id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
2801 | [
"Octamer",
"independent",
"activation",
"of",
"transcription",
"from",
"the",
"kappa",
"immunoglobulin",
"germline",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
2802 | [
"Previous",
"analyses",
"of",
"immunoglobulin",
"V",
"region",
"promoters",
"has",
"led",
"to",
"the",
"discovery",
"of",
"a",
"common",
"octamer",
"motif",
"which",
"is",
"functionally",
"important",
"in",
"the",
"tissue-specific",
"and",
"developmentally",
"regulated",
"transcriptional",
"activation",
"of",
"immunoglobulin",
"genes",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
2803 | [
"The",
"germline",
"promoters",
"(",
"Ko",
")",
"located",
"upstream",
"of",
"the",
"J",
"region",
"gene",
"segments",
"of",
"the",
"kappa",
"locus",
"also",
"contain",
"an",
"octamer",
"motif",
"(",
"containing",
"a",
"single",
"base",
"pair",
"mutation",
"and",
"referred",
"to",
"as",
"the",
"variant",
"octamer",
")",
"which",
"has",
"been",
"shown",
"previously",
"to",
"bind",
"Oct-1",
"and",
"Oct-2",
"transcription",
"factors",
"in",
"vitro",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
10,
0,
0,
0
] |
2804 | [
"To",
"further",
"elucidate",
"the",
"role",
"of",
"this",
"variant",
"octamer",
"motif",
"in",
"the",
"regulation",
"of",
"germline",
"transcription",
"from",
"the",
"unrearranged",
"kappa",
"locus",
",",
"we",
"have",
"quantitated",
"the",
"relative",
"binding",
"affinity",
"of",
"Oct-1",
"and",
"Oct-2",
"for",
"the",
"variant",
"octamer",
"motif",
"and",
"determined",
"the",
"functional",
"role",
"of",
"this",
"octamer",
"motif",
"in",
"transcriptional",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2805 | [
"We",
"find",
"that",
",",
"although",
"the",
"variant",
"octamer",
"motif",
"binds",
"Oct-1",
"and",
"Oct-2",
"in",
"vitro",
"with",
"5-fold",
"lower",
"affinity",
"than",
"the",
"consensus",
"octamer",
"motif",
",",
"mutation",
"of",
"the",
"variant",
"octamer",
"motif",
"to",
"either",
"a",
"consensus",
"octamer",
"or",
"non-octamer",
"motif",
"has",
"no",
"effect",
"on",
"transcriptional",
"activation",
"from",
"the",
"germline",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2806 | [
"We",
"also",
"find",
"significant",
"differences",
"in",
"activation",
"of",
"germline",
"and",
"V",
"region",
"promoters",
"by",
"kappa",
"enhancers",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
0
] |
2807 | [
"Our",
"results",
"suggest",
"that",
"the",
"germline",
"promoters",
"and",
"V",
"region",
"promoters",
"differ",
"in",
"their",
"dependence",
"on",
"octamer",
"for",
"activation",
"and",
"respond",
"differently",
"to",
"enhancer",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2808 | [
"These",
"findings",
"have",
"important",
"implications",
"in",
"regulation",
"of",
"germline",
"transcription",
"as",
"well",
"as",
"concomitant",
"activation",
"of",
"the",
"V-J",
"recombination",
"of",
"the",
"kappa",
"light",
"chain",
"locus",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
2809 | [
"Generation",
"of",
"CD1+RelB+",
"dendritic",
"cells",
"and",
"tartrate-resistant",
"acid",
"phosphatase-positive",
"osteoclast-like",
"multinucleated",
"giant",
"cells",
"from",
"human",
"monocytes",
"."
] | [
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
7,
8,
8,
0,
7,
8,
0
] |
2810 | [
"We",
"previously",
"showed",
"that",
"granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
"and",
"macrophage",
"colony-stimulating",
"factor",
"(",
"M-CSF",
")",
"stimulate",
"the",
"differentiation",
"of",
"human",
"monocytes",
"into",
"two",
"phenotypically",
"distinct",
"types",
"of",
"macrophages",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
7,
0
] |
2811 | [
"However",
",",
"in",
"vivo",
",",
"not",
"only",
"CSF",
"but",
"also",
"many",
"other",
"cytokines",
"are",
"produced",
"under",
"various",
"conditions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2812 | [
"Those",
"cytokines",
"may",
"modulate",
"the",
"differentiation",
"of",
"monocytes",
"by",
"CSFs",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
0,
9,
0
] |
2813 | [
"In",
"the",
"present",
"study",
",",
"we",
"showed",
"that",
"CD14+",
"adherent",
"human",
"monocytes",
"can",
"differentiate",
"into",
"CD1+relB+",
"dendritic",
"cells",
"(",
"DC",
")",
"by",
"the",
"combination",
"of",
"GM-CSF",
"plus",
"interleukin-4",
"(",
"IL-4",
")",
"and",
"that",
"they",
"differentiate",
"into",
"tartrate-resistant",
"acid",
"phosphatase",
"(",
"TRAP",
")",
"-positive",
"osteoclast-like",
"multinucleated",
"giant",
"cells",
"(",
"MGC",
")",
"by",
"the",
"combination",
"of",
"M-CSF",
"plus",
"IL-4",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
7,
8,
0,
7,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
7,
8,
8,
0,
7,
0,
0,
0,
0,
0,
9,
0,
9,
0
] |
2814 | [
"However",
",",
"the",
"monocyte-derived",
"DC",
"were",
"not",
"terminally",
"differentiated",
"cells",
";",
"they",
"could",
"still",
"convert",
"to",
"macrophages",
"in",
"response",
"to",
"M-CSF",
"."
