id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8301
[ "To", "test", "this", "apparent", "discrepancy", ",", "we", "realized", "that", "HTB", "and", "triflusal", "(", "but", "neither", "aspirin", "nor", "salicylate", ")", "produced", "a", "concentration-dependent", "inhibition", "of", "COX-2", "protein", "expression", "in", "peripheral", "human", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 8, 8, 0 ]
8302
[ "This", "observation", "was", "further", "confirmed", "in", "a", "rat", "air", "pouch", "model", "in", "vivo", ",", "in", "which", "both", "aspirin", "and", "triflusal", "inhibited", "PGE2", "production", "(", "ID50", "=", "18.9", "and", "11.4", "mg/kg", "p.o.", ",", "respectively", ")", "but", "only", "triflusal-treated", "animals", "showed", "a", "decrease", "in", "COX-2", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8303
[ "This", "different", "behavior", "may", "be", ",", "at", "least", "in", "part", ",", "due", "to", "the", "ability", "of", "HTB", "and", "triflusal", "to", "block", "the", "activation", "of", "the", "transcription", "factor", "nuclear", "factor-kappaB", "to", "a", "higher", "extent", "than", "aspirin", "and", "sodium", "salicylate", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8304
[ "Thus", ",", "in", "addition", "to", "inhibiting", "the", "COX-2", "activity", "at", "therapeutic", "concentrations", ",", "triflusal", "is", "able", "to", "block", "through", "its", "metabolite", "HTB", "the", "expression", "of", "new", "enzyme", ",", "and", "hence", "the", "resumption", "of", "PGE2", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8305
[ "Triflusal", "and", "HTB", "may", "exert", "beneficial", "effects", "in", "processes", "in", "which", "de", "novo", "COX-2", "expression", "is", "involved", "and", ",", "in", "a", "broader", "sense", ",", "in", "pathological", "situations", "in", "which", "genes", "under", "nuclear", "factor-kappaB", "control", "are", "up-regulated", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
8306
[ "Evidence", "for", "distinct", "intracellular", "signaling", "pathways", "in", "CD34+", "progenitor", "to", "dendritic", "cell", "differentiation", "from", "a", "human", "cell", "line", "model", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
8307
[ "Intracellular", "signals", "that", "mediate", "differentiation", "of", "pluripotent", "hemopoietic", "progenitors", "to", "dendritic", "cells", "(", "DC", ")", "are", "largely", "undefined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0 ]
8308
[ "We", "have", "previously", "shown", "that", "protein", "kinase", "C", "(", "PKC", ")", "activation", "(", "with", "phorbol", "ester", "(", "PMA", ")", "alone", ")", "specifically", "induces", "differentiation", "of", "primary", "human", "CD34+", "hemopoietic", "progenitor", "cells", "(", "HPC", ")", "to", "mature", "DC", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0, 0, 7, 0 ]
8309
[ "We", "now", "find", "that", "cytokine-driven", "(", "granulocyte-macrophage", "CSF", "and", "TNF-alpha", ")", "CD34+", "HPC", "--", ">", "DC", "differentiation", "is", "preferentially", "blocked", "by", "inhibitors", "of", "PKC", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 7, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8310
[ "To", "further", "identify", "intracellular", "signals", "and", "downstream", "events", "important", "in", "CD34+", "HPC", "--", ">", "DC", "differentiation", "we", "have", "characterized", "a", "human", "leukemic", "cell", "line", "model", "of", "this", "process", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0 ]
8311
[ "The", "CD34+", "myelomonocytic", "cell", "line", "KG1", "differentiates", "into", "dendritic-like", "cells", "in", "response", "to", "granulocyte-macrophage", "CSF", "plus", "TNF-alpha", ",", "or", "PMA", "(", "with", "or", "without", "the", "calcium", "ionophore", "ionomycin", ",", "or", "TNF-alpha", ")", ",", "with", "different", "stimuli", "mediating", "different", "aspects", "of", "the", "process", "." ]
