id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
3001
[ "Jun", "is", "essential", "for", "activation-induced", "transcription", "and", "binds", "preferably", "as", "a", "heterodimer", "with", "ATF-2", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
3002
[ "In", "contrast", ",", "CREB", "appears", "to", "dampen", "transcription", "from", "this", "element", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
3003
[ "The", "CpG", "dinucleotide", "in", "this", "element", "is", "selectively", "methylated", "in", "Th2", "T", "cells", "and", "other", "cells", "that", "do", "not", "express", "IFN-gamma", ",", "and", "methylation", "markedly", "reduces", "transcription", "factor", "binding", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3004
[ "As", "a", "target", "for", "DNA", "methylation", "and", "for", "binding", "of", "transcription", "factors", "that", "mediate", "or", "impede", "transcription", ",", "this", "element", "appears", "to", "play", "a", "central", "role", "in", "controlling", "IFN-gamma", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
3005
[ "CD40", ",", "but", "not", "lipopolysaccharide", "and", "anti-IgM", "stimulation", "of", "primary", "B", "lymphocytes", ",", "leads", "to", "a", "persistent", "nuclear", "accumulation", "of", "RelB", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
3006
[ "In", "this", "study", "we", "analyzed", "the", "effect", "of", "CD40", "stimulation", "on", "the", "activity", "and", "nuclear", "appearance", "of", "Rel/nuclear", "factor", "kappaB", "(", "NF-kappaB", ")", "factors", "in", "primary", "murine", "B", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 7, 8, 8, 0 ]
3007
[ "We", "show", "that", "triggering", "of", "CD40", "signaling", "pathway", "(", "s", ")", "by", "CD40", "ligands", "expressed", "on", "L", "cells", "led", "to", "strong", "activation", "of", "an", "NF-kappaB-controlled", "beta-globin", "reporter", "gene", "in", "primary", "B", "lymphocytes", "from", "transgenic", "mice", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 7, 8, 0, 0, 0, 0 ]
3008
[ "Analyses", "of", "nuclear", "translocation", "of", "individual", "members", "of", "Rel", "proteins", "after", "CD40", "induction", "of", "primary", "B", "cells", "showed", "a", "strong", "and", "long-lasting", "accumulation", "of", "RelB", "and", ",", "less", "pronounced", ",", "of", "c-Rel", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
3009
[ "LPS", "stimulation", "did", "not", "give", "rise", "to", "a", "persistent", "nuclear", "accumulation", "of", "RelB", "and", "c-Rel", ",", "whereas", "nuclear", "c-Rel", ",", "but", "not", "RelB", ",", "accumulated", "after", "B", "cell", "receptor", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0 ]
3010
[ "CD40", "induced", "not", "only", "nuclear", "translocation", "but", "also", "de", "novo", "synthesis", "of", "RelB", "RNA", "and", "protein", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0 ]
3011
[ "S107", "plasmacytoma", "cells", ",", "which", "express", "CD40", "but", "are", "defective", "for", "the", "nuclear", "appearance", "of", "p50/p65-NF-kappaB", ",", "do", "not", "express", "RelB", "after", "CD40", "stimulation", "." ]
[ 5, 6, 6, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
3012
[ "In", "S107", "cells", "stably", "transfected", "with", "relB", "genes", ",", "stimulation", "of", "nuclear", "RelB", "translocation", "by", "CD40", "was", "observed", "." ]
[ 0, 5, 6, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0 ]
3013
[ "These", "results", "indicate", "that", "stimulation", "of", "CD40", "signaling", "pathways", "exerts", "a", "long-lasting", "stimulatory", "effect", "on", "both", "the", "transcription", "and", "nuclear", "translocation", "of", "RelB", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
3014
[ "Since", "LPS", "and", "anti-IgM", "were", "unable", "to", "activate", "RelB", ",", "CD40", "appears", "to", "trigger", "a", "special", "program", "of", "gene", "expression", "involved", "in", "the", "proliferation", "and/or", "differentiation", "of", "B", "lymphocytes", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
3015