] | [
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
9,
0
] |
2815 | [
"Tumor",
"necrosis",
"factor-alpha",
"(",
"TNF-alpha",
")",
"stimulated",
"the",
"terminal",
"differentiation",
"of",
"the",
"DC",
"by",
"downregulating",
"the",
"expression",
"of",
"the",
"M-CSF",
"receptor",
",",
"cfms",
"mRNA",
",",
"and",
"aborting",
"the",
"potential",
"to",
"convert",
"to",
"macrophages",
"."
] | [
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
2816 | [
"In",
"contrast",
"to",
"IL-4",
",",
"interferon-gamma",
"(",
"IFN-gamma",
")",
"had",
"no",
"demonstrable",
"effect",
"on",
"the",
"differentiation",
"of",
"monocytes",
"."
] | [
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
2817 | [
"Rather",
",",
"IFN-gamma",
"antagonized",
"the",
"effect",
"of",
"IL-4",
"and",
"suppressed",
"the",
"DC",
"and",
"MGC",
"formation",
"induced",
"by",
"GM-CSF",
"+",
"IL-4",
"and",
"M-CSF",
"+",
"IL-4",
",",
"respectively",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
7,
0,
7,
0,
0,
0,
9,
0,
9,
0,
9,
0,
9,
0,
0,
0
] |
2818 | [
"Taken",
"together",
",",
"these",
"results",
"provide",
"a",
"new",
"aspect",
"to",
"our",
"knowledge",
"of",
"monocyte",
"differentiation",
"and",
"provide",
"evidence",
"that",
"human",
"monocytes",
"are",
"flexible",
"in",
"their",
"differentiation",
"potential",
"and",
"are",
"precursors",
"not",
"only",
"of",
"macrophages",
"but",
"also",
"of",
"CD1+relB+DC",
"and",
"TRAP-positive",
"MGC",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
7,
0
] |
2819 | [
"Such",
"a",
"diverse",
"pathway",
"of",
"monocyte",
"differentiation",
"may",
"constitute",
"one",
"of",
"the",
"basic",
"mechanisms",
"of",
"immune",
"regulation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2820 | [
"The",
"NF-kappa",
"B",
"inhibitor",
",",
"tepoxalin",
",",
"suppresses",
"surface",
"expression",
"of",
"the",
"cell",
"adhesion",
"molecules",
"CD62E",
",",
"CD11b/CD18",
"and",
"CD106",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0
] |
2821 | [
"Tepoxalin",
",",
"a",
"dual",
"enzyme",
"inhibitor",
"of",
"cyclooxygenase",
"and",
"5-lipoxygenase",
"has",
"been",
"shown",
"to",
"inhibit",
"T-cell",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
7,
0,
0
] |
2822 | [
"Its",
"immunosuppressive",
"property",
"is",
"distinct",
"from",
"cyclosporin",
"because",
"only",
"tepoxalin",
",",
"but",
"not",
"cyclosporin",
",",
"suppresses",
"NF-kappa",
"B",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
2823 | [
"Here",
"we",
"report",
"that",
"tepoxalin",
"selectively",
"inhibits",
"intercellular",
"adhesion",
"molecule-1",
"(",
"ICAM-1",
",",
"CD54",
")",
"/MAC-1",
"(",
"CD11b/CD18",
")",
"dependent",
"adhesion",
"of",
"polymorphonuclear",
"cells",
"to",
"IL-1",
"activated",
"human",
"umbilical",
"vein",
"endothelial",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
0,
9,
0,
7,
8,
8,
8,
8,
0
] |
2824 | [
"The",
"mechanism",
"of",
"inhibition",
"is",
"related",
"to",
"the",
"surface",
"expression",
"of",
"several",
"cell",
"adhesion",
"molecules",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2825 | [
"Flow",
"cytometry",
"analyses",
"on",
"cultured",
"cells",
"that",
"were",
"treated",
"with",
"tepoxalin",
"or",
"antisense",
"oligonucleotides",
"to",
"the",
"P65/p50",
"subunit",
"of",
"NF-kappa",
"B",
",",
"and",
"then",
"stimulated",
"with",
"PMA",
",",
"revealed",
"a",
"reduced",
"expression",
"of",
"CD11b/CD18",