[ 0, 0, 5, 6, 6, 6, 0, 0, 7, 8, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8312
[ "Phenotypic", "DC", "characteristics", "of", "KG1", "dendritic-like", "cells", "include", "morphology", "(", "loosely", "adherent", "cells", "with", "long", "neurite", "processes", ")", ",", "MHC", "I+/", "MHC", "IIbright/CD83+/CD86+/", "CD14", "-", "surface", "Ag", "expression", ",", "and", "RelB", "and", "DC", "-CK1", "gene", "expression", "." ]
[ 0, 7, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 1, 2, 2, 0, 0 ]
8313
[ "Functional", "DC", "characteristics", "include", "fluid", "phase", "macromolecule", "uptake", "(", "FITC-dextran", ")", "and", "activation", "of", "resting", "T", "cells", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8314
[ "Comparison", "of", "KG1", "to", "the", "PMA-unresponsive", "subline", "KG1a", "reveals", "differences", "in", "expression", "of", "TNF", "receptors", "1", "and", "2", ";", "PKC", "isoforms", "alpha", ",", "beta", "I", ",", "beta", "II", ",", "and", "mu", ";", "and", "RelB", ",", "suggesting", "that", "these", "components/pathways", "are", "important", "for", "DC", "differentiation", "." ]
[ 0, 0, 5, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 10, 10, 0, 9, 10, 0, 9, 10, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
8315
[ "Together", ",", "these", "findings", "demonstrate", "that", "cytokine", "or", "phorbol", "ester", "stimulation", "of", "KG1", "is", "a", "model", "of", "human", "CD34+", "HPC", "to", "DC", "differentiation", "and", "suggest", "that", "specific", "intracellular", "signaling", "pathways", "mediate", "specific", "events", "in", "DC", "lineage", "commitment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
8316
[ "Involvement", "of", "adenylate", "cyclase", "and", "p70", "(", "S6", ")", "-kinase", "activation", "in", "IL-10", "up-regulation", "in", "human", "monocytes", "by", "gp41", "envelope", "protein", "of", "human", "immunodeficiency", "virus", "type", "1", "." ]
[ 0, 0, 9, 10, 0, 9, 10, 10, 10, 10, 0, 0, 9, 0, 0, 7, 8, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
8317
[ "Our", "previous", "results", "show", "that", "recombinant", "gp41", "(", "aa565-647", ")", ",", "the", "extracellular", "domain", "of", "HIV-1", "transmembrane", "glycoprotein", ",", "stimulates", "interleukin-10", "(", "IL-10", ")", "production", "in", "human", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 7, 8, 0 ]
8318
[ "The", "signal", "cascade", "transducing", "this", "effect", "is", "not", "yet", "clear", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8319
[ "In", "this", "study", ",", "we", "examined", "whether", "gp41", "-induced", "IL-10", "up-regulation", "is", "mediated", "by", "the", "previously", "described", "synergistic", "activation", "of", "cAMP", "and", "NF-kappaB", "pathways", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8320
[ "gp41", "induced", "cAMP", "accumulation", "in", "monocytes", "in", "a", "time-", "and", "concentration-dependent", "manner", "and", "the", "adenylate", "cyclase", "inhibitor", "SQ", "22536", "suppressed", "gp41", "-induced", "IL-10", "production", "in", "monocytes", "." ]
[ 9, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 9, 0, 0, 7, 0 ]
8321
[ "In", "contrast", ",", "gp41", "failed", "to", "stimulate", "NF-kappaB", "binding", "activity", "in", "as", "much", "as", "no", "NF-kappaB", "bound", "to", "the", "main", "NF-kappaB-binding", "site", "2", "of", "the", "IL-10", "promoter", "after", "addition", "of", "gp41", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 9, 0 ]
8322
[ "We", "also", "examined", "the", "involvement", "of", "other", "signal", "transduction", "pathways", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8323