[ "Identification", "and", "characterization", "of", "a", "leukocyte-specific", "component", "of", "the", "nuclear", "body", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3016
[ "The", "nuclear", "body", "(", "NB", ")", "is", "a", "cellular", "organelle", "that", "is", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3017
[ "The", "NB", "is", "also", "a", "target", "of", "antibodies", "in", "the", "serum", "of", "patients", "with", "the", "autoimmune", "disease", "primary", "biliary", "cirrhosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3018
[ "In", "this", "study", ",", "serum", "from", "a", "patient", "with", "primary", "biliary", "cirrhosis", "was", "used", "to", "identify", "a", "cDNA", "encoding", "a", "novel", "component", "of", "the", "NB", ",", "a", "140-kDa", "protein", "designated", "Sp140", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
3019
[ "The", "predicted", "amino", "acid", "sequence", "of", "the", "amino-terminal", "portion", "of", "Sp140", "was", "similar", "to", "Sp100", ",", "a", "previously", "identified", "NB", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
3020
[ "The", "carboxyl", "portion", "of", "Sp140", "contained", "a", "zinc-finger", "domain", "and", "a", "bromodomain", ",", "motifs", "that", "are", "present", "in", "proteins", "regulating", "gene", "transcription", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3021
[ "High", "levels", "of", "Sp140", "mRNA", "were", "detected", "in", "human", "spleen", "and", "peripheral", "blood", "leukocytes", ",", "but", "not", "other", "human", "tissues", "." ]
[ 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
3022
[ "The", "level", "of", "SP140", "mRNA", "in", "myeloid", "precursor", "cell", "lines", "HL60", "and", "NB4", "markedly", "increased", "in", "response", "to", "chemically", "induced", "cellular", "differentiation", "." ]
[ 0, 0, 0, 3, 4, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3023
[ "Immunohistochemical", "techniques", "were", "used", "to", "demonstrate", "that", "SP140", "localized", "to", "the", "NB", "in", "differentiated", "HL60", "and", "NB4", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 0, 5, 6, 0 ]
3024
[ "The", "location", "of", "Sp140", "in", "the", "NB", ",", "and", "expression", "of", "this", "gene", "in", "cells", "involved", "in", "host", "defense", ",", "suggest", "that", "Sp140", "may", "be", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3025
[ "Regulation", "of", "cytokine", "and", "cytokine", "receptor", "expression", "by", "glucocorticoids", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3026
[ "Glucocorticoids", "(", "GCS", ")", "profoundly", "inhibit", "several", "aspects", "of", "T", "cell", "immunity", "largely", "through", "inhibition", "of", "cytokine", "expression", "at", "the", "transcriptional", "and", "posttranscriptional", "levels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3027
[ "GCS", "were", "also", "reported", "to", "act", "indirectly", "by", "inducing", "transforming", "growth", "factor-beta", "expression", ",", "which", "in", "turn", "blocks", "T", "cell", "immunity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
3028
[ "In", "exerting", "their", "antiproliferative", "effects", ",", "GCS", "diffuse", "into", "target", "cells", "where", "they", "bind", "their", "cytoplasmic", "receptor", ",", "which", "in", "turn", "translocates", "to", "the", "nucleus", "where", "it", "inhibits", "transcription", "of", "cytokine", "genes", "through", "direct", "binding", "to", "the", "glucocorticoid", "response", "elements", "(", "GRE", ")", ",", "which", "are", "located", "in", "the", "promoter", "region", "of", "cytokine", "genes", "or", ",", "alternatively", ",", "through", "antagonism", "of", "the", "action", "of", "transcription", "factors", "required", "for", "optimal", "transcriptional", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3029
[ "In", "contrast", "to", "their", "inhibitory", "effects", "on", "cytokine", "expression", ",", "GCS", "up-regulate", "cytokine", "receptor", "expression", "that", "correlates", "with", "enhanced", "cytokine", "effects", "on", "target", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3030
