phosphorylation", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1970
[ "Ligation", "of", "Ag", "receptors", "in", "T", "and", "B", "lymphocytes", "initiates", "signal", "transduction", "cascades", "which", "alter", "the", "expression", "of", "genes", "that", "regulate", "cellular", "proliferation", "and", "differentiation", "." ]
[ 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7571
[ "Smad6", "and", "Smad7", "prevent", "ligand-induced", "activation", "of", "signal-transducing", "Smad", "proteins", "in", "the", "transforming", "growth", "factor-beta", "family", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 0 ]
7912
[ "This", "study", "assessed", "the", "effects", "of", "anti-inflammatory", "glucocorticoids", "on", "this", "leukocyte", "clearance", "mechanism", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4986
[ "On", "the", "other", "hand", ",", "the", "up-regulation", "of", "CD80", "Ag", ",", "found", "on", "monocytes", "obtained", "from", "PBMC", "incubated", "with", "OKT3", ",", "is", "not", "detected", "after", "addition", "of", "IL-10", ",", "and", "the", "anti-CD28", "mAb", "CLB-CD28/1", "restores", "the", "NF-kappa", "B/Rel", "nuclear", "activity", "in", "IL-10-inhibited", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 0, 0, 7, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 9, 0, 0, 9, 10, 0, 0, 0, 5, 6, 0 ]
18510
[ "A", "central", "role", "for", "a", "single", "c-Myb", "binding", "site", "in", "a", "thymic", "locus", "control", "region", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0 ]
14743
[ "Two", "sets", "of", "nested", "primers", "were", "designed", "to", "conserved", "sequences", "in", "the", "adenovirus", "E1A", "and", "hexon", "genes", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]
9595
[ "Murine", "and", "human", "MZF-2", "proteins", "consisted", "of", "814", "and", "775", "amino", "acids", ",", "respectively", ",", "and", "have", "identity", "of", "75.3", "%", "between", "them", "." ]
[ 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10787
[ "These", "results", "show", "that", "the", "initial", "steps", "in", "the", "1", ",", "25D3", "signaling", "pathway", "are", "intact", "in", "B", "series", "resistant", "cells", "and", "lead", "to", "the", "appearance", "of", "early", "markers", "of", "monocytic", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9748
[ "Similarly", ",", "the", "Egr-1-expressing", "Ramos", "cells", "showed", "reduced", "levels", "of", "CD95", "expression", "." ]
[ 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 9, 0, 0 ]
236
[ "Secreted", "from", "activated", "T", "cells", "and", "macrophages", ",", "bone", "marrow-derived", "MIP-1", "alpha/GOS19", "inhibits", "primitive", "hematopoietic", "stem", "cells", "and", "appears", "to", "be", "involved", "in", "the", "homeostatic", "control", "of", "stem", "cell", "proliferation", "." ]
[ 0, 0, 7, 8, 8, 0, 7, 0, 0, 9, 10, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
10870
[ "Tax1", ",", "a", "transcriptional", "trans-activator", "of", "the", "Human", "T-cell", "leukemia", "virus", "type", "I", "(", "HTLV-I", ")", ",", "induces", "the", "expression", "of", "many", "cellular", "genes", "through", "interaction", "with", "at", "least", "three", "distinct", "cellular", "transcription", "factors", ";", "CREB/ATF", ",", "NF-kappaB", ",", "and", "SRF", "." ]
[ 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 0, 0, 9, 0 ]
15485
[ "The", "results", "demonstrate", "that", "the", "simultaneous", "activation", "of", "PKC", "and", "elevation", "of", "cAMP", "leads", "to", "an", "enhanced", "AP-1", "transcriptional", "activity", "in", "a", "T-leukemia", "cell", "line", ",", "suggesting", "that", "the", "previously", "observed", "interaction", "between", "the", "parallel", "signal", "transduction", "pathways", "may", "have", "functional", "consequences", "at", "the", "level", "of", "gene", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11675
[ "Among", "genes", "that", "respond", "to", "these", "transcription", "factors", ",", "IL-2", "mRNA", "induction", "was", "suppressed", "by", "PF", ",", "whereas", "IL-2R", "(", "alpha", ")", "chain", "mRNA", "induction", "was", "not", "affected", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0 ]
17163
[ "The", "thyroid", "function", "was", "normal", "regarding", "T4", ",", "free", "T4", "and", "T3", ",", "TBG", ",", "radioiodine", "uptake", ",", "TSH", "and", "T3", "suppressibility", ";", "however", "the", "TSH", "response", "to", "TRH", "was", "decreased", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]