[ "Specific", "inhibitors", "of", "p70", "(", "S6", ")", "-kinase", "(", "rapamycin", ")", ",", "and", "Gi", "protein", "(", "pertussis", "toxin", ")", ",", "prevented", "induction", "of", "IL-10", "production", "by", "gp41", "in", "monocytes", ",", "while", "inhibitors", "of", "the", "phosphatidylinositol", "3-kinase", "(", "PI", "3-kinase", ")", "(", "wortmannin", ")", "and", "mitogen-activated", "protein", "kinase", "(", "MAPK", ")", "pathway", "(", "PD", "98059", ")", "did", "not", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8324
[ "Thus", "HIV-1", "gp41", "-induced", "IL-10", "up-regulation", "in", "monocytes", "may", "not", "involve", "NF-kappaB", ",", "MAPK", ",", "or", "PI", "3-kinase", "activation", ",", "but", "rather", "may", "operate", "through", "activation", "of", "adenylate", "cyclase", "and", "pertussis-toxin-sensitive", "Gi/Go", "protein", "to", "effect", "p70", "(", "S6", ")", "-kinase", "activation", "." ]
[ 0, 9, 10, 0, 9, 0, 0, 7, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0 ]
8325
[ "Analysis", "of", "the", "modulation", "of", "transcriptional", "activity", "in", "myelopoiesis", "and", "leukemogenesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8326
[ "Acute", "myeloid", "leukemia", "(", "AML", ")", "is", "still", "associated", "with", "a", "mortality", "of", "60", "to", "80", "%", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8327
[ "AML", "is", "characterized", "by", "a", "block", "in", "myeloid", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8328
[ "The", "transcription", "factors", "PU.1", "and", "C/EBPalpha", "are", "responsible", "for", "normal", "myeloid", "differentiation", "from", "stem", "cells", "to", "monocytes", "or", "granulocytes", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 7, 0 ]
8329
[ "In", "particular", ",", "PU.1", "induces", "expression", "of", "the", "macrophage", "colony-stimulating", "factor", "(", "M-CSF", ")", "receptor", "and", "the", "development", "of", "monocytes", ",", "whereas", "C/EBPalpha", "increases", "the", "expression", "of", "the", "granulocyte", "colony-stimulating", "factor", "(", "G-CSF", ")", "receptor", "and", "leads", "to", "mature", "granulocytes", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 0 ]
8330
[ "In", "AML", ",", "chromosomal", "aberrations", "result", "in", "oncoproteins", "such", "as", "AML1/ETO", ",", "PML/RARalpha", ",", "or", "activated", "Ras", ",", "which", "can", "deregulate", "genes", "important", "for", "normal", "myelopoiesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8331
[ "Thus", ",", "AML1/ETO", "can", "bind", "to", "the", "transcription", "factor", "C/EBPalpha", ",", "inhibit", "C/EBPalpha", "-dependent", "transcription", ",", "and", "block", "granulocytic", "differentiation", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
8332
[ "However", ",", "AML1/ETO", "can", "also", "synergize", "with", "the", "transcription", "factor", "AML1", "to", "enhance", "the", "activity", "of", "the", "M-CSF", "receptor", "promoter", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
8333
[ "On", "the", "other", "hand", ",", "the", "PML/RARalpha", "fusion", "protein", "causes", "transcriptional", "repression", "by", "recruiting", "the", "nuclear", "corepressor", "(", "N-CoR", ")", "histone", "deacetylase", "complex", "to", "the", "DNA", ",", "which", "results", "in", "decreased", "histone", "acetylation", "and", "a", "repressive", "chromatin", "organization", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
8334
[ "Here", "we", "describe", "methods", "to", "investigate", "whether", "and", "how", "signaling", "agonists", "induce", "myeloid", "differentiation", "and", "how", "oncoproteins", "might", "cause", "AML", "by", "modulating", "the", "activity", "of", "transcription", "factors", "that", "are", "pivotal", "for", "normal", "myeloid", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8335
[ "Copyright", "1999", "Academic", "Press", "." ]
[ 0, 0, 0, 0, 0 ]
8336
[ "NF-ATc", "isoforms", "are", "differentially", "expressed", "and", "regulated", "in", "murine", "T", "and", "mast", "cells", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8337
