Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "SH2", "domain-containing", "protein", "76", "(", "SLP-76", ")", "interacts", "with", "the", "guanine", "nucleotide", "exchange", "factor", "Vav", "to", "activate", "the", "nuclear", "factor", "of", "activated", "cells", "(", "NF-AT", ")", ",", "and", "its", "expression", "is", "required", "for", "normal", "T", "cell", "development", "." ]

[ 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 10, 10, 9, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]

[ "Studies", "included", "structural", "comparison", "of", "the", "promoters", "for", "human", "and", "mouse", "inducible", "NO", "synthase", "(", "iNOS", ")", "genes", ",", "transfection", "and", "assay", "of", "human", "and", "mouse", "iNOS", "promoter", "regions", "in", "response", "to", "LPS", "+/-", "IFN-gamma", ",", "and", "electrophoretic", "mobility", "shift", "assays", "of", "kappa", "B", "response", "elements", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "We", "show", "that", "TLR2", "associates", "with", "the", "high-affinity", "LPS", "binding", "protein", "membrane", "CD14", "to", "serve", "as", "an", "LPS", "receptor", "complex", ",", "and", "that", "LPS", "treatment", "enhances", "the", "oligomerization", "of", "TLR2", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Electrophoretic", "mobility", "shift", "assays", "confirmed", "that", "region", "II", "interacts", "specifically", "with", "nuclear", "proteins", "from", "monocytic", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 10, 0, 7, 8, 0 ]

[ "The", "persistence", "of", "TGF-beta1-transcribing", "macrophages", ",", "despite", "paralysis", "of", "T", "cell", "function", ",", "may", "provide", "an", "explanation", "for", "the", "chronicity", "of", "the", "disease", ",", "and", "may", "identify", "a", "novel", "therapeutic", "target", "in", "this", "inflammatory", "vasculopathy", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Levels", "of", "occupied", "1", ",", "25", "(", "OH", ")", "2D3", "receptor", "protein", "increased", "in", "these", "HL-60", "cells", ";", "but", "the", "total", "number", "of", "1", ",", "25", "(", "OH", ")", "2D3", "receptors", "decreased", "about", "50", "%", "at", "24", "hours", "and", "returned", "toward", "normal", "at", "72", "hours", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "further", "demonstrate", "that", "p105", "undergoes", "degradation", "in", "lipopolysaccharide-stimulated", "human", "monocytic", "cells", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 6, 6, 0 ]

[ "There", "are", "many", "hypotheses", "concerning", "the", "pathogenesis", "of", "endometriosis", ",", "though", "no", "single", "theory", "can", "explain", "all", "cases", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Deletion", "mutants", "containing", "1.3", ",", "0.6", ",", "and", "0.2", "kb", "5'-flanking", "DNA", "were", "incrementally", "less", "transcriptionally", "active", ",", "although", "0.2", "kb", "still", "mediated", "a", "12-fold", "induction", "by", "PRL", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "PDTC", "strongly", "inhibited", "low", "shear-induced", "activation", "of", "NF-kappaB", ",", "expression", "of", "VCAM-1", ",", "and", "EC-Mn", "adhesion", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "The", "C-terminal", "half", "of", "human", "MZF-2", ",", "carrying", "the", "zinc", "finger", "domains", ",", "was", "completely", "identical", "with", "that", "of", "human", "MZF-1", ",", "whereas", "the", "N-terminal", "half", "of", "MZF-2", "was", "different", "from", "the", "corresponding", "region", "of", "human", "MZF-1", ",", "and", "was", "coded", "by", "distinct", "exons", "." ]

[ 0, 9, 10, 0, 9, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 0 ]

[ "These", "lines", "were", "established", "by", "infection", "with", "human", "T-lymphotrophic", "virus", "type", "I", "(", "HTLV-I", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "most", "cases", ",", "the", "transcriptional", "factor", "NF-kappa", "B", "is", "a", "heterodimer", "consisting", "of", "two", "subunits", ",", "p50", "and", "p65", ",", "which", "are", "encoded", "by", "two", "distinct", "genes", "of", "the", "Rel", "family", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "However", ",", "NF-YB", "did", "interact", "with", "the", "C-terminal", "Tax1", "mutants", "M22", "(", "130TL-AS", ")", "and", "M47", "(", "319LL-RS", ")", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0 ]

