Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
6201
[ "Estrogens", "affect", "vascular", "tone", "indirectly", "by", "modulating", "release", "of", "endothelium-derived", "vasoactive", "factors", "and", "directly", "by", "modulating", "intracellular", "calcium", "in", "vascular", "smooth", "muscle", "cells", "." ]
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6202
[ "Estrogens", "indirectly", "affect", "thrombotic", "events", "and", "inflammation", "by", "altering", "platelet", "aggregation", "and", "leukocyte", "adherence", "and", "migration", ",", "respectively", "." ]
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6203
[ "Estrogens", "also", "influence", "production", "of", "mitogens", "which", ",", "when", "released", "at", "sites", "of", "vascular", "injury", ",", "affect", "vascular", "remodeling", "." ]
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6204
[ "Although", "estrogens", "initiate", "vascular", "responses", ",", "genomic", "sex", "may", "influence", "and/or", "limit", "expression", "of", "estrogen", "receptors", "and", "therefore", "actions", "of", "sex", "steroid", "hormones", "throughout", "the", "vasculature", "." ]
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6205
[ "Induction", "of", "a", "functional", "vitamin", "D", "receptor", "in", "all-trans-retinoic", "acid-induced", "monocytic", "differentiation", "of", "M2-type", "leukemic", "blast", "cells", "." ]
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6206
[ "Different", "types", "of", "acute", "myeloid", "leukemia", "blast", "cells", "were", "induced", "to", "differentiate", "in", "vitro", "with", "all-trans-retinoic", "acid", "(", "ATRA", ")", "and", "vitamin", "D3", "(", "VD", ")", "." ]
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6207
[ "M0/M1", "leukemic", "cells", "are", "not", "sensitive", "to", "differentiating", "agents", ",", "whereas", "M3", "leukemic", "cells", "are", "induced", "to", "undergo", "granulocytic", "differentiation", "after", "ATRA", "treatment", "but", "are", "not", "sensitive", "to", "VD", "." ]
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6208
[ "M2", "leukemic", "blast", "cells", "behave", "differently", "because", "they", "undergo", "monocytic", "differentiation", "with", "both", "the", "differentiation", "inducers", "." ]
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6209
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6210
[ "Our", "results", "indicate", "that", "ATRA", "as", "well", "as", "VD", "efficiently", "increases", "the", "nuclear", "abundance", "of", "VD", "receptor", "(", "VDR", ")", "and", "promotes", "monocytic", "differentiation", "." ]
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6211
[ "VDR", "is", "functionally", "active", "in", "ATRA-treated", "Kasumi-1", "cells", "because", "it", "efficiently", "heterodimerizes", "with", "retinoid", "X", "receptor", ",", "binds", "to", "a", "DR3-type", "vitamin", "D-responsive", "element", ",", "and", "activates", "the", "transcription", "of", "a", "vitamin", "D-responsive", "element-regulated", "reporter", "gene", "." ]
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6212
[ "Consistent", "with", "these", "findings", ",", "VD-responsive", "genes", "are", "induced", "by", "ATRA", "treatment", "of", "Kasumi-1", "cells", ",", "suggesting", "that", "the", "genetic", "program", "underlying", "monocytic", "differentiation", "is", "activated", "." ]
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6213
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6214
[ "Protein", "kinase", "C", "and", "calcineurin", "synergize", "to", "activate", "IkappaB", "kinase", "and", "NF-kappaB", "in", "T", "lymphocytes", "." ]
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6215
[ "The", "nuclear", "factor", "of", "kappaB", "(", "NF-kappaB", ")", "is", "a", "ubiquitous", "transcription", "factor", "that", "is", "key", "in", "the", "regulation", "of", "the", "immune", "response", "and", "inflammation", "." ]
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6216
[ "T", "cell", "receptor", "(", "TCR", ")", "cross-linking", "is", "in", "part", "required", "for", "activation", "of", "NF-kappaB", ",", "which", "is", "dependent", "on", "the", "phosphorylation", "and", "degradation", "of", "IkappaBalpha", "." ]
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6217
[ "By", "using", "Jurkat", "and", "primary", "human", "T", "lymphocytes", ",", "we", "demonstrate", "that", "the", "simultaneous", "activation", "of", "two", "second", "messengers", "of", "the", "TCR", "-initiated", "signal", "transduction", ",", "protein", "kinase", "C", "(", "PKC", ")", "and", "calcineurin", ",", "results", "in", "the", "synergistic", "activation", "of", "the", "IkappaBalpha", "kinase", "(", "IKK", ")", "complex", "but", "not", "of", "another", "putative", "IkappaBalpha", "kinase", ",", "p90", "(", "rsk", ")", "." ]
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6218