[ "NF", "of", "activated", "T", "cells", "(", "NF-AT", ")", "denotes", "a", "family", "of", "transcription", "factors", "that", "regulate", "the", "activation-dependent", "expression", "of", "many", "immunologically", "important", "proteins", "." ]
[ 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8338
[ "At", "least", "four", "distinct", "genes", "encode", "the", "various", "family", "members", ",", "and", "several", "isoforms", "of", "these", "have", "been", "identified", "as", "well", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8339
[ "The", "overlapping", "expression", "patterns", "and", "similar", "in", "vitro", "binding", "and", "trans-activation", "activities", "on", "various", "promoter", "elements", "of", "NF-AT-regulated", "genes", "suggest", "some", "redundancy", "in", "the", "function", "of", "these", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8340
[ "However", ",", "the", "phenotypic", "analysis", "of", "NF-AT", "-deficient", "mice", "supports", "the", "idea", "that", "there", "are", "tissue-", "and", "gene-", "specific", "functions", "as", "well", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8341
[ "In", "this", "study", "we", "have", "characterized", "the", "expression", "of", "NF-AT", "cDNAs", "in", "murine", "mast", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 8, 0 ]
8342
[ "The", "majority", "of", "clones", "identified", "correspond", "to", "two", "NF-ATc", "isoforms", "that", "differ", "only", "in", "their", "amino-terminal", "sequence", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
8343
[ "Despite", "minimal", "discrepancies", "in", "the", "coding", "region", ",", "there", "are", "striking", "tissue-", "and", "cell", "type-specific", "differences", "in", "isoform", "expression", "patterns", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8344
[ "Detection", "of", "NF-ATc.alpha", "mRNA", "is", "strictly", "dependent", "on", "cell", "activation", "signals", "in", "both", "T", "and", "mast", "cell", "lines", "." ]
[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
8345
[ "In", "contrast", ",", "the", "beta", "isoform", "is", "expressed", "at", "very", "low", "constitutive", "levels", "in", "both", "cell", "types", "but", "is", "only", "up-regulated", "in", "response", "to", "mast", "cell", "activation", "signals", "delivered", "through", "the", "FcepsilonRI", "or", "via", "calcium", "ionophores", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
8346
[ "These", "results", "demonstrate", "another", "level", "of", "regulation", "within", "the", "NF-AT", "family", "that", "can", "contribute", "to", "cell", "type-specific", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8347
[ "Crossreactive", "recognition", "of", "viral", ",", "self", ",", "and", "bacterial", "peptide", "ligands", "by", "human", "class", "I-restricted", "cytotoxic", "T", "lymphocyte", "clonotypes", ":", "implications", "for", "molecular", "mimicry", "in", "autoimmune", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8348
[ "The", "immunodominant", ",", "CD8", "(", "+", ")", "cytotoxic", "T", "lymphocyte", "(", "CTL", ")", "response", "to", "the", "HLA-B8-restricted", "peptide", ",", "RAKFKQLL", ",", "located", "in", "the", "Epstein-Barr", "virus", "immediate-early", "antigen", ",", "BZLF1", ",", "is", "characterized", "by", "a", "diverse", "T", "cell", "receptor", "(", "TCR", ")", "repertoire", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0 ]
8349
[ "Here", ",", "we", "show", "that", "this", "diversity", "can", "be", "partitioned", "on", "the", "basis", "of", "crossreactive", "cytotoxicity", "patterns", "involving", "the", "recognition", "of", "a", "self", "peptide-RSKFRQIV-located", "in", "a", "serine/threonine", "kinase", "and", "a", "bacterial", "peptide-RRKYKQII-located", "in", "Staphylococcus", "aureus", "replication", "initiation", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8350
