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2901
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2902
[ "PHA", "-induced", "kappaB-dependent", "reporter", "activity", "was", ",", "however", ",", "effectively", "blocked", "by", "a", "dominant", "negative", "form", "of", "Raf-1", ",", "suggesting", "a", "critical", "role", "for", "a", "Raf", "kinase", "." ]
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2903
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2904
[ "Cotransfection", "of", "a", "constitutively", "active", "form", "of", "calcineurin", "largely", "substituted", "for", "the", "Ca2+", "requirement", "and", "reversed", "the", "blockade", "by", "SK", "&", "F", "96365", "." ]
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2905
[ "Consistent", "with", "these", "observations", ",", "coexpression", "of", "constitutively", "active", "forms", "of", "Raf-1", "and", "calcineurin", "synergistically", "induced", "kappaB", "-dependent", "reporter", "activity", ",", "suggesting", "a", "physiologically", "relevant", "functional", "interaction", "between", "the", "kinase", "and", "the", "phosphatase", "." ]
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2906
[ "Synergistic", "interactions", "between", "overlapping", "binding", "sites", "for", "the", "serum", "response", "factor", "and", "ELK-1", "proteins", "mediate", "both", "basal", "enhancement", "and", "phorbol", "ester", "responsiveness", "of", "primate", "cytomegalovirus", "major", "immediate-early", "promoters", "in", "monocyte", "and", "T-lymphocyte", "cell", "types", "." ]
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2907
[ "Cytomegalovirus", "(", "CMV", ")", "infection", "is", "nonpermissive", "or", "persistent", "in", "many", "lymphoid", "and", "myeloid", "cell", "types", "but", "can", "be", "activated", "in", "differentiated", "macrophages", "." ]
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2908
[ "We", "have", "shown", "elsewhere", "that", "both", "the", "major", "immediate-early", "gene", "(", "MIE", ")", "and", "lytic", "cycle", "infectious", "progeny", "virus", "expression", "can", "be", "induced", "in", "otherwise", "nonpermissive", "monocyte-like", "U-937", "cell", "cultures", "infected", "with", "either", "human", "CMV", "(", "HCMV", ")", "or", "simian", "CMV", "(", "SCMV", ")", "by", "treatment", "with", "the", "phorbol", "ester", "12-O-tetradecanoylphorbol-13-acetate", "(", "TPA", ")", "." ]
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2909
[ "Two", "multicopy", "basal", "enhancer", "motifs", "within", "the", "SCMV", "MIE", "enhancer", ",", "namely", ",", "11", "copies", "of", "the", "16-bp", "cyclic", "AMP", "response", "element", "(", "CRE", ")", "and", "3", "copies", "of", "novel", "17-bp", "serum", "response", "factor", "(", "SRF", ")", "binding", "sites", "referred", "to", "as", "the", "SNE", "(", "SRF/NFkappaB-like", "element", ")", ",", "as", "well", "as", "four", "classical", "NFkappaB", "sites", "within", "the", "HCMV", "version", ",", "contribute", "to", "TPA", "responsiveness", "in", "transient", "assays", "in", "monocyte", "and", "T-cell", "types", "." ]
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2910
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2911
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2912
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2913
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2914
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2915
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2916
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2917
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2918
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2919
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2920
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2921
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2922
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2923
[ "Some", "mice", "showed", "marked", "splenic", "lymphocyte", "depletion", "." ]
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2924
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2925
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2926
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2927
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2928
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2929
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2930
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2931
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2932
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2933
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2934
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2935
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2936
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2938
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2939
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2940
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2941
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2942
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2943
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2944
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