[ "Since", "the", "induction", "of", "NF-AT", "and", "AP-1", "is", "induced", "by", "the", "same", "stimuli", "that", "stimulate", "IL-2", "production", ",", "these", "results", "indicate", "that", "the", "immunosuppressant", "action", "of", "CsA", "and", "FK506", "is", "exerted", "at", "the", "level", "of", "these", "trans-activating", "factors", "." ]

[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "HTLV-I", "encodes", "an", "essential", "40-kDa", "protein", "termed", "Tax", "that", "not", "only", "transactivates", "the", "long", "terminal", "repeat", "of", "this", "retrovirus", "but", "also", "induces", "an", "array", "of", "cellular", "genes", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Thus", ",", "changes", "in", "the", "Sp1", "binding", "sites", "had", "the", "most", "dramatic", "effects", "on", "SIVmac", "replication", "in", "primary", "macrophage", "cultures", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "In", "mice", "a", "15-lipoxygenase", "is", "not", "expressed", ",", "but", "a", "leukocyte-type", "12-lipoxygenase", "is", "present", "in", "peritoneal", "macrophages", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0 ]

[ "Basophils", "express", "GATA-2", "and", "GATA-3", "." ]

[ 7, 0, 9, 0, 9, 0 ]

[ "In", "further", "studies", "we", "have", "shown", "that", "purified", "hsp90", "can", "bind", "to", "purified", "p23", "and", "this", "interaction", "requires", "both", "ATP", "and", "molybdate", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "and", "interleukin", "(", "IL", ")", "-3", "induced", "tyrosine", "phosphorylation", "of", "92-kDa", "protein", "in", "normal", "human", "monocytes", "." ]

[ 9, 10, 10, 0, 9, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 0 ]

[ "transcription", ",", "thereby", "amplifying", "expression", "of", "its", "own", "high-affinity", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "In", "the", "presence", "of", "1", "alpha", ",", "25", "(", "OH", ")", "2D3", ",", "cellular", "activation", "associated", "with", "stimulation", "of", "such", "a", "progression", "appears", "to", "be", "sufficient", "for", "the", "up-regulation", "of", "VDR", "message", "and", "protein", "and", "necessary", "for", "the", "establishment", "of", "VDRE", "binding", "complexes", "and", "the", "induction", "of", "24-hydroxylase", "message", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 0, 0 ]

[ "Costimulation", "of", "T", "cells", "through", "both", "the", "Ag", "receptor", "and", "CD28", "leads", "to", "high", "level", "IL-2", "production", ",", "which", "is", "vital", "to", "the", "development", "of", "an", "immune", "response", "in", "vivo", "." ]

[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Senescent", "human", "T", "lymphocyte", "cultures", "are", "unable", "to", "undergo", "proliferation", ",", "but", "show", "no", "difference", "from", "early", "passage", "cells", "in", "cytotoxic", "function", "or", "surface", "antigenic", "profile", "." ]

[ 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "wished", "to", "determine", "if", "this", "developmentally", "related", "interaction", "is", "a", "consequence", "of", "myeloid", "differentiation", "or", "an", "intrinsic", "differentiating", "stimulus", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "we", "also", "determined", "the", "effects", "of", "TS", "on", "NFkappaB", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "A", "role", "in", "thymic", "maturation", "for", "factors", "of", "the", "NF-kappaB", "family", "has", "long", "been", "suspected", ",", "but", "not", "yet", "proven", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "absence", "of", "ultraviolet", "absorbance", "maxima", "shifts", "in", "the", "presence", "of", "sodium", "acetate", "confirmed", "that", "the", "synthesized", "products", "were", "7-O-glucuronides", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "By", "contrast", ",", "priming", "under", "those", "conditions", "resulted", "in", "Th2", "differentiation", "in", "only", "9", "of", "24", "RA", "patients", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Demonstration", "of", "the", "complete", "dependence", "on", "the", "Y", "box", "in", "this", "system", "suggests", "that", ",", "despite", "its", "demonstrated", "importance", "in", "the", "DRA", "promoter", ",", "the", "DRA", "``", "octamer", "''", "does", "not", "utilize", "OTF-2", "in", "a", "manner", "analogous", "to", "immunoglobulin", "promoters", "in", "B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0 ]