[ "Thus", "CTL", "clones", "that", "recognized", "the", "viral", ",", "self", ",", "and", "bacterial", "peptides", "expressed", "a", "highly", "restricted", "alphabeta", "TCR", "phenotype", "." ]
[ 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8351
[ "The", "CTL", "clones", "that", "recognized", "viral", "and", "self", "peptides", "were", "more", "oligoclonal", ",", "whereas", "clones", "that", "strictly", "recognized", "the", "viral", "peptide", "displayed", "a", "diverse", "TCR", "profile", "." ]
[ 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8352
[ "Interestingly", ",", "the", "self", "and", "bacterial", "peptides", "equally", "were", "substantially", "less", "effective", "than", "the", "cognate", "viral", "peptide", "in", "sensitizing", "target", "cell", "lysis", ",", "and", "also", "resulted", "only", "in", "a", "weak", "reactivation", "of", "memory", "CTLs", "in", "limiting", "dilution", "assays", ",", "whereas", "the", "cognate", "peptide", "was", "highly", "immunogenic", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8353
[ "The", "described", "crossreactions", "show", "that", "human", "antiviral", ",", "CD8", "(", "+", ")", "CTL", "responses", "can", "be", "shaped", "by", "peptide", "ligands", "derived", "from", "autoantigens", "and", "environmental", "bacterial", "antigens", ",", "thereby", "providing", "a", "firm", "structural", "basis", "for", "molecular", "mimicry", "involving", "class", "I-restricted", "CTLs", "in", "the", "pathogenesis", "of", "autoimmune", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]
8354
[ "RFLAT-1", ":", "a", "new", "zinc", "finger", "transcription", "factor", "that", "activates", "RANTES", "gene", "expression", "in", "T", "lymphocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 0 ]
8355
[ "RANTES", "(", "Regulated", "upon", "Activation", ",", "Normal", "T", "cell", "Expressed", "and", "Secreted", ")", "is", "a", "chemoattractant", "cytokine", "(", "chemokine", ")", "important", "in", "the", "generation", "of", "inflammatory", "infiltrate", "and", "human", "immunodeficiency", "virus", "entry", "into", "immune", "cells", "." ]
[ 9, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8356
[ "RANTES", "is", "expressed", "late", "(", "3-5", "days", ")", "after", "activation", "in", "T", "lymphocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8357
[ "Using", "expression", "cloning", ",", "we", "identified", "the", "first", "``", "late", "''", "T", "lymphocyte", "associated", "transcription", "factor", "and", "named", "it", "``", "RANTES", "Factor", "of", "Late", "Activated", "T", "Lymphocytes-1", "``", "(", "RFLAT-1", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0 ]
8358
[ "RFLAT-1", "is", "a", "novel", ",", "phosphorylated", ",", "zinc", "finger", "transcription", "factor", "that", "is", "expressed", "in", "T", "cells", "3", "days", "after", "activation", ",", "coincident", "with", "RANTES", "expression", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8359
[ "While", "Rel", "proteins", "play", "the", "dominant", "role", "in", "RANTES", "gene", "expression", "in", "fibroblasts", ",", "RFLAT-1", "is", "a", "strong", "transactivator", "for", "RANTES", "in", "T", "cells", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
8360
[ "Fas", "ligand", "induction", "in", "human", "NK", "cells", "is", "regulated", "by", "redox", "through", "a", "calcineurin-nuclear", "factors", "of", "activated", "T", "cell-dependent", "pathway", "." ]
[ 9, 10, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
8361
[ "Fas", "ligand", "(", "FasL", ")", "on", "cytotoxic", "lymphocytes", "is", "important", "for", "mediating", "apoptosis", "of", "activated", "lymphocytes", "and", "other", "target", "cells", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
8362
[ "We", "have", "reported", "that", "NK", "cell", "functions", ",", "such", "as", "proliferation", ",", "cell", "death", ",", "and", "killing", "activity", ",", "are", "subject", "to", "regulation", "by", "cellular", "redox", "status", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8363