"on",
"monocytic",
"HL60",
"cells",
",",
"and",
"endothelial",
"adhesion",
"molecule-1",
"(",
"CD62E",
")",
"and",
"vascular",
"adhesion",
"molecule-1",
"(",
"CD106",
")",
"on",
"human",
"umbilical",
"vein",
"endothelial",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
5,
6,
6,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0,
7,
8,
8,
8,
8,
0
] |
2826 | [
"Expression",
"of",
"other",
"adhesion",
"molecules",
"such",
"as",
"lymphocyte",
"function",
"associated-antigen-1",
"(",
"CD11a/CD18",
")",
"and",
"CD54",
"were",
"unaffected",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
0,
0,
0
] |
2827 | [
"Tepoxalin",
"also",
"inhibited",
"the",
"secretion",
"of",
"a",
"NF-kappa",
"B",
"regulated",
"chemokine",
",",
"IL-8",
",",
"a",
"known",
"inducer",
"of",
"CD11b/CD18",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0
] |
2828 | [
"Thus",
"the",
"suppression",
"of",
"CD11b/CD18",
"expression",
"by",
"tepoxalin",
"may",
"involve",
"IL-8",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0
] |
2829 | [
"Our",
"results",
"suggest",
"that",
"by",
"inhibiting",
"NF-kappa",
"B",
"activation",
",",
"surface",
"expression",
"of",
"several",
"adhesion",
"molecules",
"can",
"be",
"modulated",
"and",
"that",
"tepoxalin",
"may",
"be",
"useful",
"in",
"treating",
"selected",
"adhesion",
"mediated",
"events",
"such",
"as",
"leukocyte",
"migration",
"or",
"atherosclerotic",
"plaque",
"formation",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
2830 | [
"Characterization",
"of",
"a",
"CD43/leukosialin",
"-mediated",
"pathway",
"for",
"inducing",
"apoptosis",
"in",
"human",
"T-lymphoblastoid",
"cells",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
2831 | [
"The",
"monoclonal",
"antibody",
"(",
"mAb",
")",
"J393",
"induces",
"apoptosis",
"in",
"Jurkat",
"T-cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] |
2832 | [
"NH2",
"-terminal",
"amino",
"acid",
"sequence",
"analysis",
"identified",
"the",
"140-kDa",
"surface",
"antigen",
"for",
"mAb",
"J393",
"as",
"CD43/leukosialin",
",",
"the",
"major",
"sialoglycoprotein",
"of",
"leukocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
7,
0
] |
2833 | [
"While",
"Jurkat",
"cells",
"co-expressed",
"two",
"discrete",
"cell-surface",
"isoforms",
"of",
"CD43",
",",
"recognized",
"by",
"mAb",
"J393",
"and",
"mAb",
"G10-2",
",",
"respectively",
",",
"only",
"J393/CD43",
"signaled",
"apoptosis",
"."
] | [
0,
5,
6,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2834 | [
"J393/CD43",
"was",
"found",
"to",
"be",
"hyposialylated",
",",
"bearing",
"predominantly",
"O-linked",
"monosaccharide",
"glycans",
",",
"whereas",
"G10-2/CD43",
"bore",
"complex",
"sialylated",
"tetra-",
"and",
"hexasaccharide",
"chains",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2835 | [
"Treatment",
"with",
"soluble",
",",
"bivalent",
"mAb",
"J393",
"killed",
"25-50",
"%",
"of",
"the",
"cell",
"population",
",",
"while",
"concomitant",
"engagement",
"of",
"either",
"the",
"CD3.TcR",
"complex",
"or",
"the",
"integrins",
"CD18",
"and",
"CD29",
"significantly",
"potentiated",
"this",
"effect",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0
] |
2836 | [
"Treatment",
"of",
"Jurkat",
"cells",
"with",
"mAb",
"J393",
"induced",
"tyrosine",
"phosphorylation",
"of",
"specific",
"protein",
"substrates",
"that",
"underwent",
"hyperphosphorylation",
"upon",
"antigen",
"receptor",
"costimulation",
"."