[ "In", "this", "review", ",", "we", "summarize", "the", "current", "state", "of", "knowledge", "of", "the", "mechanism", "of", "action", "of", "GCS", ",", "including", "the", "phenomenon", "of", "steroid-induced", "rebound", ",", "which", "ensues", "upon", "GCS", "withdrawal", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3031
[ "Isolation", "and", "characterization", "of", "murine", "fra-1", ":", "induction", "mediated", "by", "CD40", "and", "surface", "Ig", "is", "protein", "kinase", "C", "dependent", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 9, 10, 0, 9, 10, 10, 0, 0 ]
3032
[ "The", "murine", "fra-1", "gene", ",", "encoding", "Fos-related", "Ag", "1", ",", "was", "isolated", "from", "a", "splenic", "cDNA", "library", "and", "sequenced", "." ]
[ 0, 1, 2, 2, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3033
[ "Murine", "fra-1", "was", "highly", "homologous", "to", "rat", "and", "human", "fra-1", "." ]
[ 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
3034
[ "Oligonucleotide", "primers", "based", "on", "the", "murine", "sequence", "were", "used", "to", "construct", "a", "quantitative", "reverse", "transcription-PCR", "assay", "for", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3035
[ "B", "lymphocyte", "stimulation", "via", "both", "CD40", "and", "surface", "Ig", "(", "sIg", ")", "receptors", "substantially", "induced", "fra-1", "expression", ",", "and", "for", "both", "receptors", ",", "induction", "was", "protein", "kinase", "C", "(", "PKC", ")", "dependent", "." ]
[ 7, 8, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 10, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0 ]
3036
[ "This", "contrasts", "with", "induction", "of", "c-fos", "by", "both", "CD40", "and", "sIg", ",", "which", "is", "PKC", "independent", "and", "indicates", "that", "CD40", "is", "capable", "of", "signaling", "through", "PKC", "or", "a", "closely", "related", "kinase", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
3037
[ "Induction", "of", "fra-1", "following", "engagement", "of", "CD40", "did", "not", "require", "protein", "synthesis", ",", "suggesting", "that", "the", "PKC", "-dependent", "linkage", "between", "CD40", "and", "fra-1", "is", "direct", "." ]
[ 0, 0, 1, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 1, 0, 0, 0 ]
3038
[ "CD40", "-mediated", "fra-1", "induction", "did", "require", "tyrosine", "kinase", "activity", "." ]
[ 9, 0, 1, 0, 0, 0, 9, 10, 0, 0 ]
3039
[ "These", "results", "demonstrate", "that", "CD40", ",", "like", "sIg", ",", "may", "employ", "PKC", "in", "producing", "select", "outcomes", ",", "that", "individual", "B", "cell", "receptors", "may", "signal", "downstream", "events", "via", "both", "PKC-dependent", "and", "PKC-independent", "pathways", ",", "and", "that", "multiple", "signal", "transduction", "pathways", "may", "be", "used", "to", "activate", "the", "expression", "of", "closely", "related", "genes", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3040
[ "Pentoxifylline", "for", "the", "treatment", "of", "infection", "with", "human", "immunodeficiency", "virus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3041
[ "Cytokine", "dysregulation", "in", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "infection", "has", "been", "documented", "in", "numerous", "studies", "and", "has", "been", "cited", "as", "an", "important", "component", "in", "the", "pathogenesis", "of", "this", "retroviral", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3042
[ "Pharmacological", "modification", "of", "cytokine", "dysregulation", ",", "therefore", ",", "has", "been", "suggested", "as", "a", "therapeutic", "modality", "for", "HIV-1", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3043
[ "Dr.", "Dezube", "of", "Beth", "Israel", "Hospital", "(", "Boston", ")", "concisely", "reviews", "the", "state", "of", "our", "knowledge", "regarding", "the", "effects", "of", "pentoxifylline", "on", "expression", "of", "tumor", "necrosis", "factor-alpha", ",", "a", "cytokine", "known", "to", "influence", "HIV-1", "replication", "and", "to", "play", "a", "possible", "role", "in", "the", "clinical", "manifestations", "of", "advanced", "infection", "with", "this", "virus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3044