[ "To", "further", "explore", "the", "involvement", "of", "PI3-K", "in", "T", "cell", "activation", ",", "we", "created", "a", "set", "of", "potentially", "dominant", "negative", "PI3-K", "constructs", "comprising", "individual", "or", "tandem", "domains", "of", "the", "regulatory", "p85", "subunit", "and", "tested", "their", "effect", "on", "downstream", "signaling", "events", "like", "Erk2", "activation", "and", "transcription", "from", "an", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "element", "taken", "from", "the", "interleukin-2", "promoter", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 0 ]

[ "We", "have", "cloned", "and", "sequenced", "a", "portion", "of", "the", "ER", "upstream", "regulatory", "region", "from", "the", "ER-positive", "MCF-7", "and", "the", "ER-negative", "MDA-MB-231", "breast", "cancer", "cell", "lines", "to", "determine", "if", "sequence", "alterations", "in", "this", "region", "account", "for", "the", "ER", "-negative", "phenotype", "of", "some", "tumors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 1, 2, 2, 0, 0, 5, 6, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "The", "presence", "of", "ras", "mutations", "has", "been", "correlated", "with", "a", "poor", "prognosis", "and", "negative", "clinical", "outcome", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "RESULTS", ":", "Secretion", "of", "IL-8", "and", "RANTES", "increased", "in", "a", "dose-dependent", "manner", "with", "increasing", "concentrations", "of", "DEP-PAHs", "(", "range", ",", "0.5", "ng", "to", "50", "ng/mL", ")", "." ]

[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "has", "previously", "been", "shown", "that", "9S", ",", "untransformed", "progestin", ",", "estrogen", ",", "androgen", ",", "and", "glucocorticoid", "receptor", "complexes", "in", "rabbit", "uterine", "and", "liver", "cytosols", "contain", "a", "59-kDa", "protein", "[", "Tai", ",", "P.K.", ",", "Maeda", ",", "Y.", ",", "Nakao", ",", "K.", ",", "Wakim", ",", "N.G.", ",", "Duhring", ",", "J.L.", ",", "&", "Faber", ",", "L.E.", "(", "1986", ")", "Biochemistry", "25", ",", "5269-5275", "]", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "At", "the", "end", "of", "both", "treatment", "periods", "symptoms", "were", "scored", "after", "allergen", "provocation", "(", "100", ",", "1000", ",", "10000", "BU/mL", ")", "and", "during", "the", "9.5", "hours", "after", "this", "challenge", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Inhibition", "of", "protein", "phosphatases", "by", "okadaic", "acid", "induces", "AP1", "in", "human", "T", "cells", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0 ]

[ "We", "demonstrate", "here", "that", "STAT", "protein", "heterocomplexes", "exist", "prior", "to", "cytokine", "treatment", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0 ]

[ "The", "oxidant", "stress-induced", "signaling", "resulted", "in", "an", "increased", "surface", "expression", "of", "a", "subset", "of", "CAMs", ",", "ICAM-1", ",", "E-selectin", ",", "and", "VCAM-1", "in", "HUVEC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 5, 0 ]

[ "To", "gain", "better", "insight", "into", "the", "potential", "role", "of", "nuclear", "I", "(", "kappa", ")", "B", "(", "alpha", ")", "in", "a", "physiological", "context", "we", "have", "analysed", "its", "presence", "in", "the", "nucleus", "of", "human", "peripheral", "blood", "T", "lymphocytes", "(", "PBL", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0 ]