[ "We", "also", "demonstrate", "that", "the", "IKK", "complex", ",", "but", "not", "p90", "(", "rsk", ")", ",", "is", "responsible", "for", "the", "in", "vivo", "phosphorylation", "of", "IkappaBalpha", "mediated", "by", "the", "co-activation", "of", "PKC", "and", "calcineurin", "." ]
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6219
[ "Each", "second", "messenger", "is", "necessary", ",", "as", "inhibition", "of", "either", "one", "reverses", "the", "activation", "of", "the", "IKK", "complex", "and", "IkappaBalpha", "phosphorylation", "in", "vivo", "." ]
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6220
[ "Overexpression", "of", "dominant", "negative", "forms", "of", "IKKalpha", "and", "-beta", "demonstrates", "that", "only", "IKKbeta", "is", "the", "target", "for", "PKC", "and", "calcineurin", "." ]
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6221
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6222
[ "Diminished", "responses", "to", "IL-13", "by", "human", "monocytes", "differentiated", "in", "vitro", ":", "role", "of", "the", "IL-13Ralpha1", "chain", "and", "STAT6", "." ]
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6223
[ "The", "primary", "IL-13", "receptor", "complex", "on", "human", "monocytes", "is", "believed", "to", "be", "a", "heterodimer", "comprised", "of", "the", "IL-4R", "alpha", "chain", "and", "the", "IL-2R", "gamma", "chain", "(", "gamma", "(", "c", ")", ")", "-like", "molecule", ",", "IL-13R", "alpha1", "." ]
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6224
[ "mRNA", "levels", "for", "IL-13R", "alpha1", ",", "but", "not", "IL-4R", "alpha", ",", "were", "markedly", "decreased", "in", "in", "vitro", "monocyte-derived", "macrophages", "(", "MDMac", ")", ",", "and", "with", "increasing", "time", "of", "monocytes", "in", "culture", "correlated", "with", "the", "loss", "of", "IL-13", "regulation", "of", "lipopolysaccharide-induced", "TNF-alpha", "production", "." ]
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6225
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6226
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6227
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6228
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6229
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6230
[ "The", "p53", "paradox", "in", "the", "pathogenesis", "of", "tumor", "progression", "." ]
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6231
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6232
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6233
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6234
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6235
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6236
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6237
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6238
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6242
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6244
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6247
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6248
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6249
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6250
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6252
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6253
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6255
[ "The", "NFAT-controlled", "luciferase", "gene", "system", "distinguishes", "CIF", "from", "other", "T", "cell", "inhibitory", "activities", "present", "in", "colostrum", ",", "in", "particular", ",", "TGF", "beta", "1", "and", "TGF", "beta", "2", "and", "the", "glucocorticoids", "." ]
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6258
[ "Heat", "shock", "induces", "HIV-1", "replication", "in", "chronically", "infected", "promyelocyte", "cell", "line", "OM10.1", "." ]
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6259
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6264
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6265
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6266
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6267
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6268
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6272
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6273
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6277
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6278
[ "c-Maf", "induces", "monocytic", "differentiation", "and", "apoptosis", "in", "bipotent", "myeloid", "progenitors", "." ]
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6279
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6280
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6281
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6283
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6284
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6286
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6288
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6289
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6296
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