Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
6301
[ "Electrophoretic", "mobility", "gel", "shift", "assay", "also", "showed", "a", "reduction", "in", "the", "binding", "of", "a", "transcription", "factor", "to", "the", "MSR", "promoter", "AP-1/ets", "elements", "in", "IL-6", "-treated", "cells", "." ]
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6302
[ "Thus", ",", "exposure", "to", "IL-6", "may", "inhibit", "expression", "of", "the", "class", "A", "MSR", "in", "differentiated", "macrophages", "at", "transcriptional", "levels", "." ]
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6303
[ "This", "result", "suggests", "that", "this", "cytokine", "may", "modulate", "foam", "cell", "formation", "during", "atherogenesis", "." ]
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6304
[ "Retinoblastoma", "protein", "expression", "leads", "to", "reduced", "Oct-1", "DNA", "binding", "activity", "and", "enhances", "interleukin-8", "expression", "." ]
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6305
[ "Tumor", "cell", "lines", "with", "a", "defective", "retinoblastoma", "gene", "are", "unable", "to", "transcribe", "the", "HLA", "class", "II", "genes", "in", "response", "to", "IFN-gamma", "treatment", ",", "and", "reconstitution", "of", "functional", "Rb", "rescues", "IFN-gamma-induced", "class", "II", "gene", "expression", "." ]
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6306
[ "However", ",", "the", "molecular", "mechanism", "of", "Rb", "rescue", "of", "the", "class", "II", "genes", "is", "unknown", "." ]
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6307
[ "We", "have", "examined", "the", "effect", "of", "Rb", "expression", "on", "the", "activation", "of", "the", "promoter", "for", "HLA-DRA", ",", "the", "prototype", "class", "II", "gene", "." ]
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6308
[ "Oct-1", ",", "a", "POU", "domain", "transcription", "factor", ",", "was", "identified", "as", "a", "repressor", "of", "HLA-DRA", "promoter", "activity", "in", "the", "Rb-defective", "cells", "." ]
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6309
[ "Rb", "expression", "led", "to", "phosphorylation", "of", "Oct-1", ",", "thus", "relieving", "its", "repressive", "effect", "." ]
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6310
[ "Oct-1", "has", "also", "been", "shown", "to", "repress", "interleukin", "8", "promoter", "activity", "." ]
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6311
[ "Consistent", "with", "reduced", "levels", "of", "Oct-1", "DNA", "binding", "activity", "in", "the", "Rb-transformed", "cell", "lines", ",", "interleukin", "8", "expression", "is", "higher", "in", "these", "cell", "lines", "." ]
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6312
[ "Cell", "activation", "and", "apoptosis", "by", "bacterial", "lipoproteins", "through", "toll-like", "receptor-2", "." ]
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6313
[ "Apoptosis", "is", "implicated", "in", "the", "generation", "and", "resolution", "of", "inflammation", "in", "response", "to", "bacterial", "pathogens", "." ]
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6314
[ "All", "bacterial", "pathogens", "produce", "lipoproteins", "(", "BLPs", ")", ",", "which", "trigger", "the", "innate", "immune", "response", "." ]
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6315
[ "BLPs", "were", "found", "to", "induce", "apoptosis", "in", "THP-1", "monocytic", "cells", "through", "human", "Toll-like", "receptor-2", "(", "hTLR2", ")", "." ]
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6316
[ "BLPs", "also", "initiated", "apoptosis", "in", "an", "epithelial", "cell", "line", "transfected", "with", "hTLR2", "." ]
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6317
[ "In", "addition", ",", "BLPs", "stimulated", "nuclear", "factor-kappaB", ",", "a", "transcriptional", "activator", "of", "multiple", "host", "defense", "genes", ",", "and", "activated", "the", "respiratory", "burst", "through", "hTLR2", "." ]
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6318
[ "Thus", ",", "hTLR2", "is", "a", "molecular", "link", "between", "microbial", "products", ",", "apoptosis", ",", "and", "host", "defense", "mechanisms", "." ]
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6319
[ "Possible", "differences", "in", "the", "mechanism", "(", "s", ")", "of", "action", "of", "different", "glucocorticoid", "hormone", "compounds", "." ]
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6320
[ "Different", "glucocorticoid", "hormones", "(", "GCH", ")", "show", "differences", "in", "the", "intensity", "and", "in", "the", "kinetics", "of", "their", "immunomodulating", "activity", "." ]
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6321
[ "The", "mechanism", "(", "s", ")", "of", "action", "of", "GCH", "is", "under", "investigation", ",", "but", "is", "has", "been", "noted", "that", "they", "exert", "immune", "activity", "via", "the", "genomic", "pathway", "." ]