[ "The", "mean", "number", "of", "type", "I", "and", "type", "II", "receptors", "was", "significantly", "lower", "in", "aged", "subjects", "than", "in", "controls", "(", "respectively", ",", "198", "+/-", "96", "and", "272", "+/-", "97", "receptors", "/cell", "for", "type", "I", ",", "and", "1", ",", "794", "+/-", "803", "and", "3", ",", "339", "+/-", "918", "for", "type", "II", "receptors", ")", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "In", "conclusion", "an", "increased", "transcription", "efficiency", "of", "a", "cell", "type", "specific", "gene", "is", "accompanied", "by", "a", "higher", "hybridization", "accessibility", "in", "the", "corresponding", "cell", "nuclei", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Highly", "purified", "monocytes", "were", "incubated", "with", "IL-10", "for", "60", "to", "90", "minutes", "before", "the", "addition", "of", "IFNgamma", "or", "IFNalpha", "." ]

[ 0, 0, 7, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]

[ "Consistent", "with", "this", "phenotype", ",", "the", "myeloid", "transcription", "factor", "PU.1", ",", "but", "not", "the", "erythroid", "transcription", "factor", "GATA-1", ",", "is", "expressed", "in", "47.10", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 5, 6, 0 ]

[ "Here", "we", "show", "that", "in", "E29.1", "T", "cell", "hybridoma", "I", "kappa", "B", "alpha", "and", "I", "kappa", "B", "beta", "are", "equally", "associated", "with", "p65", "and", "that", "I", "kappa", "B", "beta", "is", "degraded", "in", "response", "to", "TNF", "alpha", "in", "contrast", "to", "what", "has", "been", "originally", "published", "." ]

[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 9, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "the", "gene", "encoding", "human", "inosine-", "5'-monophosphate", "dehydrogenase", "(", "IMPDH", ")", "type", "II", ",", "an", "enzyme", "catalyzing", "the", "rate-limiting", "step", "in", "the", "generation", "of", "guanine", "nucleotides", ",", "is", "increased", "more", "than", "10-fold", "in", "activated", "peripheral", "blood", "T", "lymphocytes", "and", "is", "required", "for", "T", "cell", "activation", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "c-Maf", "induces", "monocytic", "differentiation", "and", "apoptosis", "in", "bipotent", "myeloid", "progenitors", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "In", "addition", ",", "aberrancies", "in", "NF-kappaB", "activity", "have", "been", "implicated", "in", "the", "immunopathogenesis", "of", "diseases", "involving", "immune", "or", "inflammatory", "processes", "such", "as", "atherosclerosis", "and", "HIV-1", "infection", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "suggests", "that", "for", "senescent", "T", "cells", "the", "reduced", "ability", "to", "respond", "to", "heat", "shock", "by", "producing", "hsp70", ",", "although", "possibly", "lying", "at", "the", "level", "of", "transcriptional", "control", ",", "may", "nevertheless", "be", "unrelated", "to", "the", "reduced", "DNA", "synthesis", "or", "the", "diminished", "proliferative", "activity", "also", "manifested", "by", "these", "cells", "." ]

[ 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "putative", "NFAT-1", "region", "is", "not", "required", "for", "the", "response", "to", "anti-CD3", "or", "to", "mitogens", "in", "T-cell", ",", "B-cell", ",", "or", "monocyte/macrophage", "leukemia", "lines", ",", "nor", "is", "it", "a", "cis-acting", "negative", "regulatory", "element", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 5, 0, 5, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Only", "SRI", "responders", "showed", "GCII", "sites/cell", "upregulated", "after", "6", "weeks", "of", "treatment", "(", "t", "=", "2.1", ",", "df", "=", "10", ";", "p", "<", ".05", ")", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Detection", "of", "the", "chromosome", "16", "CBF", "beta-MYH11", "fusion", "transcript", "in", "myelomonocytic", "leukemias", "." ]

[ 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 0, 0, 0 ]