] | [
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2837 | [
"Tyrosine",
"kinase",
"inhibition",
"by",
"herbimycin",
"A",
"diminished",
"J393/CD43",
"-mediated",
"apoptosis",
",",
"whereas",
"inhibition",
"of",
"phosphotyrosine",
"phosphatase",
"activity",
"by",
"bis",
"(",
"maltolato",
")",
"oxovanadium-IV",
"enhanced",
"cell",
"death",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2838 | [
"Signal",
"transduction",
"through",
"tyrosine",
"kinase",
"activation",
"may",
"lead",
"to",
"altered",
"gene",
"expression",
",",
"as",
"J393/",
"CD43",
"ligation",
"prompted",
"decreases",
"in",
"the",
"nuclear",
"localization",
"of",
"the",
"transcriptional",
"regulatory",
"protein",
"NF-kappaB",
"and",
"proteins",
"binding",
"the",
"interferon-inducible",
"regulatory",
"element",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
1,
2,
2,
0
] |
2839 | [
"Since",
"peripheral",
"blood",
"T-lymphocytes",
"express",
"cryptic",
"epitopes",
"for",
"mAb",
"J393",
",",
"these",
"findings",
"demonstrate",
"the",
"existence",
"of",
"a",
"tightly",
"regulated",
"CD43",
"-mediated",
"pathway",
"for",
"inducing",
"apoptosis",
"in",
"human",
"T-cell",
"lineages",
"."
] | [
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
2840 | [
"Sterol",
"dependent",
"LDL-receptor",
"gene",
"transcription",
"in",
"lymphocytes",
"from",
"normal",
"and",
"CML",
"patients",
"."
] | [
0,
0,
1,
2,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
2841 | [
"Sterol",
"regulatory",
"element",
"(",
"SRE",
")",
"has",
"been",
"recognized",
"to",
"regulate",
"various",
"key",
"genes",
"coding",
"for",
"especially",
"low",
"density",
"lipoprotein",
"(",
"LDL",
")",
"-receptor",
",",
"3-hydroxy-3-methylglutaryl",
"coenzyme",
"A",
"(",
"HMG-CoA",
")",
"reductase",
"and",
"HMG-CoA",
"synthase",
"known",
"to",
"play",
"a",
"crucial",
"role",
"in",
"the",
"cholesterol",
"feedback",
"mechanism",
"."
] | [
1,
2,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
9,
10,
10,
10,
10,
10,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2842 | [
"The",
"deranged",
"cholesterol",
"feedback",
"mechanism",
"has",
"been",
"widely",
"recognised",
"in",
"initiation",
"as",
"well",
"as",
"progression",
"of",
"various",
"types",
"of",
"cancers",
"including",
"chronic",
"myeloid",
"leukaemia",
"(",
"CML",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2843 | [
"Consequently",
",",
"the",
"present",
"study",
"was",
"addressed",
"to",
"understand",
"this",
"phenomenon",
"and",
"revealed",
"the",
"existence",
"of",
"a",
"unique",
"47",
"kDa",
"protein",
"factor",
"having",
"affinity",
"for",
"this",
"SRE",
"sequence",
"in",
"lymphocytes",
"from",
"normal",
"subjects",
"as",
"well",
"as",
"its",
"absence",
"in",
"lymphocytes",
"from",
"untreated",
"CML",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0
] |
2844 | [
"However",
",",
"this",
"factor",
"appeared",
"when",
"the",
"CML",
"patients",
"achieved",
"complete",
"haematological",
"remission",
"(",
"CHR",
")",
"through",
"alpha-interferon",
"therapy",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
2845 | [
"Further",
",",
"an",
"inverse",
"relationship",
"was",
"also",
"observed",
"between",
"sterol",
"modulated",
"LDL-receptor",
"gene",
"transcription",
"and",
"the",
"binding",
"affinity",
"of",
"this",
"47",
"kDa",
"factor",
"to",
"the",
"SRE",
"sequence",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
2846 | [
"Based",
"upon",
"these",
"results",
"we",
"propose",
"that",
"alpha-interferon",
"through",
"its",
"receptor",
"initiates",
"phosphatidic",
"acid",
"dependent",
"signalling",
"which",
"in",
"turn",
"regulates",
"the",
"affinity",
"of",
"47",
"kDa",
"sterol",
"regulatory",
"element",
"binding",
"factor",
"as",
"well",
"as",
"LDL-receptor",
"gene",
"transcription",
"in",
"lymphocytes",
"from",
"CML",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
0,
0,
1,
2,
0,
0,
7,
0,
0,
0,
0
] |
2847 | [
"Multiple",
"prolactin-responsive",
"elements",
"mediate",
"G1",
"and",
"S",
"phase",
"expression",
"of",
"the",
"interferon",
"regulatory",
"factor-1",
"gene",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
2848 | [
"The",
"interferon",
"regulatory",
"factor-1",
"(",
"IRF-1",
")",
"gene",
"is",
"both",
"an",
"immediate-early",
"G1",
"phase",
"gene",
"and",
"an",
"S",
"phase",
"gene",
"inducible",
"by",
"PRL",
"in",
"rat",
"Nb2",
"T",
"lymphocytes",
"."