[ "Pentoxifylline", ",", "a", "trisubstituted", "xanthine", "derivative", ",", "has", "been", "used", "to", "decrease", "blood", "viscosity", "and", "is", "reasonably", "well", "tolerated", "by", "most", "recipients", "of", "the", "drug", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3045
[ "Results", "of", "preliminary", "studies", ",", "many", "of", "which", "were", "conducted", "by", "Dr.", "Dezube", ",", "suggest", "that", "use", "of", "this", "agent", "in", "combination", "with", "antiretroviral", "compounds", "may", "prove", "useful", "in", "the", "treatment", "of", "patients", "with", "HIV-1", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3046
[ "Activation", "of", "the", "granulocyte-macrophage", "colony-stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]
3047
[ "The", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "gene", "has", "been", "studied", "extensively", "as", "a", "model", "system", "of", "transcriptional", "induction", "during", "T-lymphocyte", "activation", "." ]
[ 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
3048
[ "The", "GM-CSF", "gene", "is", "not", "expressed", "in", "resting", "peripheral", "blood", "T", "cells", "but", "is", "rapidly", "induced", "at", "the", "transcriptional", "level", "following", "activation", "through", "the", "cell", "surface", "T-cell", "receptor", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
3049
[ "A", "highly", "conserved", "19-bp", "element", "located", "immediately", "5", "'", "of", "the", "human", "GM-CSF", "TATA", "box", "(", "bp", "-34", "to", "-52", ")", ",", "herein", "called", "purine", "box", "1", "(", "PB1", ")", ",", "has", "been", "shown", "to", "bind", "a", "T-cell", "nuclear", "protein", "complex", "and", "to", "be", "required", "for", "transcriptional", "induction", "of", "the", "GM-CSF", "gene", "following", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 0, 0 ]
3050
[ "The", "PB1", "sequence", "motif", "is", "highly", "conserved", "in", "both", "human", "and", "murine", "GM-CSF", "genes", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
3051
[ "In", "this", "report", ",", "we", "demonstrate", "that", "the", "PB1", "element", "alone", "confers", "inducibility", "on", "a", "heterologous", "promoter", "following", "transfection", "into", "human", "Jurkat", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
3052
[ "In", "addition", ",", "we", "identify", "a", "major", "PB1", "nuclear", "protein-binding", "complex", "that", "is", "not", "present", "in", "resting", "peripheral", "blood", "T", "cells", "but", "is", "rapidly", "induced", "following", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 7, 0, 0 ]
3053
[ "Sequence", "analysis", "revealed", "that", "PB1", "is", "composed", "of", "adjacent", "binding", "sites", "for", "Ets", "and", "AP-1", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]
3054
[ "In", "vitro", "mutagenesis", "experiments", "demonstrated", "that", "both", "the", "Ets", "and", "AP-1", "sites", "are", "required", "for", "binding", "of", "the", "inducible", "PB1", "nuclear", "protein", "complex", "and", "for", "the", "transcriptional", "activity", "of", "this", "element", "and", "the", "GM-CSF", "promoter", "in", "activated", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 0 ]
3055
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
[ 0, 0, 0, 0, 0, 0, 0 ]
3056
[ "Steroid-resistant", "asthma", "." ]
[ 0, 0, 0 ]
3057
[ "Cellular", "mechanisms", "contributing", "to", "inadequate", "response", "to", "glucocorticoid", "therapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3058
[ "The", "current", "study", "examined", "whether", "alterations", "in", "glucocorticoid", "receptor", "(", "GR", ")", "binding", "contribute", "to", "poor", "response", "to", "glucocorticoid", "therapy", "in", "asthma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3059
[ "29", "asthma", "patients", "with", "forced", "expiratory", "volume", "in", "1", "s", "(", "FEV1", ")", "<", "70", "%", "predicted", "were", "studied", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3060