[ "NF-kappa", "B", "binding", "activity", "was", "absent", "in", "several", "SLE", "patients", "who", "were", "not", "receiving", "any", "medication", ",", "including", "corticosteroids", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "cross", "communication", "involves", "soluble", "mediators", ",", "including", "various", "growth", "factors", ",", "cytokines", ",", "and", "neuropeptides", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0 ]

[ "In", "the", "DRA", "promoter", ",", "one", "of", "these", "cis-acting", "regulatory", "motifs", "is", "the", "X2-box", "to", "which", "nuclear", "factor", "X2", "(", "NF-X2", ")", "binds", "." ]

[ 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0 ]

[ "In", "contrast", ",", "monocytes", "and", "IFN-U937", "cells", "responded", "only", "weakly", "to", "red", "cells", "sensitized", "with", "either", "anti-D", "in", "sera", "from", "mothers", "of", "babies", "unaffected", "by", "HDN", ",", "or", "with", "antisera", "containing", "high", "titre", "antibodies", "with", "specificities", "not", "normally", "associated", "with", "significantly", "reduced", "red", "cell", "survival", "." ]

[ 0, 0, 0, 7, 0, 5, 6, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]

[ "Estrone", "potentiates", "myeloid", "cell", "differentiation", ":", "a", "role", "for", "17", "beta-hydroxysteroid", "dehydrogenase", "in", "modulating", "hemopoiesis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]

[ "PPARalpha", "activators", "inhibit", "cytokine-induced", "vascular", "cell", "adhesion", "molecule-1", "expression", "in", "human", "endothelial", "cells", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 7, 8, 8, 0 ]

[ "Oestrogen", "receptor", "gene", "polymorphisms", "in", "the", "region", "encoding", "the", "N-terminal", "portion", "of", "the", "protein", "are", "reportedly", "associated", "with", "pathological", "conditions", "including", "breast", "cancer", ",", "hypertension", ",", "spontaneous", "abortion", "and", "coronary", "heart", "disease", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "work", "reported", "here", "resolves", ",", "at", "the", "level", "of", "gene", "regulation", ",", "the", "controversy", "as", "to", "whether", "or", "not", "human", "monocytes/macrophages", "can", "produce", "nitric", "oxide", "(", "NO", ")", "when", "stimulated", "with", "lipopolysaccharide", "(", "LPS", ")", ",", "with", "or", "without", "co-stimulation", "by", "interferon-gamma", "(", "IFN-gamma", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Differanisole", "A", "in", "combination", "with", "9cisRA", "may", "have", "implications", "for", "therapy", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "rapid", "expansion", "of", "the", "number", "of", "women", "now", "suitable", "for", "X", "inactivation", "analysis", "has", "however", "given", "rise", "to", "new", "controversies", ",", "one", "of", "the", "more", "troublesome", "being", "the", "possibility", "of", "a", "modification", "of", "the", "pattern", "of", "X-", "chromosome", "inactivation", "pattern", "in", "blood", "cells", "of", "elderly", "women", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]

[ "Thus", ",", "the", "activity", "of", "a", "bHLH", "transcription", "factor", "is", "necessary", "for", "T", "lineage", "differentiation", "of", "bipotential", "precursors", ",", "in", "the", "absence", "of", "which", "a", "default", "pathway", "leading", "to", "NK", "cell", "development", "is", "chosen", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Transcriptional", "control", "of", "steroid-regulated", "apoptosis", "in", "murine", "thymoma", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Thus", ",", "the", "cooperation", "of", "two", "general", "cellular", "transcription", "factors", "may", "allow", "for", "the", "selective", "downregulation", "of", "HIV", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Changes", "in", "c-fos", "expression", "induced", "by", "radiation", "therapy", "in", "tumor", "tissues", "have", "not", "yet", "been", "reported", "." ]

[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Both", "chimeras", "were", "found", "to", "transactivate", "model", "and", "native", "promoters", "at", "equivalent", "or", "better", "levels", "than", "ZEBRA", "itself", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Inducible", "nitric", "oxide", ":", "an", "autoregulatory", "feedback", "inhibitor", "of", "vascular", "inflammation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Hypertension", "in", "pregnancy", "." ]