] | [
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
5,
6,
6,
6,
0
] |
2849 | [
"To",
"understand",
"the",
"mechanism",
"by",
"which",
"PRL",
"regulates",
"the",
"biphasic",
"expression",
"of",
"IRF-1",
",",
"we",
"cloned",
"the",
"rat",
"IRF-1",
"gene",
"and",
"functionally",
"characterized",
"the",
"IRF-1",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
0
] |
2850 | [
"Upon",
"transfection",
"into",
"Nb2",
"T",
"cells",
",",
"1.7",
"kilobases",
"(",
"kb",
")",
"of",
"IRF-1",
"5'-flanking",
"DNA",
"linked",
"to",
"a",
"chloramphenicol",
"acetyl",
"transferase",
"(",
"CAT",
")",
"reporter",
"gene",
"mediated",
"a",
"30-fold",
"induction",
"of",
"CAT",
"enzyme",
"activity",
"in",
"response",
"to",
"24",
"h",
"of",
"PRL",
"stimulation",
"."
] | [
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
2851 | [
"Deletion",
"mutants",
"containing",
"1.3",
",",
"0.6",
",",
"and",
"0.2",
"kb",
"5'-flanking",
"DNA",
"were",
"incrementally",
"less",
"transcriptionally",
"active",
",",
"although",
"0.2",
"kb",
"still",
"mediated",
"a",
"12-fold",
"induction",
"by",
"PRL",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
2852 | [
"The",
"sequence",
"between",
"-1.7",
"and",
"-0.2",
"kb",
"linked",
"to",
"a",
"heterologous",
"thymidine",
"kinase",
"promoter",
"failed",
"to",
"respond",
"to",
"PRL",
"stimulation",
",",
"suggesting",
"that",
"the",
"activity",
"of",
"upstream",
"PRL",
"response",
"elements",
"may",
"require",
"an",
"interaction",
"with",
"promoter-proximal",
"elements",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
2853 | [
"By",
"assaying",
"CAT",
"enzyme",
"activity",
"across",
"a",
"24-h",
"PRL",
"induction",
"time",
"course",
",",
"we",
"were",
"able",
"to",
"assign",
"G1",
"vs.",
"S",
"phase",
"PRL",
"responses",
"of",
"the",
"IRF-1",
"gene",
"to",
"different",
"regions",
"of",
"the",
"IRF-1",
"5'-flanking",
"and",
"promoter",
"DNA",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0
] |
2854 | [
"The",
"0.2-kb",
"IRF-CAT",
"construct",
"was",
"induced",
"by",
"PRL",
"stimulation",
"during",
"the",
"G1",
"phase",
"of",
"the",
"cell",
"cycle",
"."
] | [
0,
0,
1,
2,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2855 | [
"In",
"contrast",
",",
"the",
"1.7-kb",
"IRF-",
"CAT",
"construct",
"was",
"inducible",
"by",
"PRL",
"during",
"both",
"G1",
"and",
"S",
"phase",
"of",
"the",
"cell",
"cycle",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2856 | [
"Hence",
",",
"the",
"PRL",
"-induced",
"biphasic",
"expression",
"of",
"the",
"IRF-1",
"gene",
"appears",
"to",
"be",
"controlled",
"by",
"separate",
"PRL-responsive",
"elements",
":",
"elements",
"in",
"the",
"first",
"0.2",
"kb",
"of",
"the",
"IRF-1",
"promoter",
"region",
"act",
"during",
"early",
"activation",
",",
"and",
"elements",
"between",
"0.2",
"and",
"1.7",
"kb",
"act",
"in",
"concert",
"with",
"the",
"proximal",
"0.2-kb",
"region",
"during",
"S",
"phase",
"progression",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2857 | [
"Regulation",
"of",
"the",
"BZLF1",
"promoter",
"of",
"Epstein-Barr",
"virus",
"by",
"second",
"messengers",
"in",
"anti-immunoglobulin-treated",
"B",
"cells",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
2858 | [
"Initiation",
"of",
"the",
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"lytic",
"cycle",
"is",
"dependent",
"on",
"the",
"transcription",
"of",
"the",
"BZLF1",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
2859 | [
"The",
"BZLF1",
"gene",
"promoter",
"(",
"Zp",
")",
"was",
"activated",
"by",
"crosslinking",
"of",
"cell",
"surface",
"immunoglobulin",
"(",
"Ig",
")",
"with",
"anti-Ig",
"antibody",
"in",
"B",
"cells",
",",
"even",
"in",
"the",
"absence",
"of",
"other",
"viral",
"genes",
"."