[ "Here", ",", "we", "report", "that", "expression", "of", "FasL", "protein", "and", "mRNA", "in", "activated", "NK", "cells", "is", "also", "regulated", "by", "redox", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
8364
[ "Ligation", "of", "CD16", "on", "IL-2-preactivated", "NK", "cells", "resulted", "in", "reduction", "of", "intracellular", "peroxide", "level", "as", "well", "as", "induction", "of", "FasL", "expression", "." ]
[ 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8365
[ "This", "CD16", "-induced", "FasL", "expression", "was", "suppressed", "by", "oxidative", "stress", ",", "including", "thiol", "deprivation", "or", "treatment", "with", "hydrogen", "peroxide", "(", "H2O2", ")", "." ]
[ 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8366
[ "Addition", "of", "thiol-reducing", "compounds", ",", "such", "as", "L-cystine", ",", "2-ME", ",", "or", "N-acetyl", "cysteine", ",", "restored", "FasL", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8367
[ "These", "data", "suggest", "that", "CD16", "stimulation", "requires", "cellular", "reducing", "status", "for", "FasL", "induction", "in", "NK", "cells", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]
8368
[ "Because", "FasL", "gene", "activation", "following", "CD16", "cross-linking", "is", "regulated", "by", "the", "NF", "of", "activated", "T", "cells", "(", "NFAT", ")", ",", "we", "examined", "the", "effect", "of", "oxidative", "stresses", "on", "NFAT", "activation", "." ]
[ 0, 1, 2, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8369
[ "Electrophoretic", "mobility", "shift", "assays", "revealed", "that", "both", "thiol", "insufficiency", "and", "H2O2", "treatment", "suppressed", "DNA-binding", "activity", "of", "NFAT", "and", "that", "addition", "of", "thiol-reducing", "compounds", "reversed", "or", "even", "enhanced", "it", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8370
[ "Furthermore", ",", "these", "oxidative", "stresses", "inhibited", "activity", "of", "calcineurin", ",", "a", "serine/", "threonine", "phosphatase", "that", "regulates", "NFAT", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0 ]
8371
[ "These", "results", "suggest", "that", "suppression", "of", "calcineurin", "and", "NFAT", "activation", "is", "a", "mechanism", "by", "which", "oxidative", "stress", "inhibits", "FasL", "induction", "in", "activated", "NK", "cells", "and", "further", "support", "the", "hypothesis", "that", "thiol-reducing", "compounds", "might", "be", "required", "for", "maintenance", "of", "optimal", "NK", "functions", "under", "physiologic", "oxidative", "conditions", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8372
[ "Heterogeneity", "of", "clonal", "development", "in", "chronic", "myeloproliferative", "disorders", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8373
[ "Recent", "reports", "have", "suggested", "a", "previously", "unexpected", "variability", "in", "the", "expression", "of", "the", "dominant", "neoplastic", "clone", "in", "myeloproliferative", "disorders", "(", "MPD", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8374
[ "We", "evaluated", "49", "female", "patients", "with", "MPD", "and", "informative", "at", "the", "X-linked", "androgen", "receptor", "(", "AR", ")", "locus", "to", "establish", "the", "X", "chromosome", "inactivation", "pattern", "of", "hemopoietic", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 7, 8, 0 ]
8375
[ "Whereas", "in", "chronic", "myelogenous", "leukemia", "(", "CML", ")", "the", "granulocytes", "(", "PMN", ")", "were", "uniformly", "of", "monoclonal", "origin", ",", "a", "striking", "heterogeneity", "of", "clonal", "development", "was", "found", "in", "PMN", "from", "patients", "with", "other", "MPD", ",", "with", "up", "to", "50", "%", "of", "them", "expressing", "a", "polyclonal", "pattern", "of", "X", "inactivation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8376