[ 0, 0, 0, 0 ]

[ "Thrombin", "plays", "a", "critical", "role", "in", "platelet", "activation", ",", "hemostasis", ",", "and", "thrombosis", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "also", "examined", "the", "expression", "of", "GCRbeta", "in", "specimens", "from", "the", "airways", "of", "patients", "with", "chronic", "bronchitis", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "subunits", "of", "this", "heterodimer", "have", "been", "cloned", ",", "and", "NF90", "was", "found", "to", "encode", "a", "protein", "containing", "two", "domains", "that", "are", "predicted", "to", "form", "motifs", "capable", "of", "binding", "to", "double-stranded", "RNA", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "Our", "results", "implicate", "C/EBP", "beta", "as", "an", "important", "regulator", "of", "TNF", "alpha", "by", "myelomonocytic", "cells", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0 ]

[ "During", "recent", "years", ",", "studies", "of", "insulin-gene", "regulation", "and", ",", "in", "particular", ",", "the", "tissue-specific", "transcriptional", "control", "of", "insulin-gene", "activity", "have", "provided", "information", "on", "pancreas", "development", "in", "general", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "immunodeficiency", "virus-associated", "Hodgkin", "'s", "disease", "derives", "from", "post-germinal", "center", "B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "It", "is", "interesting", "that", "in", "humans", "and", "rats", ",", "cortical", "thymocytes", "undergoing", "negative", "selection", "can", "still", "induce", "IL-2R", "alpha", "expression", "and", "even", "be", "rescued", "in", "vitro", ",", "if", "exogenous", "IL-2", "is", "provided", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]

[ "After", "short-term", ",", "in", "vitro", "exposure", "to", "therapeutical", "levels", ",", "distinct", "changes", "in", "P-glycoprotein", ",", "steroid", "receptors", ",", "p53", "and", "Bcl-2", "expression", "take", "place", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "n-Acetyl-L-cysteine", "(", "NAC", ")", ",", "a", "potent", "antioxidant", ",", "blocked", "NF-kappa", "B", "activation", "caused", "by", "IL-4", "and", "by", "anti-CD40", "mAb", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 9, 10, 0 ]

[ "We", "performed", "an", "analysis", "of", "the", "mechanisms", "by", "which", "two", "PKC", "inhibitors", ",", "Calphostin", "C", "and", "Staurosporine", ",", "prevent", "the", "FN", "-induced", "IL-1beta", "response", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]

[ "The", "activity", "of", "A-MYB", "in", "B", "and", "not", "T", "cells", "was", "observed", "when", "either", "an", "artificial", "construct", "or", "the", "c-MYC", "promoter", "was", "used", "as", "a", "reporter", "." ]

[ 0, 0, 0, 9, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]

[ "Incubation", "of", "human", "whole", "blood", "with", "PGG-Glucan", "significantly", "enhanced", "the", "oxidative", "burst", "response", "of", "subsequently", "isolated", "blood", "leukocytes", "to", "both", "soluble", "and", "particulate", "activators", "in", "a", "dose-dependent", "manner", ",", "and", "increased", "leukocyte", "microbicidal", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "these", "results", "show", "that", "age-related", "impairments", "in", "the", "activation", "of", "AP-1", "and", "NF-AT", "are", "closely", "associated", "with", "decreased", "expression", "of", "IL-2", "and", "further", "suggest", "that", "aberrancies", "in", "the", "signaling", "pathways", "important", "for", "the", "induction", "of", "transcriptionally", "active", "c-Fos/c-Jun", "AP-1", "may", "contribute", "to", "the", "impaired", "activation", "of", "NF-AT", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "For", "cells", "of", "the", "innate", "immune", "system", "to", "mount", "a", "host", "defence", "response", "to", "infection", ",", "they", "must", "recognize", "products", "of", "microbial", "pathogens", "such", "as", "lipopolysaccharide", "(", "LPS", ")", ",", "the", "endotoxin", "secreted", "by", "Gram-negative", "bacteria", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "conducted", "functional", "studies", "of", "the", "enhancer", "elements", "of", "human", "T-cell", "leukemia", "virus", "type", "I", "(", "HTLV-I", ")", "using", "the", "human", "T-cell", "lines", "Jurkat", "and", "MOLT", "4", ",", "which", "are", "negative", "for", "HTLV-I", ",", "and", "MT-2", "and", "TL-Mor", ",", "which", "carry", "the", "proviral", "genome", "of", "HTLV-I", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Copyright", "1998", "Academic", "Press", "." ]