] | [
0,
1,
2,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
9,
10,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2860 | [
"We",
"identified",
"several",
"anti-Ig",
"response",
"elements",
"within",
"Zp",
",",
"which",
"were",
"originally",
"defined",
"as",
"12-O-tetradecanoylphorbol-13-acetate",
"(",
"TPA",
")",
"response",
"elements",
"(",
"ZI",
"repeats",
"and",
"ZII",
",",
"an",
"AP-1-like",
"domain",
")",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0
] |
2861 | [
"Since",
"anti-Ig",
"crosslinking",
"leads",
"to",
"activation",
"of",
"protein",
"kinase",
"C",
"(",
"PKC",
")",
"and",
"an",
"increase",
"in",
"intracellular",
"calcium",
"level",
",",
"Zp",
"was",
"tested",
"for",
"the",
"response",
"to",
"these",
"cellular",
"factors",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2862 | [
"Treatment",
"with",
"calcium",
"ionophore",
"A23187",
"increased",
"Zp",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
0
] |
2863 | [
"When",
"the",
"calcium",
"ionophore",
"was",
"used",
"in",
"conjunction",
"with",
"TPA",
",",
"a",
"PKC",
"activator",
",",
"the",
"Zp",
"induction",
"was",
"synergistically",
"enhanced",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
1,
0,
0,
0,
0,
0
] |
2864 | [
"1-",
"(",
"5-Isoquinolinyl",
"sulfonyl",
")",
"-2-methylpiperazine",
",",
"an",
"inhibitor",
"of",
"PKC",
",",
"inhibited",
"the",
"anti-Ig",
"inducibility",
"of",
"Zp",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
1,
0
] |
2865 | [
"Calmodulin",
"antagonists",
",",
"compound",
"R24571",
"and",
"trifluoperazine",
",",
"blocked",
"the",
"Zp",
"activation",
"with",
"anti-Ig",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
9,
0
] |
2866 | [
"These",
"findings",
"suggest",
"that",
"Zp",
"responds",
"directly",
"to",
"changes",
"in",
"the",
"activity",
"of",
"both",
"PKC",
"and",
"calcium/calmodulin-dependent",
"protein",
"kinase",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
10,
0
] |
2867 | [
"Requirement",
"of",
"tyrosine",
"kinase",
"activation",
"for",
"the",
"anti-Ig",
"-mediated",
"Zp",
"activation",
"was",
"also",
"demonstrated",
"through",
"the",
"use",
"of",
"the",
"tyrosine",
"kinase",
"inhibitor",
"herbimycin",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
9,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2868 | [
"These",
"cellular",
"gene",
"regulatory",
"molecules",
"induced",
"with",
"anti-Ig",
"may",
"cooperatively",
"play",
"an",
"important",
"part",
"in",
"achieving",
"efficient",
"EBV",
"activation",
"as",
"seen",
"with",
"anti-Ig",
"treatment",
"in",
"B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
7,
8,
0
] |
2869 | [
"The",
"SCL",
"protein",
"displays",
"cell-specific",
"heterogeneity",
"in",
"size",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0
] |
2870 | [
"SCL",
"protein",
"production",
"was",
"examined",
"in",
"a",
"variety",
"of",
"hemopoietic",
"cell",
"lines",
"by",
"immunoblotting",
"using",
"specific",
"polyclonal",
"antisera",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0
] |
2871 | [
"SCL",
"protein",
"was",
"detected",
"in",
"erythroid",
",",
"megakaryocyte",
",",
"mast",
"and",
"early",
"myeloid",
"cell",
"lines",
",",
"as",
"well",
"as",
"in",
"several",
"lymphoid",
"leukemia",
"cell",
"lines",
"which",
"are",
"known",
"to",
"harbor",
"SCL",
"gene",
"rearrangements",
"."