[ "Patients", "were", "classified", "as", "steroid", "sensitive", "(", "SS", ")", "if", "their", "morning", "FEV1", "increased", ">", "30", "%", "after", "a", "1-wk", "course", "of", "oral", "prednisone", "20", "mg", "twice", "daily", "and", "steroid", "resistant", "(", "SR", ")", "if", "they", "failed", "to", "increase", ">", "15", "%", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3061
[ "PBMC", "obtained", "from", "these", "two", "groups", ",", "17", "SR", "and", "12", "SS", ",", "as", "well", "as", "12", "normal", "controls", "were", "analyzed.", "SR", "patients", "had", "two", "distinguishable", "GR", "binding", "abnormalities", ":", "15", "of", "the", "17", "SR", "patients", "demonstrated", "a", "significantly", "reduced", "GR", "binding", "affinity", ",", "as", "compared", "with", "SS", "patients", "(", "P", "=", "0.0001", ")", "and", "normal", "controls", "(", "P", "=", "0.0001", ")", "." ]
[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3062
[ "This", "defect", "was", "localized", "to", "T", "cells", "and", "reverted", "to", "normal", "after", "48", "h", "in", "culture", "media", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3063
[ "However", ",", "incubation", "with", "a", "combination", "of", "IL-2", "and", "IL-4", "sustained", "this", "abnormality", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0 ]
3064
[ "The", "other", "two", "SR", "patients", "had", "an", "abnormally", "low", "GR", "number", "with", "normal", "binding", "affinity", "that", "was", "not", "limited", "to", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
3065
[ "Furthermore", ",", "GR", "number", "failed", "to", "normalize", "after", "incubation", "in", "media", "alone", "or", "IL-2", "and", "IL-4", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
3066
[ "Therefore", ",", "SR", "asthma", "may", "be", "due", "to", "more", "than", "one", "abnormality", ",", "the", "majority", "related", "to", "a", "reversible", "cytokine", "-induced", "reduction", "in", "GR", "binding", "affinity", "and", "the", "second", "related", "to", "an", "irreversible", "reduction", "in", "GR", "number", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
3067
[ "These", "findings", "may", "have", "important", "implications", "for", "the", "design", "of", "alternative", "treatment", "approaches", "for", "recalcitrant", "asthma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3068
[ "Prevalence", "of", "aneuploidy", ",", "overexpressed", "ER", ",", "and", "overexpressed", "EGFR", "in", "random", "breast", "aspirates", "of", "women", "at", "high", "and", "low", "risk", "for", "breast", "cancer", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3069
[ "Breast", "tissue", "biomarkers", "which", "accurately", "predict", "breast", "cancer", "development", "within", "a", "10", "year", "period", "in", "high", "risk", "women", "are", "needed", "but", "currently", "not", "available", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3070
[ "We", "initiated", "this", "study", "to", "determine", "1", ")", "the", "prevalence", "of", "one", "or", "more", "breast", "tissue", "abnormalities", "in", "a", "group", "of", "women", "at", "high", "risk", "for", "breast", "cancer", ",", "and", "2", ")", "if", "the", "prevalence", "of", "biomarker", "abnormalities", "is", "greater", "in", "high", "risk", "than", "in", "low", "risk", "women", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3071
[ "Eligible", "high", "risk", "women", "were", "those", "with", "a", "first", "degree", "relative", "with", "breast", "cancer", ",", "prior", "breast", "cancer", ",", "or", "precancerous", "mastopathy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3072
[ "Low", "risk", "women", "were", "those", "without", "these", "or", "other", "major", "identifiable", "risk", "factors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3073
[ "Ductal", "cells", "were", "obtained", "via", "random", "fine", "needle", "aspirations", "and", "cytologically", "classified", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3074
[ "Biomarkers", "included", "DNA", "ploidy", ",", "estrogen", "receptor", "(", "ER", ")", ",", "and", "epidermal", "growth", "factor", "receptor", "(", "EGFR", ")", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0 ]
3075