[ 0, 0, 0, 0, 0 ]

[ "First", "is", "an", "expansion", "phase", "prior", "to", "TCR", "rearrangement", ",", "which", "appears", "to", "be", "correlated", "with", "programming", "of", "at", "least", "some", "response", "genes", "for", "inducibility", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "therefore", "created", "and", "studied", "a", "T", "cell", "line", "expressing", "the", "cloned", "delta-opioid", "receptor", "(", "DOR1", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]

[ "This", "was", "associated", "with", "a", "reduction", "in", "endothelial", "MCP-1", "secretion", "and", "GRO-alpha", "immobilization", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0 ]

[ "5.", "Neutrophil", "apoptosis", "and", "inhibition", "of", "neutrophil", "function", "were", "induced", "at", "lower", "concentrations", "of", "SMX-NHOH", "and", "SMX-NO", "than", "those", "inducing", "loss", "of", "membrane", "viability", ",", "with", "SMX", "having", "no", "effect", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "demonstrated", "that", "native", "envelope", "glycoproteins", "of", "HIV-1", ",", "gp160", "can", "induce", "activation", "of", "the", "transcription", "factor", ",", "NF-kappa", "B", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]

[ "In", "this", "report", ",", "we", "demonstrate", "that", "the", "PB1", "element", "alone", "confers", "inducibility", "on", "a", "heterologous", "promoter", "following", "transfection", "into", "human", "Jurkat", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]

[ "In", "this", "study", ",", "we", "show", "that", "certain", "NF-kappaB/Rel", "members", ",", "predominantly", "c-Rel", ",", "interact", "with", "enhancer", "sequences", "for", "STAT5", ",", "a", "key", "transcription", "factor", "mediating", "IL-2", "-induced", "T-cell", "proliferation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Redox", "status", "of", "cells", "influences", "constitutive", "or", "induced", "NF-kappa", "B", "translocation", "and", "HIV", "long", "terminal", "repeat", "activity", "in", "human", "T", "and", "monocytic", "cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 2, 2, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]

[ "These", "results", "suggest", "that", "Fli-1", "is", "likely", "to", "regulate", "lineage-specific", "genes", "during", "megakaryocytopoiesis", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]

[ "The", "BRLF1", "product", "Rta", "functions", "as", "a", "transcriptional", "activator", "in", "both", "B", "lymphocytes", "and", "epithelial", "cells", "." ]

[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 0 ]

[ "In", "this", "study", "we", "investigated", "the", "mechanisms", "whereby", "anti-CD2", "antibodies", "stimulate", "viral", "production", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "Antioxidants", "have", "been", "proposed", "to", "be", "anti-atherosclerotic", "agents", ";", "however", ",", "the", "mechanisms", "underlying", "their", "beneficial", "effects", "are", "poorly", "understood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "agreement", "with", "this", "finding", ",", "Northern", "experiments", "where", "p65", "and", "p105", "mRNA", "levels", "were", "determined", ",", "demonstrated", "that", "expression", "of", "these", "components", "of", "the", "NF-kappa", "B", "transcription", "factor", "were", "not", "affected", "by", "IL-10", "or", "IL-4", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]

[ "Except", "for", "the", "conserved", "zinc-finger", "domains", ",", "the", "amino", "acid", "sequences", "of", "the", "three", "proteins", "are", "distinct", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]