[ "CD80", "and", "CD86", "are", "not", "equivalent", "in", "their", "ability", "to", "induce", "the", "tyrosine", "phosphorylation", "of", "CD28", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
8377
[ "Ligation", "of", "either", "CD80", "(", "B7-1", ")", "or", "CD86", "(", "B7-2", ")", ",", "two", "principal", "ligands", "for", "CD28", ",", "is", "thought", "to", "skew", "the", "immune", "response", "toward", "Th1", "or", "Th2", "differentiation", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0 ]
8378
[ "We", "have", "examined", "early", "signal", "transduction", "pathways", "recruited", "following", "T", "cell", "stimulation", "with", "either", "CD80", "or", "CD86", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0, 9, 0 ]
8379
[ "Purified", "human", "peripheral", "T", "cells", "or", "Jurkat", "T", "cells", "were", "stimulated", "with", "Chinese", "hamster", "ovary", "(", "CHO", ")", "cells", "expressing", "either", "human", "CD80", "(", "CHO-CD80", ")", "or", "human", "CD86", "(", "CHO-CD86", ")", "or", "with", "anti-CD28", "monoclonal", "antibody", "(", "mAb", ")", "." ]
[ 0, 5, 6, 6, 6, 0, 5, 6, 6, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]
8380
[ "In", "the", "presence", "of", "phorbol", "12-myristate", "13-acetate", ",", "both", "CHO-CD80", "and", "CHO-CD86", ",", "like", "anti-CD28", "mAb", ",", "were", "capable", "of", "stimulating", "cytokine", "production", "from", "both", "human", "peripheral", "T", "cells", "and", "Jurkat", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 5, 6, 6, 0 ]
8381
[ "Both", "CHO-CD80", "and", "CHO-CD86", ",", "in", "the", "presence", "of", "anti-CD3", "mAb", ",", "costimulated", "NFAT", "-dependent", "transcriptional", "activation", "." ]
[ 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0 ]
8382
[ "Several", "intracellular", "signaling", "proteins", ",", "such", "as", "CBL", "and", "VAV", ",", "were", "phosphorylated", "on", "tyrosine", "in", "response", "to", "CD80", ",", "CD86", ",", "and", "anti-CD28", "mAb", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0 ]
8383
[ "Surprisingly", ",", "although", "stimulation", "of", "Jurkat", "T", "cells", "with", "either", "CHO-CD80", "or", "anti-CD28", "mAb", "resulted", "in", "robust", "tyrosine", "phosphorylation", "of", "CD28", "itself", ",", "ligation", "with", "CHO-CD86", "was", "unable", "to", "induce", "detectable", "CD28", "tyrosyl", "phosphorylation", "over", "a", "range", "of", "stimulation", "conditions", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8384
[ "In", "addition", ",", "the", "association", "of", "phosphoinositide", "3-kinase", "with", "CD28", "and", "enhanced", "tyrosine", "phosphorylation", "of", "phospholipase", "Cgamma", "were", "seen", "after", "anti-CD28", "mAb", "and", "CHO-CD80", "stimulation", "but", "to", "a", "much", "lesser", "extent", "after", "CHO-CD86", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8385
[ "Thus", ",", "ligation", "of", "CD28", "with", "either", "CD80", "or", "CD86", "leads", "to", "shared", "early", "signal", "transduction", "events", "such", "as", "the", "tyrosine", "phosphorylation", "of", "CBL", "and", "VAV", ",", "to", "NFAT", "-mediated", "transcriptional", "activation", ",", "and", "to", "the", "costimulation", "of", "interleukin-2", "and", "granulocyte-macrophage", "colony-stimulating", "factor", "production", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0 ]
8386
[ "However", ",", "CD80", "and", "CD86", "also", "induce", "distinct", "signal", "transduction", "pathways", "including", "the", "tyrosine", "phosphorylation", "of", "CD28", "and", "phospholipase", "Cgamma1", "and", "the", "SH2", "-dependent", "association", "of", "phosphoinositide", "3-kinase", "with", "CD28", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0 ]
8387