[ "The", "prevalence", "of", "DNA", "aneuploidy", "was", "30", "%", ",", "overexpression", "of", "ER", "10", "%", ",", "and", "overexpression", "of", "EGFR", "35", "%", ",", "in", "the", "206", "high", "risk", "women", "whose", "median", "10", "year", "Gail", "risk", "(", "projected", "probability", ")", "of", "developing", "breast", "cancer", "was", "4.5", "%", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3076
[ "The", "prevalence", "of", "aneuploidy", "and", "overexpressed", "EGFR", "was", "significantly", "higher", "in", "the", "high", "risk", "women", "than", "in", "the", "25", "low", "risk", "controls", "(", "p", "<", "0.002", ")", ",", "whose", "median", "10", "year", "Gail", "risk", "was", "0.7", "%", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3077
[ "The", "difference", "in", "the", "prevalence", "of", "ER", "overexpression", "between", "high", "and", "low", "risk", "groups", "was", "not", "statistically", "significant", "(", "p", "=", "0.095", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3078
[ "This", "may", "be", "due", "to", "the", "low", "prevalence", "of", "overexpressed", "ER", "and", "the", "small", "number", "of", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
3079
[ "A", "significant", "difference", "was", "noted", "in", "the", "prevalence", "of", "one", "or", "more", "abnormal", "biomarkers", "between", "the", "high", "risk", "and", "low", "risk", "women", "(", "p", "<", "0.001", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3080
[ "A", "large", "prospective", "trial", "is", "needed", "to", "determine", "if", "one", "or", "more", "of", "these", "biomarkers", ",", "is", "predictive", "of", "breast", "cancer", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3081
[ "Inhibition", "of", "nuclear", "factor", "kappa", "B", "subunit", "p65", "mRNA", "accumulation", "in", "lipopolysaccharide-stimulated", "human", "monocytic", "cells", "treated", "with", "sodium", "salicylate", "." ]
[ 0, 0, 3, 4, 4, 4, 4, 4, 4, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]
3082
[ "Lipopolysaccharide", "is", "one", "of", "the", "most", "potent", "trigger", "substances", "for", "monocytes", "and", "macrophages", "causing", "secretion", "of", "inflammatory", "mediators", "such", "as", "tumor", "necrosis", "factor", "and", "interleukin-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
3083
[ "The", "nature", "of", "the", "nuclear", "factors", "involved", "in", "regulation", "of", "these", "cytokine", "genes", "is", "still", "unknown", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3084
[ "Nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ";", "heterodimer", "of", "p50", "and", "p65", ")", "proteins", "have", "been", "suggested", "to", "play", "an", "important", "role", "in", "gene", "transcription", "of", "inflammatory", "mediators", "when", "monocytes", "are", "stimulated", "with", "lipopolysaccharide", "." ]
[ 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
3085
[ "Nonsteroidal", "anti-inflammatory", "drugs", "such", "as", "salicylates", "have", "been", "used", "to", "treat", "symptoms", "of", "inflammation", ",", "and", "a", "new", "mechanism", "of", "drug", "action", "was", "suggested", "recently", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3086
[ "Salicylates", "have", "been", "shown", "to", "inhibit", "lipopolysaccharide-induced", "gene", "transcription", "via", "inhibition", "of", "NF-kappa", "B", "activation", "by", "preventing", "the", "degradation", "of", "NF-kappa", "B", "inhibitor", "``", "I", "kappa", "B", "``", ",", "blocking", "the", "translocation", "of", "NF-kappa", "B", "into", "the", "nuclear", "compartment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
3087
[ "However", ",", "the", "nature", "of", "the", "subunit", "involved", "in", "this", "mechanism", "has", "not", "been", "defined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3088
[ "To", "examine", "the", "mechanisms", "by", "which", "salicylates", "affect", "cytokine", "gene", "transcription", ",", "the", "amount", "of", "active", "and", "inactive", "NF-kappa", "B", "and", "NF-kappa", "B", "mRNA", ",", "in", "Porphyromonas", "gingivalis", "lipopolysaccharide-stimulated", "human", "monocytic", "cells", "was", "assessed", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 3, 4, 4, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0 ]