] | [
9,
10,
0,
0,
0,
7,
0,
7,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
2872 | [
"In",
"most",
"cell",
"lines",
",",
"proteins",
"of",
"molecular",
"weight",
"49",
"and",
"44",
"kDa",
"were",
"found",
",",
"however",
"two",
"myeloid",
"cell",
"lines",
"expressed",
"only",
"lower",
"molecular",
"weight",
"species",
"of",
"24",
"and",
"22",
"kDa",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2873 | [
"This",
"size",
"discrepancy",
"appeared",
"to",
"be",
"due",
"to",
"cell-specific",
"translational",
"regulation",
",",
"since",
"overexpression",
"of",
"a",
"retrovirally",
"transfected",
"SCL",
"gene",
"yielded",
"the",
"higher",
"molecular",
"weight",
"forms",
"in",
"most",
"cell",
"lines",
"(",
"GP+E-86",
",",
"AT2.5",
",",
"M1",
")",
"but",
"only",
"the",
"22",
"kDa",
"form",
"in",
"the",
"myeloid",
"cell",
"line",
",",
"WEHI-3B/D+",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
0
] |
2874 | [
"Overexpression",
"of",
"full-length",
"SCL",
"protein",
"in",
"the",
"lymphoid",
"cell",
"lines",
",",
"SupT1",
"and",
"Raji",
",",
"did",
"not",
"alter",
"cell",
"phenotype",
"and",
"there",
"was",
"no",
"evidence",
"for",
"autoregulation",
"of",
"SCL",
"transcription",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
5,
6,
6,
0,
5,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
2875 | [
"The",
"restricted",
"pattern",
"of",
"SCL",
"protein",
"synthesis",
"is",
"consistent",
"with",
"the",
"restricted",
"expression",
"of",
"SCL",
"mRNA",
"documented",
"previously",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0
] |
2876 | [
"In",
"addition",
",",
"the",
"present",
"results",
"indicate",
"that",
"SCL",
"protein",
"size",
"was",
"determined",
"by",
"regulation",
"of",
"translation",
"in",
"a",
"cell-specific",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2877 | [
"Description",
"and",
"functional",
"implications",
"of",
"a",
"novel",
"mutation",
"in",
"the",
"sex-determining",
"gene",
"SRY",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
2878 | [
"The",
"sex-determining",
"gene",
"SRY",
"was",
"screened",
"for",
"molecular",
"alteration",
"in",
"an",
"XY",
"sex-reversed",
"female",
"by",
"single-strand",
"conformation",
"polymorphism",
"(",
"SSCP",
")",
"technique",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2879 | [
"An",
"A-to-G",
"transition",
"was",
"detected",
"which",
"leads",
"to",
"an",
"exchange",
"of",
"a",
"tyrosine",
"by",
"a",
"cysteine",
"in",
"the",
"SRY",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
2880 | [
"The",
"affected",
"tyrosine",
"residue",
"located",
"at",
"the",
"C",
"terminus",
"of",
"the",
"DNA",
"binding",
"protein",
"is",
"evolutionarily",
"strongly",
"conserved",
"among",
"the",
"members",
"of",
"the",
"HMG",
"box",
"containing",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] |
2881 | [
"Using",
"gel",
"shift",
"assay",
"and",
"peptide",
"synthesis",
"such",
"a",
"mutation",
"is",
"shown",
"to",
"abolish",
"the",
"SRY",
"protein",
"DNA",
"binding",
"ability",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
2882 | [
"The",
"involvement",
"of",
"this",
"particular",
"amino",
"acid",
"in",
"the",
"binding",
"specificity",
"is",
"also",
"discussed",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2883 | [
"Induction",
"of",
"tyrosine",
"phosphorylation",
"and",
"T-cell",
"activation",
"by",
"vanadate",
"peroxide",
",",
"an",
"inhibitor",
"of",
"protein",
"tyrosine",
"phosphatases",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
2884 | [
"Rapid",
"tyrosine",
"phosphorylation",
"of",
"key",
"cellular",
"proteins",
"is",
"a",
"crucial",
"event",
"in",
"the",
"transduction",
"of",
"activation",
"signals",
"to",
"T-lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
2885 | [
"The",
"regulatory",
"role",
"of",
"protein",
"tyrosine",
"phosphatases",
"(",
"PTPases",
")",
"in",
"this",
"process",
"was",
"explored",
"by",
"studying",
"the",
"effects",
"of",
"a",
"powerful",
"PTPase",
"inhibitor",
",",
"vanadate",
"peroxide",
"(",
"pervanadate",
")",
",",
"on",
"the",
"activation",
"cascade",
"of",
"Jurkat",
"human",
"leukaemic",
"T-cells",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0
] |
2886 | [
"Pervanadate",
"induced",
"activation",
"of",
"the",