[ "These", "quantitative", ",", "if", "not", "qualitative", ",", "differences", "between", "signaling", "initiated", "by", "these", "two", "ligands", "for", "CD28", "may", "contribute", "to", "functional", "differences", "(", "e.g.", "Th1", "or", "Th2", "differentiation", ")", "in", "T", "cell", "responses", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 7, 8, 0, 0 ]
8388
[ "Binding", "of", "HMG-I", "(", "Y", ")", "elicits", "structural", "changes", "in", "a", "silencer", "of", "the", "human", "beta-globin", "gene", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
8389
[ "Proteins", "involved", "in", "repression", "of", "the", "human", "beta-globin", "gene", "may", "be", "useful", "in", "the", "treatment", "of", "sickle", "cell", "anemia", ",", "in", "conjunction", "with", "therapy", "to", "reactivate", "fetal", "globin", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
8390
[ "If", "there", "is", "a", "reciprocal", "elevation", "of", "gamma-globin", "expression", "upon", "repression", ",", "this", "approach", "could", "be", "useful", "in", "additional", "hemoglobinopathies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8391
[ "We", "previously", "showed", "that", "repression", "of", "the", "beta-globin", "gene", "appears", "to", "be", "mediated", "through", "two", "DNA", "sequences", ",", "silencers", "I", "and", "II", ",", "and", "identified", "a", "protein", "termed", "BP1", "which", "binds", "to", "both", "silencer", "sequences", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
8392
[ "In", "this", "study", ",", "we", "cloned", "two", "cDNAs", "encoding", "proteins", "which", "bind", "to", "an", "oligonucleotide", "in", "silencer", "I", "containing", "a", "BP1", "binding", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
8393
[ "These", "cDNAs", "correspond", "to", "HMG-I", "and", "HMG-Y", ",", "isoforms", "regarded", "as", "architectural", "proteins", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
8394
[ "We", "demonstrate", "that", "binding", "of", "HMG-I", "(", "Y", ")", "to", "this", "oligonucleotide", "causes", "bending/flexure", "of", "the", "DNA", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8395
[ "HMG-I", "(", "Y", ")", "also", "binds", "to", "a", "second", "oligonucleotide", "containing", "a", "BP1", "binding", "site", "located", "in", "a", "negative", "control", "region", "upstream", "of", "the", "delta-globin", "gene", ",", "suggesting", "a", "role", "for", "HMG-I", "(", "Y", ")", "in", "repression", "of", "adult", "globin", "genes", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 1, 2, 2, 0 ]
8396
[ "Expression", "studies", "revealed", "that", "HMG-I", "(", "Y", ")", "is", "ubiquitously", "expressed", "in", "human", "tissues", "that", "do", "not", "express", "beta-globin", ",", "being", "present", "in", "48", "of", "50", "tissues", "and", "six", "hematopoietic", "cell", "lines", "examined", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0 ]
8397
[ "Furthermore", ",", "HMG-I", "(", "Y", ")", "expression", "is", "down-regulated", "during", "differentiation", "of", "primary", "erythroid", "cells", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8398
[ "We", "present", "a", "model", "in", "which", "HMG-I", "(", "Y", ")", "alters", "DNA", "conformation", "to", "allow", "binding", "of", "repressor", "proteins", ",", "and", "in", "which", "the", "relative", "amount", "of", "HMG-I", "(", "Y", ")", "helps", "to", "determine", "the", "repressive", "state", "of", "the", "beta-globin", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
8399
[ "Interactions", "between", "the", "class", "II", "transactivator", "and", "CREB", "binding", "protein", "increase", "transcription", "of", "major", "histocompatibility", "complex", "class", "II", "genes", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
8400
[ "Class", "II", "major", "histocompatibility", "(", "class", "II", ")", "genes", "are", "regulated", "in", "a", "B-cell-specific", "and", "gamma", "interferon-inducible", "fashion", "." ]
[ 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]