3089
[ "High", "doses", "of", "sodium", "salicylate", "suppressed", "NF-kappa", "B", "p65", "mRNA", "accumulation", ",", "resulting", "in", "suppression", "of", "total", "NF-kappa", "B", ",", "p50", "on", "tissue", "oligonucleotide", "had", "no", "effects", "on", "lipopolysaccharide-induced", "NF-kappa", "B", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
3090
[ "The", "data", "demonstrate", "that", "the", "p65", "subunit", "of", "NF-kappa", "B", "is", "inhibited", "by", "salicylate", "treatment", "and", "highlight", "the", "role", "of", "salicylate", "in", "the", "control", "of", "gene", "expression", "of", "inflammatory", "mediators", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3091
[ "Glucocorticoid-mediated", "inhibition", "of", "RANTES", "expression", "in", "human", "T", "lymphocytes", "." ]
[ 0, 0, 0, 9, 0, 0, 7, 8, 8, 0 ]
3092
[ "The", "chemokine", "RANTES", "has", "been", "implicated", "in", "the", "pathogenesis", "of", "allergic", "inflammatory", "diseases", "including", "asthma", "and", "rhinitis", "which", "are", "frequently", "treated", "with", "glucocorticoids", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3093
[ "We", "observed", "that", "dexamethasone", "dramatically", "inhibited", "RANTES", "mRNA", "expression", "dose", "dependently", "in", "anti-CD3", "activated", "Hut-78", "T", "cells", "and", "human", "PBMCs", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 9, 0, 5, 6, 6, 0, 7, 8, 0 ]
3094
[ "Inhibition", "of", "RANTES", "expression", "did", "not", "appear", "to", "be", "secondary", "to", "IL-2", "inhibition", "and", "required", "binding", "to", "the", "intracellular", "glucocorticoid", "receptor", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
3095
[ "The", "down-regulation", "of", "RANTES", "expression", "by", "glucocorticoids", "in", "T", "cells", "may", "directly", "contribute", "to", "the", "efficacy", "of", "these", "agents", "in", "suppressing", "cellular", "infiltration", "and", "to", "their", "anti-inflammatory", "properties", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3096
[ "Association", "of", "TRAF1", ",", "TRAF2", ",", "and", "TRAF3", "with", "an", "Epstein-Barr", "virus", "LMP1", "domain", "important", "for", "B-lymphocyte", "transformation", ":", "role", "in", "NF-kappaB", "activation", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0, 7, 0, 0, 0, 0, 9, 0, 0 ]
3097
[ "The", "Epstein-Barr", "virus", "(", "EBV", ")", "transforming", "protein", "LMP1", "appears", "to", "be", "a", "constitutively", "activated", "tumor", "necrosis", "factor", "receptor", "(", "TNFR", ")", "on", "the", "basis", "of", "an", "intrinsic", "ability", "to", "aggregate", "in", "the", "plasma", "membrane", "and", "an", "association", "of", "its", "cytoplasmic", "carboxyl", "terminus", "(", "CT", ")", "with", "TNFR-associated", "factors", "(", "TRAFs", ")", "." ]
[ 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]
3098
[ "We", "now", "show", "that", "in", "EBV-transformed", "B", "lymphocytes", "most", "of", "TRAF1", "or", "TRAF3", "and", "5", "%", "of", "TRAF2", "are", "associated", "with", "LMP1", "and", "that", "most", "of", "LMP1", "is", "associated", "with", "TRAF1", "or", "TRAF3", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 9, 0 ]
3099
[ "TRAF1", ",", "TRAF2", ",", "and", "TRAF3", "bind", "to", "a", "single", "site", "in", "the", "LMP1", "CT", "corresponding", "to", "amino", "acids", "(", "aa", ")", "199", "to", "214", ",", "within", "a", "domain", "which", "is", "important", "for", "B-lymphocyte", "growth", "transformation", "(", "aa", "187", "to", "231", ")", "." ]
[ 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3100
[ "Further", "deletional", "and", "alanine", "mutagenesis", "analyses", "and", "comparison", "with", "TRAF", "binding", "sequences", "in", "CD40", ",", "in", "CD30", ",", "and", "in", "the", "LMP1", "of", "other", "lymphycryptoviruses", "provide", "the", "first", "evidence", "that", "PXQXT/S", "is", "a", "core", "TRAF", "binding", "motif", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]