"tyrosine",
"kinases",
"lck",
"and",
"fyn",
"(",
"4-",
"and",
"3-fold",
"respectively",
")",
"and",
"a",
"dramatic",
"increase",
"in",
"tyrosine",
"phosphorylation",
"of",
"cellular",
"proteins",
",",
"notably",
"phospholipase",
"C",
"gamma",
"1",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] |
2887 | [
"After",
"this",
"event",
",",
"we",
"observed",
"a",
"rise",
"in",
"intracellular",
"Ca2+",
"concentration",
",",
"corresponding",
"to",
"an",
"influx",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2888 | [
"This",
"effect",
"required",
"surface",
"expression",
"of",
"the",
"CD45",
"PTPase",
"and",
"was",
"not",
"observed",
"in",
"CD45-deficient",
"variants",
"of",
"Jurkat",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] |
2889 | [
"In",
"the",
"CD45-negative",
"variant",
",",
"the",
"effect",
"of",
"pervanadate",
"on",
"tyrosine",
"phosphorylation",
"was",
"globally",
"decreased",
"and",
"some",
"phosphorylated",
"substrates",
"were",
"specifically",
"missing",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2890 | [
"Pervanadate",
"also",
"stimulated",
"transcription",
"of",
"the",
"c-fos",
"gene",
"and",
"accumulation",
"of",
"its",
"mRNA",
"as",
"well",
"as",
"several",
"other",
"hallmarks",
"of",
"T-lymphocyte",
"activation",
"such",
"as",
"surface",
"expression",
"of",
"the",
"CD69",
"antigen",
"and",
"the",
"interleukin",
"2",
"receptor",
"alpha-chain",
"(",
"CD25",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0
] |
2891 | [
"Pervanadate",
"synergized",
"with",
"signals",
"delivered",
"by",
"T-cell",
"antigen",
"receptor",
"engagement",
"or",
"by",
"a",
"phorbol",
"ester",
"to",
"induce",
"interleukin",
"2",
"production",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
2892 | [
"Pervanadate",
"activated",
"NF-kappa",
"B",
",",
"as",
"shown",
"by",
"an",
"increase",
"in",
"DNA-binding",
"activity",
"of",
"this",
"transcription",
"factor",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2893 | [
"We",
"thus",
"conclude",
"that",
"PTPases",
"play",
"a",
"crucial",
"role",
"in",
"the",
"negative",
"regulation",
"of",
"signal",
"transduction",
"culminating",
"in",
"T-lymphocyte",
"activation",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
2894 | [
"Moreover",
",",
"induction",
"of",
"tyrosine",
"phosphorylation",
"appears",
"sufficient",
"per",
"se",
"to",
"initiate",
"a",
"complete",
"activation",
"programme",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2895 | [
"Activation",
"of",
"nuclear",
"factor-kappaB",
"via",
"T",
"cell",
"receptor",
"requires",
"a",
"Raf",
"kinase",
"and",
"Ca2+",
"influx",
"."
] | [
0,
0,
9,
10,
0,
9,
10,
10,
0,
0,
9,
10,
0,
0,
0,
0
] |
2896 | [
"Functional",
"synergy",
"between",
"Raf",
"and",
"calcineurin",
"."
] | [
0,
0,
0,
9,
0,
9,
0
] |
2897 | [
"Signals",
"transduced",
"via",
"the",
"TCR",
"activate",
"the",
"transcription",
"factor",
"nuclear",
"factor-kappaB",
"(",
"NF-kappaB",
")",
",",
"which",
",",
"in",
"turn",
",",
"is",
"critical",
"to",
"the",
"transcriptional",
"induction",
"of",
"many",
"genes",
"important",
"for",
"the",
"proliferation",
"and",
"expression",
"of",
"a",
"differentiated",
"phenotype",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2898 | [
"Treatment",
"of",
"T",
"cells",
"with",
"the",
"protein",
"kinase",
"C",
"activator",
"PMA",
"in",
"combination",
"with",
"Ca2+",
"ionophores",
"mimics",
"this",
"process",
",",
"and",
"the",
"two",
"agents",
"are",
"often",
"substituted",
"for",
"TCR",
"stimulation",
",",
"bypassing",
"the",
"TCR",
"."
] | [
0,
0,
7,
8,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0
] |
2899 | [
"Here",
"we",
"identify",
"intracellular",
"signaling",
"components",
"involved",
"in",
"activation",
"of",
"NF-kappaB",
"following",
"TCR",
"stimulation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0
] |
2900 | [
"TCR",
"signaling",
"was",
"triggered",
"by",
"treating",
"Jurkat",
"T",
"cells",
"with",
"PHA",
"or",
"anti-CD3",
"Abs",
",",
"and",
"NF-kappaB",
"activation",
"was",
"monitored",
"by",
"electrophoretic",
"mobility",
"shift",
"assays",
"and/or",
"by",
"kappaB",
"-dependent",
"reporter",
"assays",
"."
] | [
9,
0,
0,
0,
0,
0,
5,
6,
6,
0,
9,
0,
9,
10,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.