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6322
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6323
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6324
[ "These", "data", "are", "in", "agreement", "with", "the", "concept", "that", "different", "GCH", "compounds", "might", "differ", "in", "their", "binding", "and", "affinity", "properties", ",", "tissue-specific", "metabolism", ",", "and", "interaction", "with", "transcription", "factor", "." ]
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6325
[ "Distinctive", "expression", "pattern", "of", "the", "BCL-6", "protein", "in", "nodular", "lymphocyte", "predominance", "Hodgkin", "'s", "disease", "." ]
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6326
[ "The", "BCL-6", "gene", "encoding", "a", "nuclear-located", "Kruppel-type", "zinc", "finger", "protein", "is", "rearranged", "in", "about", "30", "%", "diffuse", "large", "B-cell", "lymphomas", "and", "is", "expressed", "predominantly", "in", "normal", "germinal", "center", "B", "cells", "and", "related", "lymphomas", "." ]
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6327
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6328
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6329
[ "Forty-one", "HD", "samples", "(", "19", "NLPHD", ",", "12", "nodular", "sclerosis", ",", "and", "10", "mixed", "cellularity", ")", "were", "immunostained", "with", "the", "monoclonal", "antibodies", "PG-B6", "and", "PG-B6p", "that", "react", "with", "a", "fixative-sensitive", "and", "a", "formalin-resistant", "epitope", "on", "the", "aminoterminal", "region", "of", "the", "BCL-6", "gene", "product", ",", "respectively", "." ]
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6330
[ "Strong", "nuclear", "positivity", "for", "the", "BCL-6", "protein", "was", "detected", "in", "tumor", "(", "L", "&", "H", ")", "cells", "in", "all", "cases", "of", "NLPHD", "." ]
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6331
[ "In", "contrast", ",", "BCL-6", "was", "expressed", "only", "in", "a", "small", "percentage", "of", "Hodgkin", "and", "Reed-Sternberg", "cells", "in", "about", "30", "%", "of", "classical", "HD", "cases", "." ]
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6332
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6333
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6334
[ "These", "results", "further", "support", "the", "concept", "that", "NLPHD", "is", "an", "histogenetically", "distinct", ",", "B-cell-derived", "subtype", "of", "HD", "and", "suggest", "a", "role", "for", "BCL-6", "in", "its", "development", "." ]
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6335
[ "Selenium-mediated", "inhibition", "of", "transcription", "factor", "NF-kappa", "B", "and", "HIV-1", "LTR", "promoter", "activity", "." ]
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6336
[ "The", "eukaryotic", "transcription", "factor", "NF-kappa", "B", "is", "involved", "in", "the", "inducible", "expression", "of", "various", "inflammatory", "genes", "as", "well", "as", "in", "HIV-1", "replication", "." ]
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6337
[ "Activation", "of", "NF-kappa", "B", "is", "induced", "by", "prooxidants", "and", "several", "stimuli", "eliciting", "oxidative", "stress", ",", "such", "as", "cytokines", ",", "lipopolysaccharide", ",", "UV", "irradiation", "and", "other", "mediators", "." ]
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6338
[ "Various", "antioxidants", "inhibit", "NF-kappa", "B", "activation", "in", "response", "to", "these", "stimuli", "." ]
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6339
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6340
[ "In", "selenium-deprived", "Jurkat", "and", "ESb-L", "T", "lymphocytes", ",", "supplementation", "of", "selenium", "led", "to", "a", "substantial", "increase", "of", "GPX", "activity", "." ]
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6341
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6342
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6343
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6344
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6345
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6346
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6347
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6348
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6349
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6350
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6351
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6352
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6353
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6354
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6355
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6356
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6357
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